Antihyperalgesic Effect of Hesperidin Improves with Diosmin in Experimental Neuropathic Pain
Identifieur interne : 002185 ( Ncbi/Curation ); précédent : 002184; suivant : 002186Antihyperalgesic Effect of Hesperidin Improves with Diosmin in Experimental Neuropathic Pain
Auteurs : Azucena I. Carballo-Villalobos [Mexique] ; María-Eva González-Trujano [Mexique] ; Francisco Pellicer [Mexique] ; Francisco J. L Pez-Mu Oz [Mexique]Source :
- BioMed Research International [ 2314-6133 ] ; 2016.
Abstract
Neuropathic pain is caused by a primary lesion, dysfunction, or transitory perturbation in the peripheral or central nervous system. In this study, we investigated the hesperidin antihyperalgesic effects alone or combined with diosmin in a model of neuropathic pain to corroborate a possible synergistic antinociceptive activity. Mechanical and thermal hyperalgesia were assessed in the aesthesiometer and plantar tests, respectively, after chronic constriction injury (CCI) model in rats receiving hesperidin (HS, 5 doses from 10 to 1000 mg/kg) alone or combined with diosmin (DS, 10 and 100 mg/kg) in comparison to gabapentin (31.6 mg/kg). UHPLC-MS analysis of cerebral samples was used to recognize the central concentrations of these flavonoids. Participation of different receptors was also investigated in the presence of haloperidol, bicuculline, and naloxone antagonists. Acute hesperidin administration significantly decreased mechanical and thermal hyperalgesia in CCI rats. Antihyperalgesic response of hesperidin, improved by a combination with diosmin (DS10/HS100) in both stimuli, was blockaded by haloperidol, bicuculline, and naloxone, but not WAY100635, antagonists. Both flavonoids were detected in brain samples. In conclusion, hesperidin alone and combined with diosmin produces antihyperalgesic response in the CCI model in rats. Antihyperalgesic effect of DS10/HS100 combination involves central activity partially modulated by D2, GABAA, and opioids, but not by 5-HT1A, receptors.
Url:
DOI: 10.1155/2016/8263463
PubMed: 27672659
PubMed Central: 5031820
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<front><div type="abstract" xml:lang="en"><p>Neuropathic pain is caused by a primary lesion, dysfunction, or transitory perturbation in the peripheral or central nervous system. In this study, we investigated the hesperidin antihyperalgesic effects alone or combined with diosmin in a model of neuropathic pain to corroborate a possible synergistic antinociceptive activity. Mechanical and thermal hyperalgesia were assessed in the aesthesiometer and plantar tests, respectively, after chronic constriction injury (CCI) model in rats receiving hesperidin (HS, 5 doses from 10 to 1000 mg/kg) alone or combined with diosmin (DS, 10 and 100 mg/kg) in comparison to gabapentin (31.6 mg/kg). UHPLC-MS analysis of cerebral samples was used to recognize the central concentrations of these flavonoids. Participation of different receptors was also investigated in the presence of haloperidol, bicuculline, and naloxone antagonists. Acute hesperidin administration significantly decreased mechanical and thermal hyperalgesia in CCI rats. Antihyperalgesic response of hesperidin, improved by a combination with diosmin (DS10/HS100) in both stimuli, was blockaded by haloperidol, bicuculline, and naloxone, but not WAY100635, antagonists. Both flavonoids were detected in brain samples. In conclusion, hesperidin alone and combined with diosmin produces antihyperalgesic response in the CCI model in rats. Antihyperalgesic effect of DS10/HS100 combination involves central activity partially modulated by D<sub>2</sub>
, GABA<sub>A</sub>
, and opioids, but not by 5-HT<sub>1A</sub>
, receptors. </p>
</div>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bouhassira, D" uniqKey="Bouhassira D">D. Bouhassira</name>
</author>
<author><name sortKey="Lanteri Minet, M" uniqKey="Lanteri Minet M">M. Lantéri-Minet</name>
</author>
<author><name sortKey="Attal, N" uniqKey="Attal N">N. Attal</name>
</author>
<author><name sortKey="Laurent, B" uniqKey="Laurent B">B. Laurent</name>
</author>
<author><name sortKey="Touboul, C" uniqKey="Touboul C">C. Touboul</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cohen, S P" uniqKey="Cohen S">S. P. Cohen</name>
</author>
<author><name sortKey="Mao, J" uniqKey="Mao J">J. Mao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Campbell, J N" uniqKey="Campbell J">J. N. Campbell</name>
</author>
<author><name sortKey="Raja, S N" uniqKey="Raja S">S. N. Raja</name>
</author>
<author><name sortKey="Meyer, R A" uniqKey="Meyer R">R. A. Meyer</name>
</author>
<author><name sortKey="Mackinnon, S E" uniqKey="Mackinnon S">S. E. Mackinnon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drew, G M" uniqKey="Drew G">G. M. Drew</name>
</author>
<author><name sortKey="Siddall, P J" uniqKey="Siddall P">P. J. Siddall</name>
</author>
<author><name sortKey="Duggan, A W" uniqKey="Duggan A">A. W. Duggan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Damon, M" uniqKey="Damon M">M. Damon</name>
</author>
<author><name sortKey="Flandre, O" uniqKey="Flandre O">O. Flandre</name>
</author>
<author><name sortKey="Michel, F" uniqKey="Michel F">F. Michel</name>
</author>
<author><name sortKey="Perdrix, L" uniqKey="Perdrix L">L. Perdrix</name>
</author>
<author><name sortKey="Labrid, C" uniqKey="Labrid C">C. Labrid</name>
</author>
<author><name sortKey="Crastes De Paulet, A" uniqKey="Crastes De Paulet A">A. Crastes de Paulet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jean, T" uniqKey="Jean T">T. Jean</name>
</author>
<author><name sortKey="Bodinier, M C" uniqKey="Bodinier M">M. C. Bodinier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Krief, I" uniqKey="Krief I">I. Krief</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Benavente Garcia, O" uniqKey="Benavente Garcia O">O. Benavente-García</name>
</author>
<author><name sortKey="Castillo, J" uniqKey="Castillo J">J. Castillo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kang, S R" uniqKey="Kang S">S. R. Kang</name>
</author>
<author><name sortKey="Park, K I" uniqKey="Park K">K. I. Park</name>
</author>
<author><name sortKey="Park, H S" uniqKey="Park H">H. S. Park</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Olszanecki, R" uniqKey="Olszanecki R">R. Olszanecki</name>
</author>
<author><name sortKey="Gebska, A" uniqKey="Gebska A">A. Gebska</name>
</author>
<author><name sortKey="Kozlovski, V I" uniqKey="Kozlovski V">V. I. Kozlovski</name>
</author>
<author><name sortKey="Gryglewski, R J" uniqKey="Gryglewski R">R. J. Gryglewski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Raza, S S" uniqKey="Raza S">S. S. Raza</name>
</author>
<author><name sortKey="Khan, M M" uniqKey="Khan M">M. M. Khan</name>
</author>
<author><name sortKey="Ahmad, A" uniqKey="Ahmad A">A. Ahmad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fernandez, S P" uniqKey="Fernandez S">S. P. Fernández</name>
</author>
<author><name sortKey="Wasowski, C" uniqKey="Wasowski C">C. Wasowski</name>
</author>
<author><name sortKey="Loscalzo, L M" uniqKey="Loscalzo L">L. M. Loscalzo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mahmoud, A M" uniqKey="Mahmoud A">A. M. Mahmoud</name>
</author>
<author><name sortKey="Ashour, M B" uniqKey="Ashour M">M. B. Ashour</name>
</author>
<author><name sortKey="Abdel Moneim, A" uniqKey="Abdel Moneim A">A. Abdel-Moneim</name>
</author>
<author><name sortKey="Ahmed, O M" uniqKey="Ahmed O">O. M. Ahmed</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guzman Gutierrez, S L" uniqKey="Guzman Gutierrez S">S. L. Guzmán-Gutiérrez</name>
</author>
<author><name sortKey="Navarrete, A" uniqKey="Navarrete A">A. Navarrete</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Loscalzo, L M" uniqKey="Loscalzo L">L. M. Loscalzo</name>
</author>
<author><name sortKey="Wasowski, C" uniqKey="Wasowski C">C. Wasowski</name>
</author>
<author><name sortKey="Paladini, A C" uniqKey="Paladini A">A. C. Paladini</name>
</author>
<author><name sortKey="Marder, M" uniqKey="Marder M">M. Marder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Souza, L C" uniqKey="Souza L">L. C. Souza</name>
</author>
<author><name sortKey="De Gomes, M G" uniqKey="De Gomes M">M. G. de Gomes</name>
</author>
<author><name sortKey="Goes, A T R" uniqKey="Goes A">A. T. R. Goes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Visnagri, A" uniqKey="Visnagri A">A. Visnagri</name>
</author>
<author><name sortKey="Kandhare, A D" uniqKey="Kandhare A">A. D. Kandhare</name>
</author>
<author><name sortKey="Chakravarty, S" uniqKey="Chakravarty S">S. Chakravarty</name>
</author>
<author><name sortKey="Ghosh, P" uniqKey="Ghosh P">P. Ghosh</name>
</author>
<author><name sortKey="Bodhankar, S L" uniqKey="Bodhankar S">S. L. Bodhankar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kamisli, S" uniqKey="Kamisli S">S. Kamisli</name>
</author>
<author><name sortKey="Ciftci, O" uniqKey="Ciftci O">O. Ciftci</name>
</author>
<author><name sortKey="Kaya, K" uniqKey="Kaya K">K. Kaya</name>
</author>
<author><name sortKey="Cetin, A" uniqKey="Cetin A">A. Cetin</name>
</author>
<author><name sortKey="Kamisli, O" uniqKey="Kamisli O">O. Kamisli</name>
</author>
<author><name sortKey="Ozcan, C" uniqKey="Ozcan C">C. Ozcan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Gysel, J P" uniqKey="Van Gysel J">J. P. Van Gysel</name>
</author>
<author><name sortKey="Veroft, R" uniqKey="Veroft R">R. Veroft</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Srilatha, D" uniqKey="Srilatha D">D. Srilatha</name>
</author>
<author><name sortKey="Nasare, M" uniqKey="Nasare M">M. Nasare</name>
</author>
<author><name sortKey="Nagasandhya, B" uniqKey="Nagasandhya B">B. Nagasandhya</name>
</author>
<author><name sortKey="Prasad, V" uniqKey="Prasad V">V. Prasad</name>
</author>
<author><name sortKey="Diwan, P" uniqKey="Diwan P">P. Diwan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Swies, J" uniqKey="Swies J">J. Swies</name>
</author>
<author><name sortKey="Robak, J" uniqKey="Robak J">J. Robak</name>
</author>
<author><name sortKey="Dabrowski, L" uniqKey="Dabrowski L">L. Dabrowski</name>
</author>
<author><name sortKey="Duniec, Z" uniqKey="Duniec Z">Z. Duniec</name>
</author>
<author><name sortKey="Michalska, Z" uniqKey="Michalska Z">Z. Michalska</name>
</author>
<author><name sortKey="Gryglewski, R J" uniqKey="Gryglewski R">R. J. Gryglewski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Duniec, Z" uniqKey="Duniec Z">Z. Duniec</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rovensk, J" uniqKey="Rovensk J">J. Rovenský</name>
</author>
<author><name sortKey="Stan Kova, M" uniqKey="Stan Kova M">M. Stančíková</name>
</author>
<author><name sortKey="Rovenska, E" uniqKey="Rovenska E">E. Rovenská</name>
</author>
<author><name sortKey="Stvrtina, S" uniqKey="Stvrtina S">S. Štvrtina</name>
</author>
<author><name sortKey="Stvrtinova, V" uniqKey="Stvrtinova V">V. Štvrtinová</name>
</author>
<author><name sortKey="Svik, K" uniqKey="Svik K">K. Švík</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aswar, M" uniqKey="Aswar M">M. Aswar</name>
</author>
<author><name sortKey="Kute, P" uniqKey="Kute P">P. Kute</name>
</author>
<author><name sortKey="Mahajan, S" uniqKey="Mahajan S">S. Mahajan</name>
</author>
<author><name sortKey="Mahajan, U" uniqKey="Mahajan U">U. Mahajan</name>
</author>
<author><name sortKey="Nerurkar, G" uniqKey="Nerurkar G">G. Nerurkar</name>
</author>
<author><name sortKey="Aswar, U" uniqKey="Aswar U">U. Aswar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bennett, G J" uniqKey="Bennett G">G. J. Bennett</name>
</author>
<author><name sortKey="Xie, Y K" uniqKey="Xie Y">Y.-K. Xie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martinez, A L" uniqKey="Martinez A">A. L. Martínez</name>
</author>
<author><name sortKey="Gonzalez Trujano, M E" uniqKey="Gonzalez Trujano M">M. E. González-Trujano</name>
</author>
<author><name sortKey="Chavez, M" uniqKey="Chavez M">M. Chávez</name>
</author>
<author><name sortKey="Pellicer, F" uniqKey="Pellicer F">F. Pellicer</name>
</author>
<author><name sortKey="Moreno, J" uniqKey="Moreno J">J. Moreno</name>
</author>
<author><name sortKey="L Pez Mu Oz, F J" uniqKey="L Pez Mu Oz F">F. J. López-Muñoz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hargreaves, K" uniqKey="Hargreaves K">K. Hargreaves</name>
</author>
<author><name sortKey="Dubner, R" uniqKey="Dubner R">R. Dubner</name>
</author>
<author><name sortKey="Brown, F" uniqKey="Brown F">F. Brown</name>
</author>
<author><name sortKey="Flores, C" uniqKey="Flores C">C. Flores</name>
</author>
<author><name sortKey="Joris, J" uniqKey="Joris J">J. Joris</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hemsley, K M" uniqKey="Hemsley K">K. M. Hemsley</name>
</author>
<author><name sortKey="Hopwood, J J" uniqKey="Hopwood J">J. J. Hopwood</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dowdall, T" uniqKey="Dowdall T">T. Dowdall</name>
</author>
<author><name sortKey="Robinson, I" uniqKey="Robinson I">I. Robinson</name>
</author>
<author><name sortKey="Meert, T F" uniqKey="Meert T">T. F. Meert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ashafaq, M" uniqKey="Ashafaq M">M. Ashafaq</name>
</author>
<author><name sortKey="Varshney, L" uniqKey="Varshney L">L. Varshney</name>
</author>
<author><name sortKey="Khan, M H A" uniqKey="Khan M">M. H. A. Khan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaulaskar, S" uniqKey="Kaulaskar S">S. Kaulaskar</name>
</author>
<author><name sortKey="Bhutada, P" uniqKey="Bhutada P">P. Bhutada</name>
</author>
<author><name sortKey="Rahigude, A" uniqKey="Rahigude A">A. Rahigude</name>
</author>
<author><name sortKey="Jain, D" uniqKey="Jain D">D. Jain</name>
</author>
<author><name sortKey="Harle, U" uniqKey="Harle U">U. Harle</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hara, K" uniqKey="Hara K">K. Hara</name>
</author>
<author><name sortKey="Haranishi, Y" uniqKey="Haranishi Y">Y. Haranishi</name>
</author>
<author><name sortKey="Terada, T" uniqKey="Terada T">T. Terada</name>
</author>
<author><name sortKey="Takahashi, Y" uniqKey="Takahashi Y">Y. Takahashi</name>
</author>
<author><name sortKey="Nakamura, M" uniqKey="Nakamura M">M. Nakamura</name>
</author>
<author><name sortKey="Sata, T" uniqKey="Sata T">T. Sata</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, X" uniqKey="Zhao X">X. Zhao</name>
</author>
<author><name sortKey="Wang, C" uniqKey="Wang C">C. Wang</name>
</author>
<author><name sortKey="Cui, W G" uniqKey="Cui W">W.-G. Cui</name>
</author>
<author><name sortKey="Ma, Q" uniqKey="Ma Q">Q. Ma</name>
</author>
<author><name sortKey="Zhou, W H" uniqKey="Zhou W">W.-H. Zhou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hagenacker, T" uniqKey="Hagenacker T">T. Hagenacker</name>
</author>
<author><name sortKey="Hillebrand, I" uniqKey="Hillebrand I">I. Hillebrand</name>
</author>
<author><name sortKey="Wissmann, A" uniqKey="Wissmann A">A. Wissmann</name>
</author>
<author><name sortKey="Busselberg, D" uniqKey="Busselberg D">D. Büsselberg</name>
</author>
<author><name sortKey="Sch Fers, M" uniqKey="Sch Fers M">M. Schäfers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meotti, F C" uniqKey="Meotti F">F. C. Meotti</name>
</author>
<author><name sortKey="Missau, F C" uniqKey="Missau F">F. C. Missau</name>
</author>
<author><name sortKey="Ferreira, J" uniqKey="Ferreira J">J. Ferreira</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anjaneyulu, M" uniqKey="Anjaneyulu M">M. Anjaneyulu</name>
</author>
<author><name sortKey="Chopra, K" uniqKey="Chopra K">K. Chopra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Valsecchi, A E" uniqKey="Valsecchi A">A. E. Valsecchi</name>
</author>
<author><name sortKey="Franchi, S" uniqKey="Franchi S">S. Franchi</name>
</author>
<author><name sortKey="Panerai, A E" uniqKey="Panerai A">A. E. Panerai</name>
</author>
<author><name sortKey="Rossi, A" uniqKey="Rossi A">A. Rossi</name>
</author>
<author><name sortKey="Sacerdote, P" uniqKey="Sacerdote P">P. Sacerdote</name>
</author>
<author><name sortKey="Colleoni, M" uniqKey="Colleoni M">M. Colleoni</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Valsecchi, A E" uniqKey="Valsecchi A">A. E. Valsecchi</name>
</author>
<author><name sortKey="Franchi, S" uniqKey="Franchi S">S. Franchi</name>
</author>
<author><name sortKey="Panerai, A E" uniqKey="Panerai A">A. E. Panerai</name>
</author>
<author><name sortKey="Sacerdote, P" uniqKey="Sacerdote P">P. Sacerdote</name>
</author>
<author><name sortKey="Trovato, A E" uniqKey="Trovato A">A. E. Trovato</name>
</author>
<author><name sortKey="Colleoni, M" uniqKey="Colleoni M">M. Colleoni</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Spanakis, M" uniqKey="Spanakis M">M. Spanakis</name>
</author>
<author><name sortKey="Kasmas, S" uniqKey="Kasmas S">S. Kasmas</name>
</author>
<author><name sortKey="Niopas, I" uniqKey="Niopas I">I. Niopas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cova, D" uniqKey="Cova D">D. Cova</name>
</author>
<author><name sortKey="De Angelis, L" uniqKey="De Angelis L">L. De Angelis</name>
</author>
<author><name sortKey="Giavarini, F" uniqKey="Giavarini F">F. Giavarini</name>
</author>
<author><name sortKey="Palladini, G" uniqKey="Palladini G">G. Palladini</name>
</author>
<author><name sortKey="Perego, R" uniqKey="Perego R">R. Perego</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meyer, O C" uniqKey="Meyer O">O. C. Meyer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="L Pez Mu Oz, F J" uniqKey="L Pez Mu Oz F">F. J. López-Muñoz</name>
</author>
<author><name sortKey="Diaz Reval, M I" uniqKey="Diaz Reval M">M. I. Díaz-Reval</name>
</author>
<author><name sortKey="Terr N, J A" uniqKey="Terr N J">J. A. Terrón</name>
</author>
<author><name sortKey="Deciga Campos, M" uniqKey="Deciga Campos M">M. Déciga Campos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Enna, S J" uniqKey="Enna S">S. J. Enna</name>
</author>
<author><name sortKey="Mccarson, K E" uniqKey="Mccarson K">K. E. McCarson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ness, T" uniqKey="Ness T">T. Ness</name>
</author>
<author><name sortKey="Randich, A" uniqKey="Randich A">A. Randich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ortega Legaspi, J M" uniqKey="Ortega Legaspi J">J. M. Ortega-Legaspi</name>
</author>
<author><name sortKey="De Gortari, P" uniqKey="De Gortari P">P. de Gortari</name>
</author>
<author><name sortKey="Gardu O Gutierrez, R" uniqKey="Gardu O Gutierrez R">R. Garduño-Gutiérrez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kita, T" uniqKey="Kita T">T. Kita</name>
</author>
<author><name sortKey="Asanuma, M" uniqKey="Asanuma M">M. Asanuma</name>
</author>
<author><name sortKey="Miyazaki, I" uniqKey="Miyazaki I">I. Miyazaki</name>
</author>
<author><name sortKey="Takeshima, M" uniqKey="Takeshima M">M. Takeshima</name>
</author>
</analytic>
</biblStruct>
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