A sensitive method for determination of allergenic fragrance terpene hydroperoxides using liquid chromatography coupled with tandem mass spectrometry
Identifieur interne : 000E41 ( Istex/Curation ); précédent : 000E40; suivant : 000E42A sensitive method for determination of allergenic fragrance terpene hydroperoxides using liquid chromatography coupled with tandem mass spectrometry
Auteurs : Johanna Rudb Ck [Suède] ; Nurul Islam [Suède] ; Ulrika Nilsson [Suède] ; Ann-Therese Karlberg [Suède]Source :
- Journal of Separation Science [ 1615-9306 ] ; 2013-04.
Abstract
Different compositions of monoterpenes are utilized for their pleasant scent in cosmetics and perfumes. However, the most commonly used fragrance terpenes easily oxidize upon contact with air, forming strongly skin‐sensitizing hydroperoxides. Due to their thermolability and low UV absorbance, detection methods for hydroperoxides are scarce. For the first time, a simple and sensitive method using LC/ESI‐MS/MS was developed to quantitatively determine hydroperoxides from the common fragrance compounds linalool, linalyl acetate, and limonene. The method was applied to autoxidized petitgrain oil and sweet orange oil. A separation was accomplished using a C3 column. The method LOD for the investigated hydroperoxides in the essential oils was below 0.3 μg/mL, corresponding to 0.3 ppm. For prevention purposes and according to EU regulations, concentrations in cosmetics exceeding 100 ppm in “rinse‐off” and 10 ppm in “stay‐on” products of linalool and limonene must be labeled. However, the products may still contain allergens, such as hydroperoxides, formed by oxidative degradation of their parent terpenes. The sensitivity and selectivity of the presented LC/MS/MS method enables detection of hydroperoxides from the fragrance terpenes linalool, linalyl acetate, and limonene. However, for routine measurements, the method requires further validation.
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DOI: 10.1002/jssc.201200855
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and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, Gothenburg, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, Gothenburg</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>: Professor Ann‐Therese Karlberg, Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, SE‐412 96 Gothenburg, Sweden: +46‐31‐772 1394</mods:affiliation><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>: Professor Ann‐Therese Karlberg, Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, SE‐412 96 Gothenburg</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: karlberg@chem.gu.se</mods:affiliation><country 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Allergy, University of Gothenburg, Gothenburg, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, Gothenburg</wicri:regionArea></affiliation></author><author><name sortKey="Islam, Nurul" sort="Islam, Nurul" uniqKey="Islam N" first="Nurul" last="Islam">Nurul Islam</name><affiliation wicri:level="1"><mods:affiliation>Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, Gothenburg, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, Gothenburg</wicri:regionArea></affiliation></author><author><name sortKey="Nilsson, Ulrika" sort="Nilsson, Ulrika" uniqKey="Nilsson U" first="Ulrika" last="Nilsson">Ulrika Nilsson</name><affiliation wicri:level="1"><mods:affiliation>Department of Analytical Chemistry, Stockholm University, Stockholm, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Analytical Chemistry, Stockholm University, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Karlberg, Ann Herese" sort="Karlberg, Ann Herese" uniqKey="Karlberg A" first="Ann-Therese" last="Karlberg">Ann-Therese Karlberg</name><affiliation wicri:level="1"><mods:affiliation>Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, Gothenburg, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, Gothenburg</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>: Professor Ann‐Therese Karlberg, Department of Chemistry and Molecular Biology, Dermatochemistry and 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However, the most commonly used fragrance terpenes easily oxidize upon contact with air, forming strongly skin‐sensitizing hydroperoxides. Due to their thermolability and low UV absorbance, detection methods for hydroperoxides are scarce. For the first time, a simple and sensitive method using LC/ESI‐MS/MS was developed to quantitatively determine hydroperoxides from the common fragrance compounds linalool, linalyl acetate, and limonene. The method was applied to autoxidized petitgrain oil and sweet orange oil. A separation was accomplished using a C3 column. The method LOD for the investigated hydroperoxides in the essential oils was below 0.3 μg/mL, corresponding to 0.3 ppm. For prevention purposes and according to EU regulations, concentrations in cosmetics exceeding 100 ppm in “rinse‐off” and 10 ppm in “stay‐on” products of linalool and limonene must be labeled. However, the products may still contain allergens, such as hydroperoxides, formed by oxidative degradation of their parent terpenes. The sensitivity and selectivity of the presented LC/MS/MS method enables detection of hydroperoxides from the fragrance terpenes linalool, linalyl acetate, and limonene. However, for routine measurements, the method requires further validation.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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