Glutathione, glutathione utilizing enzymes and thioltransferase in platelets of insulin-dependent diabetic patients: relation with platelet aggregation and with microangiopatic complications.
Identifieur interne : 001223 ( Main/Exploration ); précédent : 001222; suivant : 001224Glutathione, glutathione utilizing enzymes and thioltransferase in platelets of insulin-dependent diabetic patients: relation with platelet aggregation and with microangiopatic complications.
Auteurs : P. Di Simplicio [Italie] ; L A De Giorgio ; E. Cardaioli ; R. Lecis ; M. Miceli ; R. Rossi ; R. Anichini ; M. Mian ; G. Seghieri ; F. FranconiSource :
- European journal of clinical investigation [ 0014-2972 ] ; 1995.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Agrégation plaquettaire (MeSH), Angiopathies diabétiques (sang), Diabète de type 1 (sang), Femelle (MeSH), Glucose 6-phosphate dehydrogenase (sang), Glutarédoxines (MeSH), Glutathion (métabolisme), Glutathione peroxidase (sang), Glutathione transferase (sang), Humains (MeSH), Mâle (MeSH), Oxidoreductases (sang), Plaquettes (métabolisme), Protein-disulfide reductase (glutathione) (MeSH).
- MESH :
- métabolisme : Glutathion, Plaquettes.
- sang : Angiopathies diabétiques, Diabète de type 1, Glucose 6-phosphate dehydrogenase, Glutathione peroxidase, Glutathione transferase, Oxidoreductases.
- Adulte, Agrégation plaquettaire, Femelle, Glutarédoxines, Humains, Mâle, Protein-disulfide reductase (glutathione).
English descriptors
- KwdEn :
- Adult (MeSH), Blood Platelets (metabolism), Diabetes Mellitus, Type 1 (blood), Diabetic Angiopathies (blood), Female (MeSH), Glucosephosphate Dehydrogenase (blood), Glutaredoxins (MeSH), Glutathione (metabolism), Glutathione Peroxidase (blood), Glutathione Transferase (blood), Humans (MeSH), Male (MeSH), Oxidoreductases (blood), Platelet Aggregation (MeSH), Protein Disulfide Reductase (Glutathione) (MeSH).
- MESH :
- chemical , blood : Glucosephosphate Dehydrogenase, Glutathione Peroxidase, Glutathione Transferase, Oxidoreductases.
- blood : Diabetes Mellitus, Type 1, Diabetic Angiopathies.
- metabolism : Blood Platelets, Glutathione.
- Adult, Female, Glutaredoxins, Humans, Male, Platelet Aggregation, Protein Disulfide Reductase (Glutathione).
Abstract
Reduced glutathione (GSH) and activity of GSH related enzymes play a key role in defence against oxygen free radicals, whose production is, as known, raised in patients affected by diabetes mellitus, and at the same time they may contribute to the process of platelet aggregation. The purpose of this study was to evaluate GSH levels and activity of glutathione peroxidase (GSH-Px), glutathione reductase (GSSG-Red), glutathione transferase (GSH-Tr), glucose-6-phosphate-dehydrogenase (G6PDH), and thioltransferase (TT) in platelets of insulin-dependent diabetic patients in fair metabolic control (mean glycated haemoglobin: 6.5%), as related to presence of retinopathy, neuropathy or nephropathy and to platelet aggregation by arachidonic acid (AA) in vitro. Mean effective dose (ED50) of AA was on average significantly lower in the group of insulin-dependent diabetic patients (0.41 +/- 0.02 mM (SEM), n = 46) as compared with that of control subjects strictly matched for age, sex and weight (0.77 +/- 0.02, n = 51; P = 0.0001). Mean platelet GSH as well as the activity of GSH related enzymes expressed as geometric mean (95% confidence intervals) were similar in diabetic patients and in controls, except for GSSG-Red whose activity was significantly higher in diabetic subjects (28.5 (14.4-57.5) mU 10(-9) platelets vs. 20.3 (8.7-56) mU 10(-9) platelets; P = 0.01). In the diabetic group TT was reduced when compared with healthy controls (3.8 (0.9-12.2) mU 10(-9) platelets vs. 6 (1.6-26.1) mU 10(-9) platelets; P = 0.04).(ABSTRACT TRUNCATED AT 250 WORDS)
DOI: 10.1111/j.1365-2362.1995.tb01983.x
PubMed: 7498240
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Di Simplicio</name><affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Biologia Ambientale, University of Siena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Biologia Ambientale, University of Siena</wicri:regionArea><wicri:noRegion>University of Siena</wicri:noRegion></affiliation></author><author><name sortKey="De Giorgio, L A" sort="De Giorgio, L A" uniqKey="De Giorgio L" first="L A" last="De Giorgio">L A De Giorgio</name></author><author><name sortKey="Cardaioli, E" sort="Cardaioli, E" uniqKey="Cardaioli E" first="E" last="Cardaioli">E. Cardaioli</name></author><author><name sortKey="Lecis, R" sort="Lecis, R" uniqKey="Lecis R" first="R" last="Lecis">R. Lecis</name></author><author><name sortKey="Miceli, M" sort="Miceli, M" uniqKey="Miceli M" first="M" last="Miceli">M. Miceli</name></author><author><name sortKey="Rossi, R" sort="Rossi, R" uniqKey="Rossi R" first="R" last="Rossi">R. Rossi</name></author><author><name sortKey="Anichini, R" sort="Anichini, R" uniqKey="Anichini R" first="R" last="Anichini">R. Anichini</name></author><author><name sortKey="Mian, M" sort="Mian, M" uniqKey="Mian M" first="M" last="Mian">M. Mian</name></author><author><name sortKey="Seghieri, G" sort="Seghieri, G" uniqKey="Seghieri G" first="G" last="Seghieri">G. Seghieri</name></author><author><name sortKey="Franconi, F" sort="Franconi, F" uniqKey="Franconi F" first="F" last="Franconi">F. Franconi</name></author></analytic><series><title level="j">European journal of clinical investigation</title><idno type="ISSN">0014-2972</idno><imprint><date when="1995" type="published">1995</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Blood Platelets (metabolism)</term><term>Diabetes Mellitus, Type 1 (blood)</term><term>Diabetic Angiopathies (blood)</term><term>Female (MeSH)</term><term>Glucosephosphate Dehydrogenase (blood)</term><term>Glutaredoxins (MeSH)</term><term>Glutathione (metabolism)</term><term>Glutathione Peroxidase (blood)</term><term>Glutathione Transferase (blood)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Oxidoreductases (blood)</term><term>Platelet Aggregation (MeSH)</term><term>Protein Disulfide Reductase (Glutathione) (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Agrégation plaquettaire (MeSH)</term><term>Angiopathies diabétiques (sang)</term><term>Diabète de type 1 (sang)</term><term>Femelle (MeSH)</term><term>Glucose 6-phosphate dehydrogenase (sang)</term><term>Glutarédoxines (MeSH)</term><term>Glutathion (métabolisme)</term><term>Glutathione peroxidase (sang)</term><term>Glutathione transferase (sang)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Oxidoreductases (sang)</term><term>Plaquettes (métabolisme)</term><term>Protein-disulfide reductase (glutathione) (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Glucosephosphate Dehydrogenase</term><term>Glutathione Peroxidase</term><term>Glutathione Transferase</term><term>Oxidoreductases</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Diabetes Mellitus, Type 1</term><term>Diabetic Angiopathies</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Blood Platelets</term><term>Glutathione</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glutathion</term><term>Plaquettes</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Angiopathies diabétiques</term><term>Diabète de type 1</term><term>Glucose 6-phosphate dehydrogenase</term><term>Glutathione peroxidase</term><term>Glutathione transferase</term><term>Oxidoreductases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Glutaredoxins</term><term>Humans</term><term>Male</term><term>Platelet Aggregation</term><term>Protein Disulfide Reductase (Glutathione)</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Agrégation plaquettaire</term><term>Femelle</term><term>Glutarédoxines</term><term>Humains</term><term>Mâle</term><term>Protein-disulfide reductase (glutathione)</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Reduced glutathione (GSH) and activity of GSH related enzymes play a key role in defence against oxygen free radicals, whose production is, as known, raised in patients affected by diabetes mellitus, and at the same time they may contribute to the process of platelet aggregation. The purpose of this study was to evaluate GSH levels and activity of glutathione peroxidase (GSH-Px), glutathione reductase (GSSG-Red), glutathione transferase (GSH-Tr), glucose-6-phosphate-dehydrogenase (G6PDH), and thioltransferase (TT) in platelets of insulin-dependent diabetic patients in fair metabolic control (mean glycated haemoglobin: 6.5%), as related to presence of retinopathy, neuropathy or nephropathy and to platelet aggregation by arachidonic acid (AA) in vitro. Mean effective dose (ED50) of AA was on average significantly lower in the group of insulin-dependent diabetic patients (0.41 +/- 0.02 mM (SEM), n = 46) as compared with that of control subjects strictly matched for age, sex and weight (0.77 +/- 0.02, n = 51; P = 0.0001). Mean platelet GSH as well as the activity of GSH related enzymes expressed as geometric mean (95% confidence intervals) were similar in diabetic patients and in controls, except for GSSG-Red whose activity was significantly higher in diabetic subjects (28.5 (14.4-57.5) mU 10(-9) platelets vs. 20.3 (8.7-56) mU 10(-9) platelets; P = 0.01). In the diabetic group TT was reduced when compared with healthy controls (3.8 (0.9-12.2) mU 10(-9) platelets vs. 6 (1.6-26.1) mU 10(-9) platelets; P = 0.04).(ABSTRACT TRUNCATED AT 250 WORDS)</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">7498240</PMID><DateCompleted><Year>1996</Year><Month>01</Month><Day>17</Day></DateCompleted><DateRevised><Year>2019</Year><Month>08</Month><Day>25</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0014-2972</ISSN><JournalIssue CitedMedium="Print"><Volume>25</Volume><Issue>9</Issue><PubDate><Year>1995</Year><Month>Sep</Month></PubDate></JournalIssue><Title>European journal of clinical investigation</Title><ISOAbbreviation>Eur J Clin Invest</ISOAbbreviation></Journal><ArticleTitle>Glutathione, glutathione utilizing enzymes and thioltransferase in platelets of insulin-dependent diabetic patients: relation with platelet aggregation and with microangiopatic complications.</ArticleTitle><Pagination><MedlinePgn>665-9</MedlinePgn></Pagination><Abstract><AbstractText>Reduced glutathione (GSH) and activity of GSH related enzymes play a key role in defence against oxygen free radicals, whose production is, as known, raised in patients affected by diabetes mellitus, and at the same time they may contribute to the process of platelet aggregation. The purpose of this study was to evaluate GSH levels and activity of glutathione peroxidase (GSH-Px), glutathione reductase (GSSG-Red), glutathione transferase (GSH-Tr), glucose-6-phosphate-dehydrogenase (G6PDH), and thioltransferase (TT) in platelets of insulin-dependent diabetic patients in fair metabolic control (mean glycated haemoglobin: 6.5%), as related to presence of retinopathy, neuropathy or nephropathy and to platelet aggregation by arachidonic acid (AA) in vitro. Mean effective dose (ED50) of AA was on average significantly lower in the group of insulin-dependent diabetic patients (0.41 +/- 0.02 mM (SEM), n = 46) as compared with that of control subjects strictly matched for age, sex and weight (0.77 +/- 0.02, n = 51; P = 0.0001). Mean platelet GSH as well as the activity of GSH related enzymes expressed as geometric mean (95% confidence intervals) were similar in diabetic patients and in controls, except for GSSG-Red whose activity was significantly higher in diabetic subjects (28.5 (14.4-57.5) mU 10(-9) platelets vs. 20.3 (8.7-56) mU 10(-9) platelets; P = 0.01). In the diabetic group TT was reduced when compared with healthy controls (3.8 (0.9-12.2) mU 10(-9) platelets vs. 6 (1.6-26.1) mU 10(-9) platelets; P = 0.04).(ABSTRACT TRUNCATED AT 250 WORDS)</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Di Simplicio</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Dipartimento di Biologia Ambientale, University of Siena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Giorgio</LastName><ForeName>L A</ForeName><Initials>LA</Initials></Author><Author ValidYN="Y"><LastName>Cardaioli</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Lecis</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Miceli</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Rossi</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Anichini</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Mian</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Seghieri</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Franconi</LastName><ForeName>F</ForeName><Initials>F</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Eur J Clin Invest</MedlineTA><NlmUniqueID>0245331</NlmUniqueID><ISSNLinking>0014-2972</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054477">Glutaredoxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.-</RegistryNumber><NameOfSubstance UI="D010088">Oxidoreductases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.1.1.49</RegistryNumber><NameOfSubstance UI="D005954">Glucosephosphate Dehydrogenase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.11.1.9</RegistryNumber><NameOfSubstance UI="D005979">Glutathione Peroxidase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.8.4.2</RegistryNumber><NameOfSubstance UI="D011490">Protein Disulfide Reductase (Glutathione)</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.5.1.18</RegistryNumber><NameOfSubstance UI="D005982">Glutathione Transferase</NameOfSubstance></Chemical><Chemical><RegistryNumber>GAN16C9B8O</RegistryNumber><NameOfSubstance UI="D005978">Glutathione</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001792" MajorTopicYN="N">Blood Platelets</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003922" MajorTopicYN="N">Diabetes Mellitus, Type 1</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003925" MajorTopicYN="N">Diabetic Angiopathies</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005954" MajorTopicYN="N">Glucosephosphate Dehydrogenase</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D054477" MajorTopicYN="N">Glutaredoxins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005978" MajorTopicYN="N">Glutathione</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005979" MajorTopicYN="N">Glutathione Peroxidase</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005982" MajorTopicYN="N">Glutathione Transferase</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010088" MajorTopicYN="N">Oxidoreductases</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010974" MajorTopicYN="Y">Platelet Aggregation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011490" MajorTopicYN="Y">Protein Disulfide Reductase (Glutathione)</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1995</Year><Month>9</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1995</Year><Month>9</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1995</Year><Month>9</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">7498240</ArticleId><ArticleId IdType="doi">10.1111/j.1365-2362.1995.tb01983.x</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Anichini, R" sort="Anichini, R" uniqKey="Anichini R" first="R" last="Anichini">R. Anichini</name><name sortKey="Cardaioli, E" sort="Cardaioli, E" uniqKey="Cardaioli E" first="E" last="Cardaioli">E. Cardaioli</name><name sortKey="De Giorgio, L A" sort="De Giorgio, L A" uniqKey="De Giorgio L" first="L A" last="De Giorgio">L A De Giorgio</name><name sortKey="Franconi, F" sort="Franconi, F" uniqKey="Franconi F" first="F" last="Franconi">F. Franconi</name><name sortKey="Lecis, R" sort="Lecis, R" uniqKey="Lecis R" first="R" last="Lecis">R. Lecis</name><name sortKey="Mian, M" sort="Mian, M" uniqKey="Mian M" first="M" last="Mian">M. Mian</name><name sortKey="Miceli, M" sort="Miceli, M" uniqKey="Miceli M" first="M" last="Miceli">M. Miceli</name><name sortKey="Rossi, R" sort="Rossi, R" uniqKey="Rossi R" first="R" last="Rossi">R. Rossi</name><name sortKey="Seghieri, G" sort="Seghieri, G" uniqKey="Seghieri G" first="G" last="Seghieri">G. Seghieri</name></noCountry><country name="Italie"><noRegion><name sortKey="Di Simplicio, P" sort="Di Simplicio, P" uniqKey="Di Simplicio P" first="P" last="Di Simplicio">P. Di Simplicio</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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