Pharmacokinetics of flavanone glycosides after ingestion of single doses of fresh-squeezed orange juice versus commercially processed orange juice in healthy humans.
Identifieur interne : 001946 ( Ncbi/Merge ); précédent : 001945; suivant : 001947Pharmacokinetics of flavanone glycosides after ingestion of single doses of fresh-squeezed orange juice versus commercially processed orange juice in healthy humans.
Auteurs : Jacqueline Q. Silveira [Brésil] ; Thais B. Cesar ; John A. Manthey ; Elizabeth A. Baldwin ; Jinhe Bai ; Smita RaithoreSource :
- Journal of agricultural and food chemistry [ 1520-5118 ] ; 2014.
English descriptors
- KwdEn :
- Adult, Beverages (analysis), Beverages (economics), Citrus sinensis (metabolism), Eating, Female, Flavanones (blood), Flavanones (metabolism), Flavanones (pharmacokinetics), Flavanones (urine), Food Handling, Glycosides (blood), Glycosides (metabolism), Glycosides (pharmacokinetics), Glycosides (urine), Humans, Male, Plant Preparations (blood), Plant Preparations (metabolism), Plant Preparations (pharmacokinetics), Plant Preparations (urine), Young Adult.
- MESH :
- chemical , blood : Flavanones, Glycosides, Plant Preparations.
- analysis : Beverages.
- economics : Beverages.
- metabolism : Citrus sinensis, Flavanones, Glycosides, Plant Preparations.
- chemical , pharmacokinetics : Flavanones, Glycosides, Plant Preparations.
- chemical , urine : Flavanones, Glycosides, Plant Preparations.
- Adult, Eating, Female, Food Handling, Humans, Male, Young Adult.
Abstract
Orange juice is a rich source of flavonoids considered beneficial to cardiovascular health in humans. The objective of this study was to analyze the pharmacokinetics of the main flavanone glycosides, hesperidin and narirutin, in humans after the consumption of two styles of orange juice, fresh-squeezed (FOJ) and commercially processed (POJ), differing in their amounts of soluble and insoluble forms of these compounds. Healthy human subjects consumed 11.5 mL/kg body weight of FOJ, and after an interval of 30 days, consumed the same quantity of POJ. The results showed that there were no significant differences in the Tmax of the pharmacokinetic curves for the metabolites of hesperidin and narirutin following the consumption of the two styles of juices, and corrected for differences in doses in the POJ and FOJ, there were also no significant differences in the AUC and Cmax values and percent absorption of these compounds.
DOI: 10.1021/jf5038163
PubMed: 25495754
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pharmacokinetics of flavanone glycosides after ingestion of single doses of fresh-squeezed orange juice versus commercially processed orange juice in healthy humans.</title><author><name sortKey="Silveira, Jacqueline Q" sort="Silveira, Jacqueline Q" uniqKey="Silveira J" first="Jacqueline Q" last="Silveira">Jacqueline Q. Silveira</name><affiliation wicri:level="1"><nlm:affiliation>Food and Nutrition Department, Faculty of Pharmaceutical Sciences, São Paulo State University-UNESP , Rodovia Araraquara-Jau km1, Araraquara, SP 14801-902, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Food and Nutrition Department, Faculty of Pharmaceutical Sciences, São Paulo State University-UNESP , Rodovia Araraquara-Jau km1, Araraquara, SP 14801-902</wicri:regionArea><wicri:noRegion>SP 14801-902</wicri:noRegion></affiliation></author><author><name sortKey="Cesar, Thais B" sort="Cesar, Thais B" uniqKey="Cesar T" first="Thais B" last="Cesar">Thais B. Cesar</name></author><author><name sortKey="Manthey, John A" sort="Manthey, John A" uniqKey="Manthey J" first="John A" last="Manthey">John A. Manthey</name></author><author><name sortKey="Baldwin, Elizabeth A" sort="Baldwin, Elizabeth A" uniqKey="Baldwin E" first="Elizabeth A" last="Baldwin">Elizabeth A. Baldwin</name></author><author><name sortKey="Bai, Jinhe" sort="Bai, Jinhe" uniqKey="Bai J" first="Jinhe" last="Bai">Jinhe Bai</name></author><author><name sortKey="Raithore, Smita" sort="Raithore, Smita" uniqKey="Raithore S" first="Smita" last="Raithore">Smita Raithore</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25495754</idno><idno type="pmid">25495754</idno><idno type="doi">10.1021/jf5038163</idno><idno type="wicri:Area/PubMed/Corpus">000261</idno><idno type="wicri:Area/PubMed/Curation">000261</idno><idno type="wicri:Area/PubMed/Checkpoint">000261</idno><idno type="wicri:Area/Ncbi/Merge">001946</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pharmacokinetics of flavanone glycosides after ingestion of single doses of fresh-squeezed orange juice versus commercially processed orange juice in healthy humans.</title><author><name sortKey="Silveira, Jacqueline Q" sort="Silveira, Jacqueline Q" uniqKey="Silveira J" first="Jacqueline Q" last="Silveira">Jacqueline Q. Silveira</name><affiliation wicri:level="1"><nlm:affiliation>Food and Nutrition Department, Faculty of Pharmaceutical Sciences, São Paulo State University-UNESP , Rodovia Araraquara-Jau km1, Araraquara, SP 14801-902, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Food and Nutrition Department, Faculty of Pharmaceutical Sciences, São Paulo State University-UNESP , Rodovia Araraquara-Jau km1, Araraquara, SP 14801-902</wicri:regionArea><wicri:noRegion>SP 14801-902</wicri:noRegion></affiliation></author><author><name sortKey="Cesar, Thais B" sort="Cesar, Thais B" uniqKey="Cesar T" first="Thais B" last="Cesar">Thais B. Cesar</name></author><author><name sortKey="Manthey, John A" sort="Manthey, John A" uniqKey="Manthey J" first="John A" last="Manthey">John A. Manthey</name></author><author><name sortKey="Baldwin, Elizabeth A" sort="Baldwin, Elizabeth A" uniqKey="Baldwin E" first="Elizabeth A" last="Baldwin">Elizabeth A. Baldwin</name></author><author><name sortKey="Bai, Jinhe" sort="Bai, Jinhe" uniqKey="Bai J" first="Jinhe" last="Bai">Jinhe Bai</name></author><author><name sortKey="Raithore, Smita" sort="Raithore, Smita" uniqKey="Raithore S" first="Smita" last="Raithore">Smita Raithore</name></author></analytic><series><title level="j">Journal of agricultural and food chemistry</title><idno type="eISSN">1520-5118</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Beverages (analysis)</term><term>Beverages (economics)</term><term>Citrus sinensis (metabolism)</term><term>Eating</term><term>Female</term><term>Flavanones (blood)</term><term>Flavanones (metabolism)</term><term>Flavanones (pharmacokinetics)</term><term>Flavanones (urine)</term><term>Food Handling</term><term>Glycosides (blood)</term><term>Glycosides (metabolism)</term><term>Glycosides (pharmacokinetics)</term><term>Glycosides (urine)</term><term>Humans</term><term>Male</term><term>Plant Preparations (blood)</term><term>Plant Preparations (metabolism)</term><term>Plant Preparations (pharmacokinetics)</term><term>Plant Preparations (urine)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Flavanones</term><term>Glycosides</term><term>Plant Preparations</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Beverages</term></keywords><keywords scheme="MESH" qualifier="economics" xml:lang="en"><term>Beverages</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Citrus sinensis</term><term>Flavanones</term><term>Glycosides</term><term>Plant Preparations</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Flavanones</term><term>Glycosides</term><term>Plant Preparations</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Flavanones</term><term>Glycosides</term><term>Plant Preparations</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Eating</term><term>Female</term><term>Food Handling</term><term>Humans</term><term>Male</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Orange juice is a rich source of flavonoids considered beneficial to cardiovascular health in humans. The objective of this study was to analyze the pharmacokinetics of the main flavanone glycosides, hesperidin and narirutin, in humans after the consumption of two styles of orange juice, fresh-squeezed (FOJ) and commercially processed (POJ), differing in their amounts of soluble and insoluble forms of these compounds. Healthy human subjects consumed 11.5 mL/kg body weight of FOJ, and after an interval of 30 days, consumed the same quantity of POJ. The results showed that there were no significant differences in the Tmax of the pharmacokinetic curves for the metabolites of hesperidin and narirutin following the consumption of the two styles of juices, and corrected for differences in doses in the POJ and FOJ, there were also no significant differences in the AUC and Cmax values and percent absorption of these compounds.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25495754</PMID><DateCreated><Year>2015</Year><Month>1</Month><Day>1</Day></DateCreated><DateCompleted><Year>2015</Year><Month>09</Month><Day>03</Day></DateCompleted><DateRevised><Year>2015</Year><Month>1</Month><Day>1</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1520-5118</ISSN><JournalIssue CitedMedium="Internet"><Volume>62</Volume><Issue>52</Issue><PubDate><Year>2014</Year><Month>Dec</Month><Day>31</Day></PubDate></JournalIssue><Title>Journal of agricultural and food chemistry</Title><ISOAbbreviation>J. Agric. Food Chem.</ISOAbbreviation></Journal><ArticleTitle>Pharmacokinetics of flavanone glycosides after ingestion of single doses of fresh-squeezed orange juice versus commercially processed orange juice in healthy humans.</ArticleTitle><Pagination><MedlinePgn>12576-84</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/jf5038163</ELocationID><Abstract><AbstractText>Orange juice is a rich source of flavonoids considered beneficial to cardiovascular health in humans. The objective of this study was to analyze the pharmacokinetics of the main flavanone glycosides, hesperidin and narirutin, in humans after the consumption of two styles of orange juice, fresh-squeezed (FOJ) and commercially processed (POJ), differing in their amounts of soluble and insoluble forms of these compounds. Healthy human subjects consumed 11.5 mL/kg body weight of FOJ, and after an interval of 30 days, consumed the same quantity of POJ. The results showed that there were no significant differences in the Tmax of the pharmacokinetic curves for the metabolites of hesperidin and narirutin following the consumption of the two styles of juices, and corrected for differences in doses in the POJ and FOJ, there were also no significant differences in the AUC and Cmax values and percent absorption of these compounds.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Silveira</LastName><ForeName>Jacqueline Q</ForeName><Initials>JQ</Initials><AffiliationInfo><Affiliation>Food and Nutrition Department, Faculty of Pharmaceutical Sciences, São Paulo State University-UNESP , Rodovia Araraquara-Jau km1, Araraquara, SP 14801-902, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cesar</LastName><ForeName>Thais B</ForeName><Initials>TB</Initials></Author><Author ValidYN="Y"><LastName>Manthey</LastName><ForeName>John A</ForeName><Initials>JA</Initials></Author><Author ValidYN="Y"><LastName>Baldwin</LastName><ForeName>Elizabeth A</ForeName><Initials>EA</Initials></Author><Author ValidYN="Y"><LastName>Bai</LastName><ForeName>Jinhe</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Raithore</LastName><ForeName>Smita</ForeName><Initials>S</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>Dec</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Agric Food Chem</MedlineTA><NlmUniqueID>0374755</NlmUniqueID><ISSNLinking>0021-8561</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044950">Flavanones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006027">Glycosides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D028321">Plant Preparations</NameOfSubstance></Chemical><Chemical><RegistryNumber>487-26-3</RegistryNumber><NameOfSubstance UI="C028610">flavanone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001628" MajorTopicYN="N">Beverages</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName><QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032084" MajorTopicYN="N">Citrus sinensis</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004435" MajorTopicYN="N">Eating</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044950" MajorTopicYN="N">Flavanones</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005511" MajorTopicYN="N">Food Handling</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006027" MajorTopicYN="N">Glycosides</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D028321" MajorTopicYN="N">Plant Preparations</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">bioavailability</Keyword><Keyword MajorTopicYN="N">hesperidin</Keyword><Keyword MajorTopicYN="N">juice cloud</Keyword><Keyword MajorTopicYN="N">metabolites</Keyword><Keyword MajorTopicYN="N">narirutin</Keyword><Keyword MajorTopicYN="N">pharmacokinetics</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>12</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>12</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>9</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25495754</ArticleId><ArticleId IdType="doi">10.1021/jf5038163</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Brésil</li></country></list><tree><noCountry><name sortKey="Bai, Jinhe" sort="Bai, Jinhe" uniqKey="Bai J" first="Jinhe" last="Bai">Jinhe Bai</name><name sortKey="Baldwin, Elizabeth A" sort="Baldwin, Elizabeth A" uniqKey="Baldwin E" first="Elizabeth A" last="Baldwin">Elizabeth A. Baldwin</name><name sortKey="Cesar, Thais B" sort="Cesar, Thais B" uniqKey="Cesar T" first="Thais B" last="Cesar">Thais B. Cesar</name><name sortKey="Manthey, John A" sort="Manthey, John A" uniqKey="Manthey J" first="John A" last="Manthey">John A. Manthey</name><name sortKey="Raithore, Smita" sort="Raithore, Smita" uniqKey="Raithore S" first="Smita" last="Raithore">Smita Raithore</name></noCountry><country name="Brésil"><noRegion><name sortKey="Silveira, Jacqueline Q" sort="Silveira, Jacqueline Q" uniqKey="Silveira J" first="Jacqueline Q" last="Silveira">Jacqueline Q. Silveira</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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