OrangerV1, Main, Exploration, bibRecord, 001434

Moro orange juice prevents fatty liver in mice

Identifieur interne : 001434 ( Main/Exploration ); précédent : 001433; suivant : 001435

Moro orange juice prevents fatty liver in mice

Auteurs : Federico Salamone ; Giovanni Li Volti ; Lucilla Titta ; Lidia Puzzo ; Ignazio Barbagallo ; Francesco La Delia ; Shira Zelber-Sagi ; Michele Malaguarnera ; Pier Giuseppe Pelicci ; Marco Giorgio ; Fabio Galvano

Source :

World Journal of Gastroenterology : WJG [ 1007-9327 ] ; 2012.

RBID : PMC:3413058

English descriptors

KwdEn :
- Acyl-CoA Oxidase (genetics), Animals, Beverages, Citrus sinensis, Diet, High-Fat, Disease Models, Animal, Dyslipidemias (diet therapy), Fatty Acid Synthases (genetics), Fatty Liver (genetics), Fatty Liver (metabolism), Fatty Liver (prevention & control), Glycerol-3-Phosphate O-Acyltransferase (genetics), Insulin Resistance, Lipogenesis, Liver (metabolism), Liver (pathology), Male, Mice, Mice, Inbred C57BL, Non-alcoholic Fatty Liver Disease, Orphan Nuclear Receptors (genetics), PPAR alpha (genetics).
MESH :
- chemical , genetics : Acyl-CoA Oxidase, Fatty Acid Synthases, Glycerol-3-Phosphate O-Acyltransferase, Orphan Nuclear Receptors, PPAR alpha.
- diet therapy : Dyslipidemias.
- genetics : Fatty Liver.
- metabolism : Fatty Liver, Liver.
- pathology : Liver.
- prevention & control : Fatty Liver.
- Animals, Beverages, Citrus sinensis, Diet, High-Fat, Disease Models, Animal, Insulin Resistance, Lipogenesis, Male, Mice, Mice, Inbred C57BL, Non-alcoholic Fatty Liver Disease.

Abstract

AIM: To establish if the juice of Moro, an anthocyanin-rich orange, may improve liver damage in mice with diet-induced obesity.

METHODS: Eight-week-old mice were fed a high-fat diet (HFD) and were administrated water or Moro juice for 12 wk. Liver morphology, gene expression of lipid transcription factors, and metabolic enzymes were assessed.

RESULTS: Mice fed HFD displayed increased body weight, insulin resistance and dyslipidemia. Moro juice administration limited body weight gain, enhanced insulin sensitivity, and decreased serum triglycerides and total cholesterol. Mice fed HFD showed liver steatosis associated with ballooning. Dietary Moro juice markedly improved liver steatosis by inducing the expression of peroxisome proliferator-activated receptor-α and its target gene acylCoA-oxidase, a key enzyme of lipid oxidation. Consistently, Moro juice consumption suppressed the expression of liver X receptor-α and its target gene fatty acid synthase, and restored liver glycerol-3-phosphate acyltransferase 1 activity.

CONCLUSION: Moro juice counteracts liver steatogenesis in mice with diet-induced obesity and thus may represent a promising dietary option for the prevention of fatty liver.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413058

DOI: 10.3748/wjg.v18.i29.3862
PubMed: 22876038
PubMed Central: 3413058

Affiliations:

Le document en format XML

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 orange juice prevents fatty liver in mice</title>
<author><name sortKey="Salamone, Federico" sort="Salamone, Federico" uniqKey="Salamone F" first="Federico" last="Salamone">Federico Salamone</name>
</author>
<author><name sortKey="Li Volti, Giovanni" sort="Li Volti, Giovanni" uniqKey="Li Volti G" first="Giovanni" last="Li Volti">Giovanni Li Volti</name>
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<author><name sortKey="Titta, Lucilla" sort="Titta, Lucilla" uniqKey="Titta L" first="Lucilla" last="Titta">Lucilla Titta</name>
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<author><name sortKey="Puzzo, Lidia" sort="Puzzo, Lidia" uniqKey="Puzzo L" first="Lidia" last="Puzzo">Lidia Puzzo</name>
</author>
<author><name sortKey="Barbagallo, Ignazio" sort="Barbagallo, Ignazio" uniqKey="Barbagallo I" first="Ignazio" last="Barbagallo">Ignazio Barbagallo</name>
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<author><name sortKey="La Delia, Francesco" sort="La Delia, Francesco" uniqKey="La Delia F" first="Francesco" last="La Delia">Francesco La Delia</name>
</author>
<author><name sortKey="Zelber Sagi, Shira" sort="Zelber Sagi, Shira" uniqKey="Zelber Sagi S" first="Shira" last="Zelber-Sagi">Shira Zelber-Sagi</name>
</author>
<author><name sortKey="Malaguarnera, Michele" sort="Malaguarnera, Michele" uniqKey="Malaguarnera M" first="Michele" last="Malaguarnera">Michele Malaguarnera</name>
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<author><name sortKey="Pelicci, Pier Giuseppe" sort="Pelicci, Pier Giuseppe" uniqKey="Pelicci P" first="Pier Giuseppe" last="Pelicci">Pier Giuseppe Pelicci</name>
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<author><name sortKey="Giorgio, Marco" sort="Giorgio, Marco" uniqKey="Giorgio M" first="Marco" last="Giorgio">Marco Giorgio</name>
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<author><name sortKey="Galvano, Fabio" sort="Galvano, Fabio" uniqKey="Galvano F" first="Fabio" last="Galvano">Fabio Galvano</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>Moro</italic>
 orange juice prevents fatty liver in mice</title>
<author><name sortKey="Salamone, Federico" sort="Salamone, Federico" uniqKey="Salamone F" first="Federico" last="Salamone">Federico Salamone</name>
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<author><name sortKey="Li Volti, Giovanni" sort="Li Volti, Giovanni" uniqKey="Li Volti G" first="Giovanni" last="Li Volti">Giovanni Li Volti</name>
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<author><name sortKey="Titta, Lucilla" sort="Titta, Lucilla" uniqKey="Titta L" first="Lucilla" last="Titta">Lucilla Titta</name>
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<author><name sortKey="Puzzo, Lidia" sort="Puzzo, Lidia" uniqKey="Puzzo L" first="Lidia" last="Puzzo">Lidia Puzzo</name>
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<author><name sortKey="Barbagallo, Ignazio" sort="Barbagallo, Ignazio" uniqKey="Barbagallo I" first="Ignazio" last="Barbagallo">Ignazio Barbagallo</name>
</author>
<author><name sortKey="La Delia, Francesco" sort="La Delia, Francesco" uniqKey="La Delia F" first="Francesco" last="La Delia">Francesco La Delia</name>
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<author><name sortKey="Zelber Sagi, Shira" sort="Zelber Sagi, Shira" uniqKey="Zelber Sagi S" first="Shira" last="Zelber-Sagi">Shira Zelber-Sagi</name>
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<author><name sortKey="Malaguarnera, Michele" sort="Malaguarnera, Michele" uniqKey="Malaguarnera M" first="Michele" last="Malaguarnera">Michele Malaguarnera</name>
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<author><name sortKey="Pelicci, Pier Giuseppe" sort="Pelicci, Pier Giuseppe" uniqKey="Pelicci P" first="Pier Giuseppe" last="Pelicci">Pier Giuseppe Pelicci</name>
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<author><name sortKey="Giorgio, Marco" sort="Giorgio, Marco" uniqKey="Giorgio M" first="Marco" last="Giorgio">Marco Giorgio</name>
</author>
<author><name sortKey="Galvano, Fabio" sort="Galvano, Fabio" uniqKey="Galvano F" first="Fabio" last="Galvano">Fabio Galvano</name>
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<series><title level="j">World Journal of Gastroenterology : WJG</title>
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<term>Animals</term>
<term>Beverages</term>
<term>Citrus sinensis</term>
<term>Diet, High-Fat</term>
<term>Disease Models, Animal</term>
<term>Dyslipidemias (diet therapy)</term>
<term>Fatty Acid Synthases (genetics)</term>
<term>Fatty Liver (genetics)</term>
<term>Fatty Liver (metabolism)</term>
<term>Fatty Liver (prevention & control)</term>
<term>Glycerol-3-Phosphate O-Acyltransferase (genetics)</term>
<term>Insulin Resistance</term>
<term>Lipogenesis</term>
<term>Liver (metabolism)</term>
<term>Liver (pathology)</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Non-alcoholic Fatty Liver Disease</term>
<term>Orphan Nuclear Receptors (genetics)</term>
<term>PPAR alpha (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Acyl-CoA Oxidase</term>
<term>Fatty Acid Synthases</term>
<term>Glycerol-3-Phosphate O-Acyltransferase</term>
<term>Orphan Nuclear Receptors</term>
<term>PPAR alpha</term>
</keywords>
<keywords scheme="MESH" qualifier="diet therapy" xml:lang="en"><term>Dyslipidemias</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Fatty Liver</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Fatty Liver</term>
<term>Liver</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Liver</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Fatty Liver</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Beverages</term>
<term>Citrus sinensis</term>
<term>Diet, High-Fat</term>
<term>Disease Models, Animal</term>
<term>Insulin Resistance</term>
<term>Lipogenesis</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Non-alcoholic Fatty Liver Disease</term>
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<front><div type="abstract" xml:lang="en"><p>AIM: To establish if the juice of <italic>Moro</italic>
, an anthocyanin-rich orange, may improve liver damage in mice with diet-induced obesity.</p>
<p>METHODS: Eight-week-old mice were fed a high-fat diet (HFD) and were administrated water or <italic>Moro</italic>
 juice for 12 wk. Liver morphology, gene expression of lipid transcription factors, and metabolic enzymes were assessed.</p>
<p>RESULTS: Mice fed HFD displayed increased body weight, insulin resistance and dyslipidemia. <italic>Moro</italic>
 juice administration limited body weight gain, enhanced insulin sensitivity, and decreased serum triglycerides and total cholesterol. Mice fed HFD showed liver steatosis associated with ballooning. Dietary <italic>Moro</italic>
 juice markedly improved liver steatosis by inducing the expression of peroxisome proliferator-activated receptor-α and its target gene acylCoA-oxidase, a key enzyme of lipid oxidation. Consistently, <italic>Moro</italic>
 juice consumption suppressed the expression of liver X receptor-α and its target gene fatty acid synthase, and restored liver glycerol-3-phosphate acyltransferase 1 activity.</p>
<p>CONCLUSION: <italic>Moro</italic>
 juice counteracts liver steatogenesis in mice with diet-induced obesity and thus may represent a promising dietary option for the prevention of fatty liver.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Barbagallo, Ignazio" sort="Barbagallo, Ignazio" uniqKey="Barbagallo I" first="Ignazio" last="Barbagallo">Ignazio Barbagallo</name>
<name sortKey="Galvano, Fabio" sort="Galvano, Fabio" uniqKey="Galvano F" first="Fabio" last="Galvano">Fabio Galvano</name>
<name sortKey="Giorgio, Marco" sort="Giorgio, Marco" uniqKey="Giorgio M" first="Marco" last="Giorgio">Marco Giorgio</name>
<name sortKey="La Delia, Francesco" sort="La Delia, Francesco" uniqKey="La Delia F" first="Francesco" last="La Delia">Francesco La Delia</name>
<name sortKey="Li Volti, Giovanni" sort="Li Volti, Giovanni" uniqKey="Li Volti G" first="Giovanni" last="Li Volti">Giovanni Li Volti</name>
<name sortKey="Malaguarnera, Michele" sort="Malaguarnera, Michele" uniqKey="Malaguarnera M" first="Michele" last="Malaguarnera">Michele Malaguarnera</name>
<name sortKey="Pelicci, Pier Giuseppe" sort="Pelicci, Pier Giuseppe" uniqKey="Pelicci P" first="Pier Giuseppe" last="Pelicci">Pier Giuseppe Pelicci</name>
<name sortKey="Puzzo, Lidia" sort="Puzzo, Lidia" uniqKey="Puzzo L" first="Lidia" last="Puzzo">Lidia Puzzo</name>
<name sortKey="Salamone, Federico" sort="Salamone, Federico" uniqKey="Salamone F" first="Federico" last="Salamone">Federico Salamone</name>
<name sortKey="Titta, Lucilla" sort="Titta, Lucilla" uniqKey="Titta L" first="Lucilla" last="Titta">Lucilla Titta</name>
<name sortKey="Zelber Sagi, Shira" sort="Zelber Sagi, Shira" uniqKey="Zelber Sagi S" first="Shira" last="Zelber-Sagi">Shira Zelber-Sagi</name>
</noCountry>
</tree>
</affiliations>
</record>

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Moro orange juice prevents fatty liver in mice

Moro orange juice prevents fatty liver in mice

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English descriptors

Abstract

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