GlutaredoxinV1, Main, Exploration, bibRecord, 001366

Enzymes involved in glutathione metabolism in rat liver and blood after carbon tetrachloride intoxication.

Identifieur interne : 001366 ( Main/Exploration ); précédent : 001365; suivant : 001367

Enzymes involved in glutathione metabolism in rat liver and blood after carbon tetrachloride intoxication.

Auteurs : P. Di Simplicio ; B. Mannervik

Source :

Toxicology letters [ 0378-4274 ] ; 1983.

RBID : pubmed:6665803

Descripteurs français

KwdFr :
- Animaux (MeSH), Foie (enzymologie), Glutarédoxines (MeSH), Glutathion (métabolisme), Glutathione peroxidase (métabolisme), Glutathione reductase (métabolisme), Glutathione transferase (métabolisme), Intoxication au tétrachlorure de carbone (enzymologie), Lactoyl glutathione lyase (métabolisme), Mâle (MeSH), Oxidoreductases (métabolisme), Protein-disulfide reductase (glutathione) (MeSH), Rats (MeSH).
MESH :
- enzymologie : Foie, Intoxication au tétrachlorure de carbone.
- métabolisme : Glutathion, Glutathione peroxidase, Glutathione reductase, Glutathione transferase, Lactoyl glutathione lyase, Oxidoreductases.
- Animaux, Glutarédoxines, Mâle, Protein-disulfide reductase (glutathione), Rats.

English descriptors

KwdEn :
- Animals (MeSH), Carbon Tetrachloride Poisoning (enzymology), Glutaredoxins (MeSH), Glutathione (metabolism), Glutathione Peroxidase (metabolism), Glutathione Reductase (metabolism), Glutathione Transferase (metabolism), Lactoylglutathione Lyase (metabolism), Liver (enzymology), Male (MeSH), Oxidoreductases (metabolism), Protein Disulfide Reductase (Glutathione) (MeSH), Rats (MeSH).
MESH :
- chemical , metabolism : Glutathione, Glutathione Peroxidase, Glutathione Reductase, Glutathione Transferase, Lactoylglutathione Lyase, Oxidoreductases.
- chemical : Glutaredoxins, Protein Disulfide Reductase (Glutathione).
- enzymology : Carbon Tetrachloride Poisoning, Liver.
- Animals, Male, Rats.

Abstract

Some glutathione-metabolizing enzymes in rat liver cytosol, blood plasma and urine of rats administered carbon tetrachloride (CCl4) were investigated. After CCl4 at different doses (0.3, 1.2, 2.5 ml/kg at 24, 12 and 3 or 6 h, respectively) liver glutathione reductase (GR), glyoxalase I (GLY-I) and glutathione S-transferases (GST) significantly decreased, while thioltransferase and glutathione peroxidase (GPX) did not change their activity. At the times under investigation the glutathione level significantly increased in the liver and the above-mentioned enzymes in plasma, thus evidencing a liver injury. The GR, GPX and GST assayed in urine within 72 h after CCl4 administration showed a maximum of activity at 35-48 h.

DOI: 10.1016/0378-4274(83)90108-x
PubMed: 6665803

Affiliations:

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Le document en format XML

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<author><name sortKey="Di Simplicio, P" sort="Di Simplicio, P" uniqKey="Di Simplicio P" first="P" last="Di Simplicio">P. Di Simplicio</name>
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<author><name sortKey="Mannervik, B" sort="Mannervik, B" uniqKey="Mannervik B" first="B" last="Mannervik">B. Mannervik</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Carbon Tetrachloride Poisoning (enzymology)</term>
<term>Glutaredoxins (MeSH)</term>
<term>Glutathione (metabolism)</term>
<term>Glutathione Peroxidase (metabolism)</term>
<term>Glutathione Reductase (metabolism)</term>
<term>Glutathione Transferase (metabolism)</term>
<term>Lactoylglutathione Lyase (metabolism)</term>
<term>Liver (enzymology)</term>
<term>Male (MeSH)</term>
<term>Oxidoreductases (metabolism)</term>
<term>Protein Disulfide Reductase (Glutathione) (MeSH)</term>
<term>Rats (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Foie (enzymologie)</term>
<term>Glutarédoxines (MeSH)</term>
<term>Glutathion (métabolisme)</term>
<term>Glutathione peroxidase (métabolisme)</term>
<term>Glutathione reductase (métabolisme)</term>
<term>Glutathione transferase (métabolisme)</term>
<term>Intoxication au tétrachlorure de carbone (enzymologie)</term>
<term>Lactoyl glutathione lyase (métabolisme)</term>
<term>Mâle (MeSH)</term>
<term>Oxidoreductases (métabolisme)</term>
<term>Protein-disulfide reductase (glutathione) (MeSH)</term>
<term>Rats (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glutathione</term>
<term>Glutathione Peroxidase</term>
<term>Glutathione Reductase</term>
<term>Glutathione Transferase</term>
<term>Lactoylglutathione Lyase</term>
<term>Oxidoreductases</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Glutaredoxins</term>
<term>Protein Disulfide Reductase (Glutathione)</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Foie</term>
<term>Intoxication au tétrachlorure de carbone</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Carbon Tetrachloride Poisoning</term>
<term>Liver</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glutathion</term>
<term>Glutathione peroxidase</term>
<term>Glutathione reductase</term>
<term>Glutathione transferase</term>
<term>Lactoyl glutathione lyase</term>
<term>Oxidoreductases</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Male</term>
<term>Rats</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Glutarédoxines</term>
<term>Mâle</term>
<term>Protein-disulfide reductase (glutathione)</term>
<term>Rats</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Some glutathione-metabolizing enzymes in rat liver cytosol, blood plasma and urine of rats administered carbon tetrachloride (CCl4) were investigated. After CCl4 at different doses (0.3, 1.2, 2.5 ml/kg at 24, 12 and 3 or 6 h, respectively) liver glutathione reductase (GR), glyoxalase I (GLY-I) and glutathione S-transferases (GST) significantly decreased, while thioltransferase and glutathione peroxidase (GPX) did not change their activity. At the times under investigation the glutathione level significantly increased in the liver and the above-mentioned enzymes in plasma, thus evidencing a liver injury. The GR, GPX and GST assayed in urine within 72 h after CCl4 administration showed a maximum of activity at 35-48 h.</div>
</front>
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<DateCompleted><Year>1984</Year>
<Month>03</Month>
<Day>23</Day>
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<DateRevised><Year>2019</Year>
<Month>08</Month>
<Day>19</Day>
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<JournalIssue CitedMedium="Print"><Volume>18</Volume>
<Issue>3</Issue>
<PubDate><Year>1983</Year>
<Month>Sep</Month>
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<Title>Toxicology letters</Title>
<ISOAbbreviation>Toxicol Lett</ISOAbbreviation>
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<ArticleTitle>Enzymes involved in glutathione metabolism in rat liver and blood after carbon tetrachloride intoxication.</ArticleTitle>
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<Abstract><AbstractText>Some glutathione-metabolizing enzymes in rat liver cytosol, blood plasma and urine of rats administered carbon tetrachloride (CCl4) were investigated. After CCl4 at different doses (0.3, 1.2, 2.5 ml/kg at 24, 12 and 3 or 6 h, respectively) liver glutathione reductase (GR), glyoxalase I (GLY-I) and glutathione S-transferases (GST) significantly decreased, while thioltransferase and glutathione peroxidase (GPX) did not change their activity. At the times under investigation the glutathione level significantly increased in the liver and the above-mentioned enzymes in plasma, thus evidencing a liver injury. The GR, GPX and GST assayed in urine within 72 h after CCl4 administration showed a maximum of activity at 35-48 h.</AbstractText>
</Abstract>
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<Language>eng</Language>
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<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Toxicol Lett</MedlineTA>
<NlmUniqueID>7709027</NlmUniqueID>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D054477">Glutaredoxins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.-</RegistryNumber>
<NameOfSubstance UI="D010088">Oxidoreductases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.11.1.9</RegistryNumber>
<NameOfSubstance UI="D005979">Glutathione Peroxidase</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.8.1.7</RegistryNumber>
<NameOfSubstance UI="D005980">Glutathione Reductase</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.8.4.2</RegistryNumber>
<NameOfSubstance UI="D011490">Protein Disulfide Reductase (Glutathione)</NameOfSubstance>
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<Chemical><RegistryNumber>EC 2.5.1.18</RegistryNumber>
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<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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Enzymes involved in glutathione metabolism in rat liver and blood after carbon tetrachloride intoxication.

Enzymes involved in glutathione metabolism in rat liver and blood after carbon tetrachloride intoxication.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki