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Morphine-induced suppression of conditioned stimulus intake: Effects of stimulus type and insular cortex lesions

Identifieur interne : 001D95 ( Main/Merge ); précédent : 001D94; suivant : 001D96

Morphine-induced suppression of conditioned stimulus intake: Effects of stimulus type and insular cortex lesions

Auteurs : Jian-You Lin ; Christopher Roman ; Steve Reilly

Source :

RBID : PMC:2752605

English descriptors

Abstract

Intake of an unconditionally preferred taste stimulus (e.g., saccharin) is reduced by contingent administration of a drug of abuse (e.g., morphine). We examined the influence of insular cortex (IC) lesions on morphine-induced suppression of an olfactory cue and two taste stimuli with different levels of perceived innate reward value. Two major findings emerged from this study. First, morphine suppressed intake of an aqueous odor as well as each taste stimulus in neurologically intact rats. Second, IC lesions disrupted morphine-induced suppression of the taste stimuli but not the aqueous odor cue. These results indicate that the perceived innate reward value of the CS is not a factor that governs drug-induced intake suppression.


Url:
DOI: 10.1016/j.brainres.2009.07.033
PubMed: 19631620
PubMed Central: 2752605

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PMC:2752605

Le document en format XML

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<term>Citrus sinensis</term>
<term>Conditioning, Classical (drug effects)</term>
<term>Conditioning, Classical (physiology)</term>
<term>Cues</term>
<term>Drinking Behavior (drug effects)</term>
<term>Drinking Behavior (physiology)</term>
<term>Malates</term>
<term>Male</term>
<term>Morphine (pharmacology)</term>
<term>Narcotics (pharmacology)</term>
<term>Odors</term>
<term>Olfactory Perception (drug effects)</term>
<term>Olfactory Perception (physiology)</term>
<term>Parietal Lobe (physiology)</term>
<term>Physical Stimulation</term>
<term>Random Allocation</term>
<term>Rats</term>
<term>Reward</term>
<term>Sodium Chloride</term>
<term>Taste Perception (drug effects)</term>
<term>Taste Perception (physiology)</term>
<term>Temporal Lobe (physiology)</term>
<term>Time Factors</term>
<term>Water</term>
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<term>Morphine</term>
<term>Narcotics</term>
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<term>Olfactory Perception</term>
<term>Taste Perception</term>
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<term>Conditioning, Classical</term>
<term>Drinking Behavior</term>
<term>Olfactory Perception</term>
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