Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids.
Identifieur interne : 003788 ( PubMed/Curation ); précédent : 003787; suivant : 003789Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids.
Auteurs : Lynnette Fernandez-Cuesta [Allemagne] ; Martin Peifer [Allemagne] ; Xin Lu [Allemagne] ; Ruping Sun [Allemagne] ; Luka Ozreti [Allemagne] ; Danila Seidal [Allemagne] ; Thomas Zander [Allemagne] ; Frauke Leenders [Allemagne] ; Julie George [Allemagne] ; Christian Müller [Allemagne] ; Ilona Dahmen [Allemagne] ; Berit Pinther [Allemagne] ; Graziella Bosco [Allemagne] ; Kathryn Konrad [Allemagne] ; Janine Altmüller [Allemagne] ; Peter Nürnberg [Allemagne] ; Viktor Achter [Allemagne] ; Ulrich Lang [Allemagne] ; Peter M. Schneider [Allemagne] ; Magdalena Bogus [Allemagne] ; Alex Soltermann [Suisse] ; Odd Terje Brustugun [Norvège] ; Slaug Helland [Norvège] ; Steinar Solberg [Norvège] ; Marius Lund-Iversen [Norvège] ; Sascha Ansén [Allemagne] ; Erich Stoelben [Allemagne] ; Gavin M. Wright [Australie] ; Prudence Russell [Australie] ; Zoe Wainer [Australie] ; Benjamin Solomon [Australie] ; John K. Field [Royaume-Uni] ; Russell Hyde [Royaume-Uni] ; Michael Pa Davies [Royaume-Uni] ; Lukas C. Heukamp [Allemagne] ; Iver Petersen [Allemagne] ; Sven Perner [Allemagne] ; Christine Lovly [États-Unis] ; Federico Cappuzzo [Italie] ; William D. Travis [États-Unis] ; Jürgen Wolf [Allemagne] ; Martin Vingron [Allemagne] ; Elisabeth Brambilla [France] ; Stefan A. Haas [Allemagne] ; Reinhard Buettner [Allemagne] ; Roman K. Thomas [Allemagne]Source :
- Nature communications [ 2041-1723 ] ; 2014.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Analyse de profil d'expression de gènes, Analyse de séquence d'ADN, Assemblage et désassemblage de la chromatine (génétique), Cartographie chromosomique, Données de séquences moléculaires, Dosage génique, Exome (génétique), Femelle, Génome humain (génétique), Humains, Jeune adulte, Mutation, Mâle, Polymorphisme de nucléotide simple, Régulation de l'expression des gènes tumoraux, Sujet âgé, Séquence nucléotidique, Tumeur carcinoïde (anatomopathologie), Tumeur carcinoïde (génétique), Tumeurs du poumon (anatomopathologie), Tumeurs du poumon (génétique), Variations de nombre de copies de segment d'ADN.
- MESH :
- anatomopathologie : Tumeur carcinoïde, Tumeurs du poumon.
- génétique : Assemblage et désassemblage de la chromatine, Exome, Génome humain, Tumeur carcinoïde, Tumeurs du poumon.
- Adolescent, Adulte, Adulte d'âge moyen, Analyse de profil d'expression de gènes, Analyse de séquence d'ADN, Cartographie chromosomique, Données de séquences moléculaires, Dosage génique, Femelle, Humains, Jeune adulte, Mutation, Mâle, Polymorphisme de nucléotide simple, Régulation de l'expression des gènes tumoraux, Sujet âgé, Séquence nucléotidique, Variations de nombre de copies de segment d'ADN.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Base Sequence, Carcinoid Tumor (genetics), Carcinoid Tumor (pathology), Chromatin Assembly and Disassembly (genetics), Chromosome Mapping, DNA Copy Number Variations, Exome (genetics), Female, Gene Dosage, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Genome, Human (genetics), Humans, Lung Neoplasms (genetics), Lung Neoplasms (pathology), Male, Middle Aged, Molecular Sequence Data, Mutation, Polymorphism, Single Nucleotide, Sequence Analysis, DNA, Young Adult.
- MESH :
- genetics : Carcinoid Tumor, Chromatin Assembly and Disassembly, Exome, Genome, Human, Lung Neoplasms.
- pathology : Carcinoid Tumor, Lung Neoplasms.
- Adolescent, Adult, Aged, Base Sequence, Chromosome Mapping, DNA Copy Number Variations, Female, Gene Dosage, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Male, Middle Aged, Molecular Sequence Data, Mutation, Polymorphism, Single Nucleotide, Sequence Analysis, DNA, Young Adult.
Abstract
Pulmonary carcinoids are rare neuroendocrine tumours of the lung. The molecular alterations underlying the pathogenesis of these tumours have not been systematically studied so far. Here we perform gene copy number analysis (n=54), genome/exome (n=44) and transcriptome (n=69) sequencing of pulmonary carcinoids and observe frequent mutations in chromatin-remodelling genes. Covalent histone modifiers and subunits of the SWI/SNF complex are mutated in 40 and 22.2% of the cases, respectively, with MEN1, PSIP1 and ARID1A being recurrently affected. In contrast to small-cell lung cancer and large-cell neuroendocrine lung tumours, TP53 and RB1 mutations are rare events, suggesting that pulmonary carcinoids are not early progenitor lesions of the highly aggressive lung neuroendocrine tumours but arise through independent cellular mechanisms. These data also suggest that inactivation of chromatin-remodelling genes is sufficient to drive transformation in pulmonary carcinoids.
DOI: 10.1038/ncomms4518
PubMed: 24670920
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003903
Links to Exploration step
pubmed:24670920Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids.</title>
<author><name sortKey="Fernandez Cuesta, Lynnette" sort="Fernandez Cuesta, Lynnette" uniqKey="Fernandez Cuesta L" first="Lynnette" last="Fernandez-Cuesta">Lynnette Fernandez-Cuesta</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peifer, Martin" sort="Peifer, Martin" uniqKey="Peifer M" first="Martin" last="Peifer">Martin Peifer</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lu, Xin" sort="Lu, Xin" uniqKey="Lu X" first="Xin" last="Lu">Xin Lu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sun, Ruping" sort="Sun, Ruping" uniqKey="Sun R" first="Ruping" last="Sun">Ruping Sun</name>
<affiliation wicri:level="1"><nlm:affiliation>Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ozreti, Luka" sort="Ozreti, Luka" uniqKey="Ozreti L" first="Luka" last="Ozreti">Luka Ozreti</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Seidal, Danila" sort="Seidal, Danila" uniqKey="Seidal D" first="Danila" last="Seidal">Danila Seidal</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zander, Thomas" sort="Zander, Thomas" uniqKey="Zander T" first="Thomas" last="Zander">Thomas Zander</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Leenders, Frauke" sort="Leenders, Frauke" uniqKey="Leenders F" first="Frauke" last="Leenders">Frauke Leenders</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="George, Julie" sort="George, Julie" uniqKey="George J" first="Julie" last="George">Julie George</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Muller, Christian" sort="Muller, Christian" uniqKey="Muller C" first="Christian" last="Müller">Christian Müller</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dahmen, Ilona" sort="Dahmen, Ilona" uniqKey="Dahmen I" first="Ilona" last="Dahmen">Ilona Dahmen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pinther, Berit" sort="Pinther, Berit" uniqKey="Pinther B" first="Berit" last="Pinther">Berit Pinther</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bosco, Graziella" sort="Bosco, Graziella" uniqKey="Bosco G" first="Graziella" last="Bosco">Graziella Bosco</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Konrad, Kathryn" sort="Konrad, Kathryn" uniqKey="Konrad K" first="Kathryn" last="Konrad">Kathryn Konrad</name>
<affiliation wicri:level="1"><nlm:affiliation>Cologne Center for Genomics (CCG), University of Cologne, Cologne, 50931 Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne Center for Genomics (CCG), University of Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Altmuller, Janine" sort="Altmuller, Janine" uniqKey="Altmuller J" first="Janine" last="Altmüller">Janine Altmüller</name>
<affiliation wicri:level="1"><nlm:affiliation>Cologne Center for Genomics (CCG), University of Cologne, Cologne, 50931 Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne Center for Genomics (CCG), University of Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nurnberg, Peter" sort="Nurnberg, Peter" uniqKey="Nurnberg P" first="Peter" last="Nürnberg">Peter Nürnberg</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Achter, Viktor" sort="Achter, Viktor" uniqKey="Achter V" first="Viktor" last="Achter">Viktor Achter</name>
<affiliation wicri:level="1"><nlm:affiliation>Computing Center, University of Cologne, 50931 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Computing Center, University of Cologne, 50931 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lang, Ulrich" sort="Lang, Ulrich" uniqKey="Lang U" first="Ulrich" last="Lang">Ulrich Lang</name>
<affiliation wicri:level="1"><nlm:affiliation>Computing Center, University of Cologne, 50931 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Computing Center, University of Cologne, 50931 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schneider, Peter M" sort="Schneider, Peter M" uniqKey="Schneider P" first="Peter M" last="Schneider">Peter M. Schneider</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Legal Medicine, University of Cologne, 50823 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Legal Medicine, University of Cologne, 50823 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bogus, Magdalena" sort="Bogus, Magdalena" uniqKey="Bogus M" first="Magdalena" last="Bogus">Magdalena Bogus</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Legal Medicine, University of Cologne, 50823 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Legal Medicine, University of Cologne, 50823 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Soltermann, Alex" sort="Soltermann, Alex" uniqKey="Soltermann A" first="Alex" last="Soltermann">Alex Soltermann</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute for Surgical Pathology, University Hospital Zurich, 8091 Zurich, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute for Surgical Pathology, University Hospital Zurich, 8091 Zurich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brustugun, Odd Terje" sort="Brustugun, Odd Terje" uniqKey="Brustugun O" first="Odd Terje" last="Brustugun">Odd Terje Brustugun</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of clinical medicine, Faculty of Medicine, University of Oslo, N-0424 Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Institute of clinical medicine, Faculty of Medicine, University of Oslo, N-0424 Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Helland, Slaug" sort="Helland, Slaug" uniqKey="Helland " first=" Slaug" last="Helland"> Slaug Helland</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of clinical medicine, Faculty of Medicine, University of Oslo, N-0424 Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Institute of clinical medicine, Faculty of Medicine, University of Oslo, N-0424 Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Solberg, Steinar" sort="Solberg, Steinar" uniqKey="Solberg S" first="Steinar" last="Solberg">Steinar Solberg</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Thoracic Surgery, Rikshospitalet, Oslo University Hospital, N-0027 Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Thoracic Surgery, Rikshospitalet, Oslo University Hospital, N-0027 Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lund Iversen, Marius" sort="Lund Iversen, Marius" uniqKey="Lund Iversen M" first="Marius" last="Lund-Iversen">Marius Lund-Iversen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of pathology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of pathology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ansen, Sascha" sort="Ansen, Sascha" uniqKey="Ansen S" first="Sascha" last="Ansén">Sascha Ansén</name>
<affiliation wicri:level="1"><nlm:affiliation>Department I of Internal Medicine, Center of Integrated Oncology Kö ln-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department I of Internal Medicine, Center of Integrated Oncology Kö ln-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stoelben, Erich" sort="Stoelben, Erich" uniqKey="Stoelben E" first="Erich" last="Stoelben">Erich Stoelben</name>
<affiliation wicri:level="1"><nlm:affiliation>Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wright, Gavin M" sort="Wright, Gavin M" uniqKey="Wright G" first="Gavin M" last="Wright">Gavin M. Wright</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Melbourne Department of Surgery, St Vincent's Hospital, Melbourne, 3065 Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University of Melbourne Department of Surgery, St Vincent's Hospital, Melbourne, 3065 Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Russell, Prudence" sort="Russell, Prudence" uniqKey="Russell P" first="Prudence" last="Russell">Prudence Russell</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, St. Vincent's Hospital, Melbourne, 3065 Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Pathology, St. Vincent's Hospital, Melbourne, 3065 Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wainer, Zoe" sort="Wainer, Zoe" uniqKey="Wainer Z" first="Zoe" last="Wainer">Zoe Wainer</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Melbourne Department of Surgery, St Vincent's Hospital, Melbourne, 3065 Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University of Melbourne Department of Surgery, St Vincent's Hospital, Melbourne, 3065 Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Solomon, Benjamin" sort="Solomon, Benjamin" uniqKey="Solomon B" first="Benjamin" last="Solomon">Benjamin Solomon</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, 3002 Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, 3002 Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Field, John K" sort="Field, John K" uniqKey="Field J" first="John K" last="Field">John K. Field</name>
<affiliation wicri:level="1"><nlm:affiliation>Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool Cancer Research Centre, Liverpool, L3 9TA, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool Cancer Research Centre, Liverpool, L3 9TA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hyde, Russell" sort="Hyde, Russell" uniqKey="Hyde R" first="Russell" last="Hyde">Russell Hyde</name>
<affiliation wicri:level="1"><nlm:affiliation>Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool Cancer Research Centre, Liverpool, L3 9TA, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool Cancer Research Centre, Liverpool, L3 9TA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Davies, Michael Pa" sort="Davies, Michael Pa" uniqKey="Davies M" first="Michael Pa" last="Davies">Michael Pa Davies</name>
<affiliation wicri:level="1"><nlm:affiliation>Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool Cancer Research Centre, Liverpool, L3 9TA, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool Cancer Research Centre, Liverpool, L3 9TA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heukamp, Lukas C" sort="Heukamp, Lukas C" uniqKey="Heukamp L" first="Lukas C" last="Heukamp">Lukas C. Heukamp</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Petersen, Iver" sort="Petersen, Iver" uniqKey="Petersen I" first="Iver" last="Petersen">Iver Petersen</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Perner, Sven" sort="Perner, Sven" uniqKey="Perner S" first="Sven" last="Perner">Sven Perner</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Prostate Cancer Research, Institute of Pathology, University Hospital of Bonn, 53127 Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Prostate Cancer Research, Institute of Pathology, University Hospital of Bonn, 53127 Bonn</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lovly, Christine" sort="Lovly, Christine" uniqKey="Lovly C" first="Christine" last="Lovly">Christine Lovly</name>
<affiliation wicri:level="1"><nlm:affiliation>Vanderbilt-Ingram Cancer Center, Nashville, TN37232, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Vanderbilt-Ingram Cancer Center, Nashville, TN37232</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cappuzzo, Federico" sort="Cappuzzo, Federico" uniqKey="Cappuzzo F" first="Federico" last="Cappuzzo">Federico Cappuzzo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Istituto Toscano Tumouri, 57100 Livorno, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical Oncology, Istituto Toscano Tumouri, 57100 Livorno</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Travis, William D" sort="Travis, William D" uniqKey="Travis W" first="William D" last="Travis">William D. Travis</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Memorial Sloan Kettering Cancer Center, New York 10065, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Memorial Sloan Kettering Cancer Center, New York 10065</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wolf, Jurgen" sort="Wolf, Jurgen" uniqKey="Wolf J" first="Jürgen" last="Wolf">Jürgen Wolf</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Cologne - Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Cologne - Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vingron, Martin" sort="Vingron, Martin" uniqKey="Vingron M" first="Martin" last="Vingron">Martin Vingron</name>
<affiliation wicri:level="1"><nlm:affiliation>Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brambilla, Elisabeth" sort="Brambilla, Elisabeth" uniqKey="Brambilla E" first="Elisabeth" last="Brambilla">Elisabeth Brambilla</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, CHU Grenoble INSERM U823, Institute Albert Bonniot 38043 CS10217 Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pathology, CHU Grenoble INSERM U823, Institute Albert Bonniot 38043 CS10217 Grenoble</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haas, Stefan A" sort="Haas, Stefan A" uniqKey="Haas S" first="Stefan A" last="Haas">Stefan A. Haas</name>
<affiliation wicri:level="1"><nlm:affiliation>Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Buettner, Reinhard" sort="Buettner, Reinhard" uniqKey="Buettner R" first="Reinhard" last="Buettner">Reinhard Buettner</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thomas, Roman K" sort="Thomas, Roman K" uniqKey="Thomas R" first="Roman K" last="Thomas">Roman K. Thomas</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
<idno type="RBID">pubmed:24670920</idno>
<idno type="pmid">24670920</idno>
<idno type="doi">10.1038/ncomms4518</idno>
<idno type="wicri:Area/PubMed/Corpus">003903</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003903</idno>
<idno type="wicri:Area/PubMed/Curation">003788</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003788</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids.</title>
<author><name sortKey="Fernandez Cuesta, Lynnette" sort="Fernandez Cuesta, Lynnette" uniqKey="Fernandez Cuesta L" first="Lynnette" last="Fernandez-Cuesta">Lynnette Fernandez-Cuesta</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peifer, Martin" sort="Peifer, Martin" uniqKey="Peifer M" first="Martin" last="Peifer">Martin Peifer</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lu, Xin" sort="Lu, Xin" uniqKey="Lu X" first="Xin" last="Lu">Xin Lu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sun, Ruping" sort="Sun, Ruping" uniqKey="Sun R" first="Ruping" last="Sun">Ruping Sun</name>
<affiliation wicri:level="1"><nlm:affiliation>Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ozreti, Luka" sort="Ozreti, Luka" uniqKey="Ozreti L" first="Luka" last="Ozreti">Luka Ozreti</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Seidal, Danila" sort="Seidal, Danila" uniqKey="Seidal D" first="Danila" last="Seidal">Danila Seidal</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zander, Thomas" sort="Zander, Thomas" uniqKey="Zander T" first="Thomas" last="Zander">Thomas Zander</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Leenders, Frauke" sort="Leenders, Frauke" uniqKey="Leenders F" first="Frauke" last="Leenders">Frauke Leenders</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="George, Julie" sort="George, Julie" uniqKey="George J" first="Julie" last="George">Julie George</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Muller, Christian" sort="Muller, Christian" uniqKey="Muller C" first="Christian" last="Müller">Christian Müller</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dahmen, Ilona" sort="Dahmen, Ilona" uniqKey="Dahmen I" first="Ilona" last="Dahmen">Ilona Dahmen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pinther, Berit" sort="Pinther, Berit" uniqKey="Pinther B" first="Berit" last="Pinther">Berit Pinther</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bosco, Graziella" sort="Bosco, Graziella" uniqKey="Bosco G" first="Graziella" last="Bosco">Graziella Bosco</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Konrad, Kathryn" sort="Konrad, Kathryn" uniqKey="Konrad K" first="Kathryn" last="Konrad">Kathryn Konrad</name>
<affiliation wicri:level="1"><nlm:affiliation>Cologne Center for Genomics (CCG), University of Cologne, Cologne, 50931 Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne Center for Genomics (CCG), University of Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Altmuller, Janine" sort="Altmuller, Janine" uniqKey="Altmuller J" first="Janine" last="Altmüller">Janine Altmüller</name>
<affiliation wicri:level="1"><nlm:affiliation>Cologne Center for Genomics (CCG), University of Cologne, Cologne, 50931 Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne Center for Genomics (CCG), University of Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nurnberg, Peter" sort="Nurnberg, Peter" uniqKey="Nurnberg P" first="Peter" last="Nürnberg">Peter Nürnberg</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Achter, Viktor" sort="Achter, Viktor" uniqKey="Achter V" first="Viktor" last="Achter">Viktor Achter</name>
<affiliation wicri:level="1"><nlm:affiliation>Computing Center, University of Cologne, 50931 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Computing Center, University of Cologne, 50931 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lang, Ulrich" sort="Lang, Ulrich" uniqKey="Lang U" first="Ulrich" last="Lang">Ulrich Lang</name>
<affiliation wicri:level="1"><nlm:affiliation>Computing Center, University of Cologne, 50931 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Computing Center, University of Cologne, 50931 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schneider, Peter M" sort="Schneider, Peter M" uniqKey="Schneider P" first="Peter M" last="Schneider">Peter M. Schneider</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Legal Medicine, University of Cologne, 50823 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Legal Medicine, University of Cologne, 50823 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bogus, Magdalena" sort="Bogus, Magdalena" uniqKey="Bogus M" first="Magdalena" last="Bogus">Magdalena Bogus</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Legal Medicine, University of Cologne, 50823 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Legal Medicine, University of Cologne, 50823 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Soltermann, Alex" sort="Soltermann, Alex" uniqKey="Soltermann A" first="Alex" last="Soltermann">Alex Soltermann</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute for Surgical Pathology, University Hospital Zurich, 8091 Zurich, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute for Surgical Pathology, University Hospital Zurich, 8091 Zurich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brustugun, Odd Terje" sort="Brustugun, Odd Terje" uniqKey="Brustugun O" first="Odd Terje" last="Brustugun">Odd Terje Brustugun</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of clinical medicine, Faculty of Medicine, University of Oslo, N-0424 Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Institute of clinical medicine, Faculty of Medicine, University of Oslo, N-0424 Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Helland, Slaug" sort="Helland, Slaug" uniqKey="Helland " first=" Slaug" last="Helland"> Slaug Helland</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of clinical medicine, Faculty of Medicine, University of Oslo, N-0424 Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Institute of clinical medicine, Faculty of Medicine, University of Oslo, N-0424 Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Solberg, Steinar" sort="Solberg, Steinar" uniqKey="Solberg S" first="Steinar" last="Solberg">Steinar Solberg</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Thoracic Surgery, Rikshospitalet, Oslo University Hospital, N-0027 Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Thoracic Surgery, Rikshospitalet, Oslo University Hospital, N-0027 Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lund Iversen, Marius" sort="Lund Iversen, Marius" uniqKey="Lund Iversen M" first="Marius" last="Lund-Iversen">Marius Lund-Iversen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of pathology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of pathology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ansen, Sascha" sort="Ansen, Sascha" uniqKey="Ansen S" first="Sascha" last="Ansén">Sascha Ansén</name>
<affiliation wicri:level="1"><nlm:affiliation>Department I of Internal Medicine, Center of Integrated Oncology Kö ln-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department I of Internal Medicine, Center of Integrated Oncology Kö ln-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stoelben, Erich" sort="Stoelben, Erich" uniqKey="Stoelben E" first="Erich" last="Stoelben">Erich Stoelben</name>
<affiliation wicri:level="1"><nlm:affiliation>Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wright, Gavin M" sort="Wright, Gavin M" uniqKey="Wright G" first="Gavin M" last="Wright">Gavin M. Wright</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Melbourne Department of Surgery, St Vincent's Hospital, Melbourne, 3065 Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University of Melbourne Department of Surgery, St Vincent's Hospital, Melbourne, 3065 Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Russell, Prudence" sort="Russell, Prudence" uniqKey="Russell P" first="Prudence" last="Russell">Prudence Russell</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, St. Vincent's Hospital, Melbourne, 3065 Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Pathology, St. Vincent's Hospital, Melbourne, 3065 Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wainer, Zoe" sort="Wainer, Zoe" uniqKey="Wainer Z" first="Zoe" last="Wainer">Zoe Wainer</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Melbourne Department of Surgery, St Vincent's Hospital, Melbourne, 3065 Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University of Melbourne Department of Surgery, St Vincent's Hospital, Melbourne, 3065 Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Solomon, Benjamin" sort="Solomon, Benjamin" uniqKey="Solomon B" first="Benjamin" last="Solomon">Benjamin Solomon</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, 3002 Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, 3002 Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Field, John K" sort="Field, John K" uniqKey="Field J" first="John K" last="Field">John K. Field</name>
<affiliation wicri:level="1"><nlm:affiliation>Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool Cancer Research Centre, Liverpool, L3 9TA, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool Cancer Research Centre, Liverpool, L3 9TA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hyde, Russell" sort="Hyde, Russell" uniqKey="Hyde R" first="Russell" last="Hyde">Russell Hyde</name>
<affiliation wicri:level="1"><nlm:affiliation>Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool Cancer Research Centre, Liverpool, L3 9TA, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool Cancer Research Centre, Liverpool, L3 9TA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Davies, Michael Pa" sort="Davies, Michael Pa" uniqKey="Davies M" first="Michael Pa" last="Davies">Michael Pa Davies</name>
<affiliation wicri:level="1"><nlm:affiliation>Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool Cancer Research Centre, Liverpool, L3 9TA, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool Cancer Research Centre, Liverpool, L3 9TA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heukamp, Lukas C" sort="Heukamp, Lukas C" uniqKey="Heukamp L" first="Lukas C" last="Heukamp">Lukas C. Heukamp</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Petersen, Iver" sort="Petersen, Iver" uniqKey="Petersen I" first="Iver" last="Petersen">Iver Petersen</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Perner, Sven" sort="Perner, Sven" uniqKey="Perner S" first="Sven" last="Perner">Sven Perner</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Prostate Cancer Research, Institute of Pathology, University Hospital of Bonn, 53127 Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Prostate Cancer Research, Institute of Pathology, University Hospital of Bonn, 53127 Bonn</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lovly, Christine" sort="Lovly, Christine" uniqKey="Lovly C" first="Christine" last="Lovly">Christine Lovly</name>
<affiliation wicri:level="1"><nlm:affiliation>Vanderbilt-Ingram Cancer Center, Nashville, TN37232, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Vanderbilt-Ingram Cancer Center, Nashville, TN37232</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cappuzzo, Federico" sort="Cappuzzo, Federico" uniqKey="Cappuzzo F" first="Federico" last="Cappuzzo">Federico Cappuzzo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Istituto Toscano Tumouri, 57100 Livorno, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical Oncology, Istituto Toscano Tumouri, 57100 Livorno</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Travis, William D" sort="Travis, William D" uniqKey="Travis W" first="William D" last="Travis">William D. Travis</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Memorial Sloan Kettering Cancer Center, New York 10065, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Memorial Sloan Kettering Cancer Center, New York 10065</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wolf, Jurgen" sort="Wolf, Jurgen" uniqKey="Wolf J" first="Jürgen" last="Wolf">Jürgen Wolf</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Cologne - Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Cologne - Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vingron, Martin" sort="Vingron, Martin" uniqKey="Vingron M" first="Martin" last="Vingron">Martin Vingron</name>
<affiliation wicri:level="1"><nlm:affiliation>Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brambilla, Elisabeth" sort="Brambilla, Elisabeth" uniqKey="Brambilla E" first="Elisabeth" last="Brambilla">Elisabeth Brambilla</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, CHU Grenoble INSERM U823, Institute Albert Bonniot 38043 CS10217 Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pathology, CHU Grenoble INSERM U823, Institute Albert Bonniot 38043 CS10217 Grenoble</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haas, Stefan A" sort="Haas, Stefan A" uniqKey="Haas S" first="Stefan A" last="Haas">Stefan A. Haas</name>
<affiliation wicri:level="1"><nlm:affiliation>Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Buettner, Reinhard" sort="Buettner, Reinhard" uniqKey="Buettner R" first="Reinhard" last="Buettner">Reinhard Buettner</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thomas, Roman K" sort="Thomas, Roman K" uniqKey="Thomas R" first="Roman K" last="Thomas">Roman K. Thomas</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature communications</title>
<idno type="eISSN">2041-1723</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Base Sequence</term>
<term>Carcinoid Tumor (genetics)</term>
<term>Carcinoid Tumor (pathology)</term>
<term>Chromatin Assembly and Disassembly (genetics)</term>
<term>Chromosome Mapping</term>
<term>DNA Copy Number Variations</term>
<term>Exome (genetics)</term>
<term>Female</term>
<term>Gene Dosage</term>
<term>Gene Expression Profiling</term>
<term>Gene Expression Regulation, Neoplastic</term>
<term>Genome, Human (genetics)</term>
<term>Humans</term>
<term>Lung Neoplasms (genetics)</term>
<term>Lung Neoplasms (pathology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Molecular Sequence Data</term>
<term>Mutation</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Sequence Analysis, DNA</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de profil d'expression de gènes</term>
<term>Analyse de séquence d'ADN</term>
<term>Assemblage et désassemblage de la chromatine (génétique)</term>
<term>Cartographie chromosomique</term>
<term>Données de séquences moléculaires</term>
<term>Dosage génique</term>
<term>Exome (génétique)</term>
<term>Femelle</term>
<term>Génome humain (génétique)</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mutation</term>
<term>Mâle</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Régulation de l'expression des gènes tumoraux</term>
<term>Sujet âgé</term>
<term>Séquence nucléotidique</term>
<term>Tumeur carcinoïde (anatomopathologie)</term>
<term>Tumeur carcinoïde (génétique)</term>
<term>Tumeurs du poumon (anatomopathologie)</term>
<term>Tumeurs du poumon (génétique)</term>
<term>Variations de nombre de copies de segment d'ADN</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeur carcinoïde</term>
<term>Tumeurs du poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Carcinoid Tumor</term>
<term>Chromatin Assembly and Disassembly</term>
<term>Exome</term>
<term>Genome, Human</term>
<term>Lung Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Assemblage et désassemblage de la chromatine</term>
<term>Exome</term>
<term>Génome humain</term>
<term>Tumeur carcinoïde</term>
<term>Tumeurs du poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoid Tumor</term>
<term>Lung Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Base Sequence</term>
<term>Chromosome Mapping</term>
<term>DNA Copy Number Variations</term>
<term>Female</term>
<term>Gene Dosage</term>
<term>Gene Expression Profiling</term>
<term>Gene Expression Regulation, Neoplastic</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Molecular Sequence Data</term>
<term>Mutation</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Sequence Analysis, DNA</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de profil d'expression de gènes</term>
<term>Analyse de séquence d'ADN</term>
<term>Cartographie chromosomique</term>
<term>Données de séquences moléculaires</term>
<term>Dosage génique</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mutation</term>
<term>Mâle</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Régulation de l'expression des gènes tumoraux</term>
<term>Sujet âgé</term>
<term>Séquence nucléotidique</term>
<term>Variations de nombre de copies de segment d'ADN</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Pulmonary carcinoids are rare neuroendocrine tumours of the lung. The molecular alterations underlying the pathogenesis of these tumours have not been systematically studied so far. Here we perform gene copy number analysis (n=54), genome/exome (n=44) and transcriptome (n=69) sequencing of pulmonary carcinoids and observe frequent mutations in chromatin-remodelling genes. Covalent histone modifiers and subunits of the SWI/SNF complex are mutated in 40 and 22.2% of the cases, respectively, with MEN1, PSIP1 and ARID1A being recurrently affected. In contrast to small-cell lung cancer and large-cell neuroendocrine lung tumours, TP53 and RB1 mutations are rare events, suggesting that pulmonary carcinoids are not early progenitor lesions of the highly aggressive lung neuroendocrine tumours but arise through independent cellular mechanisms. These data also suggest that inactivation of chromatin-remodelling genes is sufficient to drive transformation in pulmonary carcinoids.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24670920</PMID>
<DateCreated><Year>2014</Year>
<Month>03</Month>
<Day>27</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>12</Month>
<Day>03</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>07</Month>
<Day>18</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2041-1723</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>5</Volume>
<PubDate><Year>2014</Year>
<Month>Mar</Month>
<Day>27</Day>
</PubDate>
</JournalIssue>
<Title>Nature communications</Title>
<ISOAbbreviation>Nat Commun</ISOAbbreviation>
</Journal>
<ArticleTitle>Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids.</ArticleTitle>
<Pagination><MedlinePgn>3518</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/ncomms4518</ELocationID>
<Abstract><AbstractText>Pulmonary carcinoids are rare neuroendocrine tumours of the lung. The molecular alterations underlying the pathogenesis of these tumours have not been systematically studied so far. Here we perform gene copy number analysis (n=54), genome/exome (n=44) and transcriptome (n=69) sequencing of pulmonary carcinoids and observe frequent mutations in chromatin-remodelling genes. Covalent histone modifiers and subunits of the SWI/SNF complex are mutated in 40 and 22.2% of the cases, respectively, with MEN1, PSIP1 and ARID1A being recurrently affected. In contrast to small-cell lung cancer and large-cell neuroendocrine lung tumours, TP53 and RB1 mutations are rare events, suggesting that pulmonary carcinoids are not early progenitor lesions of the highly aggressive lung neuroendocrine tumours but arise through independent cellular mechanisms. These data also suggest that inactivation of chromatin-remodelling genes is sufficient to drive transformation in pulmonary carcinoids.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Fernandez-Cuesta</LastName>
<ForeName>Lynnette</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y" EqualContrib="Y"><LastName>Peifer</LastName>
<ForeName>Martin</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lu</LastName>
<ForeName>Xin</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sun</LastName>
<ForeName>Ruping</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ozretić</LastName>
<ForeName>Luka</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Seidal</LastName>
<ForeName>Danila</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Cologne - Bonn, University of Cologne, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zander</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department I of Internal Medicine, Center of Integrated Oncology Kö ln-Bonn, University of Cologne, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Network Genomic Medicine, University Hospital Cologne, Center of Integrated Oncology Cologne Bonn, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Leenders</LastName>
<ForeName>Frauke</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Cologne - Bonn, University of Cologne, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>George</LastName>
<ForeName>Julie</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Müller</LastName>
<ForeName>Christian</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dahmen</LastName>
<ForeName>Ilona</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pinther</LastName>
<ForeName>Berit</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bosco</LastName>
<ForeName>Graziella</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Konrad</LastName>
<ForeName>Kathryn</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Cologne Center for Genomics (CCG), University of Cologne, Cologne, 50931 Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Altmüller</LastName>
<ForeName>Janine</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Cologne Center for Genomics (CCG), University of Cologne, Cologne, 50931 Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Human Genetics, University of Cologne, Cologne 50931, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nürnberg</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Cologne Center for Genomics (CCG), University of Cologne, Cologne, 50931 Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Achter</LastName>
<ForeName>Viktor</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Computing Center, University of Cologne, 50931 Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lang</LastName>
<ForeName>Ulrich</ForeName>
<Initials>U</Initials>
<AffiliationInfo><Affiliation>Computing Center, University of Cologne, 50931 Cologne, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Informatics, University of Cologne, 50931 Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schneider</LastName>
<ForeName>Peter M</ForeName>
<Initials>PM</Initials>
<AffiliationInfo><Affiliation>Institute of Legal Medicine, University of Cologne, 50823 Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bogus</LastName>
<ForeName>Magdalena</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Institute of Legal Medicine, University of Cologne, 50823 Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Soltermann</LastName>
<ForeName>Alex</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Institute for Surgical Pathology, University Hospital Zurich, 8091 Zurich, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Brustugun</LastName>
<ForeName>Odd Terje</ForeName>
<Initials>OT</Initials>
<AffiliationInfo><Affiliation>Institute of clinical medicine, Faculty of Medicine, University of Oslo, N-0424 Oslo, Norway.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of oncology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Helland</LastName>
<ForeName>Åslaug</ForeName>
<Initials>Å</Initials>
<AffiliationInfo><Affiliation>Institute of clinical medicine, Faculty of Medicine, University of Oslo, N-0424 Oslo, Norway.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of oncology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Solberg</LastName>
<ForeName>Steinar</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Thoracic Surgery, Rikshospitalet, Oslo University Hospital, N-0027 Oslo, Norway.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lund-Iversen</LastName>
<ForeName>Marius</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of pathology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ansén</LastName>
<ForeName>Sascha</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department I of Internal Medicine, Center of Integrated Oncology Kö ln-Bonn, University of Cologne, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stoelben</LastName>
<ForeName>Erich</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wright</LastName>
<ForeName>Gavin M</ForeName>
<Initials>GM</Initials>
<AffiliationInfo><Affiliation>University of Melbourne Department of Surgery, St Vincent's Hospital, Melbourne, 3065 Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Russell</LastName>
<ForeName>Prudence</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, St. Vincent's Hospital, Melbourne, 3065 Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wainer</LastName>
<ForeName>Zoe</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>University of Melbourne Department of Surgery, St Vincent's Hospital, Melbourne, 3065 Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Solomon</LastName>
<ForeName>Benjamin</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, 3002 Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Field</LastName>
<ForeName>John K</ForeName>
<Initials>JK</Initials>
<AffiliationInfo><Affiliation>Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool Cancer Research Centre, Liverpool, L3 9TA, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hyde</LastName>
<ForeName>Russell</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool Cancer Research Centre, Liverpool, L3 9TA, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Davies</LastName>
<ForeName>Michael Pa</ForeName>
<Initials>MP</Initials>
<AffiliationInfo><Affiliation>Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool Cancer Research Centre, Liverpool, L3 9TA, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Heukamp</LastName>
<ForeName>Lukas C</ForeName>
<Initials>LC</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Network Genomic Medicine, University Hospital Cologne, Center of Integrated Oncology Cologne Bonn, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Petersen</LastName>
<ForeName>Iver</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Perner</LastName>
<ForeName>Sven</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Prostate Cancer Research, Institute of Pathology, University Hospital of Bonn, 53127 Bonn, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lovly</LastName>
<ForeName>Christine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Vanderbilt-Ingram Cancer Center, Nashville, TN37232, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cappuzzo</LastName>
<ForeName>Federico</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Medical Oncology, Istituto Toscano Tumouri, 57100 Livorno, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Travis</LastName>
<ForeName>William D</ForeName>
<Initials>WD</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Memorial Sloan Kettering Cancer Center, New York 10065, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wolf</LastName>
<ForeName>Jürgen</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Cologne - Bonn, University of Cologne, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department I of Internal Medicine, Center of Integrated Oncology Kö ln-Bonn, University of Cologne, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Network Genomic Medicine, University Hospital Cologne, Center of Integrated Oncology Cologne Bonn, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vingron</LastName>
<ForeName>Martin</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Brambilla</LastName>
<ForeName>Elisabeth</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, CHU Grenoble INSERM U823, Institute Albert Bonniot 38043 CS10217 Grenoble, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Haas</LastName>
<ForeName>Stefan A</ForeName>
<Initials>SA</Initials>
<AffiliationInfo><Affiliation>Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Buettner</LastName>
<ForeName>Reinhard</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Cologne - Bonn, University of Cologne, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Network Genomic Medicine, University Hospital Cologne, Center of Integrated Oncology Cologne Bonn, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thomas</LastName>
<ForeName>Roman K</ForeName>
<Initials>RK</Initials>
<AffiliationInfo><Affiliation>Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Cologne - Bonn, University of Cologne, 50924 Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>K12 CA090625</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>K12 CA9060625</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>03</Month>
<Day>27</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Nat Commun</MedlineTA>
<NlmUniqueID>101528555</NlmUniqueID>
<ISSNLinking>2041-1723</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Mol Cell. 2000 Feb;5(2):243-54</RefSource>
<PMID Version="1">10882066</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell. 2012 Sep 14;150(6):1107-20</RefSource>
<PMID Version="1">22980975</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Cell Biol. 2004 Aug;6(8):784-91</RefSource>
<PMID Version="1">15247924</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biostatistics. 2004 Oct;5(4):557-72</RefSource>
<PMID Version="1">15475419</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Cancer. 2005 May;5(5):367-75</RefSource>
<PMID Version="1">15864278</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50</RefSource>
<PMID Version="1">16199517</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell. 2007 Jan 12;128(1):101-14</RefSource>
<PMID Version="1">17218258</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Biol Evol. 2008 Feb;25(2):362-74</RefSource>
<PMID Version="1">18042807</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cancer Cell. 2008 Jul 8;14(1):36-46</RefSource>
<PMID Version="1">18598942</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Genes Dev. 2008 Nov 15;22(22):3089-114</RefSource>
<PMID Version="1">19056890</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell. 2009 Jan 23;136(2):200-6</RefSource>
<PMID Version="1">19167321</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Bioinformatics. 2009 Jul 15;25(14):1754-60</RefSource>
<PMID Version="1">19451168</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell Mol Life Sci. 2010 Mar;67(5):677-700</RefSource>
<PMID Version="1">19859661</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Bioinformatics. 2010 Apr 1;26(7):873-81</RefSource>
<PMID Version="1">20147302</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Bioinformatics. 2010 Jun 15;26(12):1572-3</RefSource>
<PMID Version="1">20427518</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2010 Sep 23;467(7314):430-5</RefSource>
<PMID Version="1">20720539</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell. 2011 Jan 7;144(1):27-40</RefSource>
<PMID Version="1">21215367</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Cancer. 2011 Jul;11(7):481-92</RefSource>
<PMID Version="1">21654818</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>RNA. 2011 Dec;17(12):2108-18</RefSource>
<PMID Version="1">22028362</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biochim Biophys Acta. 2012 Dec;1826(2):255-71</RefSource>
<PMID Version="1">22579738</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2012 Oct;44(10):1104-10</RefSource>
<PMID Version="1">22941188</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2012 Oct;44(10):1111-6</RefSource>
<PMID Version="1">22941189</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Annu Rev Genet. 2012;46:561-89</RefSource>
<PMID Version="1">22994356</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Cell. 2012 Nov 30;48(4):491-507</RefSource>
<PMID Version="1">23200123</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell Death Dis. 2013;4:e583</RefSource>
<PMID Version="1">23579270</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2013 Jun;45(6):592-601</RefSource>
<PMID Version="1">23644491</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Cancer. 2013 Jul;13(7):497-510</RefSource>
<PMID Version="1">23760024</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2013 Jul 11;499(7457):214-8</RefSource>
<PMID Version="1">23770567</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr Opin Genet Dev. 2013 Oct;23(5):591-8</RefSource>
<PMID Version="1">24035011</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Cancer. 2004 Feb;4(2):133-42</RefSource>
<PMID Version="1">14964309</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002276" MajorTopicYN="N">Carcinoid Tumor</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D042002" MajorTopicYN="N">Chromatin Assembly and Disassembly</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002874" MajorTopicYN="N">Chromosome Mapping</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D056915" MajorTopicYN="N">DNA Copy Number Variations</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059472" MajorTopicYN="N">Exome</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018628" MajorTopicYN="N">Gene Dosage</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020869" MajorTopicYN="N">Gene Expression Profiling</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015972" MajorTopicYN="N">Gene Expression Regulation, Neoplastic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015894" MajorTopicYN="N">Genome, Human</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008175" MajorTopicYN="N">Lung Neoplasms</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009154" MajorTopicYN="Y">Mutation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020641" MajorTopicYN="N">Polymorphism, Single Nucleotide</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<OtherID Source="NLM">NIHMS571151</OtherID>
<OtherID Source="NLM">PMC4132974</OtherID>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year>
<Month>08</Month>
<Day>13</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2014</Year>
<Month>02</Month>
<Day>26</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2014</Year>
<Month>3</Month>
<Day>28</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2014</Year>
<Month>3</Month>
<Day>29</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2014</Year>
<Month>12</Month>
<Day>15</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">24670920</ArticleId>
<ArticleId IdType="doi">10.1038/ncomms4518</ArticleId>
<ArticleId IdType="pmc">PMC4132974</ArticleId>
<ArticleId IdType="mid">NIHMS571151</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003788 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 003788 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= PubMed |étape= Curation |type= RBID |clé= pubmed:24670920 |texte= Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:24670920" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |