Glutaredoxin is a direct target of oncogenic jun.
Identifieur interne : 001142 ( Main/Exploration ); précédent : 001141; suivant : 001143Glutaredoxin is a direct target of oncogenic jun.
Auteurs : M E Goller [États-Unis] ; J S Iacovoni ; P K Vogt ; U. KruseSource :
- Oncogene [ 0950-9232 ] ; 1998.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : GAP-43 Protein, Oncogene Protein p65(gag-jun), Proteins.
- Animals, Chick Embryo, Gene Expression Regulation, Glutaredoxins, Oxidoreductases.
Abstract
We have analysed differential gene expression in v-jun-transformed chicken embryo fibroblasts (CEF) compared to normal CEF by using the directional tag PCR subtraction method. From a first generation of putative Jun targets four clones were selected for study; they are upregulated in jun-transformed cells. Three of these clones showed homology to known genes: glutaredoxin, growth associated protein (GAP)-43/neuromodulin, and phenobarbital-induced cytochrome P450. The expression of these genes was analysed in fibroblasts transformed by various oncogenes. Expression of the glutaredoxin mRNA could be induced by a Jun-estrogen receptor chimaera in the absence of de novo protein biosynthesis. Based on this observation we conclude that glutaredoxin is a direct target of v-Jun.
DOI: 10.1038/sj.onc.1201819
PubMed: 9671415
Affiliations:
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From a first generation of putative Jun targets four clones were selected for study; they are upregulated in jun-transformed cells. Three of these clones showed homology to known genes: glutaredoxin, growth associated protein (GAP)-43/neuromodulin, and phenobarbital-induced cytochrome P450. The expression of these genes was analysed in fibroblasts transformed by various oncogenes. Expression of the glutaredoxin mRNA could be induced by a Jun-estrogen receptor chimaera in the absence of de novo protein biosynthesis. Based on this observation we conclude that glutaredoxin is a direct target of v-Jun.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9671415</PMID><DateCompleted><Year>1998</Year><Month>08</Month><Day>05</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0950-9232</ISSN><JournalIssue CitedMedium="Print"><Volume>16</Volume><Issue>22</Issue><PubDate><Year>1998</Year><Month>Jun</Month><Day>04</Day></PubDate></JournalIssue><Title>Oncogene</Title><ISOAbbreviation>Oncogene</ISOAbbreviation></Journal><ArticleTitle>Glutaredoxin is a direct target of oncogenic jun.</ArticleTitle><Pagination><MedlinePgn>2945-8</MedlinePgn></Pagination><Abstract><AbstractText>We have analysed differential gene expression in v-jun-transformed chicken embryo fibroblasts (CEF) compared to normal CEF by using the directional tag PCR subtraction method. From a first generation of putative Jun targets four clones were selected for study; they are upregulated in jun-transformed cells. Three of these clones showed homology to known genes: glutaredoxin, growth associated protein (GAP)-43/neuromodulin, and phenobarbital-induced cytochrome P450. The expression of these genes was analysed in fibroblasts transformed by various oncogenes. Expression of the glutaredoxin mRNA could be induced by a Jun-estrogen receptor chimaera in the absence of de novo protein biosynthesis. 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Kruse</name><name sortKey="Vogt, P K" sort="Vogt, P K" uniqKey="Vogt P" first="P K" last="Vogt">P K Vogt</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Goller, M E" sort="Goller, M E" uniqKey="Goller M" first="M E" last="Goller">M E Goller</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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