Differential Effects of Cream, Glucose, and Orange Juice on Inflammation, Endotoxin, and the Expression of Toll-Like Receptor-4 and Suppressor of Cytokine Signaling-3
Identifieur interne : 000F63 ( Pmc/Checkpoint ); précédent : 000F62; suivant : 000F64Differential Effects of Cream, Glucose, and Orange Juice on Inflammation, Endotoxin, and the Expression of Toll-Like Receptor-4 and Suppressor of Cytokine Signaling-3
Auteurs : Rupali Deopurkar ; Husam Ghanim ; Jay Friedman ; Sanaa Abuaysheh ; Chang Ling Sia ; Priya Mohanty ; Prabhakar Viswanathan ; Ajay Chaudhuri ; Paresh DandonaSource :
- Diabetes Care [ 0149-5992 ] ; 2010.
Abstract
We have recently shown that a high-fat high-carbohydrate (HFHC) meal induces an increase in plasma concentrations of endotoxin (lipopolysaccharide [LPS]) and the expression of Toll-like receptor-4 (TLR-4) and suppresser of cytokine signaling-3 (SOCS3) in mononuclear cells (MNCs) in addition to oxidative stress and cellular inflammation. Saturated fat and carbohydrates, components of the HFHC meal, known to induce oxidative stress and inflammation, also induce an increase in LPS, TLR-4, and SOCS3.
Fasting normal subjects were given 300-calorie drinks of either glucose, saturated fat as cream, orange juice, or only water to ingest. Blood samples were obtained at 0, 1, 3, and 5 h for analysis.
Indexes of inflammation including nuclear factor-κB (NF-κB) binding, and the expression of SOCS3, tumor necrosis factor-α (TNF-α), and interleukin (IL)-1β in MNCs, increased significantly after glucose and cream intake, but TLR-4 expression and plasma LPS concentrations increased only after cream intake. The intake of orange juice or water did not induce any change in any of the indexes measured.
Although both glucose and cream induce NF-κB binding and an increase in the expression of SOCS3, TNF-α, and IL-1β in MNCs, only cream caused an increase in LPS concentration and TLR-4 expression. Equicaloric amounts of orange juice or water did not induce a change in any of these indexes. These changes are relevant to the pathogenesis of atherosclerosis and insulin resistance.
Url:
DOI: 10.2337/dc09-1630
PubMed: 20067961
PubMed Central: 2858203
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:2858203Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differential Effects of Cream, Glucose, and Orange Juice on Inflammation, Endotoxin, and the Expression of Toll-Like Receptor-4 and Suppressor of Cytokine Signaling-3</title><author><name sortKey="Deopurkar, Rupali" sort="Deopurkar, Rupali" uniqKey="Deopurkar R" first="Rupali" last="Deopurkar">Rupali Deopurkar</name><affiliation><nlm:aff id="aff1">From the Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York.</nlm:aff><wicri:noCountry code="subfield">New York.</wicri:noCountry></affiliation></author><author><name sortKey="Ghanim, Husam" sort="Ghanim, Husam" uniqKey="Ghanim H" first="Husam" last="Ghanim">Husam Ghanim</name><affiliation><nlm:aff id="aff1">From the Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York.</nlm:aff><wicri:noCountry code="subfield">New York.</wicri:noCountry></affiliation></author><author><name sortKey="Friedman, Jay" sort="Friedman, Jay" uniqKey="Friedman J" first="Jay" last="Friedman">Jay Friedman</name><affiliation><nlm:aff id="aff1">From the Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York.</nlm:aff><wicri:noCountry code="subfield">New York.</wicri:noCountry></affiliation></author><author><name sortKey="Abuaysheh, Sanaa" sort="Abuaysheh, Sanaa" uniqKey="Abuaysheh S" first="Sanaa" last="Abuaysheh">Sanaa Abuaysheh</name><affiliation><nlm:aff id="aff1">From the Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York.</nlm:aff><wicri:noCountry code="subfield">New York.</wicri:noCountry></affiliation></author><author><name sortKey="Sia, Chang Ling" sort="Sia, Chang Ling" uniqKey="Sia C" first="Chang Ling" last="Sia">Chang Ling Sia</name><affiliation><nlm:aff id="aff1">From the Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York.</nlm:aff><wicri:noCountry code="subfield">New York.</wicri:noCountry></affiliation></author><author><name sortKey="Mohanty, Priya" sort="Mohanty, Priya" uniqKey="Mohanty P" first="Priya" last="Mohanty">Priya Mohanty</name><affiliation><nlm:aff id="aff1">From the Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York.</nlm:aff><wicri:noCountry code="subfield">New York.</wicri:noCountry></affiliation></author><author><name sortKey="Viswanathan, Prabhakar" sort="Viswanathan, Prabhakar" uniqKey="Viswanathan P" first="Prabhakar" last="Viswanathan">Prabhakar Viswanathan</name><affiliation><nlm:aff id="aff1">From the Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York.</nlm:aff><wicri:noCountry code="subfield">New York.</wicri:noCountry></affiliation></author><author><name sortKey="Chaudhuri, Ajay" sort="Chaudhuri, Ajay" uniqKey="Chaudhuri A" first="Ajay" last="Chaudhuri">Ajay Chaudhuri</name><affiliation><nlm:aff id="aff1">From the Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York.</nlm:aff><wicri:noCountry code="subfield">New York.</wicri:noCountry></affiliation></author><author><name sortKey="Dandona, Paresh" sort="Dandona, Paresh" uniqKey="Dandona P" first="Paresh" last="Dandona">Paresh Dandona</name><affiliation><nlm:aff id="aff1">From the Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York.</nlm:aff><wicri:noCountry code="subfield">New York.</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20067961</idno><idno type="pmc">2858203</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858203</idno><idno type="RBID">PMC:2858203</idno><idno type="doi">10.2337/dc09-1630</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000E81</idno><idno type="wicri:Area/Pmc/Curation">000E80</idno><idno type="wicri:Area/Pmc/Checkpoint">000F63</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Differential Effects of Cream, Glucose, and Orange Juice on Inflammation, Endotoxin, and the Expression of Toll-Like Receptor-4 and Suppressor of Cytokine Signaling-3</title><author><name sortKey="Deopurkar, Rupali" sort="Deopurkar, Rupali" uniqKey="Deopurkar R" first="Rupali" last="Deopurkar">Rupali Deopurkar</name><affiliation><nlm:aff id="aff1">From the Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York.</nlm:aff><wicri:noCountry code="subfield">New York.</wicri:noCountry></affiliation></author><author><name sortKey="Ghanim, Husam" sort="Ghanim, Husam" uniqKey="Ghanim H" first="Husam" last="Ghanim">Husam Ghanim</name><affiliation><nlm:aff id="aff1">From the Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York.</nlm:aff><wicri:noCountry code="subfield">New York.</wicri:noCountry></affiliation></author><author><name sortKey="Friedman, Jay" sort="Friedman, Jay" uniqKey="Friedman J" first="Jay" last="Friedman">Jay Friedman</name><affiliation><nlm:aff id="aff1">From the Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York.</nlm:aff><wicri:noCountry code="subfield">New York.</wicri:noCountry></affiliation></author><author><name sortKey="Abuaysheh, Sanaa" sort="Abuaysheh, Sanaa" uniqKey="Abuaysheh S" first="Sanaa" last="Abuaysheh">Sanaa Abuaysheh</name><affiliation><nlm:aff id="aff1">From the Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York.</nlm:aff><wicri:noCountry code="subfield">New York.</wicri:noCountry></affiliation></author><author><name sortKey="Sia, Chang Ling" sort="Sia, Chang Ling" uniqKey="Sia C" first="Chang Ling" last="Sia">Chang Ling Sia</name><affiliation><nlm:aff id="aff1">From the Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York.</nlm:aff><wicri:noCountry code="subfield">New York.</wicri:noCountry></affiliation></author><author><name sortKey="Mohanty, Priya" sort="Mohanty, Priya" uniqKey="Mohanty P" first="Priya" last="Mohanty">Priya Mohanty</name><affiliation><nlm:aff id="aff1">From the Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York.</nlm:aff><wicri:noCountry code="subfield">New York.</wicri:noCountry></affiliation></author><author><name sortKey="Viswanathan, Prabhakar" sort="Viswanathan, Prabhakar" uniqKey="Viswanathan P" first="Prabhakar" last="Viswanathan">Prabhakar Viswanathan</name><affiliation><nlm:aff id="aff1">From the Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York.</nlm:aff><wicri:noCountry code="subfield">New York.</wicri:noCountry></affiliation></author><author><name sortKey="Chaudhuri, Ajay" sort="Chaudhuri, Ajay" uniqKey="Chaudhuri A" first="Ajay" last="Chaudhuri">Ajay Chaudhuri</name><affiliation><nlm:aff id="aff1">From the Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York.</nlm:aff><wicri:noCountry code="subfield">New York.</wicri:noCountry></affiliation></author><author><name sortKey="Dandona, Paresh" sort="Dandona, Paresh" uniqKey="Dandona P" first="Paresh" last="Dandona">Paresh Dandona</name><affiliation><nlm:aff id="aff1">From the Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York.</nlm:aff><wicri:noCountry code="subfield">New York.</wicri:noCountry></affiliation></author></analytic><series><title level="j">Diabetes Care</title><idno type="ISSN">0149-5992</idno><idno type="eISSN">1935-5548</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>OBJECTIVE</title><p>We have recently shown that a high-fat high-carbohydrate (HFHC) meal induces an increase in plasma concentrations of endotoxin (lipopolysaccharide [LPS]) and the expression of Toll-like receptor-4 (TLR-4) and suppresser of cytokine signaling-3 (SOCS3) in mononuclear cells (MNCs) in addition to oxidative stress and cellular inflammation. Saturated fat and carbohydrates, components of the HFHC meal, known to induce oxidative stress and inflammation, also induce an increase in LPS, TLR-4, and SOCS3.</p></sec><sec><title>RESEARCH DESIGN AND METHODS</title><p>Fasting normal subjects were given 300-calorie drinks of either glucose, saturated fat as cream, orange juice, or only water to ingest. Blood samples were obtained at 0, 1, 3, and 5 h for analysis.</p></sec><sec><title>RESULTS</title><p>Indexes of inflammation including nuclear factor-κB (NF-κB) binding, and the expression of SOCS3, tumor necrosis factor-α (TNF-α), and interleukin (IL)-1β in MNCs, increased significantly after glucose and cream intake, but TLR-4 expression and plasma LPS concentrations increased only after cream intake. The intake of orange juice or water did not induce any change in any of the indexes measured.</p></sec><sec><title>CONCLUSIONS</title><p>Although both glucose and cream induce NF-κB binding and an increase in the expression of SOCS3, TNF-α, and IL-1β in MNCs, only cream caused an increase in LPS concentration and TLR-4 expression. Equicaloric amounts of orange juice or water did not induce a change in any of these indexes. These changes are relevant to the pathogenesis of atherosclerosis and insulin resistance.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ghanim, H" uniqKey="Ghanim H">H Ghanim</name></author><author><name sortKey="Abuaysheh, S" uniqKey="Abuaysheh S">S Abuaysheh</name></author><author><name sortKey="Sia, Cl" uniqKey="Sia C">CL Sia</name></author><author><name sortKey="Korzeniewski, K" uniqKey="Korzeniewski K">K Korzeniewski</name></author><author><name sortKey="Chaudhuri, A" uniqKey="Chaudhuri A">A Chaudhuri</name></author><author><name sortKey="Fernandez Real, Jm" uniqKey="Fernandez Real J">JM Fernandez-Real</name></author><author><name sortKey="Dandona, P" uniqKey="Dandona P">P Dandona</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rui, L" uniqKey="Rui L">L Rui</name></author><author><name sortKey="Yuan, M" uniqKey="Yuan M">M Yuan</name></author><author><name sortKey="Frantz, D" uniqKey="Frantz D">D Frantz</name></author><author><name sortKey="Shoelson, S" uniqKey="Shoelson S">S Shoelson</name></author><author><name sortKey="White, Mf" uniqKey="White M">MF White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Senn, Jj" uniqKey="Senn J">JJ Senn</name></author><author><name sortKey="Klover, Pj" uniqKey="Klover P">PJ Klover</name></author><author><name sortKey="Nowak, Ia" uniqKey="Nowak I">IA Nowak</name></author><author><name sortKey="Zimmers, Ta" uniqKey="Zimmers T">TA Zimmers</name></author><author><name sortKey="Koniaris, Lg" uniqKey="Koniaris L">LG Koniaris</name></author><author><name sortKey="Furlanetto, Rw" uniqKey="Furlanetto R">RW Furlanetto</name></author><author><name sortKey="Mooney, Ra" uniqKey="Mooney R">RA Mooney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Emanuelli, B" uniqKey="Emanuelli B">B Emanuelli</name></author><author><name sortKey="Peraldi, P" uniqKey="Peraldi P">P Peraldi</name></author><author><name sortKey="Filloux, C" uniqKey="Filloux C">C Filloux</name></author><author><name sortKey="Chavey, C" uniqKey="Chavey C">C Chavey</name></author><author><name sortKey="Freidinger, K" uniqKey="Freidinger K">K Freidinger</name></author><author><name sortKey="Hilton, Dj" uniqKey="Hilton D">DJ Hilton</name></author><author><name sortKey="Hotamisligil, Gs" uniqKey="Hotamisligil G">GS Hotamisligil</name></author><author><name sortKey="Van Obberghen, E" uniqKey="Van Obberghen E">E Van Obberghen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bj Rbaek, C" uniqKey="Bj Rbaek C">C Bjørbaek</name></author><author><name sortKey="El Haschimi, K" uniqKey="El Haschimi K">K El-Haschimi</name></author><author><name sortKey="Frantz, Jd" uniqKey="Frantz J">JD Frantz</name></author><author><name sortKey="Flier, Js" uniqKey="Flier J">JS Flier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghanim, H" uniqKey="Ghanim H">H Ghanim</name></author><author><name sortKey="Aljada, A" uniqKey="Aljada A">A Aljada</name></author><author><name sortKey="Daoud, N" uniqKey="Daoud N">N Daoud</name></author><author><name sortKey="Deopurkar, R" uniqKey="Deopurkar R">R Deopurkar</name></author><author><name sortKey="Chaudhuri, A" uniqKey="Chaudhuri A">A Chaudhuri</name></author><author><name sortKey="Dandona, P" uniqKey="Dandona P">P Dandona</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bistrian, Br" uniqKey="Bistrian B">BR Bistrian</name></author><author><name sortKey="Khaodhiar, L" uniqKey="Khaodhiar L">L Khaodhiar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghanim, H" uniqKey="Ghanim H">H Ghanim</name></author><author><name sortKey="Aljada, A" uniqKey="Aljada A">A Aljada</name></author><author><name sortKey="Hofmeyer, D" uniqKey="Hofmeyer D">D Hofmeyer</name></author><author><name sortKey="Syed, T" uniqKey="Syed T">T Syed</name></author><author><name sortKey="Mohanty, P" uniqKey="Mohanty P">P Mohanty</name></author><author><name sortKey="Dandona, P" uniqKey="Dandona P">P Dandona</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Emanuelli, B" uniqKey="Emanuelli B">B Emanuelli</name></author><author><name sortKey="Glondu, M" uniqKey="Glondu M">M Glondu</name></author><author><name sortKey="Filloux, C" uniqKey="Filloux C">C Filloux</name></author><author><name sortKey="Peraldi, P" uniqKey="Peraldi P">P Peraldi</name></author><author><name sortKey="Van Obberghen, E" uniqKey="Van Obberghen E">E Van Obberghen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohanty, P" uniqKey="Mohanty P">P Mohanty</name></author><author><name sortKey="Hamouda, W" uniqKey="Hamouda W">W Hamouda</name></author><author><name sortKey="Garg, R" uniqKey="Garg R">R Garg</name></author><author><name sortKey="Aljada, A" uniqKey="Aljada A">A Aljada</name></author><author><name sortKey="Ghanim, H" uniqKey="Ghanim H">H Ghanim</name></author><author><name sortKey="Dandona, P" uniqKey="Dandona P">P Dandona</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohanty, P" uniqKey="Mohanty P">P Mohanty</name></author><author><name sortKey="Ghanim, H" uniqKey="Ghanim H">H Ghanim</name></author><author><name sortKey="Hamouda, W" uniqKey="Hamouda W">W Hamouda</name></author><author><name sortKey="Aljada, A" uniqKey="Aljada A">A Aljada</name></author><author><name sortKey="Garg, R" uniqKey="Garg R">R Garg</name></author><author><name sortKey="Dandona, P" uniqKey="Dandona P">P Dandona</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aljada, A" uniqKey="Aljada A">A Aljada</name></author><author><name sortKey="Mohanty, P" uniqKey="Mohanty P">P Mohanty</name></author><author><name sortKey="Ghanim, H" uniqKey="Ghanim H">H Ghanim</name></author><author><name sortKey="Abdo, T" uniqKey="Abdo T">T Abdo</name></author><author><name sortKey="Tripathy, D" uniqKey="Tripathy D">D Tripathy</name></author><author><name sortKey="Chaudhuri, A" uniqKey="Chaudhuri A">A Chaudhuri</name></author><author><name sortKey="Dandona, P" uniqKey="Dandona P">P Dandona</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aljada, A" uniqKey="Aljada A">A Aljada</name></author><author><name sortKey="Friedman, J" uniqKey="Friedman J">J Friedman</name></author><author><name sortKey="Ghanim, H" uniqKey="Ghanim H">H Ghanim</name></author><author><name sortKey="Mohanty, P" uniqKey="Mohanty P">P Mohanty</name></author><author><name sortKey="Hofmeyer, D" uniqKey="Hofmeyer D">D Hofmeyer</name></author><author><name sortKey="Chaudhuri, A" uniqKey="Chaudhuri A">A Chaudhuri</name></author><author><name sortKey="Dandona, P" uniqKey="Dandona P">P Dandona</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shi, H" uniqKey="Shi H">H Shi</name></author><author><name sortKey="Kokoeva, Mv" uniqKey="Kokoeva M">MV Kokoeva</name></author><author><name sortKey="Inouye, K" uniqKey="Inouye K">K Inouye</name></author><author><name sortKey="Tzameli, I" uniqKey="Tzameli I">I Tzameli</name></author><author><name sortKey="Yin, H" uniqKey="Yin H">H Yin</name></author><author><name sortKey="Flier, Js" uniqKey="Flier J">JS Flier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsukumo, Dm" uniqKey="Tsukumo D">DM Tsukumo</name></author><author><name sortKey="Carvalho Filho, Ma" uniqKey="Carvalho Filho M">MA Carvalho-Filho</name></author><author><name sortKey="Carvalheira, Jb" uniqKey="Carvalheira J">JB Carvalheira</name></author><author><name sortKey="Prada, Po" uniqKey="Prada P">PO Prada</name></author><author><name sortKey="Hirabara, Sm" uniqKey="Hirabara S">SM Hirabara</name></author><author><name sortKey="Schenka, Aa" uniqKey="Schenka A">AA Schenka</name></author><author><name sortKey="Araujo, Ep" uniqKey="Araujo E">EP Araújo</name></author><author><name sortKey="Vassallo, J" uniqKey="Vassallo J">J Vassallo</name></author><author><name sortKey="Curi, R" uniqKey="Curi R">R Curi</name></author><author><name sortKey="Velloso, La" uniqKey="Velloso L">LA Velloso</name></author><author><name sortKey="Saad, Mj" uniqKey="Saad M">MJ Saad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Creely, Sj" uniqKey="Creely S">SJ Creely</name></author><author><name sortKey="Mcternan, Pg" uniqKey="Mcternan P">PG McTernan</name></author><author><name sortKey="Kusminski, Cm" uniqKey="Kusminski C">CM Kusminski</name></author><author><name sortKey="Fisher, M" uniqKey="Fisher M">M Fisher</name></author><author><name sortKey="Da Silva, Nf" uniqKey="Da Silva N">NF Da Silva</name></author><author><name sortKey="Khanolkar, M" uniqKey="Khanolkar M">M Khanolkar</name></author><author><name sortKey="Evans, M" uniqKey="Evans M">M Evans</name></author><author><name sortKey="Harte, Al" uniqKey="Harte A">AL Harte</name></author><author><name sortKey="Kumar, S" uniqKey="Kumar S">S Kumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghanim, H" uniqKey="Ghanim H">H Ghanim</name></author><author><name sortKey="Mohanty, P" uniqKey="Mohanty P">P Mohanty</name></author><author><name sortKey="Pathak, R" uniqKey="Pathak R">R Pathak</name></author><author><name sortKey="Chaudhuri, A" uniqKey="Chaudhuri A">A Chaudhuri</name></author><author><name sortKey="Sia, Cl" uniqKey="Sia C">CL Sia</name></author><author><name sortKey="Dandona, P" uniqKey="Dandona P">P Dandona</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yeh, Cc" uniqKey="Yeh C">CC Yeh</name></author><author><name sortKey="Kao, Sj" uniqKey="Kao S">SJ Kao</name></author><author><name sortKey="Lin, Cc" uniqKey="Lin C">CC Lin</name></author><author><name sortKey="Wang, Sd" uniqKey="Wang S">SD Wang</name></author><author><name sortKey="Liu, Cj" uniqKey="Liu C">CJ Liu</name></author><author><name sortKey="Kao, St" uniqKey="Kao S">ST Kao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bodet, C" uniqKey="Bodet C">C Bodet</name></author><author><name sortKey="La, Vd" uniqKey="La V">VD La</name></author><author><name sortKey="Epifano, F" uniqKey="Epifano F">F Epifano</name></author><author><name sortKey="Grenier, D" uniqKey="Grenier D">D Grenier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghanim, H" uniqKey="Ghanim H">H Ghanim</name></author><author><name sortKey="Sia, Cl" uniqKey="Sia C">CL Sia</name></author><author><name sortKey="Upadhyay, M" uniqKey="Upadhyay M">M Upadhyay</name></author><author><name sortKey="Korzeniewski, K" uniqKey="Korzeniewski K">K Korzeniewski</name></author><author><name sortKey="Viswanathan, P" uniqKey="Viswanathan P">P Viswanathan</name></author><author><name sortKey="Abuaysheh, S" uniqKey="Abuaysheh S">S Abuaysheh</name></author><author><name sortKey="Mohanty, P" uniqKey="Mohanty P">P Mohanty</name></author><author><name sortKey="Dandona, P" uniqKey="Dandona P">P Dandona</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Howard, Jk" uniqKey="Howard J">JK Howard</name></author><author><name sortKey="Cave, Bj" uniqKey="Cave B">BJ Cave</name></author><author><name sortKey="Oksanen, Lj" uniqKey="Oksanen L">LJ Oksanen</name></author><author><name sortKey="Tzameli, I" uniqKey="Tzameli I">I Tzameli</name></author><author><name sortKey="Bj Rbaek, C" uniqKey="Bj Rbaek C">C Bjørbaek</name></author><author><name sortKey="Flier, Js" uniqKey="Flier J">JS Flier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Banks, As" uniqKey="Banks A">AS Banks</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Mckeag, L" uniqKey="Mckeag L">L McKeag</name></author><author><name sortKey="Hribal, Ml" uniqKey="Hribal M">ML Hribal</name></author><author><name sortKey="Kashiwada, M" uniqKey="Kashiwada M">M Kashiwada</name></author><author><name sortKey="Accili, D" uniqKey="Accili D">D Accili</name></author><author><name sortKey="Rothman, Pb" uniqKey="Rothman P">PB Rothman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Emanuelli, B" uniqKey="Emanuelli B">B Emanuelli</name></author><author><name sortKey="Peraldi, P" uniqKey="Peraldi P">P Peraldi</name></author><author><name sortKey="Filloux, C" uniqKey="Filloux C">C Filloux</name></author><author><name sortKey="Sawka Verhelle, D" uniqKey="Sawka Verhelle D">D Sawka-Verhelle</name></author><author><name sortKey="Hilton, D" uniqKey="Hilton D">D Hilton</name></author><author><name sortKey="Van Obberghen, E" uniqKey="Van Obberghen E">E Van Obberghen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gautier, El" uniqKey="Gautier E">EL Gautier</name></author><author><name sortKey="Jakubzick, C" uniqKey="Jakubzick C">C Jakubzick</name></author><author><name sortKey="Randolph, Gj" uniqKey="Randolph G">GJ Randolph</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dasu, Mr" uniqKey="Dasu M">MR Dasu</name></author><author><name sortKey="Devaraj, S" uniqKey="Devaraj S">S Devaraj</name></author><author><name sortKey="Zhao, L" uniqKey="Zhao L">L Zhao</name></author><author><name sortKey="Hwang, Dh" uniqKey="Hwang D">DH Hwang</name></author><author><name sortKey="Jialal, I" uniqKey="Jialal I">I Jialal</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Diabetes Care</journal-id><journal-id journal-id-type="hwp">diacare</journal-id><journal-id journal-id-type="pmc">dcare</journal-id><journal-id journal-id-type="publisher-id">Diabetes Care</journal-id><journal-title-group><journal-title>Diabetes Care</journal-title></journal-title-group><issn pub-type="ppub">0149-5992</issn><issn pub-type="epub">1935-5548</issn><publisher><publisher-name>American Diabetes Association</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20067961</article-id><article-id pub-id-type="pmc">2858203</article-id><article-id pub-id-type="publisher-id">1630</article-id><article-id pub-id-type="doi">10.2337/dc09-1630</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Research</subject><subj-group><subject>Clinical Care/Education/Nutrition/Psychosocial Research</subject></subj-group></subj-group></article-categories><title-group><article-title>Differential Effects of Cream, Glucose, and Orange Juice on Inflammation, Endotoxin, and the Expression of Toll-Like Receptor-4 and Suppressor of Cytokine Signaling-3</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Deopurkar</surname><given-names>Rupali</given-names></name><degrees>PHD</degrees><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Ghanim</surname><given-names>Husam</given-names></name><degrees>PHD</degrees><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Friedman</surname><given-names>Jay</given-names></name><degrees>PHD</degrees><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Abuaysheh</surname><given-names>Sanaa</given-names></name><degrees>BSC</degrees><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Sia</surname><given-names>Chang Ling</given-names></name><degrees>BSC</degrees><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Mohanty</surname><given-names>Priya</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Viswanathan</surname><given-names>Prabhakar</given-names></name><degrees>PHD</degrees><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Chaudhuri</surname><given-names>Ajay</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Dandona</surname><given-names>Paresh</given-names></name><degrees>MD, PHD</degrees><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><aff id="aff1">From the Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York.</aff></contrib-group><author-notes><corresp id="cor1">Corresponding author: Paresh Dandona, <email>pdandona@kaleidahealth.org</email>.</corresp><fn fn-type="equal"><p>R.D., H.G., and J.F. contributed equally to this study.</p></fn></author-notes><pub-date pub-type="ppub"><month>5</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>12</day><month>1</month><year>2010</year></pub-date><volume>33</volume><issue>5</issue><fpage>991</fpage><lpage>997</lpage><history><date date-type="received"><day>2</day><month>9</month><year>2009</year></date><date date-type="accepted"><day>5</day><month>1</month><year>2010</year></date></history><permissions><copyright-statement>© 2010 by the American Diabetes Association.</copyright-statement><license license-type="creative-commons"><license-p>Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/3.0/">http://creativecommons.org/licenses/by-nc-nd/3.0/</ext-link> for details.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zdc00510000991.pdf"></self-uri><abstract><sec><title>OBJECTIVE</title><p>We have recently shown that a high-fat high-carbohydrate (HFHC) meal induces an increase in plasma concentrations of endotoxin (lipopolysaccharide [LPS]) and the expression of Toll-like receptor-4 (TLR-4) and suppresser of cytokine signaling-3 (SOCS3) in mononuclear cells (MNCs) in addition to oxidative stress and cellular inflammation. Saturated fat and carbohydrates, components of the HFHC meal, known to induce oxidative stress and inflammation, also induce an increase in LPS, TLR-4, and SOCS3.</p></sec><sec><title>RESEARCH DESIGN AND METHODS</title><p>Fasting normal subjects were given 300-calorie drinks of either glucose, saturated fat as cream, orange juice, or only water to ingest. Blood samples were obtained at 0, 1, 3, and 5 h for analysis.</p></sec><sec><title>RESULTS</title><p>Indexes of inflammation including nuclear factor-κB (NF-κB) binding, and the expression of SOCS3, tumor necrosis factor-α (TNF-α), and interleukin (IL)-1β in MNCs, increased significantly after glucose and cream intake, but TLR-4 expression and plasma LPS concentrations increased only after cream intake. The intake of orange juice or water did not induce any change in any of the indexes measured.</p></sec><sec><title>CONCLUSIONS</title><p>Although both glucose and cream induce NF-κB binding and an increase in the expression of SOCS3, TNF-α, and IL-1β in MNCs, only cream caused an increase in LPS concentration and TLR-4 expression. Equicaloric amounts of orange juice or water did not induce a change in any of these indexes. These changes are relevant to the pathogenesis of atherosclerosis and insulin resistance.</p></sec></abstract><funding-group><award-group><funding-source id="CS100">National Institutes of Health</funding-source><award-id rid="CS100">R01-DK-069805</award-id><award-id rid="CS100">R01-DK-075877</award-id></award-group></funding-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Abuaysheh, Sanaa" sort="Abuaysheh, Sanaa" uniqKey="Abuaysheh S" first="Sanaa" last="Abuaysheh">Sanaa Abuaysheh</name><name sortKey="Chaudhuri, Ajay" sort="Chaudhuri, Ajay" uniqKey="Chaudhuri A" first="Ajay" last="Chaudhuri">Ajay Chaudhuri</name><name sortKey="Dandona, Paresh" sort="Dandona, Paresh" uniqKey="Dandona P" first="Paresh" last="Dandona">Paresh Dandona</name><name sortKey="Deopurkar, Rupali" sort="Deopurkar, Rupali" uniqKey="Deopurkar R" first="Rupali" last="Deopurkar">Rupali Deopurkar</name><name sortKey="Friedman, Jay" sort="Friedman, Jay" uniqKey="Friedman J" first="Jay" last="Friedman">Jay Friedman</name><name sortKey="Ghanim, Husam" sort="Ghanim, Husam" uniqKey="Ghanim H" first="Husam" last="Ghanim">Husam Ghanim</name><name sortKey="Mohanty, Priya" sort="Mohanty, Priya" uniqKey="Mohanty P" first="Priya" last="Mohanty">Priya Mohanty</name><name sortKey="Sia, Chang Ling" sort="Sia, Chang Ling" uniqKey="Sia C" first="Chang Ling" last="Sia">Chang Ling Sia</name><name sortKey="Viswanathan, Prabhakar" sort="Viswanathan, Prabhakar" uniqKey="Viswanathan P" first="Prabhakar" last="Viswanathan">Prabhakar Viswanathan</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/OrangerV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F63 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000F63 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Bois
|area= OrangerV1
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:2858203
|texte= Differential Effects of Cream, Glucose, and Orange Juice on Inflammation, Endotoxin, and the Expression of Toll-Like Receptor-4 and Suppressor of Cytokine Signaling-3
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:20067961" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a OrangerV1
| This area was generated with Dilib version V0.6.25. |  |