Serveur d'exploration sur la glutarédoxine - Exploration (Accueil)

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Les termes de plus forte occurence

1364glutaredoxin
1072protein
881glutathione
817redox
790these
768proteins
697activity
683thioredoxin
663were
606grx
599cells
592results
576also
573oxidative
562role
556disulfide
553stress
538but
527dependent
511reductase
496both
487expression
478glutaredoxins
466active
462cell
458thiol
452reduced
428function
415cellular
413regulation
409study
386other
379reduction
372here
371enzyme
368gsh
366however
356cysteine
349site
349induced
349gene
343levels
340mechanism
340found
335specific
335involved
332system
330may
326analysis
321increased
317human
315important
312enzymes
310species
303genes
292during
291type
291molecular
290high
290acid
287including
285showed
284different
278well
277under
277coli
275suggest
274than
274response
270residues
270present
270form
268only
267reactive
264oxygen
262formation
260functions
257identified
254known
252potential
251systems
250studies
250all
248sequence
246against
245mitochondrial
244escherichia
244cys
241structure
241oxidation
241antioxidant
239presence
239growth
239conditions
239binding
238show
236through
235essential
234mechanisms
233glutathionylation
232iron
231via
228signaling
228data
224three
224related
224conserved
223functional
223associated
223addition
222like
219most
213thus
213state
213mediated
212low
210several
210mutant
208whereas
208oxidized
206could
205vitro
205first
205after
204revealed
204family
204expressed
204control
204compared
203observed
203changes
202intracellular
202homeostasis
201trx
201metabolism
200complex
200activities
199when
199effect
198similar
198effects
197vivo
197structural
197shown
197regulated
197reducing
196major
194containing
192yeast
192novel
191treatment
188amino
184model
184cytosolic
183sulfur
183higher
183further
182sensitive
182catalytic
179roles
179required
179monothiol
178factor
175various
175key
174development
173fold
172transcription
172reaction
172plant
172physiological
172hydrogen
171small
171pathway
170processes
170dna
170decreased
169significantly
169demonstrated
168while
167previously
167pathways
167oxidoreductase
165either
165cluster
163increase
162thioredoxins
162respectively
161plants
161disulfides
160nadph
160demonstrate
158mixed
158characterization
157purified
157play
155significant
155new
155highly
154wild
154suggesting
152target
152grxs
152furthermore
151terminal
151regulatory
150synthesis
150level
150critical
150contrast
149substrate
149determined
148damage
147properties
147non
147mutants
147many
147biochemical
146thioltransferase
146indicate
146evidence
145within
144ros
144domain
144characterized
144activation
143reactions
143although
142inhibition
141provide
141plays
141interaction
139factors
137modification
137methods
136time
136reduce
136mammalian
135mitochondria
133recombinant
133dithiol
132oxidoreductases
131reversible
131mice
131had
131findings
130process
129report
129production
127thiols
127peroxidase
127organisms
126together
126did
125ribonucleotide
125investigated
124regulating
123disease
122defense
121motif
121cysteines
120recently
120class
119review
119forms
119exchange
118single
118peroxide
118gssg
118electron
118due
117reported
117mass
115those
115contains
115concentrations
115cerevisiae
115arabidopsis
114saccharomyces
114loss
114encoding
113rate
113indicating
112responses
112recent
112each
112bond
110status
109substrates
109nuclear
109normal
109identification
109groups
109enhanced
108number
108liver
107same
107possible
106suggests
106enzymatic
105upon
105regulate
105isolated
105interactions
104tissues
104there
104resistance
104residue
103therefore
103exposure
102multiple
102examined
102caused
102because
101cycle
101bonds
100likely
100free
99very
99unknown
99transferase
99overexpression
99clusters
98four
98cytosol
97signal
97linked
97lacking
97biological
97ability
96targets
96group
96absence
95mouse
95distinct
95concentration
94protection
94peroxiredoxin
94mrna
94lower
94detected
93putative
93inhibited
93glutathionylated
93beta
93apoptosis
92transcriptional
92survival
92moreover
92members
92conclusion
92components
91total
91exposed
91diseases
91contain
91catalyze
91accumulation
90transfer
90superoxide
90genetic
90donor
90deglutathionylation
90bacterial
89reductases
89pro
89less
89directly
89bacteria
89able
88suggested
88second
88experiments
88differences
87molecules
87inhibitor
87genome
86rat
86obtained
86metabolic
85work
85resulted
85regulates
85range
85membrane
85kinase
85anti
85analyses
84shows
84kda
84encoded
84additional
83weight
83unique
83structures
83post
83might
83identify
82whether
82decrease
81over
81glrx
81conclusions
81common
81catalyzes
80sensitivity
80part
80biosynthesis
80background
79provides
79environment
79described
79death
79crucial
78tissue
78studied
78since
78indicated
78importance
78general
77understanding
77strain
77result
77increases
77confirmed
77comparison
76primary
76peroxiredoxins
76mutations
76derived
76basis
76acids
75superfamily
75significance
75large
75central
75assay
75affected
74sites
74proposed
74located
74catalyzed
73treated
73rna
73localization
73generated
73does
73deficient
73corresponding
73consistent
73assembly
72ubiquitous
72thaliana
72sequences
72implicated
72content
72activated
71overall
71following
70where
70manner
70induction
70formed
70followed
70coupled
70balance
69spectrometry
69specificity
69molecule
69modifications
69drug
69controls
69capacity
69being
69affect
68types
68taken
68stable
68specifically
68led
68involving
68inactivation
68efficient
68discussed
68dehydrogenase
68catalysis
68altered
68act
67wide
67variety
67responsible
67phosphate
67oxidant
67min
67exhibited
66interact
66catalase
66alpha
65region
65produced

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