Citrus nobiletin suppresses inducible nitric oxide synthase gene expression in interleukin-1β-treated hepatocytes.
Identifieur interne : 001394 ( Ncbi/Merge ); précédent : 001393; suivant : 001395Citrus nobiletin suppresses inducible nitric oxide synthase gene expression in interleukin-1β-treated hepatocytes.
Auteurs : Emi Yoshigai [Japon] ; Toru Machida ; Tetsuya Okuyama ; Masatoshi Mori ; Hiromitsu Murase ; Ryota Yamanishi ; Tadayoshi Okumura ; Yukinobu Ikeya ; Hoyoku Nishino ; Mikio NishizawaSource :
- Biochemical and biophysical research communications [ 1090-2104 ] ; 2013.
English descriptors
- KwdEn :
- Animals, Anti-Inflammatory Agents (pharmacology), Cells, Cultured, Chromatography, High Pressure Liquid, Citrus (chemistry), Dose-Response Relationship, Drug, Flavones (pharmacology), Gene Expression Regulation, Enzymologic, Hepatocytes (drug effects), Hepatocytes (metabolism), Interleukin-1beta (pharmacology), L-Lactate Dehydrogenase (metabolism), NF-kappa B (metabolism), Nitric Oxide (metabolism), Nitric Oxide Synthase Type II (genetics), Nitric Oxide Synthase Type II (metabolism), Rats.
- MESH :
- chemical , genetics : Nitric Oxide Synthase Type II.
- chemical , metabolism : L-Lactate Dehydrogenase, NF-kappa B, Nitric Oxide, Nitric Oxide Synthase Type II.
- chemical , pharmacology : Anti-Inflammatory Agents, Flavones, Interleukin-1beta.
- chemistry : Citrus.
- drug effects : Hepatocytes.
- metabolism : Hepatocytes.
- Animals, Cells, Cultured, Chromatography, High Pressure Liquid, Dose-Response Relationship, Drug, Gene Expression Regulation, Enzymologic, Rats.
Abstract
Nobiletin is a polymethoxylated flavone that is abundant in the peels of citrus fruits, such as Citrus unshiu (Satsuma mandarin) and Citrus sinensis. The dried peels of C. unshiu (chinpi) have been included in several formulae of Japanese Kampo medicines. Nobiletin may suppress the induction of inducible nitric oxide synthase (iNOS), which synthesizes the inflammatory mediator nitric oxide (NO) in hepatocytes.
DOI: 10.1016/j.bbrc.2013.08.029
PubMed: 23958298
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000437
- to stream PubMed, to step Curation: 000437
- to stream PubMed, to step Checkpoint: 000437
Links to Exploration step
pubmed:23958298Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Citrus nobiletin suppresses inducible nitric oxide synthase gene expression in interleukin-1β-treated hepatocytes.</title><author><name sortKey="Yoshigai, Emi" sort="Yoshigai, Emi" uniqKey="Yoshigai E" first="Emi" last="Yoshigai">Emi Yoshigai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, College of Life Sciences, Kusatsu, Shiga, Japan; Ritsumeikan Global Innovation Research Organization (R-GIRO), Kusatsu, Shiga, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biomedical Sciences, College of Life Sciences, Kusatsu, Shiga, Japan; Ritsumeikan Global Innovation Research Organization (R-GIRO), Kusatsu, Shiga</wicri:regionArea><wicri:noRegion>Shiga</wicri:noRegion></affiliation></author><author><name sortKey="Machida, Toru" sort="Machida, Toru" uniqKey="Machida T" first="Toru" last="Machida">Toru Machida</name></author><author><name sortKey="Okuyama, Tetsuya" sort="Okuyama, Tetsuya" uniqKey="Okuyama T" first="Tetsuya" last="Okuyama">Tetsuya Okuyama</name></author><author><name sortKey="Mori, Masatoshi" sort="Mori, Masatoshi" uniqKey="Mori M" first="Masatoshi" last="Mori">Masatoshi Mori</name></author><author><name sortKey="Murase, Hiromitsu" sort="Murase, Hiromitsu" uniqKey="Murase H" first="Hiromitsu" last="Murase">Hiromitsu Murase</name></author><author><name sortKey="Yamanishi, Ryota" sort="Yamanishi, Ryota" uniqKey="Yamanishi R" first="Ryota" last="Yamanishi">Ryota Yamanishi</name></author><author><name sortKey="Okumura, Tadayoshi" sort="Okumura, Tadayoshi" uniqKey="Okumura T" first="Tadayoshi" last="Okumura">Tadayoshi Okumura</name></author><author><name sortKey="Ikeya, Yukinobu" sort="Ikeya, Yukinobu" uniqKey="Ikeya Y" first="Yukinobu" last="Ikeya">Yukinobu Ikeya</name></author><author><name sortKey="Nishino, Hoyoku" sort="Nishino, Hoyoku" uniqKey="Nishino H" first="Hoyoku" last="Nishino">Hoyoku Nishino</name></author><author><name sortKey="Nishizawa, Mikio" sort="Nishizawa, Mikio" uniqKey="Nishizawa M" first="Mikio" last="Nishizawa">Mikio Nishizawa</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23958298</idno><idno type="pmid">23958298</idno><idno type="doi">10.1016/j.bbrc.2013.08.029</idno><idno type="wicri:Area/PubMed/Corpus">000437</idno><idno type="wicri:Area/PubMed/Curation">000437</idno><idno type="wicri:Area/PubMed/Checkpoint">000437</idno><idno type="wicri:Area/Ncbi/Merge">001394</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Citrus nobiletin suppresses inducible nitric oxide synthase gene expression in interleukin-1β-treated hepatocytes.</title><author><name sortKey="Yoshigai, Emi" sort="Yoshigai, Emi" uniqKey="Yoshigai E" first="Emi" last="Yoshigai">Emi Yoshigai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, College of Life Sciences, Kusatsu, Shiga, Japan; Ritsumeikan Global Innovation Research Organization (R-GIRO), Kusatsu, Shiga, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biomedical Sciences, College of Life Sciences, Kusatsu, Shiga, Japan; Ritsumeikan Global Innovation Research Organization (R-GIRO), Kusatsu, Shiga</wicri:regionArea><wicri:noRegion>Shiga</wicri:noRegion></affiliation></author><author><name sortKey="Machida, Toru" sort="Machida, Toru" uniqKey="Machida T" first="Toru" last="Machida">Toru Machida</name></author><author><name sortKey="Okuyama, Tetsuya" sort="Okuyama, Tetsuya" uniqKey="Okuyama T" first="Tetsuya" last="Okuyama">Tetsuya Okuyama</name></author><author><name sortKey="Mori, Masatoshi" sort="Mori, Masatoshi" uniqKey="Mori M" first="Masatoshi" last="Mori">Masatoshi Mori</name></author><author><name sortKey="Murase, Hiromitsu" sort="Murase, Hiromitsu" uniqKey="Murase H" first="Hiromitsu" last="Murase">Hiromitsu Murase</name></author><author><name sortKey="Yamanishi, Ryota" sort="Yamanishi, Ryota" uniqKey="Yamanishi R" first="Ryota" last="Yamanishi">Ryota Yamanishi</name></author><author><name sortKey="Okumura, Tadayoshi" sort="Okumura, Tadayoshi" uniqKey="Okumura T" first="Tadayoshi" last="Okumura">Tadayoshi Okumura</name></author><author><name sortKey="Ikeya, Yukinobu" sort="Ikeya, Yukinobu" uniqKey="Ikeya Y" first="Yukinobu" last="Ikeya">Yukinobu Ikeya</name></author><author><name sortKey="Nishino, Hoyoku" sort="Nishino, Hoyoku" uniqKey="Nishino H" first="Hoyoku" last="Nishino">Hoyoku Nishino</name></author><author><name sortKey="Nishizawa, Mikio" sort="Nishizawa, Mikio" uniqKey="Nishizawa M" first="Mikio" last="Nishizawa">Mikio Nishizawa</name></author></analytic><series><title level="j">Biochemical and biophysical research communications</title><idno type="eISSN">1090-2104</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Anti-Inflammatory Agents (pharmacology)</term><term>Cells, Cultured</term><term>Chromatography, High Pressure Liquid</term><term>Citrus (chemistry)</term><term>Dose-Response Relationship, Drug</term><term>Flavones (pharmacology)</term><term>Gene Expression Regulation, Enzymologic</term><term>Hepatocytes (drug effects)</term><term>Hepatocytes (metabolism)</term><term>Interleukin-1beta (pharmacology)</term><term>L-Lactate Dehydrogenase (metabolism)</term><term>NF-kappa B (metabolism)</term><term>Nitric Oxide (metabolism)</term><term>Nitric Oxide Synthase Type II (genetics)</term><term>Nitric Oxide Synthase Type II (metabolism)</term><term>Rats</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Nitric Oxide Synthase Type II</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>L-Lactate Dehydrogenase</term><term>NF-kappa B</term><term>Nitric Oxide</term><term>Nitric Oxide Synthase Type II</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Inflammatory Agents</term><term>Flavones</term><term>Interleukin-1beta</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Hepatocytes</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Hepatocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Chromatography, High Pressure Liquid</term><term>Dose-Response Relationship, Drug</term><term>Gene Expression Regulation, Enzymologic</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nobiletin is a polymethoxylated flavone that is abundant in the peels of citrus fruits, such as Citrus unshiu (Satsuma mandarin) and Citrus sinensis. The dried peels of C. unshiu (chinpi) have been included in several formulae of Japanese Kampo medicines. Nobiletin may suppress the induction of inducible nitric oxide synthase (iNOS), which synthesizes the inflammatory mediator nitric oxide (NO) in hepatocytes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23958298</PMID><DateCreated><Year>2013</Year><Month>9</Month><Day>16</Day></DateCreated><DateCompleted><Year>2013</Year><Month>11</Month><Day>12</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1090-2104</ISSN><JournalIssue CitedMedium="Internet"><Volume>439</Volume><Issue>1</Issue><PubDate><Year>2013</Year><Month>Sep</Month><Day>13</Day></PubDate></JournalIssue><Title>Biochemical and biophysical research communications</Title><ISOAbbreviation>Biochem. Biophys. Res. Commun.</ISOAbbreviation></Journal><ArticleTitle>Citrus nobiletin suppresses inducible nitric oxide synthase gene expression in interleukin-1β-treated hepatocytes.</ArticleTitle><Pagination><MedlinePgn>54-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbrc.2013.08.029</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0006-291X(13)01355-7</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Nobiletin is a polymethoxylated flavone that is abundant in the peels of citrus fruits, such as Citrus unshiu (Satsuma mandarin) and Citrus sinensis. The dried peels of C. unshiu (chinpi) have been included in several formulae of Japanese Kampo medicines. Nobiletin may suppress the induction of inducible nitric oxide synthase (iNOS), which synthesizes the inflammatory mediator nitric oxide (NO) in hepatocytes.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A C. unshiu peel (CUP) extract was prepared. Primary cultured rat hepatocytes were treated with the CUP extract or nobiletin in the presence of interleukin 1β (IL-1β), which induces iNOS expression. NO production and iNOS gene expression were analyzed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">High-performance liquid chromatography analyses revealed that the nobiletin content in the CUP extract was 0.14%. Nobiletin dose-dependently reduced the NO levels and decreased iNOS expression at the protein, mRNA and antisense transcript levels. Flavone, which does not contain any methoxy groups, also suppressed iNOS induction. Nobiletin reduced the transcriptional activity of iNOS promoter-luciferase constructs and the DNA-binding activity of nuclear factor κB (NF-κB) in the nuclei.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The suppression of iNOS induction by nobiletin suggests that nobiletin may be responsible for the anti-inflammatory effects of citrus peels and have a therapeutic potential for liver diseases.</AbstractText><CopyrightInformation>Copyright © 2013 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yoshigai</LastName><ForeName>Emi</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Biomedical Sciences, College of Life Sciences, Kusatsu, Shiga, Japan; Ritsumeikan Global Innovation Research Organization (R-GIRO), Kusatsu, Shiga, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Machida</LastName><ForeName>Toru</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Okuyama</LastName><ForeName>Tetsuya</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Mori</LastName><ForeName>Masatoshi</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Murase</LastName><ForeName>Hiromitsu</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Yamanishi</LastName><ForeName>Ryota</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Okumura</LastName><ForeName>Tadayoshi</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Ikeya</LastName><ForeName>Yukinobu</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Nishino</LastName><ForeName>Hoyoku</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Nishizawa</LastName><ForeName>Mikio</ForeName><Initials>M</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>Aug</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Biochem Biophys Res Commun</MedlineTA><NlmUniqueID>0372516</NlmUniqueID><ISSNLinking>0006-291X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000893">Anti-Inflammatory Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D047309">Flavones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053583">Interleukin-1beta</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016328">NF-kappa B</NameOfSubstance></Chemical><Chemical><RegistryNumber>31C4KY9ESH</RegistryNumber><NameOfSubstance UI="D009569">Nitric Oxide</NameOfSubstance></Chemical><Chemical><RegistryNumber>D65ILJ7WLY</RegistryNumber><NameOfSubstance UI="C008661">nobiletin</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.1.1.27</RegistryNumber><NameOfSubstance UI="D007770">L-Lactate Dehydrogenase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.13.39</RegistryNumber><NameOfSubstance UI="D052247">Nitric Oxide Synthase Type II</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.13.39</RegistryNumber><NameOfSubstance UI="C496318">Nos2 protein, rat</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000893" MajorTopicYN="N">Anti-Inflammatory Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002851" MajorTopicYN="N">Chromatography, High Pressure Liquid</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002957" MajorTopicYN="N">Citrus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D047309" MajorTopicYN="N">Flavones</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015971" MajorTopicYN="Y">Gene Expression Regulation, Enzymologic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D022781" MajorTopicYN="N">Hepatocytes</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053583" MajorTopicYN="N">Interleukin-1beta</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007770" MajorTopicYN="N">L-Lactate Dehydrogenase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016328" MajorTopicYN="N">NF-kappa B</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009569" MajorTopicYN="N">Nitric Oxide</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D052247" MajorTopicYN="N">Nitric Oxide Synthase Type II</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Chinpi</Keyword><Keyword MajorTopicYN="N">Flavone</Keyword><Keyword MajorTopicYN="N">Flavonoid</Keyword><Keyword MajorTopicYN="N">Inflammation</Keyword><Keyword MajorTopicYN="N">Nitric oxide</Keyword><Keyword MajorTopicYN="N">Plant polyphenol</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>7</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>8</Month><Day>2</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>8</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>8</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>11</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23958298</ArticleId><ArticleId IdType="pii">S0006-291X(13)01355-7</ArticleId><ArticleId IdType="doi">10.1016/j.bbrc.2013.08.029</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Ikeya, Yukinobu" sort="Ikeya, Yukinobu" uniqKey="Ikeya Y" first="Yukinobu" last="Ikeya">Yukinobu Ikeya</name><name sortKey="Machida, Toru" sort="Machida, Toru" uniqKey="Machida T" first="Toru" last="Machida">Toru Machida</name><name sortKey="Mori, Masatoshi" sort="Mori, Masatoshi" uniqKey="Mori M" first="Masatoshi" last="Mori">Masatoshi Mori</name><name sortKey="Murase, Hiromitsu" sort="Murase, Hiromitsu" uniqKey="Murase H" first="Hiromitsu" last="Murase">Hiromitsu Murase</name><name sortKey="Nishino, Hoyoku" sort="Nishino, Hoyoku" uniqKey="Nishino H" first="Hoyoku" last="Nishino">Hoyoku Nishino</name><name sortKey="Nishizawa, Mikio" sort="Nishizawa, Mikio" uniqKey="Nishizawa M" first="Mikio" last="Nishizawa">Mikio Nishizawa</name><name sortKey="Okumura, Tadayoshi" sort="Okumura, Tadayoshi" uniqKey="Okumura T" first="Tadayoshi" last="Okumura">Tadayoshi Okumura</name><name sortKey="Okuyama, Tetsuya" sort="Okuyama, Tetsuya" uniqKey="Okuyama T" first="Tetsuya" last="Okuyama">Tetsuya Okuyama</name><name sortKey="Yamanishi, Ryota" sort="Yamanishi, Ryota" uniqKey="Yamanishi R" first="Ryota" last="Yamanishi">Ryota Yamanishi</name></noCountry><country name="Japon"><noRegion><name sortKey="Yoshigai, Emi" sort="Yoshigai, Emi" uniqKey="Yoshigai E" first="Emi" last="Yoshigai">Emi Yoshigai</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/OrangerV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001394 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 001394 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Bois
|area= OrangerV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= pubmed:23958298
|texte= Citrus nobiletin suppresses inducible nitric oxide synthase gene expression in interleukin-1β-treated hepatocytes.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:23958298" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a OrangerV1
| This area was generated with Dilib version V0.6.25. |  |