p-Synephrine Suppresses Glucose Production but Not Lipid Accumulation in H4IIE Liver Cells
Identifieur interne : 000830 ( Main/Merge ); précédent : 000829; suivant : 000831p-Synephrine Suppresses Glucose Production but Not Lipid Accumulation in H4IIE Liver Cells
Auteurs : Zhigang Cui ; Youngil Lee ; Youngki Lee ; Deokbae ParkSource :
- Journal of Medicinal Food [ 1096-620X ] ; 2015.
Abstract
Url:
DOI: 10.1089/jmf.2013.3133
PubMed: 25379695
PubMed Central: 4281838
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PMC:4281838Le document en format XML
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-Synephrine Suppresses Glucose Production but Not Lipid Accumulation in H4IIE Liver Cells</title>
<author><name sortKey="Cui, Zhigang" sort="Cui, Zhigang" uniqKey="Cui Z" first="Zhigang" last="Cui">Zhigang Cui</name>
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<author><name sortKey="Lee, Youngil" sort="Lee, Youngil" uniqKey="Lee Y" first="Youngil" last="Lee">Youngil Lee</name>
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<author><name sortKey="Lee, Youngki" sort="Lee, Youngki" uniqKey="Lee Y" first="Youngki" last="Lee">Youngki Lee</name>
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<author><name sortKey="Park, Deokbae" sort="Park, Deokbae" uniqKey="Park D" first="Deokbae" last="Park">Deokbae Park</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>p</italic>
-Synephrine Suppresses Glucose Production but Not Lipid Accumulation in H4IIE Liver Cells</title>
<author><name sortKey="Cui, Zhigang" sort="Cui, Zhigang" uniqKey="Cui Z" first="Zhigang" last="Cui">Zhigang Cui</name>
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<author><name sortKey="Lee, Youngil" sort="Lee, Youngil" uniqKey="Lee Y" first="Youngil" last="Lee">Youngil Lee</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lee, Youngki" sort="Lee, Youngki" uniqKey="Lee Y" first="Youngki" last="Lee">Youngki Lee</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Park, Deokbae" sort="Park, Deokbae" uniqKey="Park D" first="Deokbae" last="Park">Deokbae Park</name>
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<series><title level="j">Journal of Medicinal Food</title>
<idno type="ISSN">1096-620X</idno>
<idno type="eISSN">1557-7600</idno>
<imprint><date when="2015">2015</date>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p><italic>p</italic>
-Synephrine, the primary protoalkaloid in the extract of bitter orange and other citrus species, has gained interest due to its lipolytic activity in adipose tissues. We previously found that <italic>p</italic>
-synephrine stimulates glucose consumption via AMP-activated protein kinase (AMPK) in L6 skeletal muscle cells. This study investigated the effect of <italic>p</italic>
-synephrine on glucose production and lipid accumulation in H4IIE rat liver cells. Glucose production was increased in H4llE cells that were incubated in glucose-free medium but decreased dose dependently (1–100 <italic>μ</italic>
M) with <italic>p</italic>
-synephrine treatment. Protein levels of glucose-6-phosphatase (G6Pase) and phosphoenol pyruvate carboxykinase (PEPCK) were also decreased by treatment (4 h) with <italic>p</italic>
-synephrine. Antagonists against <italic>α</italic>
- and <italic>β</italic>
-adrenergic receptors (phentolamine and propranolol) and other inhibitors against signaling molecules did not interrupt <italic>p</italic>
-synephrine-induced suppression in glucose production. However, H7 (an inhibitor of serine/threonine kinases PKA, PKC, and PKG) significantly blocked <italic>p</italic>
-synephrine-induced suppression of glucose production and further increased basal glucose production. Unlike the suppressive effect on glucose production, <italic>p</italic>
-synephrine failed to affect palmitic acid-induced cytoplasmic lipid accumulation. Protein levels of fatty acid synthase (FAS) and phosphorylation levels of AMPK and ACC were not changed by <italic>p</italic>
-synephrine. Altogether, <italic>p</italic>
-synephrine can suppress glucose production but does not affect lipid accumulation in H4IIE liver cells.</p>
</div>
</front>
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