Anti‐HIV‐1 limonoid: first isolation from Clausena excavata
Identifieur interne : 000780 ( Istex/Corpus ); précédent : 000779; suivant : 000781Anti‐HIV‐1 limonoid: first isolation from Clausena excavata
Auteurs : Arunrat Sunthitikawinsakul ; Ngampong Kongkathip ; Boonsong Kongkathip ; Sida Phonnakhu ; John W. Daly ; Thomas F. Spande ; Yuth Nimit ; Chanita Napaswat ; Jittra Kasisit ; Chalobon YoosookSource :
- Phytotherapy Research [ 0951-418X ] ; 2003-11.
English descriptors
Abstract
A limonoid, clausenolide‐1‐ethyl ether (1) and two coumarins, dentatin (2) and nor‐dentatin (3), were isolated from Clausena excavata. Limonoid 1 was obtained from the crude ethanol extract of the rhizomes and the roots but had not previously been isolated from C. excavata and exhibited HIV‐1 inhibitory activity. Coumarins 2 and 3, with their structures related to an anti‐HIV‐1 substance, (+)‐calanolide A (4), were obtained from the crude chloroform extract of the rhizomes. Both induced toxicity to cells used in a syncytium assay for anti‐HIV‐1 activity. These compounds, 1–3, did not show any cytotoxic effect against KB and BC‐1 cell lines (IC50 value > 20 µg/mL). Copyright © 2003 John Wiley & Sons, Ltd.
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DOI: 10.1002/ptr.1381
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Copyright © 2003 John Wiley & Sons, Ltd.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Arunrat Sunthitikawinsakul</name><affiliations><json:string>Natural Products and Organic Synthesis Research Unit (NPOS), Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand</json:string></affiliations></json:item><json:item><name>Ngampong Kongkathip</name><affiliations><json:string>Natural Products and Organic Synthesis Research Unit (NPOS), Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand</json:string></affiliations></json:item><json:item><name>Boonsong Kongkathip</name><affiliations><json:string>Natural Products and Organic Synthesis Research Unit (NPOS), Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand</json:string></affiliations></json:item><json:item><name>Sida Phonnakhu</name><affiliations><json:string>Natural Products and Organic Synthesis Research Unit (NPOS), Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand</json:string></affiliations></json:item><json:item><name>John W. 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Limonoid 1 was obtained from the crude ethanol extract of the rhizomes and the roots but had not previously been isolated from C. excavata and exhibited HIV‐1 inhibitory activity. Coumarins 2 and 3, with their structures related to an anti‐HIV‐1 substance, (+)‐calanolide A (4), were obtained from the crude chloroform extract of the rhizomes. Both induced toxicity to cells used in a syncytium assay for anti‐HIV‐1 activity. These compounds, 1–3, did not show any cytotoxic effect against KB and BC‐1 cell lines (IC50 value > 20 µg/mL). 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number="14"></count></countGroup><titleGroup><title type="main" xml:lang="en">Anti‐HIV‐1 limonoid: first isolation from <i>Clausena excavata</i></title><title type="short" xml:lang="en">ANTI‐HIV‐1 LIMONOID</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Arunrat</givenNames><familyName>Sunthitikawinsakul</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Ngampong</givenNames><familyName>Kongkathip</familyName></personName><contactDetails><email>fscinpk@ku.ac.th</email></contactDetails></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Boonsong</givenNames><familyName>Kongkathip</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Sida</givenNames><familyName>Phonnakhu</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2"><personName><givenNames>John W.</givenNames><familyName>Daly</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Thomas F.</givenNames><familyName>Spande</familyName></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Yuth</givenNames><familyName>Nimit</familyName></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Chanita</givenNames><familyName>Napaswat</familyName></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Jittra</givenNames><familyName>Kasisit</familyName></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Chalobon</givenNames><familyName>Yoosook</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="TH" type="organization"><unparsedAffiliation>Natural Products and Organic Synthesis Research Unit (NPOS), Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Laboratory of Bioorganic Chemistry, NIDDK, NIH, DHHS, Bethesda, Maryland, USA</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="TH" type="organization"><unparsedAffiliation>Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1"><i>Clausena excavata</i></keyword><keyword xml:id="kwd2">limonoid</keyword><keyword xml:id="kwd3">anti‐HIV‐1 activity</keyword><keyword xml:id="kwd4">clausenolide‐1‐ethyl ether</keyword><keyword xml:id="kwd5">coumarin</keyword></keywordGroup><fundingInfo><fundingAgency>Thailand Research Fund</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Biodiversity Research and Training Programme</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>A limonoid, clausenolide‐1‐ethyl ether (1) and two coumarins, dentatin (2) and <i>nor</i>‐dentatin (3), were isolated from <i>Clausena excavata</i>. Limonoid 1 was obtained from the crude ethanol extract of the rhizomes and the roots but had not previously been isolated from <i>C. excavata</i> and exhibited HIV‐1 inhibitory activity. Coumarins 2 and 3, with their structures related to an anti‐HIV‐1 substance, (+)‐calanolide A (4), were obtained from the crude chloroform extract of the rhizomes. Both induced toxicity to cells used in a syncytium assay for anti‐HIV‐1 activity. These compounds, 1–3, did not show any cytotoxic effect against KB and BC‐1 cell lines (IC<sub>50</sub> value > 20 µg/mL). Copyright © 2003 John Wiley & Sons, Ltd.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Anti‐HIV‐1 limonoid: first isolation from Clausena excavata</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>ANTI‐HIV‐1 LIMONOID</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Anti‐HIV‐1 limonoid: first isolation from Clausena excavata</title></titleInfo><name type="personal"><namePart type="given">Arunrat</namePart><namePart type="family">Sunthitikawinsakul</namePart><affiliation>Natural Products and Organic Synthesis Research Unit (NPOS), Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ngampong</namePart><namePart type="family">Kongkathip</namePart><affiliation>Natural Products and Organic Synthesis Research Unit (NPOS), Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand</affiliation><description>Correspondence: Department of Chemistry, Faculty of Science, Kasetsart University, Chatujak, Bangkok 10900, Thailand.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Boonsong</namePart><namePart type="family">Kongkathip</namePart><affiliation>Natural Products and Organic Synthesis Research Unit (NPOS), Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sida</namePart><namePart type="family">Phonnakhu</namePart><affiliation>Natural Products and Organic Synthesis Research Unit (NPOS), Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John W.</namePart><namePart type="family">Daly</namePart><affiliation>Laboratory of Bioorganic Chemistry, NIDDK, NIH, DHHS, Bethesda, Maryland, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thomas F.</namePart><namePart type="family">Spande</namePart><affiliation>Laboratory of Bioorganic Chemistry, NIDDK, NIH, DHHS, Bethesda, Maryland, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yuth</namePart><namePart type="family">Nimit</namePart><affiliation>Laboratory of Bioorganic Chemistry, NIDDK, NIH, DHHS, Bethesda, Maryland, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chanita</namePart><namePart type="family">Napaswat</namePart><affiliation>Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jittra</namePart><namePart type="family">Kasisit</namePart><affiliation>Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chalobon</namePart><namePart type="family">Yoosook</namePart><affiliation>Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>John Wiley & Sons, Ltd.</publisher><place><placeTerm type="text">Chichester, UK</placeTerm></place><dateIssued encoding="w3cdtf">2003-11</dateIssued><dateCaptured encoding="w3cdtf">2003-05-14</dateCaptured><dateValid encoding="w3cdtf">2003-06-12</dateValid><copyrightDate encoding="w3cdtf">2003</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">1</extent><extent unit="references">14</extent></physicalDescription><abstract lang="en">A limonoid, clausenolide‐1‐ethyl ether (1) and two coumarins, dentatin (2) and nor‐dentatin (3), were isolated from Clausena excavata. Limonoid 1 was obtained from the crude ethanol extract of the rhizomes and the roots but had not previously been isolated from C. excavata and exhibited HIV‐1 inhibitory activity. Coumarins 2 and 3, with their structures related to an anti‐HIV‐1 substance, (+)‐calanolide A (4), were obtained from the crude chloroform extract of the rhizomes. Both induced toxicity to cells used in a syncytium assay for anti‐HIV‐1 activity. These compounds, 1–3, did not show any cytotoxic effect against KB and BC‐1 cell lines (IC50 value > 20 µg/mL). Copyright © 2003 John Wiley & Sons, Ltd.</abstract><note type="funding">Thailand Research Fund</note><note type="funding">Biodiversity Research and Training Programme</note><subject lang="en"><genre>keywords</genre><topic>Clausena excavata</topic><topic>limonoid</topic><topic>anti‐HIV‐1 activity</topic><topic>clausenolide‐1‐ethyl ether</topic><topic>coumarin</topic></subject><relatedItem type="host"><titleInfo><title>Phytotherapy Research</title><subTitle>An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives</subTitle></titleInfo><titleInfo type="abbreviated"><title>Phytother. Res.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0951-418X</identifier><identifier type="eISSN">1099-1573</identifier><identifier type="DOI">10.1002/(ISSN)1099-1573</identifier><identifier type="PublisherID">PTR</identifier><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><detail type="issue"><caption>no.</caption><number>9</number></detail><extent unit="pages"><start>1101</start><end>1103</end><total>3</total></extent></part></relatedItem><identifier type="istex">57DE4A46FC3184B7CAD10894793E4C5ED9DE97F1</identifier><identifier type="DOI">10.1002/ptr.1381</identifier><identifier type="ArticleID">PTR1381</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2003 John Wiley & Sons, Ltd.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>John Wiley & Sons, Ltd.</recordOrigin></recordInfo></mods></metadata><enrichments><json:item><type>multicat</type><uri>https://api.istex.fr/document/57DE4A46FC3184B7CAD10894793E4C5ED9DE97F1/enrichments/multicat</uri></json:item></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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