Dietary lignans: physiology and potential for cardiovascular disease risk reduction
Identifieur interne : 000F64 ( Pmc/Checkpoint ); précédent : 000F63; suivant : 000F65Dietary lignans: physiology and potential for cardiovascular disease risk reduction
Auteurs : Julia Peterson [États-Unis] ; Johanna Dwyer [États-Unis] ; Herman Adlercreutz [Finlande] ; Augustin Scalbert ; Paul Jacques [États-Unis] ; Marjorie L. Mccullough [États-Unis]Source :
- Nutrition reviews [ 0029-6643 ] ; 2010.
Abstract
We reviewed lignan physiology and lignan intervention and epidemiological studies to determine if they decreased the risks of cardiovascular disease in Western populations. Five intervention studies using flaxseed lignan supplements indicated beneficial associations with C-reactive protein and a meta-analysis, which included these studies, also suggested a lowering effect on plasma total and low-density lipoprotein cholesterol. Three intervention studies using sesamin supplements indicated possible lipid and blood pressure lowering associations. Eleven human observational epidemiological studies examined dietary intakes of lignans in relation to cardiovascular disease risk. Five showed decreased risk with either increasing dietary intakes of lignans or increased levels of serum enterolactone (an enterolignan used as a biomarker of lignan intake), five studies were of borderline significance, and one was null. The associations between lignans and decreased risk of cardiovascular disease are promising, but are yet not well established, perhaps due to low lignan intakes in habitual Western diets. At the higher doses used in intervention studies, associations were more evident.
Url:
DOI: 10.1111/j.1753-4887.2010.00319.x
PubMed: 20883417
PubMed Central: 2951311
Affiliations:
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Five intervention studies using flaxseed lignan supplements indicated beneficial associations with C-reactive protein and a meta-analysis, which included these studies, also suggested a lowering effect on plasma total and low-density lipoprotein cholesterol. Three intervention studies using sesamin supplements indicated possible lipid and blood pressure lowering associations. Eleven human observational epidemiological studies examined dietary intakes of lignans in relation to cardiovascular disease risk. Five showed decreased risk with either increasing dietary intakes of lignans or increased levels of serum enterolactone (an enterolignan used as a biomarker of lignan intake), five studies were of borderline significance, and one was null. The associations between lignans and decreased risk of cardiovascular disease are promising, but are yet not well established, perhaps due to low lignan intakes in habitual Western diets. At the higher doses used in intervention studies, associations were more evident.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0376405</journal-id><journal-id journal-id-type="pubmed-jr-id">6181</journal-id><journal-id journal-id-type="nlm-ta">Nutr Rev</journal-id><journal-title>Nutrition reviews</journal-title><issn pub-type="ppub">0029-6643</issn><issn pub-type="epub">1753-4887</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20883417</article-id><article-id pub-id-type="pmc">2951311</article-id><article-id pub-id-type="doi">10.1111/j.1753-4887.2010.00319.x</article-id><article-id pub-id-type="manuscript">NIHMS227108</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Dietary lignans: physiology and potential for cardiovascular disease risk reduction</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Peterson</surname><given-names>Julia</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Dwyer</surname><given-names>Johanna</given-names></name><xref rid="A1" ref-type="aff">1</xref><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Adlercreutz</surname><given-names>Herman</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Scalbert</surname><given-names>Augustin</given-names></name><xref rid="A4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Jacques</surname><given-names>Paul</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>McCullough</surname><given-names>Marjorie L</given-names></name><xref rid="A5" ref-type="aff">5</xref></contrib></contrib-group><aff id="A1"><label>1</label>Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging and Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA</aff><aff id="A2"><label>2</label>School of Medicine, Tufts University and Frances Stern Nutrition Center, Tufts Medical Center, Boston, MA</aff><aff id="A3"><label>3</label>Institute for Preventive Medicine, Nutrition, and Cancer, Folkhälsan Research Center, Biomedicum, and Division of Clinical Chemistry, University of Helsinki, Finland</aff><aff id="A4"><label>4</label>Unité de Nutrition Humaine INRA Centre de Recherche de Clermont-Ferrand/Theix 63122 Saint-Genes-Champanelle France</aff><aff id="A5"><label>5</label>Epidemiology Research Program, American Cancer Society, Atlanta, GA</aff><author-notes><corresp id="FN1">Correspondence: Johanna Dwyer, DSc, RD, Director, Frances Stern Nutrition Center, Tufts Medical Center, 800 Washington St. Box 783, Boston, MA 02111, T (617) 636-5273, F (617) 636-8325, <email>jdwyer1@tuftsmedicalcenter.org</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>21</day><month>8</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>10</month><year>2011</year></pub-date><volume>68</volume><issue>10</issue><fpage>571</fpage><lpage>603</lpage><abstract><p id="P1">We reviewed lignan physiology and lignan intervention and epidemiological studies to determine if they decreased the risks of cardiovascular disease in Western populations. Five intervention studies using flaxseed lignan supplements indicated beneficial associations with C-reactive protein and a meta-analysis, which included these studies, also suggested a lowering effect on plasma total and low-density lipoprotein cholesterol. Three intervention studies using sesamin supplements indicated possible lipid and blood pressure lowering associations. Eleven human observational epidemiological studies examined dietary intakes of lignans in relation to cardiovascular disease risk. Five showed decreased risk with either increasing dietary intakes of lignans or increased levels of serum enterolactone (an enterolignan used as a biomarker of lignan intake), five studies were of borderline significance, and one was null. The associations between lignans and decreased risk of cardiovascular disease are promising, but are yet not well established, perhaps due to low lignan intakes in habitual Western diets. At the higher doses used in intervention studies, associations were more evident.</p></abstract><kwd-group><kwd>lignans</kwd><kwd>cardiovascular disease</kwd><kwd>review</kwd></kwd-group><contract-num rid="HL1">R21 HL087217-01A1
||HL</contract-num><contract-sponsor id="HL1">National Heart, Lung, and Blood Institute : NHLBI</contract-sponsor></article-meta></front></pmc><affiliations><list><country><li>Finlande</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Massachusetts</li><li>Uusimaa</li></region><settlement><li>Helsinki</li></settlement><orgName><li>Université d'Helsinki</li></orgName></list><tree><noCountry><name sortKey="Scalbert, Augustin" sort="Scalbert, Augustin" uniqKey="Scalbert A" first="Augustin" last="Scalbert">Augustin Scalbert</name></noCountry><country name="États-Unis"><region name="Massachusetts"><name sortKey="Peterson, Julia" sort="Peterson, Julia" uniqKey="Peterson J" first="Julia" last="Peterson">Julia Peterson</name></region><name sortKey="Dwyer, Johanna" sort="Dwyer, Johanna" uniqKey="Dwyer J" first="Johanna" last="Dwyer">Johanna Dwyer</name><name sortKey="Dwyer, Johanna" sort="Dwyer, Johanna" uniqKey="Dwyer J" first="Johanna" last="Dwyer">Johanna Dwyer</name><name sortKey="Jacques, Paul" sort="Jacques, Paul" uniqKey="Jacques P" first="Paul" last="Jacques">Paul Jacques</name><name sortKey="Mccullough, Marjorie L" sort="Mccullough, Marjorie L" uniqKey="Mccullough M" first="Marjorie L" last="Mccullough">Marjorie L. Mccullough</name></country><country name="Finlande"><region name="Uusimaa"><name sortKey="Adlercreutz, Herman" sort="Adlercreutz, Herman" uniqKey="Adlercreutz H" first="Herman" last="Adlercreutz">Herman Adlercreutz</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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