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Postpartum weight change among HIV-infected mothers by antiretroviral prophylaxis and infant feeding modality in a research setting.

Identifieur interne : 003876 ( PubMed/Curation ); précédent : 003875; suivant : 003877

Postpartum weight change among HIV-infected mothers by antiretroviral prophylaxis and infant feeding modality in a research setting.

Auteurs : Cecile Cames [États-Unis] ; Amandine Cournil ; Isabelle De Vincenzi ; Philippe Gaillard ; Nicolas Meda ; Stanley Luchters ; Ruth Nduati ; Kevindra Naidu ; Marie-Louise Newell ; Jennifer S. Read ; Kirsten Bork

Source :

RBID : pubmed:24413262

Descripteurs français

English descriptors

Abstract

To assess the relationship between infant feeding, triple-antiretroviral prophylaxis and weight from 2 weeks (baseline) to 6 months postpartum among HIV-infected mothers in a mother-to-child transmission (MTCT) of HIV-prevention trial in five sub-Saharan African sites.

DOI: 10.1097/01.aids.0000433243.24481.c3
PubMed: 24413262

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pubmed:24413262

Le document en format XML

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<nlm:affiliation>aInstitut de Recherche pour le Développement (IRD), Montpellier, France bWHO, Reproductive Health and Research, Geneva, Switzerland cCentre Muraz, Bobo-Dioulasso, Burkina Faso dInternational Centre for Reproductive Health (ICRH), Mombasa, Kenya eInternational Centre for Reproductive Health, Ghent University, Belgium fCentre for International Health, Burnet Institute, Melbourne, Australia gUniversity of Nairobi, Kenya hAfrica Centre for Health and Population Studies, University of KwaZulu-Natal, South Africa iEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland jNVPO/OASH/OS/DHHS, Washington, DC, USA. *The Kesho Bora Study Group members are listed in the acknowledgement section.</nlm:affiliation>
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<term>Adult</term>
<term>Africa South of the Sahara</term>
<term>Anti-Retroviral Agents (therapeutic use)</term>
<term>Breast Feeding</term>
<term>Disease Transmission, Infectious (prevention & control)</term>
<term>Female</term>
<term>HIV Infections (drug therapy)</term>
<term>HIV Infections (prevention & control)</term>
<term>Humans</term>
<term>Infant</term>
<term>Infant Formula (administration & dosage)</term>
<term>Infant, Newborn</term>
<term>Male</term>
<term>Postpartum Period</term>
<term>Pregnancy</term>
<term>Weight Gain</term>
<term>Young Adult</term>
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<term>Adulte</term>
<term>Afrique subsaharienne</term>
<term>Allaitement maternel</term>
<term>Antirétroviraux (usage thérapeutique)</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Humains</term>
<term>Infections à VIH ()</term>
<term>Infections à VIH (traitement médicamenteux)</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Nouveau-né</term>
<term>Prise de poids</term>
<term>Préparation pour nourrissons (administration et posologie)</term>
<term>Période du postpartum</term>
<term>Transmission de maladie infectieuse ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en">
<term>Anti-Retroviral Agents</term>
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<term>Africa South of the Sahara</term>
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<keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en">
<term>Infant Formula</term>
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<term>Préparation pour nourrissons</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en">
<term>HIV Infections</term>
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<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en">
<term>Disease Transmission, Infectious</term>
<term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr">
<term>Infections à VIH</term>
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<term>Antirétroviraux</term>
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<keywords scheme="MESH" xml:lang="en">
<term>Adult</term>
<term>Breast Feeding</term>
<term>Female</term>
<term>Humans</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Male</term>
<term>Postpartum Period</term>
<term>Pregnancy</term>
<term>Weight Gain</term>
<term>Young Adult</term>
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<term>Adulte</term>
<term>Afrique subsaharienne</term>
<term>Allaitement maternel</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Humains</term>
<term>Infections à VIH</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Nourrisson</term>
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<front>
<div type="abstract" xml:lang="en">To assess the relationship between infant feeding, triple-antiretroviral prophylaxis and weight from 2 weeks (baseline) to 6 months postpartum among HIV-infected mothers in a mother-to-child transmission (MTCT) of HIV-prevention trial in five sub-Saharan African sites.</div>
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<Month>01</Month>
<Day>13</Day>
</DateCreated>
<DateCompleted>
<Year>2014</Year>
<Month>08</Month>
<Day>28</Day>
</DateCompleted>
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<Year>2017</Year>
<Month>09</Month>
<Day>22</Day>
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<ISSN IssnType="Electronic">1473-5571</ISSN>
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<Volume>28</Volume>
<Issue>1</Issue>
<PubDate>
<Year>2014</Year>
<Month>Jan</Month>
<Day>02</Day>
</PubDate>
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<Title>AIDS (London, England)</Title>
<ISOAbbreviation>AIDS</ISOAbbreviation>
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<ArticleTitle>Postpartum weight change among HIV-infected mothers by antiretroviral prophylaxis and infant feeding modality in a research setting.</ArticleTitle>
<Pagination>
<MedlinePgn>85-94</MedlinePgn>
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<ELocationID EIdType="doi" ValidYN="Y">10.1097/01.aids.0000433243.24481.c3</ELocationID>
<Abstract>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To assess the relationship between infant feeding, triple-antiretroviral prophylaxis and weight from 2 weeks (baseline) to 6 months postpartum among HIV-infected mothers in a mother-to-child transmission (MTCT) of HIV-prevention trial in five sub-Saharan African sites.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">HIV-infected pregnant women with CD4 cell counts of 200-500 cells/μl were counselled to choose breastfeeding to 6 months or replacement feeding from delivery. They were randomized to receive perinatal zidovudine and single-dose nevirapine or triple-antiretroviral MTCT prophylaxis until breastfeeding cessation. Mixed-effect linear models were used to compare maternal weight trajectories over time by infant feeding mode. Antiretroviral prophylaxis and BMI at baseline were examined as potential effect modifiers.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Among 797 mothers, 620 (78%) initiated breastfeeding. Wasting (BMI <18.5) was rare at baseline (2%), whereas overweight/obesity (BMI ≥ 25) was common (40%). In the model including all women, breastfeeding was not associated with weight loss up to 6 months, irrespective of baseline BMI and antiretroviral prophylaxis. Triple-antiretroviral prophylaxis was associated with weight gain among replacement-feeding mothers with baseline BMI at least 25 (+0.54 kg/month; P < 0.0001). In the model including breastfeeding mothers only, triple-antiretroviral prophylaxis was associated with weight gain among mothers with baseline BMI at least 25 who ceased breastfeeding before 3 months postpartum (+0.33 kg/month; P = 0.03).</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The results suggest that breastfeeding up to 6 months postpartum is not detrimental for postpartum weight among well nourished HIV-infected mothers at intermediate-disease stage. In the absence of breastfeeding or after weaning, triple-antiretroviral prophylaxis is associated with weight gain among women with high BMI, even after cessation of prophylaxis.</AbstractText>
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<Language>eng</Language>
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<Grant>
<GrantID>097410</GrantID>
<Agency>Wellcome Trust</Agency>
<Country>United Kingdom</Country>
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<MedlineTA>AIDS</MedlineTA>
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