p-Synephrine Suppresses Glucose Production but Not Lipid Accumulation in H4IIE Liver Cells
Identifieur interne : 001895 ( Ncbi/Merge ); précédent : 001894; suivant : 001896p-Synephrine Suppresses Glucose Production but Not Lipid Accumulation in H4IIE Liver Cells
Auteurs : Zhigang Cui ; Youngil Lee ; Youngki Lee ; Deokbae ParkSource :
- Journal of Medicinal Food [ 1096-620X ] ; 2015.
Abstract
Url:
DOI: 10.1089/jmf.2013.3133
PubMed: 25379695
PubMed Central: 4281838
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000C68
- to stream Pmc, to step Curation: 000C67
- to stream Pmc, to step Checkpoint: 000635
Links to Exploration step
PMC:4281838Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>p</italic>
-Synephrine Suppresses Glucose Production but Not Lipid Accumulation in H4IIE Liver Cells</title>
<author><name sortKey="Cui, Zhigang" sort="Cui, Zhigang" uniqKey="Cui Z" first="Zhigang" last="Cui">Zhigang Cui</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lee, Youngil" sort="Lee, Youngil" uniqKey="Lee Y" first="Youngil" last="Lee">Youngil Lee</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lee, Youngki" sort="Lee, Youngki" uniqKey="Lee Y" first="Youngki" last="Lee">Youngki Lee</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Park, Deokbae" sort="Park, Deokbae" uniqKey="Park D" first="Deokbae" last="Park">Deokbae Park</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25379695</idno>
<idno type="pmc">4281838</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281838</idno>
<idno type="RBID">PMC:4281838</idno>
<idno type="doi">10.1089/jmf.2013.3133</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000C68</idno>
<idno type="wicri:Area/Pmc/Curation">000C67</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000635</idno>
<idno type="wicri:Area/Ncbi/Merge">001895</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>p</italic>
-Synephrine Suppresses Glucose Production but Not Lipid Accumulation in H4IIE Liver Cells</title>
<author><name sortKey="Cui, Zhigang" sort="Cui, Zhigang" uniqKey="Cui Z" first="Zhigang" last="Cui">Zhigang Cui</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lee, Youngil" sort="Lee, Youngil" uniqKey="Lee Y" first="Youngil" last="Lee">Youngil Lee</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lee, Youngki" sort="Lee, Youngki" uniqKey="Lee Y" first="Youngki" last="Lee">Youngki Lee</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Park, Deokbae" sort="Park, Deokbae" uniqKey="Park D" first="Deokbae" last="Park">Deokbae Park</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Medicinal Food</title>
<idno type="ISSN">1096-620X</idno>
<idno type="eISSN">1557-7600</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p><italic>p</italic>
-Synephrine, the primary protoalkaloid in the extract of bitter orange and other citrus species, has gained interest due to its lipolytic activity in adipose tissues. We previously found that <italic>p</italic>
-synephrine stimulates glucose consumption via AMP-activated protein kinase (AMPK) in L6 skeletal muscle cells. This study investigated the effect of <italic>p</italic>
-synephrine on glucose production and lipid accumulation in H4IIE rat liver cells. Glucose production was increased in H4llE cells that were incubated in glucose-free medium but decreased dose dependently (1–100 <italic>μ</italic>
M) with <italic>p</italic>
-synephrine treatment. Protein levels of glucose-6-phosphatase (G6Pase) and phosphoenol pyruvate carboxykinase (PEPCK) were also decreased by treatment (4 h) with <italic>p</italic>
-synephrine. Antagonists against <italic>α</italic>
- and <italic>β</italic>
-adrenergic receptors (phentolamine and propranolol) and other inhibitors against signaling molecules did not interrupt <italic>p</italic>
-synephrine-induced suppression in glucose production. However, H7 (an inhibitor of serine/threonine kinases PKA, PKC, and PKG) significantly blocked <italic>p</italic>
-synephrine-induced suppression of glucose production and further increased basal glucose production. Unlike the suppressive effect on glucose production, <italic>p</italic>
-synephrine failed to affect palmitic acid-induced cytoplasmic lipid accumulation. Protein levels of fatty acid synthase (FAS) and phosphorylation levels of AMPK and ACC were not changed by <italic>p</italic>
-synephrine. Altogether, <italic>p</italic>
-synephrine can suppress glucose production but does not affect lipid accumulation in H4IIE liver cells.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Med Food</journal-id>
<journal-id journal-id-type="iso-abbrev">J Med Food</journal-id>
<journal-id journal-id-type="publisher-id">jmf</journal-id>
<journal-title-group><journal-title>Journal of Medicinal Food</journal-title>
</journal-title-group>
<issn pub-type="ppub">1096-620X</issn>
<issn pub-type="epub">1557-7600</issn>
<publisher><publisher-name>Mary Ann Liebert, Inc.</publisher-name>
<publisher-loc>140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25379695</article-id>
<article-id pub-id-type="pmc">4281838</article-id>
<article-id pub-id-type="publisher-id">10.1089/jmf.2013.3133</article-id>
<article-id pub-id-type="doi">10.1089/jmf.2013.3133</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Full Communications</subject>
</subj-group>
</article-categories>
<title-group><article-title><italic>p</italic>
-Synephrine Suppresses Glucose Production but Not Lipid Accumulation in H4IIE Liver Cells</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Cui</surname>
<given-names>Zhigang</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lee</surname>
<given-names>Youngil</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lee</surname>
<given-names>Youngki</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Park</surname>
<given-names>Deokbae</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<aff id="aff1"><label><sup>1</sup>
</label>
Department of Histology and Embryology,<institution>Hainan Medical University</institution>
, Haikou,<country>China</country>
.</aff>
<aff id="aff2"><label><sup>2</sup>
</label>
<institution>Dankook University Medical College</institution>
, Cheonan-Si, Korea.</aff>
<aff id="aff3"><label><sup>3</sup>
</label>
Department of Histology, School of Medicine, Institute of Medical Science,<institution>Jeju National University</institution>
, Jeju, Korea.</aff>
</contrib-group>
<author-notes><corresp><italic>Address correspondence to: Deokbae Park, PhD, Department of Histology, School of Medicine, Institute of Medical Science,</italic>
<institution><italic>Jeju National University</italic>
</institution>
<italic>, Jeju 690-756, Korea, E-mail:</italic>
<email xlink:href="mailto:parkdb@jejunu.ac.kr">parkdb@jejunu.ac.kr</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>01</day>
<month>1</month>
<year>2015</year>
<pmc-comment>string-date: January 2015</pmc-comment>
</pub-date>
<volume>18</volume>
<issue>1</issue>
<fpage>76</fpage>
<lpage>82</lpage>
<history><date date-type="received"><day>17</day>
<month>12</month>
<year>2013</year>
<pmc-comment>string-date: Manuscript received 17 December 2013</pmc-comment>
</date>
<date date-type="accepted"><day>26</day>
<month>8</month>
<year>2014</year>
<pmc-comment>string-date: Revision accepted 26 August 2014</pmc-comment>
</date>
</history>
<permissions><copyright-statement>Copyright 2015, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition</copyright-statement>
<copyright-year>2015</copyright-year>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="jmf.2013.3133.pdf"></self-uri>
<abstract><title>Abstract</title>
<p><italic>p</italic>
-Synephrine, the primary protoalkaloid in the extract of bitter orange and other citrus species, has gained interest due to its lipolytic activity in adipose tissues. We previously found that <italic>p</italic>
-synephrine stimulates glucose consumption via AMP-activated protein kinase (AMPK) in L6 skeletal muscle cells. This study investigated the effect of <italic>p</italic>
-synephrine on glucose production and lipid accumulation in H4IIE rat liver cells. Glucose production was increased in H4llE cells that were incubated in glucose-free medium but decreased dose dependently (1–100 <italic>μ</italic>
M) with <italic>p</italic>
-synephrine treatment. Protein levels of glucose-6-phosphatase (G6Pase) and phosphoenol pyruvate carboxykinase (PEPCK) were also decreased by treatment (4 h) with <italic>p</italic>
-synephrine. Antagonists against <italic>α</italic>
- and <italic>β</italic>
-adrenergic receptors (phentolamine and propranolol) and other inhibitors against signaling molecules did not interrupt <italic>p</italic>
-synephrine-induced suppression in glucose production. However, H7 (an inhibitor of serine/threonine kinases PKA, PKC, and PKG) significantly blocked <italic>p</italic>
-synephrine-induced suppression of glucose production and further increased basal glucose production. Unlike the suppressive effect on glucose production, <italic>p</italic>
-synephrine failed to affect palmitic acid-induced cytoplasmic lipid accumulation. Protein levels of fatty acid synthase (FAS) and phosphorylation levels of AMPK and ACC were not changed by <italic>p</italic>
-synephrine. Altogether, <italic>p</italic>
-synephrine can suppress glucose production but does not affect lipid accumulation in H4IIE liver cells.</p>
</abstract>
<kwd-group kwd-group-type="author"><title><bold>Key Words:</bold>
</title>
<kwd><italic>glucose production</italic>
</kwd>
<kwd><italic>H4IIE liver cells</italic>
</kwd>
<kwd><italic>lipid accumulation</italic>
</kwd>
<kwd><bold>p</bold>
<bold><italic>-synephrine</italic>
</bold>
</kwd>
</kwd-group>
<counts><fig-count count="4"></fig-count>
<ref-count count="30"></ref-count>
<page-count count="7"></page-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Cui, Zhigang" sort="Cui, Zhigang" uniqKey="Cui Z" first="Zhigang" last="Cui">Zhigang Cui</name>
<name sortKey="Lee, Youngil" sort="Lee, Youngil" uniqKey="Lee Y" first="Youngil" last="Lee">Youngil Lee</name>
<name sortKey="Lee, Youngki" sort="Lee, Youngki" uniqKey="Lee Y" first="Youngki" last="Lee">Youngki Lee</name>
<name sortKey="Park, Deokbae" sort="Park, Deokbae" uniqKey="Park D" first="Deokbae" last="Park">Deokbae Park</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/OrangerV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001895 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 001895 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Bois |area= OrangerV1 |flux= Ncbi |étape= Merge |type= RBID |clé= PMC:4281838 |texte= p-Synephrine Suppresses Glucose Production but Not Lipid Accumulation in H4IIE Liver Cells }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:25379695" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a OrangerV1
This area was generated with Dilib version V0.6.25. |