Direct evidences for sympathetic hyperactivity and baroreflex impairment in Tako Tsubo cardiopathy.
Identifieur interne : 003789 ( PubMed/Curation ); précédent : 003788; suivant : 003790Direct evidences for sympathetic hyperactivity and baroreflex impairment in Tako Tsubo cardiopathy.
Auteurs : Angelica Vaccaro [France] ; Fabien Despas [France] ; Clement Delmas [France] ; Olivier Lairez [France] ; Elisabeth Lambert [Australie] ; Gavin Lambert [Australie] ; Marc Labrunee [France] ; Thibaut Guiraud [France] ; Murray Esler [Australie] ; Michel Galinier [France] ; Jean Michel Senard [France] ; Atul Pathak [France]Source :
- PloS one [ 1932-6203 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- physiologie : Pression sanguine, Rythme cardiaque.
- physiopathologie : Syndrome de tako-tsubo, Système nerveux sympathique.
- innervation : Adulte d'âge moyen, Baroréflexe, Femelle, Humains, Muscles, Mâle, Sujet âgé de 80 ans ou plus, Études cas-témoins.
English descriptors
- KwdEn :
- MESH :
- innervation : Muscles.
- physiology : Blood Pressure, Heart Rate.
- physiopathology : Sympathetic Nervous System, Takotsubo Cardiomyopathy.
- Aged, 80 and over, Baroreflex, Case-Control Studies, Female, Humans, Male, Middle Aged.
Abstract
The exact pathophysiology of Tako-Tsubo cardiomyopathy (TTC) remains unknown but a role for sympathetic hyperactivity has been suggested. Up to now, no direct evidence of sympathetic nerve hyperactivity has been established nor involvement of sympathetic baroreflex identified. The aim of our study was to determine, by direct sympathetic nerve activity (SNS) recording if sympathetic nervous system activity is increased and spontaneous baroreflex control of sympathetic activity reduced in patients with TTC.
DOI: 10.1371/journal.pone.0093278
PubMed: 24667435
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Toulouse University III Paul Sabatier, Toulouse, France; Clinical Pharmacology Department, University Hospital of Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Clinical Pharmacology Department, University Hospital of Toulouse, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Delmas, Clement" sort="Delmas, Clement" uniqKey="Delmas C" first="Clement" last="Delmas">Clement Delmas</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Lairez, Olivier" sort="Lairez, Olivier" uniqKey="Lairez O" first="Olivier" last="Lairez">Olivier Lairez</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Lambert, Elisabeth" sort="Lambert, Elisabeth" uniqKey="Lambert E" first="Elisabeth" last="Lambert">Elisabeth Lambert</name><affiliation wicri:level="1"><nlm:affiliation>Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Lambert, Gavin" sort="Lambert, Gavin" uniqKey="Lambert G" first="Gavin" last="Lambert">Gavin Lambert</name><affiliation wicri:level="1"><nlm:affiliation>Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Labrunee, Marc" sort="Labrunee, Marc" uniqKey="Labrunee M" first="Marc" last="Labrunee">Marc Labrunee</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Guiraud, Thibaut" sort="Guiraud, Thibaut" uniqKey="Guiraud T" first="Thibaut" last="Guiraud">Thibaut Guiraud</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Esler, Murray" sort="Esler, Murray" uniqKey="Esler M" first="Murray" last="Esler">Murray Esler</name><affiliation wicri:level="1"><nlm:affiliation>Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Galinier, Michel" sort="Galinier, Michel" uniqKey="Galinier M" first="Michel" last="Galinier">Michel Galinier</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Senard, Jean Michel" sort="Senard, Jean Michel" uniqKey="Senard J" first="Jean Michel" last="Senard">Jean Michel Senard</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Clinical Pharmacology Department, University Hospital of Toulouse, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Clinical Pharmacology Department, University Hospital of Toulouse, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Pathak, Atul" sort="Pathak, Atul" uniqKey="Pathak A" first="Atul" last="Pathak">Atul Pathak</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Clinical Pharmacology Department, University Hospital of Toulouse, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse, France; Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia; C.I.C., Clinical Investigation Center, University Hospital of Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Clinical Pharmacology Department, University Hospital of Toulouse, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse, France; Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia; C.I.C., Clinical Investigation Center, University Hospital of Toulouse, Toulouse</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24667435</idno><idno type="pmid">24667435</idno><idno type="doi">10.1371/journal.pone.0093278</idno><idno type="wicri:Area/PubMed/Corpus">003904</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003904</idno><idno type="wicri:Area/PubMed/Curation">003789</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003789</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Direct evidences for sympathetic hyperactivity and baroreflex impairment in Tako Tsubo cardiopathy.</title><author><name sortKey="Vaccaro, Angelica" sort="Vaccaro, Angelica" uniqKey="Vaccaro A" first="Angelica" last="Vaccaro">Angelica Vaccaro</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; C.I.C., Clinical Investigation Center, University Hospital of Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; C.I.C., Clinical Investigation Center, University Hospital of Toulouse, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Despas, Fabien" sort="Despas, Fabien" uniqKey="Despas F" first="Fabien" last="Despas">Fabien Despas</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Clinical Pharmacology Department, University Hospital of Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Clinical Pharmacology Department, University Hospital of Toulouse, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Delmas, Clement" sort="Delmas, Clement" uniqKey="Delmas C" first="Clement" last="Delmas">Clement Delmas</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Lairez, Olivier" sort="Lairez, Olivier" uniqKey="Lairez O" first="Olivier" last="Lairez">Olivier Lairez</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Lambert, Elisabeth" sort="Lambert, Elisabeth" uniqKey="Lambert E" first="Elisabeth" last="Lambert">Elisabeth Lambert</name><affiliation wicri:level="1"><nlm:affiliation>Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Lambert, Gavin" sort="Lambert, Gavin" uniqKey="Lambert G" first="Gavin" last="Lambert">Gavin Lambert</name><affiliation wicri:level="1"><nlm:affiliation>Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Labrunee, Marc" sort="Labrunee, Marc" uniqKey="Labrunee M" first="Marc" last="Labrunee">Marc Labrunee</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Guiraud, Thibaut" sort="Guiraud, Thibaut" uniqKey="Guiraud T" first="Thibaut" last="Guiraud">Thibaut Guiraud</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Esler, Murray" sort="Esler, Murray" uniqKey="Esler M" first="Murray" last="Esler">Murray Esler</name><affiliation wicri:level="1"><nlm:affiliation>Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Galinier, Michel" sort="Galinier, Michel" uniqKey="Galinier M" first="Michel" last="Galinier">Michel Galinier</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Senard, Jean Michel" sort="Senard, Jean Michel" uniqKey="Senard J" first="Jean Michel" last="Senard">Jean Michel Senard</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Clinical Pharmacology Department, University Hospital of Toulouse, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Clinical Pharmacology Department, University Hospital of Toulouse, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Pathak, Atul" sort="Pathak, Atul" uniqKey="Pathak A" first="Atul" last="Pathak">Atul Pathak</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Clinical Pharmacology Department, University Hospital of Toulouse, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse, France; Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia; C.I.C., Clinical Investigation Center, University Hospital of Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Clinical Pharmacology Department, University Hospital of Toulouse, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse, France; Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia; C.I.C., Clinical Investigation Center, University Hospital of Toulouse, Toulouse</wicri:regionArea></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged, 80 and over</term><term>Baroreflex</term><term>Blood Pressure (physiology)</term><term>Case-Control Studies</term><term>Female</term><term>Heart Rate (physiology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Muscles (innervation)</term><term>Sympathetic Nervous System (physiopathology)</term><term>Takotsubo Cardiomyopathy (physiopathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Baroréflexe</term><term>Femelle</term><term>Humains</term><term>Muscles (innervation)</term><term>Mâle</term><term>Pression sanguine (physiologie)</term><term>Rythme cardiaque (physiologie)</term><term>Sujet âgé de 80 ans ou plus</term><term>Syndrome de tako-tsubo (physiopathologie)</term><term>Système nerveux sympathique (physiopathologie)</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Muscles</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Pression sanguine</term><term>Rythme cardiaque</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blood Pressure</term><term>Heart Rate</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Syndrome de tako-tsubo</term><term>Système nerveux sympathique</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Sympathetic Nervous System</term><term>Takotsubo Cardiomyopathy</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged, 80 and over</term><term>Baroreflex</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Baroréflexe</term><term>Femelle</term><term>Humains</term><term>Muscles</term><term>Mâle</term><term>Sujet âgé de 80 ans ou plus</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The exact pathophysiology of Tako-Tsubo cardiomyopathy (TTC) remains unknown but a role for sympathetic hyperactivity has been suggested. Up to now, no direct evidence of sympathetic nerve hyperactivity has been established nor involvement of sympathetic baroreflex identified. The aim of our study was to determine, by direct sympathetic nerve activity (SNS) recording if sympathetic nervous system activity is increased and spontaneous baroreflex control of sympathetic activity reduced in patients with TTC.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24667435</PMID><DateCreated><Year>2014</Year><Month>03</Month><Day>26</Day></DateCreated><DateCompleted><Year>2014</Year><Month>11</Month><Day>12</Day></DateCompleted><DateRevised><Year>2015</Year><Month>05</Month><Day>14</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>3</Issue><PubDate><Year>2014</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Direct evidences for sympathetic hyperactivity and baroreflex impairment in Tako Tsubo cardiopathy.</ArticleTitle><Pagination><MedlinePgn>e93278</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0093278</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The exact pathophysiology of Tako-Tsubo cardiomyopathy (TTC) remains unknown but a role for sympathetic hyperactivity has been suggested. Up to now, no direct evidence of sympathetic nerve hyperactivity has been established nor involvement of sympathetic baroreflex identified. The aim of our study was to determine, by direct sympathetic nerve activity (SNS) recording if sympathetic nervous system activity is increased and spontaneous baroreflex control of sympathetic activity reduced in patients with TTC.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We included 13 patients who presented with TTC and compared their SNS activity and spontaneous baroreflex control of sympathetic activity with that of 13 control patients with acutely decompensated chronic heart failure. SNS activity was evaluated by microneurography, a technique assessing muscle sympathetic nerve activity (MSNA). Spontaneous baroreflex control of sympathetic activity was evaluated as the absolute value of the slope of the regression line representing the relationship between spontaneous diastolic blood pressure values and concomitant SNS activity. Control patients were matched for age, sex, left ventricular ejection fraction and creatinine clearance.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The mean age of the patients with TTC was 80 years, all patients were women. There were no significant differences between the two groups of patients for blood pressure, heart rate or oxygen saturation level. TTC patients presented a significant increase in sympathetic nerve activity (MSNA median 63.3 bursts/min [interquartile range 61.3 to 66.0] vs median 55.7 bursts/min [interquartile range 51.0 to 61.7]; p = 0.0089) and a decrease in spontaneous baroreflex control of sympathetic activity compared to matched control patients (spontaneous baroreflex control of sympathetic activity median 0.7%burst/mmHg [interquartile range 0.4 to 1.9] vs median 2.4%burst/mmHg [interquartile range 1.8 to 2.9]; p = 0.005).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">We report for the first time, through direct measurement of sympathetic nerve activity, that patients with TTC exhibit elevated SNS activity associated with a decrease in spontaneous baroreflex control of sympathetic activity. These data may explain the pathophysiology and clinical presentation of patient with TTC.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vaccaro</LastName><ForeName>Angelica</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; C.I.C., Clinical Investigation Center, University Hospital of Toulouse, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Despas</LastName><ForeName>Fabien</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Clinical Pharmacology Department, University Hospital of Toulouse, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Delmas</LastName><ForeName>Clement</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lairez</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lambert</LastName><ForeName>Elisabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lambert</LastName><ForeName>Gavin</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Labrunee</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guiraud</LastName><ForeName>Thibaut</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Esler</LastName><ForeName>Murray</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Galinier</LastName><ForeName>Michel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Senard</LastName><ForeName>Jean Michel</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Clinical Pharmacology Department, University Hospital of Toulouse, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pathak</LastName><ForeName>Atul</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>National Institute of Health and Medical Research (INSERM) UMR-1048, Institute of Metabolic and Cardiovascular diseases, Toulouse, France; Toulouse University III Paul Sabatier, Toulouse, France; Clinical Pharmacology Department, University Hospital of Toulouse, Toulouse, France; Department of Cardiology, University Hospital of Toulouse, Toulouse, France; Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia; C.I.C., Clinical Investigation Center, University Hospital of Toulouse, Toulouse, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>03</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections 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MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009132" MajorTopicYN="N">Muscles</DescriptorName><QualifierName UI="Q000294" MajorTopicYN="N">innervation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013564" MajorTopicYN="N">Sympathetic Nervous System</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D054549" MajorTopicYN="N">Takotsubo Cardiomyopathy</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading></MeshHeadingList><OtherID 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