A Chinese herbal formula "Gan-Lu-Yin" suppresses vascular smooth muscle cell migration by inhibiting matrix metalloproteinase-2/9 through the PI3K/AKT and ERK signaling pathways
Identifieur interne : 001433 ( Main/Exploration ); précédent : 001432; suivant : 001434A Chinese herbal formula "Gan-Lu-Yin" suppresses vascular smooth muscle cell migration by inhibiting matrix metalloproteinase-2/9 through the PI3K/AKT and ERK signaling pathways
Auteurs : Yi-Chung Chien [Taïwan] ; Ming-Jyh Sheu [Taïwan] ; Chieh-Hsi Wu [Taïwan] ; Wen-Hsin Lin [Taïwan] ; Ying-Yi Chen [Taïwan] ; Po-Liang Cheng [Taïwan] ; Hsu-Chen Cheng [Taïwan]Source :
- BMC Complementary and Alternative Medicine [ 1472-6882 ] ; 2012.
Abstract
This study was to explore the effects of Gan-Lu-Yin (GLY) on the migration of vascular smooth muscle cells (VSMCs) induced by fetal bovine serum and on neointima formation in a rat model of carotid artery balloon injury.
VSMCs were treated with different concentrations of GLY, and then analyzed with Flow cytometric analysis, zymography, transwell, and western blotting. SD rats received balloon-injury were analyzed with H&E staining.
Our results showed that GLY significantly decreased the thickness of neointima. The inhibition by non-cytoxic doses of GLY of VSMCs migration was through its negative regulatory effects on phosphorylated ERK1/2, PI3K/AKT, and FAK. The data showed that GLY can inhibit the migration of VSMCs cells, and might block injury-induced neointima hyperplasia via the inhibition of VSMCs migration, without inducing apoptosis.
These observations provide a mechanism of GLY in attenuating cell migration, thus as a potential intervention for restenosis.
Url:
DOI: 10.1186/1472-6882-12-137
PubMed: 22920190
PubMed Central: 3475136
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Chinese herbal formula "Gan-Lu-Yin" suppresses vascular smooth muscle cell migration by inhibiting matrix metalloproteinase-2/9 through the PI3K/AKT and ERK signaling pathways</title><author><name sortKey="Chien, Yi Chung" sort="Chien, Yi Chung" uniqKey="Chien Y" first="Yi-Chung" last="Chien">Yi-Chung Chien</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Life Sciences, and Agricultural Biotechnology Center, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, 402, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences, and Agricultural Biotechnology Center, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, 402</wicri:regionArea><wicri:noRegion>402</wicri:noRegion></affiliation></author><author><name sortKey="Sheu, Ming Jyh" sort="Sheu, Ming Jyh" uniqKey="Sheu M" first="Ming-Jyh" last="Sheu">Ming-Jyh Sheu</name><affiliation wicri:level="1"><nlm:aff id="I2">School of Pharmacy, China Medical University, 91 Hsueh-Shih Road, Taichung, 404, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Pharmacy, China Medical University, 91 Hsueh-Shih Road, Taichung, 404</wicri:regionArea><wicri:noRegion>404</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Chieh Hsi" sort="Wu, Chieh Hsi" uniqKey="Wu C" first="Chieh-Hsi" last="Wu">Chieh-Hsi Wu</name><affiliation wicri:level="1"><nlm:aff id="I2">School of Pharmacy, China Medical University, 91 Hsueh-Shih Road, Taichung, 404, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Pharmacy, China Medical University, 91 Hsueh-Shih Road, Taichung, 404</wicri:regionArea><wicri:noRegion>404</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Wen Hsin" sort="Lin, Wen Hsin" uniqKey="Lin W" first="Wen-Hsin" last="Lin">Wen-Hsin Lin</name><affiliation wicri:level="1"><nlm:aff id="I2">School of Pharmacy, China Medical University, 91 Hsueh-Shih Road, Taichung, 404, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Pharmacy, China Medical University, 91 Hsueh-Shih Road, Taichung, 404</wicri:regionArea><wicri:noRegion>404</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Ying Yi" sort="Chen, Ying Yi" uniqKey="Chen Y" first="Ying-Yi" last="Chen">Ying-Yi Chen</name><affiliation wicri:level="1"><nlm:aff id="I2">School of Pharmacy, China Medical University, 91 Hsueh-Shih Road, Taichung, 404, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Pharmacy, China Medical University, 91 Hsueh-Shih Road, Taichung, 404</wicri:regionArea><wicri:noRegion>404</wicri:noRegion></affiliation></author><author><name sortKey="Cheng, Po Liang" sort="Cheng, Po Liang" uniqKey="Cheng P" first="Po-Liang" last="Cheng">Po-Liang Cheng</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Life Sciences, and Agricultural Biotechnology Center, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, 402, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences, and Agricultural Biotechnology Center, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, 402</wicri:regionArea><wicri:noRegion>402</wicri:noRegion></affiliation></author><author><name sortKey="Cheng, Hsu Chen" sort="Cheng, Hsu Chen" uniqKey="Cheng H" first="Hsu-Chen" last="Cheng">Hsu-Chen Cheng</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Life Sciences, and Agricultural Biotechnology Center, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, 402, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences, and Agricultural Biotechnology Center, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, 402</wicri:regionArea><wicri:noRegion>402</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22920190</idno><idno type="pmc">3475136</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475136</idno><idno type="RBID">PMC:3475136</idno><idno type="doi">10.1186/1472-6882-12-137</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000A95</idno><idno type="wicri:Area/Pmc/Curation">000A94</idno><idno type="wicri:Area/Pmc/Checkpoint">000D84</idno><idno type="wicri:Area/Ncbi/Merge">001077</idno><idno type="wicri:Area/Ncbi/Curation">001077</idno><idno type="wicri:Area/Ncbi/Checkpoint">001077</idno><idno type="wicri:Area/Main/Merge">001448</idno><idno type="wicri:Area/Main/Curation">001433</idno><idno type="wicri:Area/Main/Exploration">001433</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Chinese herbal formula "Gan-Lu-Yin" suppresses vascular smooth muscle cell migration by inhibiting matrix metalloproteinase-2/9 through the PI3K/AKT and ERK signaling pathways</title><author><name sortKey="Chien, Yi Chung" sort="Chien, Yi Chung" uniqKey="Chien Y" first="Yi-Chung" last="Chien">Yi-Chung Chien</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Life Sciences, and Agricultural Biotechnology Center, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, 402, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences, and Agricultural Biotechnology Center, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, 402</wicri:regionArea><wicri:noRegion>402</wicri:noRegion></affiliation></author><author><name sortKey="Sheu, Ming Jyh" sort="Sheu, Ming Jyh" uniqKey="Sheu M" first="Ming-Jyh" last="Sheu">Ming-Jyh Sheu</name><affiliation wicri:level="1"><nlm:aff id="I2">School of Pharmacy, China Medical University, 91 Hsueh-Shih Road, Taichung, 404, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Pharmacy, China Medical University, 91 Hsueh-Shih Road, Taichung, 404</wicri:regionArea><wicri:noRegion>404</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Chieh Hsi" sort="Wu, Chieh Hsi" uniqKey="Wu C" first="Chieh-Hsi" last="Wu">Chieh-Hsi Wu</name><affiliation wicri:level="1"><nlm:aff id="I2">School of Pharmacy, China Medical University, 91 Hsueh-Shih Road, Taichung, 404, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Pharmacy, China Medical University, 91 Hsueh-Shih Road, Taichung, 404</wicri:regionArea><wicri:noRegion>404</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Wen Hsin" sort="Lin, Wen Hsin" uniqKey="Lin W" first="Wen-Hsin" last="Lin">Wen-Hsin Lin</name><affiliation wicri:level="1"><nlm:aff id="I2">School of Pharmacy, China Medical University, 91 Hsueh-Shih Road, Taichung, 404, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Pharmacy, China Medical University, 91 Hsueh-Shih Road, Taichung, 404</wicri:regionArea><wicri:noRegion>404</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Ying Yi" sort="Chen, Ying Yi" uniqKey="Chen Y" first="Ying-Yi" last="Chen">Ying-Yi Chen</name><affiliation wicri:level="1"><nlm:aff id="I2">School of Pharmacy, China Medical University, 91 Hsueh-Shih Road, Taichung, 404, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Pharmacy, China Medical University, 91 Hsueh-Shih Road, Taichung, 404</wicri:regionArea><wicri:noRegion>404</wicri:noRegion></affiliation></author><author><name sortKey="Cheng, Po Liang" sort="Cheng, Po Liang" uniqKey="Cheng P" first="Po-Liang" last="Cheng">Po-Liang Cheng</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Life Sciences, and Agricultural Biotechnology Center, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, 402, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences, and Agricultural Biotechnology Center, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, 402</wicri:regionArea><wicri:noRegion>402</wicri:noRegion></affiliation></author><author><name sortKey="Cheng, Hsu Chen" sort="Cheng, Hsu Chen" uniqKey="Cheng H" first="Hsu-Chen" last="Cheng">Hsu-Chen Cheng</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Life Sciences, and Agricultural Biotechnology Center, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, 402, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences, and Agricultural Biotechnology Center, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, 402</wicri:regionArea><wicri:noRegion>402</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Complementary and Alternative Medicine</title><idno type="eISSN">1472-6882</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>This study was to explore the effects of Gan-Lu-Yin (GLY) on the migration of vascular smooth muscle cells (VSMCs) induced by fetal bovine serum and on neointima formation in a rat model of carotid artery balloon injury.</p></sec><sec><title>Methods</title><p>VSMCs were treated with different concentrations of GLY, and then analyzed with Flow cytometric analysis, zymography, transwell, and western blotting. SD rats received balloon-injury were analyzed with H&E staining.</p></sec><sec><title>Results</title><p>Our results showed that GLY significantly decreased the thickness of neointima. The inhibition by non-cytoxic doses of GLY of VSMCs migration was through its negative regulatory effects on phosphorylated ERK1/2, PI3K/AKT, and FAK. The data showed that GLY can inhibit the migration of VSMCs cells, and might block injury-induced neointima hyperplasia via the inhibition of VSMCs migration, without inducing apoptosis.</p></sec><sec><title>Conclusions</title><p>These observations provide a mechanism of GLY in attenuating cell migration, thus as a potential intervention for restenosis.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Gruntzig, Ar" uniqKey="Gruntzig A">AR Grüntzig</name></author><author><name sortKey="Senning, A" uniqKey="Senning A">A Senning</name></author><author><name sortKey="Siegenthaler, We" uniqKey="Siegenthaler W">WE Siegenthaler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bauters, C" uniqKey="Bauters C">C Bauters</name></author><author><name sortKey="Lablanche, Jm" uniqKey="Lablanche J">JM Lablanche</name></author><author><name sortKey="Mcfadden, Ep" uniqKey="Mcfadden E">EP 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uniqKey="Jenkins D">D Jenkins</name></author><author><name sortKey="Di Lorenzo, A" uniqKey="Di Lorenzo A">A Di Lorenzo</name></author><author><name sortKey="Sessa, Wc" uniqKey="Sessa W">WC Sessa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seo, Jm" uniqKey="Seo J">JM Seo</name></author><author><name sortKey="Kim, Tj" uniqKey="Kim T">TJ Kim</name></author><author><name sortKey="Jin, Yr" uniqKey="Jin Y">YR Jin</name></author><author><name sortKey="Han, Hj" uniqKey="Han H">HJ Han</name></author><author><name sortKey="Ryu, Ck" uniqKey="Ryu C">CK Ryu</name></author><author><name sortKey="Sheen, Yy" uniqKey="Sheen Y">YY Sheen</name></author><author><name sortKey="Kim, Dw" uniqKey="Kim D">DW Kim</name></author><author><name sortKey="Yun, Yp" uniqKey="Yun Y">YP Yun</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Chien, Yi Chung" sort="Chien, Yi Chung" uniqKey="Chien Y" first="Yi-Chung" last="Chien">Yi-Chung Chien</name></noRegion><name sortKey="Chen, Ying Yi" sort="Chen, Ying Yi" uniqKey="Chen Y" first="Ying-Yi" last="Chen">Ying-Yi Chen</name><name sortKey="Cheng, Hsu Chen" sort="Cheng, Hsu Chen" uniqKey="Cheng H" first="Hsu-Chen" last="Cheng">Hsu-Chen Cheng</name><name sortKey="Cheng, Po Liang" sort="Cheng, Po Liang" uniqKey="Cheng P" first="Po-Liang" last="Cheng">Po-Liang Cheng</name><name sortKey="Lin, Wen Hsin" sort="Lin, Wen Hsin" uniqKey="Lin W" first="Wen-Hsin" last="Lin">Wen-Hsin Lin</name><name sortKey="Sheu, Ming Jyh" sort="Sheu, Ming Jyh" uniqKey="Sheu M" first="Ming-Jyh" last="Sheu">Ming-Jyh Sheu</name><name sortKey="Wu, Chieh Hsi" sort="Wu, Chieh Hsi" uniqKey="Wu C" first="Chieh-Hsi" last="Wu">Chieh-Hsi Wu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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