Innovative Delivery of Cu(II) Ions by a Nanostructured Hydroxyapatite: Potential Application in Planta to Enhance the Sustainable Control of Plasmopara viticola.
Identifieur interne : 000211 ( Main/Corpus ); précédent : 000210; suivant : 000212Innovative Delivery of Cu(II) Ions by a Nanostructured Hydroxyapatite: Potential Application in Planta to Enhance the Sustainable Control of Plasmopara viticola.
Auteurs : Enrico Battiston ; Livio Antonielli ; Stefano Di Marco ; Florence Fontaine ; Laura MugnaiSource :
- Phytopathology [ 0031-949X ] ; 2019.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Copper.
- chemical : Durapatite, Ions.
- microbiology : Plant Diseases, Vitis.
- pathogenicity : Oomycetes.
- prevention & control : Plant Diseases.
- Nanostructures.
Abstract
Downy mildew caused by Plasmopara viticola is probably the most serious disease affecting grapevine (Vitis vinifera), and it is capable of causing consistent yield losses. In organic viticulture, the only acceptable and effective means to control the disease is by applications of copper-based fungicides. However, the use of copper in agriculture is expected to be further restricted by European countries because of its critical ecotoxicological and phytotoxicological profile. Research on ways to reduce the effective amounts of copper by developing innovative formulations as well as optimization of the distribution and persistence of copper-based pesticides for downy mildew control seems to be a promising approach. This research investigated the delivery properties of biomimetic synthetic hydroxyapatite (HA) to enhance the biological activity of Cu(II) ions. To this aim, four Cu(II) compounds were formulated with the innovative HA component and applied in an in vitro antifungal assay against Botrytis cinerea, a common grapevine pathogen suitable for in vitro activity tests, and finally, in in planta efficacy assays against P. viticola under greenhouse conditions. The in vitro results highlighted a different inhibition activity for each Cu(II) compound and indicated a different interaction between the cupric compounds and HA, potentially related to different delivery mechanisms of Cu(II) from HA. Under greenhouse conditions, additional findings on the biological activity of the applied formulations were gained, especially on the efficacy of various concentrations of HA in the formulations, the influence of dose variation of the formulation and the treatment efficiency, and the persistence under rain-washing effect. This study revealed promising findings on the formulation based on the HA particles and the soluble Cu(II) compound, which resulted in reduced disease severity and incidence in all of the experimental conditions, including the lower Cu(II) dosage and the rain-washing effect. This suggests that coformulation of the three insoluble Cu(II) compounds with HA might significantly enhance the adsorption and release of Cu(II) ions by HA particles.
DOI: 10.1094/PHYTO-02-18-0033-R
PubMed: 30522386
Links to Exploration step
pubmed:30522386Le document en format XML
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and.</nlm:affiliation></affiliation></author><author><name sortKey="Di Marco, Stefano" sort="Di Marco, Stefano" uniqKey="Di Marco S" first="Stefano" last="Di Marco">Stefano Di Marco</name><affiliation><nlm:affiliation>4 Istituto di Biometeorologia, Consiglio Nazionale delle Ricerche, Bologna I-40129, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Fontaine, Florence" sort="Fontaine, Florence" uniqKey="Fontaine F" first="Florence" last="Fontaine">Florence Fontaine</name><affiliation><nlm:affiliation>2 Structure Fédératrice de Recherche Condorcet FR CNRS 3417, Université de Reims Champagne-Ardenne, Unité Recherche EA 4707, Résistance Induite et Bioprotection des Plantes, Reims F-51687, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mugnai, Laura" sort="Mugnai, Laura" uniqKey="Mugnai L" first="Laura" last="Mugnai">Laura Mugnai</name><affiliation><nlm:affiliation>1 Dipartimento di Scienze e Tecnologie Agrarie, Alimentari, Ambientali e Forestali, Sezione Patologia Vegetale ed Entomologia, Università degli Studi di Firenze, Firenze I-50144, Italy.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30522386</idno><idno type="pmid">30522386</idno><idno type="doi">10.1094/PHYTO-02-18-0033-R</idno><idno type="wicri:Area/Main/Corpus">000211</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000211</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Innovative Delivery of Cu(II) Ions by a Nanostructured Hydroxyapatite: Potential Application in Planta to Enhance the Sustainable Control of <i>Plasmopara viticola</i>.</title><author><name sortKey="Battiston, Enrico" sort="Battiston, Enrico" uniqKey="Battiston E" first="Enrico" last="Battiston">Enrico Battiston</name><affiliation><nlm:affiliation>1 Dipartimento di Scienze e Tecnologie Agrarie, Alimentari, Ambientali e Forestali, Sezione Patologia Vegetale ed Entomologia, Università degli Studi di Firenze, Firenze I-50144, Italy.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>2 Structure Fédératrice de Recherche Condorcet FR CNRS 3417, Université de Reims Champagne-Ardenne, Unité Recherche EA 4707, Résistance Induite et Bioprotection des Plantes, Reims F-51687, France.</nlm:affiliation></affiliation></author><author><name sortKey="Antonielli, Livio" sort="Antonielli, Livio" uniqKey="Antonielli L" first="Livio" last="Antonielli">Livio Antonielli</name><affiliation><nlm:affiliation>3 Health & Environment Department, Bioresources Unit, Austrian Institute of Technology GmbH, Tulln A-3430, Austria; and.</nlm:affiliation></affiliation></author><author><name sortKey="Di Marco, Stefano" sort="Di Marco, Stefano" uniqKey="Di Marco S" first="Stefano" last="Di Marco">Stefano Di Marco</name><affiliation><nlm:affiliation>4 Istituto di Biometeorologia, Consiglio Nazionale delle Ricerche, Bologna I-40129, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Fontaine, Florence" sort="Fontaine, Florence" uniqKey="Fontaine F" first="Florence" last="Fontaine">Florence Fontaine</name><affiliation><nlm:affiliation>2 Structure Fédératrice de Recherche Condorcet FR CNRS 3417, Université de Reims Champagne-Ardenne, Unité Recherche EA 4707, Résistance Induite et Bioprotection des Plantes, Reims F-51687, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mugnai, Laura" sort="Mugnai, Laura" uniqKey="Mugnai L" first="Laura" last="Mugnai">Laura Mugnai</name><affiliation><nlm:affiliation>1 Dipartimento di Scienze e Tecnologie Agrarie, Alimentari, Ambientali e Forestali, Sezione Patologia Vegetale ed Entomologia, Università degli Studi di Firenze, Firenze I-50144, Italy.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Phytopathology</title><idno type="ISSN">0031-949X</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Copper (pharmacology)</term><term>Durapatite (MeSH)</term><term>Ions (MeSH)</term><term>Nanostructures (MeSH)</term><term>Oomycetes (pathogenicity)</term><term>Plant Diseases (microbiology)</term><term>Plant Diseases (prevention & control)</term><term>Vitis (microbiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Copper</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Durapatite</term><term>Ions</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Plant Diseases</term><term>Vitis</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Oomycetes</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Plant Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Nanostructures</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Downy mildew caused by <i>Plasmopara viticola</i> is probably the most serious disease affecting grapevine (<i>Vitis vinifera</i>), and it is capable of causing consistent yield losses. In organic viticulture, the only acceptable and effective means to control the disease is by applications of copper-based fungicides. However, the use of copper in agriculture is expected to be further restricted by European countries because of its critical ecotoxicological and phytotoxicological profile. Research on ways to reduce the effective amounts of copper by developing innovative formulations as well as optimization of the distribution and persistence of copper-based pesticides for downy mildew control seems to be a promising approach. This research investigated the delivery properties of biomimetic synthetic hydroxyapatite (HA) to enhance the biological activity of Cu(II) ions. To this aim, four Cu(II) compounds were formulated with the innovative HA component and applied in an in vitro antifungal assay against <i>Botrytis cinerea</i>, a common grapevine pathogen suitable for in vitro activity tests, and finally, in in planta efficacy assays against <i>P. viticola</i> under greenhouse conditions. The in vitro results highlighted a different inhibition activity for each Cu(II) compound and indicated a different interaction between the cupric compounds and HA, potentially related to different delivery mechanisms of Cu(II) from HA. Under greenhouse conditions, additional findings on the biological activity of the applied formulations were gained, especially on the efficacy of various concentrations of HA in the formulations, the influence of dose variation of the formulation and the treatment efficiency, and the persistence under rain-washing effect. This study revealed promising findings on the formulation based on the HA particles and the soluble Cu(II) compound, which resulted in reduced disease severity and incidence in all of the experimental conditions, including the lower Cu(II) dosage and the rain-washing effect. This suggests that coformulation of the three insoluble Cu(II) compounds with HA might significantly enhance the adsorption and release of Cu(II) ions by HA particles.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">30522386</PMID><DateCompleted><Year>2019</Year><Month>08</Month><Day>19</Day></DateCompleted><DateRevised><Year>2019</Year><Month>08</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0031-949X</ISSN><JournalIssue CitedMedium="Print"><Volume>109</Volume><Issue>5</Issue><PubDate><Year>2019</Year><Month>May</Month></PubDate></JournalIssue><Title>Phytopathology</Title><ISOAbbreviation>Phytopathology</ISOAbbreviation></Journal><ArticleTitle>Innovative Delivery of Cu(II) Ions by a Nanostructured Hydroxyapatite: Potential Application in Planta to Enhance the Sustainable Control of <i>Plasmopara viticola</i>.</ArticleTitle><Pagination><MedlinePgn>748-759</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1094/PHYTO-02-18-0033-R</ELocationID><Abstract><AbstractText>Downy mildew caused by <i>Plasmopara viticola</i> is probably the most serious disease affecting grapevine (<i>Vitis vinifera</i>), and it is capable of causing consistent yield losses. In organic viticulture, the only acceptable and effective means to control the disease is by applications of copper-based fungicides. However, the use of copper in agriculture is expected to be further restricted by European countries because of its critical ecotoxicological and phytotoxicological profile. Research on ways to reduce the effective amounts of copper by developing innovative formulations as well as optimization of the distribution and persistence of copper-based pesticides for downy mildew control seems to be a promising approach. This research investigated the delivery properties of biomimetic synthetic hydroxyapatite (HA) to enhance the biological activity of Cu(II) ions. To this aim, four Cu(II) compounds were formulated with the innovative HA component and applied in an in vitro antifungal assay against <i>Botrytis cinerea</i>, a common grapevine pathogen suitable for in vitro activity tests, and finally, in in planta efficacy assays against <i>P. viticola</i> under greenhouse conditions. The in vitro results highlighted a different inhibition activity for each Cu(II) compound and indicated a different interaction between the cupric compounds and HA, potentially related to different delivery mechanisms of Cu(II) from HA. Under greenhouse conditions, additional findings on the biological activity of the applied formulations were gained, especially on the efficacy of various concentrations of HA in the formulations, the influence of dose variation of the formulation and the treatment efficiency, and the persistence under rain-washing effect. This study revealed promising findings on the formulation based on the HA particles and the soluble Cu(II) compound, which resulted in reduced disease severity and incidence in all of the experimental conditions, including the lower Cu(II) dosage and the rain-washing effect. This suggests that coformulation of the three insoluble Cu(II) compounds with HA might significantly enhance the adsorption and release of Cu(II) ions by HA particles.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Battiston</LastName><ForeName>Enrico</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>1 Dipartimento di Scienze e Tecnologie Agrarie, Alimentari, Ambientali e Forestali, Sezione Patologia Vegetale ed Entomologia, Università degli Studi di Firenze, Firenze I-50144, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>2 Structure Fédératrice de Recherche Condorcet FR CNRS 3417, Université de Reims Champagne-Ardenne, Unité Recherche EA 4707, Résistance Induite et Bioprotection des Plantes, Reims F-51687, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Antonielli</LastName><ForeName>Livio</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>3 Health & Environment Department, Bioresources Unit, Austrian Institute of Technology GmbH, Tulln A-3430, Austria; and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Di Marco</LastName><ForeName>Stefano</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>4 Istituto di Biometeorologia, Consiglio Nazionale delle Ricerche, Bologna I-40129, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fontaine</LastName><ForeName>Florence</ForeName><Initials>F</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-2918-8812</Identifier><AffiliationInfo><Affiliation>2 Structure Fédératrice de Recherche Condorcet FR CNRS 3417, Université de Reims Champagne-Ardenne, Unité Recherche EA 4707, Résistance Induite et Bioprotection des Plantes, Reims F-51687, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mugnai</LastName><ForeName>Laura</ForeName><Initials>L</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-2508-9764</Identifier><AffiliationInfo><Affiliation>1 Dipartimento di Scienze e Tecnologie Agrarie, Alimentari, Ambientali e Forestali, Sezione Patologia Vegetale ed Entomologia, Università degli Studi di Firenze, Firenze I-50144, Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>04</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Phytopathology</MedlineTA><NlmUniqueID>9427222</NlmUniqueID><ISSNLinking>0031-949X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007477">Ions</NameOfSubstance></Chemical><Chemical><RegistryNumber>789U1901C5</RegistryNumber><NameOfSubstance UI="D003300">Copper</NameOfSubstance></Chemical><Chemical><RegistryNumber>91D9GV0Z28</RegistryNumber><NameOfSubstance UI="D017886">Durapatite</NameOfSubstance></Chemical></ChemicalList><MeshHeadingList><MeshHeading><DescriptorName UI="D003300" MajorTopicYN="N">Copper</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017886" MajorTopicYN="N">Durapatite</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007477" MajorTopicYN="N">Ions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049329" MajorTopicYN="N">Nanostructures</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009868" MajorTopicYN="N">Oomycetes</DescriptorName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010935" MajorTopicYN="N">Plant Diseases</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D027843" MajorTopicYN="N">Vitis</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">drug delivery</Keyword><Keyword MajorTopicYN="N">smart pesticides</Keyword><Keyword MajorTopicYN="N">sustainability</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>12</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>8</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>12</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30522386</ArticleId><ArticleId IdType="doi">10.1094/PHYTO-02-18-0033-R</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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