Citrus nobiletin suppresses inducible nitric oxide synthase gene expression in interleukin-1β-treated hepatocytes.
Identifieur interne : 001394 ( Ncbi/Checkpoint ); précédent : 001393; suivant : 001395Citrus nobiletin suppresses inducible nitric oxide synthase gene expression in interleukin-1β-treated hepatocytes.
Auteurs : Emi Yoshigai [Japon] ; Toru Machida ; Tetsuya Okuyama ; Masatoshi Mori ; Hiromitsu Murase ; Ryota Yamanishi ; Tadayoshi Okumura ; Yukinobu Ikeya ; Hoyoku Nishino ; Mikio NishizawaSource :
- Biochemical and biophysical research communications [ 1090-2104 ] ; 2013.
English descriptors
- KwdEn :
- Animals, Anti-Inflammatory Agents (pharmacology), Cells, Cultured, Chromatography, High Pressure Liquid, Citrus (chemistry), Dose-Response Relationship, Drug, Flavones (pharmacology), Gene Expression Regulation, Enzymologic, Hepatocytes (drug effects), Hepatocytes (metabolism), Interleukin-1beta (pharmacology), L-Lactate Dehydrogenase (metabolism), NF-kappa B (metabolism), Nitric Oxide (metabolism), Nitric Oxide Synthase Type II (genetics), Nitric Oxide Synthase Type II (metabolism), Rats.
- MESH :
- chemical , genetics : Nitric Oxide Synthase Type II.
- chemical , metabolism : L-Lactate Dehydrogenase, NF-kappa B, Nitric Oxide, Nitric Oxide Synthase Type II.
- chemical , pharmacology : Anti-Inflammatory Agents, Flavones, Interleukin-1beta.
- chemistry : Citrus.
- drug effects : Hepatocytes.
- metabolism : Hepatocytes.
- Animals, Cells, Cultured, Chromatography, High Pressure Liquid, Dose-Response Relationship, Drug, Gene Expression Regulation, Enzymologic, Rats.
Abstract
Nobiletin is a polymethoxylated flavone that is abundant in the peels of citrus fruits, such as Citrus unshiu (Satsuma mandarin) and Citrus sinensis. The dried peels of C. unshiu (chinpi) have been included in several formulae of Japanese Kampo medicines. Nobiletin may suppress the induction of inducible nitric oxide synthase (iNOS), which synthesizes the inflammatory mediator nitric oxide (NO) in hepatocytes.
DOI: 10.1016/j.bbrc.2013.08.029
PubMed: 23958298
Affiliations:
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Ritsumeikan Global Innovation Research Organization (R-GIRO), Kusatsu, Shiga, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biomedical Sciences, College of Life Sciences, Kusatsu, Shiga, Japan; Ritsumeikan Global Innovation Research Organization (R-GIRO), Kusatsu, Shiga</wicri:regionArea><wicri:noRegion>Shiga</wicri:noRegion></affiliation></author><author><name sortKey="Machida, Toru" sort="Machida, Toru" uniqKey="Machida T" first="Toru" last="Machida">Toru Machida</name></author><author><name sortKey="Okuyama, Tetsuya" sort="Okuyama, Tetsuya" uniqKey="Okuyama T" first="Tetsuya" last="Okuyama">Tetsuya Okuyama</name></author><author><name sortKey="Mori, Masatoshi" sort="Mori, Masatoshi" uniqKey="Mori M" first="Masatoshi" last="Mori">Masatoshi Mori</name></author><author><name sortKey="Murase, Hiromitsu" sort="Murase, Hiromitsu" uniqKey="Murase H" first="Hiromitsu" last="Murase">Hiromitsu Murase</name></author><author><name sortKey="Yamanishi, Ryota" sort="Yamanishi, Ryota" uniqKey="Yamanishi R" first="Ryota" last="Yamanishi">Ryota Yamanishi</name></author><author><name sortKey="Okumura, Tadayoshi" sort="Okumura, Tadayoshi" uniqKey="Okumura T" first="Tadayoshi" last="Okumura">Tadayoshi Okumura</name></author><author><name sortKey="Ikeya, Yukinobu" sort="Ikeya, Yukinobu" uniqKey="Ikeya Y" first="Yukinobu" last="Ikeya">Yukinobu Ikeya</name></author><author><name sortKey="Nishino, Hoyoku" sort="Nishino, Hoyoku" uniqKey="Nishino H" first="Hoyoku" last="Nishino">Hoyoku Nishino</name></author><author><name sortKey="Nishizawa, Mikio" sort="Nishizawa, Mikio" uniqKey="Nishizawa M" first="Mikio" last="Nishizawa">Mikio Nishizawa</name></author></analytic><series><title level="j">Biochemical and biophysical research communications</title><idno type="eISSN">1090-2104</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Anti-Inflammatory Agents (pharmacology)</term><term>Cells, Cultured</term><term>Chromatography, High Pressure Liquid</term><term>Citrus (chemistry)</term><term>Dose-Response Relationship, Drug</term><term>Flavones (pharmacology)</term><term>Gene Expression Regulation, Enzymologic</term><term>Hepatocytes (drug effects)</term><term>Hepatocytes (metabolism)</term><term>Interleukin-1beta (pharmacology)</term><term>L-Lactate Dehydrogenase (metabolism)</term><term>NF-kappa B (metabolism)</term><term>Nitric Oxide (metabolism)</term><term>Nitric Oxide Synthase Type II (genetics)</term><term>Nitric Oxide Synthase Type II (metabolism)</term><term>Rats</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Nitric Oxide Synthase Type II</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>L-Lactate Dehydrogenase</term><term>NF-kappa B</term><term>Nitric Oxide</term><term>Nitric Oxide Synthase Type II</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Inflammatory Agents</term><term>Flavones</term><term>Interleukin-1beta</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Hepatocytes</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Hepatocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Chromatography, High Pressure Liquid</term><term>Dose-Response Relationship, Drug</term><term>Gene Expression Regulation, Enzymologic</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nobiletin is a polymethoxylated flavone that is abundant in the peels of citrus fruits, such as Citrus unshiu (Satsuma mandarin) and Citrus sinensis. The dried peels of C. unshiu (chinpi) have been included in several formulae of Japanese Kampo medicines. Nobiletin may suppress the induction of inducible nitric oxide synthase (iNOS), which synthesizes the inflammatory mediator nitric oxide (NO) in hepatocytes.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Ikeya, Yukinobu" sort="Ikeya, Yukinobu" uniqKey="Ikeya Y" first="Yukinobu" last="Ikeya">Yukinobu Ikeya</name><name sortKey="Machida, Toru" sort="Machida, Toru" uniqKey="Machida T" first="Toru" last="Machida">Toru Machida</name><name sortKey="Mori, Masatoshi" sort="Mori, Masatoshi" uniqKey="Mori M" first="Masatoshi" last="Mori">Masatoshi Mori</name><name sortKey="Murase, Hiromitsu" sort="Murase, Hiromitsu" uniqKey="Murase H" first="Hiromitsu" last="Murase">Hiromitsu Murase</name><name sortKey="Nishino, Hoyoku" sort="Nishino, Hoyoku" uniqKey="Nishino H" first="Hoyoku" last="Nishino">Hoyoku Nishino</name><name sortKey="Nishizawa, Mikio" sort="Nishizawa, Mikio" uniqKey="Nishizawa M" first="Mikio" last="Nishizawa">Mikio Nishizawa</name><name sortKey="Okumura, Tadayoshi" sort="Okumura, Tadayoshi" uniqKey="Okumura T" first="Tadayoshi" last="Okumura">Tadayoshi Okumura</name><name sortKey="Okuyama, Tetsuya" sort="Okuyama, Tetsuya" uniqKey="Okuyama T" first="Tetsuya" last="Okuyama">Tetsuya Okuyama</name><name sortKey="Yamanishi, Ryota" sort="Yamanishi, Ryota" uniqKey="Yamanishi R" first="Ryota" last="Yamanishi">Ryota Yamanishi</name></noCountry><country name="Japon"><noRegion><name sortKey="Yoshigai, Emi" sort="Yoshigai, Emi" uniqKey="Yoshigai E" first="Emi" last="Yoshigai">Emi Yoshigai</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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