Interactions between iron(III)-hydroxide polymaltose complex and commonly used drugs / simulations and in vitro studies.
Identifieur interne : 002293 ( Main/Exploration ); précédent : 002292; suivant : 002294Interactions between iron(III)-hydroxide polymaltose complex and commonly used drugs / simulations and in vitro studies.
Auteurs : Susanna Burckhardt-Herold [Suisse] ; Jürgen Klotz ; Felix Funk ; Ruth Büchi ; Jeannine Petrig-Schaffland ; Peter GeisserSource :
- Arzneimittel-Forschung [ 0004-4172 ] ; 2007.
English descriptors
- KwdEn :
- Acetaminophen (chemistry), Anaerobiosis, Ascorbic Acid (chemistry), Aspartic Acid (chemistry), Beverages, Calcium Phosphates (chemistry), Citrus sinensis, Drug Interactions, Ferric Compounds (chemistry), Food-Drug Interactions, Hydrogen-Ion Concentration, Indicators and Reagents, Methyldopa (chemistry), Salicylic Acid (chemistry), Spectrophotometry, Ultraviolet, Tetracycline (chemistry).
- MESH :
- chemical , chemistry : Acetaminophen, Ascorbic Acid, Aspartic Acid, Calcium Phosphates, Ferric Compounds, Methyldopa, Salicylic Acid, Tetracycline.
- Anaerobiosis, Beverages, Citrus sinensis, Drug Interactions, Food-Drug Interactions, Hydrogen-Ion Concentration, Indicators and Reagents, Spectrophotometry, Ultraviolet.
Abstract
Under physiological conditions, ferric ions are essentially insoluble because of the formation of polynuclear hydroxo-bridged complexes. Ferrous ions are more soluble but may produce hydroxyl radicals on reaction with hydrogen peroxide. Chelation of ferric and ferrous ions with organic ligands may prevent these undesirable reactions. Alternatively, iron(III)-hydroxide/oxide can be stabilized and solubilized by tight interactions with carbohydrates. The data presented in this work show that, because of its physicochemical properties, the iron(III)-hydroxide polymaltose complex (IPC, Maltofer) does not interact with the active ingredients of commonly used drugs such as acetylsalicylic acid (CAS 50-78-2), tetracycline hydrochloride (CAS 64-75-5), calcium hydrogen-phosphate (CAS 7757-93-9), methyl-L-dopa sesquihydrate (CAS 41372-08-1), and magnesium-L-aspartate hydrochloride (CAS 28184-71-6). In contrast, as confirmed by calculations using thermodynamic parameters, FeCl3 x 6H2O (CAS 10025-77-1) can form different types of complexes with these substances. Moreover, the data show that under aerobic conditions high concentrations of ascorbic acid (CAS 50-81-7) can lead to mobilization of iron from IPC and, thus, support the observation that orange juice slightly increases the uptake of iron from IPC.
DOI: 10.1055/s-0031-1296684
PubMed: 17691585
Affiliations:
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sortKey="Buchi, Ruth" sort="Buchi, Ruth" uniqKey="Buchi R" first="Ruth" last="Büchi">Ruth Büchi</name></author><author><name sortKey="Petrig Schaffland, Jeannine" sort="Petrig Schaffland, Jeannine" uniqKey="Petrig Schaffland J" first="Jeannine" last="Petrig-Schaffland">Jeannine Petrig-Schaffland</name></author><author><name sortKey="Geisser, Peter" sort="Geisser, Peter" uniqKey="Geisser P" first="Peter" last="Geisser">Peter Geisser</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17691585</idno><idno type="pmid">17691585</idno><idno type="doi">10.1055/s-0031-1296684</idno><idno type="wicri:Area/PubMed/Corpus">000B68</idno><idno type="wicri:Area/PubMed/Curation">000B68</idno><idno type="wicri:Area/PubMed/Checkpoint">000B68</idno><idno type="wicri:Area/Ncbi/Merge">000730</idno><idno type="wicri:Area/Ncbi/Curation">000730</idno><idno type="wicri:Area/Ncbi/Checkpoint">000730</idno><idno 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Jurgen" sort="Klotz, Jurgen" uniqKey="Klotz J" first="Jürgen" last="Klotz">Jürgen Klotz</name></author><author><name sortKey="Funk, Felix" sort="Funk, Felix" uniqKey="Funk F" first="Felix" last="Funk">Felix Funk</name></author><author><name sortKey="Buchi, Ruth" sort="Buchi, Ruth" uniqKey="Buchi R" first="Ruth" last="Büchi">Ruth Büchi</name></author><author><name sortKey="Petrig Schaffland, Jeannine" sort="Petrig Schaffland, Jeannine" uniqKey="Petrig Schaffland J" first="Jeannine" last="Petrig-Schaffland">Jeannine Petrig-Schaffland</name></author><author><name sortKey="Geisser, Peter" sort="Geisser, Peter" uniqKey="Geisser P" first="Peter" last="Geisser">Peter Geisser</name></author></analytic><series><title level="j">Arzneimittel-Forschung</title><idno type="ISSN">0004-4172</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetaminophen (chemistry)</term><term>Anaerobiosis</term><term>Ascorbic Acid (chemistry)</term><term>Aspartic Acid (chemistry)</term><term>Beverages</term><term>Calcium Phosphates (chemistry)</term><term>Citrus sinensis</term><term>Drug Interactions</term><term>Ferric Compounds (chemistry)</term><term>Food-Drug Interactions</term><term>Hydrogen-Ion Concentration</term><term>Indicators and Reagents</term><term>Methyldopa (chemistry)</term><term>Salicylic Acid (chemistry)</term><term>Spectrophotometry, Ultraviolet</term><term>Tetracycline (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Acetaminophen</term><term>Ascorbic Acid</term><term>Aspartic Acid</term><term>Calcium Phosphates</term><term>Ferric Compounds</term><term>Methyldopa</term><term>Salicylic Acid</term><term>Tetracycline</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Anaerobiosis</term><term>Beverages</term><term>Citrus sinensis</term><term>Drug Interactions</term><term>Food-Drug Interactions</term><term>Hydrogen-Ion Concentration</term><term>Indicators and Reagents</term><term>Spectrophotometry, Ultraviolet</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Under physiological conditions, ferric ions are essentially insoluble because of the formation of polynuclear hydroxo-bridged complexes. Ferrous ions are more soluble but may produce hydroxyl radicals on reaction with hydrogen peroxide. Chelation of ferric and ferrous ions with organic ligands may prevent these undesirable reactions. Alternatively, iron(III)-hydroxide/oxide can be stabilized and solubilized by tight interactions with carbohydrates. The data presented in this work show that, because of its physicochemical properties, the iron(III)-hydroxide polymaltose complex (IPC, Maltofer) does not interact with the active ingredients of commonly used drugs such as acetylsalicylic acid (CAS 50-78-2), tetracycline hydrochloride (CAS 64-75-5), calcium hydrogen-phosphate (CAS 7757-93-9), methyl-L-dopa sesquihydrate (CAS 41372-08-1), and magnesium-L-aspartate hydrochloride (CAS 28184-71-6). In contrast, as confirmed by calculations using thermodynamic parameters, FeCl3 x 6H2O (CAS 10025-77-1) can form different types of complexes with these substances. Moreover, the data show that under aerobic conditions high concentrations of ascorbic acid (CAS 50-81-7) can lead to mobilization of iron from IPC and, thus, support the observation that orange juice slightly increases the uptake of iron from IPC.</div></front></TEI><affiliations><list><country><li>Suisse</li></country></list><tree><noCountry><name sortKey="Buchi, Ruth" sort="Buchi, Ruth" uniqKey="Buchi R" first="Ruth" last="Büchi">Ruth Büchi</name><name sortKey="Funk, Felix" sort="Funk, Felix" uniqKey="Funk F" first="Felix" last="Funk">Felix Funk</name><name sortKey="Geisser, Peter" sort="Geisser, Peter" uniqKey="Geisser P" first="Peter" last="Geisser">Peter Geisser</name><name sortKey="Klotz, Jurgen" sort="Klotz, Jurgen" uniqKey="Klotz J" first="Jürgen" last="Klotz">Jürgen Klotz</name><name sortKey="Petrig Schaffland, Jeannine" sort="Petrig Schaffland, Jeannine" uniqKey="Petrig Schaffland J" first="Jeannine" last="Petrig-Schaffland">Jeannine Petrig-Schaffland</name></noCountry><country name="Suisse"><noRegion><name sortKey="Burckhardt Herold, Susanna" sort="Burckhardt Herold, Susanna" uniqKey="Burckhardt Herold S" first="Susanna" last="Burckhardt-Herold">Susanna Burckhardt-Herold</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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