Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson's Disease
Identifieur interne : 001482 ( Ncbi/Curation ); précédent : 001481; suivant : 001483Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson's Disease
Auteurs : Kuppusamy Tamilselvam [Inde] ; Nady Braidy [Australie] ; Thamilarasan Manivasagam [Inde] ; Musthafa Mohamed Essa [Oman] ; Nagarajan Rajendra Prasad [Inde] ; Subburayan Karthikeyan [Inde] ; Arokyasamy Justin Thenmozhi [Inde] ; Subash Selvaraju [Oman] ; Gilles J. Guillemin [Australie]Source :
- Oxidative Medicine and Cellular Longevity [ 1942-0900 ] ; 2013.
Abstract
Rotenone a widely used pesticide that inhibits mitochondrial complex I has been used to investigate the pathobiology of PD both
Url:
DOI: 10.1155/2013/102741
PubMed: 24205431
PubMed Central: 3800605
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Box 50, Muscat 123, Oman</nlm:aff><country xml:lang="fr">Oman</country><wicri:regionArea>Department of Food Science and Nutrition, College of Agriculture and Marine Sciences, Sultan Qaboos University, P.O. 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Box 50, Muscat 123, Oman</nlm:aff><country xml:lang="fr">Oman</country><wicri:regionArea>Department of Food Science and Nutrition, College of Agriculture and Marine Sciences, Sultan Qaboos University, P.O. Box 50, Muscat 123</wicri:regionArea><wicri:noRegion>Muscat 123</wicri:noRegion></affiliation></author><author><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name><affiliation wicri:level="1"><nlm:aff id="I4">Neuropharmacology Group, MND and Neurodegenerative Diseases Research Centre, Australian School of Advanced Medicine, Macquarie University, Balaclava Road, North Ryde, Sydney, NSW 2109, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Neuropharmacology Group, MND and Neurodegenerative Diseases Research Centre, Australian School of Advanced Medicine, Macquarie University, Balaclava Road, North Ryde, Sydney, NSW 2109</wicri:regionArea><wicri:noRegion>NSW 2109</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24205431</idno><idno type="pmc">3800605</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800605</idno><idno type="RBID">PMC:3800605</idno><idno type="doi">10.1155/2013/102741</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001090</idno><idno type="wicri:Area/Pmc/Curation">001089</idno><idno type="wicri:Area/Pmc/Checkpoint">000A18</idno><idno type="wicri:Area/Ncbi/Merge">001482</idno><idno type="wicri:Area/Ncbi/Curation">001482</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson's Disease</title><author><name sortKey="Tamilselvam, Kuppusamy" sort="Tamilselvam, Kuppusamy" uniqKey="Tamilselvam K" first="Kuppusamy" last="Tamilselvam">Kuppusamy Tamilselvam</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry and Biotechnology, Faculty of Science, College Rd, Annamalai Nagar, Chidambaram, Tamil Nadu 608002, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry and Biotechnology, Faculty of Science, College Rd, Annamalai Nagar, Chidambaram, Tamil Nadu 608002</wicri:regionArea><wicri:noRegion>Tamil Nadu 608002</wicri:noRegion></affiliation></author><author><name sortKey="Braidy, Nady" sort="Braidy, Nady" uniqKey="Braidy N" first="Nady" last="Braidy">Nady Braidy</name><affiliation wicri:level="1"><nlm:aff id="I2">Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New SouthWales, Sydney 2031, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New SouthWales, Sydney 2031</wicri:regionArea><placeName><settlement type="city">Sydney</settlement></placeName></affiliation></author><author><name sortKey="Manivasagam, Thamilarasan" sort="Manivasagam, Thamilarasan" uniqKey="Manivasagam T" first="Thamilarasan" last="Manivasagam">Thamilarasan Manivasagam</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry and Biotechnology, Faculty of Science, College Rd, Annamalai Nagar, Chidambaram, Tamil Nadu 608002, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry and Biotechnology, Faculty of Science, College Rd, Annamalai Nagar, Chidambaram, Tamil Nadu 608002</wicri:regionArea><wicri:noRegion>Tamil Nadu 608002</wicri:noRegion></affiliation></author><author><name sortKey="Essa, Musthafa Mohamed" sort="Essa, Musthafa Mohamed" uniqKey="Essa M" first="Musthafa Mohamed" last="Essa">Musthafa Mohamed Essa</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Food Science and Nutrition, College of Agriculture and Marine Sciences, Sultan Qaboos University, P.O. Box 50, Muscat 123, Oman</nlm:aff><country xml:lang="fr">Oman</country><wicri:regionArea>Department of Food Science and Nutrition, College of Agriculture and Marine Sciences, Sultan Qaboos University, P.O. Box 50, Muscat 123</wicri:regionArea><wicri:noRegion>Muscat 123</wicri:noRegion></affiliation></author><author><name sortKey="Prasad, Nagarajan Rajendra" sort="Prasad, Nagarajan Rajendra" uniqKey="Prasad N" first="Nagarajan Rajendra" last="Prasad">Nagarajan Rajendra Prasad</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry and Biotechnology, Faculty of Science, College Rd, Annamalai Nagar, Chidambaram, Tamil Nadu 608002, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry and Biotechnology, Faculty of Science, College Rd, Annamalai Nagar, Chidambaram, Tamil Nadu 608002</wicri:regionArea><wicri:noRegion>Tamil Nadu 608002</wicri:noRegion></affiliation></author><author><name sortKey="Karthikeyan, Subburayan" sort="Karthikeyan, Subburayan" uniqKey="Karthikeyan S" first="Subburayan" last="Karthikeyan">Subburayan Karthikeyan</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry and Biotechnology, Faculty of Science, College Rd, Annamalai Nagar, Chidambaram, Tamil Nadu 608002, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry and Biotechnology, Faculty of Science, College Rd, Annamalai Nagar, Chidambaram, Tamil Nadu 608002</wicri:regionArea><wicri:noRegion>Tamil Nadu 608002</wicri:noRegion></affiliation></author><author><name sortKey="Thenmozhi, Arokyasamy Justin" sort="Thenmozhi, Arokyasamy Justin" uniqKey="Thenmozhi A" first="Arokyasamy Justin" last="Thenmozhi">Arokyasamy Justin Thenmozhi</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry and Biotechnology, Faculty of Science, College Rd, Annamalai Nagar, Chidambaram, Tamil Nadu 608002, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry and Biotechnology, Faculty of Science, College Rd, Annamalai Nagar, Chidambaram, Tamil Nadu 608002</wicri:regionArea><wicri:noRegion>Tamil Nadu 608002</wicri:noRegion></affiliation></author><author><name sortKey="Selvaraju, Subash" sort="Selvaraju, Subash" uniqKey="Selvaraju S" first="Subash" last="Selvaraju">Subash Selvaraju</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Food Science and Nutrition, College of Agriculture and Marine Sciences, Sultan Qaboos University, P.O. Box 50, Muscat 123, Oman</nlm:aff><country xml:lang="fr">Oman</country><wicri:regionArea>Department of Food Science and Nutrition, College of Agriculture and Marine Sciences, Sultan Qaboos University, P.O. Box 50, Muscat 123</wicri:regionArea><wicri:noRegion>Muscat 123</wicri:noRegion></affiliation></author><author><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name><affiliation wicri:level="1"><nlm:aff id="I4">Neuropharmacology Group, MND and Neurodegenerative Diseases Research Centre, Australian School of Advanced Medicine, Macquarie University, Balaclava Road, North Ryde, Sydney, NSW 2109, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Neuropharmacology Group, MND and Neurodegenerative Diseases Research Centre, Australian School of Advanced Medicine, Macquarie University, Balaclava Road, North Ryde, Sydney, NSW 2109</wicri:regionArea><wicri:noRegion>NSW 2109</wicri:noRegion></affiliation></author></analytic><series><title level="j">Oxidative Medicine and Cellular Longevity</title><idno type="ISSN">1942-0900</idno><idno type="eISSN">1942-0994</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Rotenone a widely used pesticide that inhibits mitochondrial complex I has been used to investigate the pathobiology of PD both <italic>in vitro</italic> and <italic>in vivo</italic>. Studies have shown that the neurotoxicity of rotenone may be related to its ability to generate reactive oxygen species (ROS), leading to neuronal apoptosis. The current study was carried out to investigate the neuroprotective effects of hesperidin, a citrus fruit flavanol, against rotenone-induced apoptosis in human neuroblastoma SK-N-SH cells. We assessed cell death, mitochondrial membrane potential, ROS generation, ATP levels, thiobarbituric acid reactive substances, reduced glutathione (GSH) levels, and the activity of catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx) using well established assays. Apoptosis was determined in normal, rotenone, and hesperidin treated cells, by measuring the protein expression of cytochrome c (cyt c), caspases 3 and 9, Bax, and Bcl-2 using the standard western blotting technique. The apoptosis in rotenone-induced SK-N-SH cells was accompanied by the loss of mitochondrial membrane potential, increased ROS generation, the depletion of GSH, enhanced activities of enzymatic antioxidants, upregulation of Bax, cyt c, and caspases 3 and 9, and downregulation of Bcl-2, which were attenuated in the presence of hesperidin. Our data suggests that hesperidin exerts its neuroprotective effect against rotenone due to its antioxidant, maintenance of mitochondrial function, and antiapoptotic properties in a neuroblastoma cell line.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Dauer, W" uniqKey="Dauer W">W Dauer</name></author><author><name sortKey="Przedborski, S" uniqKey="Przedborski S">S Przedborski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anantharam, V" uniqKey="Anantharam V">V Anantharam</name></author><author><name sortKey="Lehrmann, E" uniqKey="Lehrmann E">E Lehrmann</name></author><author><name sortKey="Kanthasamy, A" uniqKey="Kanthasamy A">A Kanthasamy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jenner, P" uniqKey="Jenner P">P Jenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Przedborski, S" uniqKey="Przedborski S">S 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Raza</name></author><author><name sortKey="Khan, Mm" uniqKey="Khan M">MM Khan</name></author><author><name sortKey="Ahmad, A" uniqKey="Ahmad A">A Ahmad</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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