Circulating mycobacterial-reactive CD4+ T cells with an immunosuppressive phenotype are higher in active tuberculosis than latent tuberculosis infection.
Identifieur interne : 003351 ( PubMed/Curation ); précédent : 003350; suivant : 003352Circulating mycobacterial-reactive CD4+ T cells with an immunosuppressive phenotype are higher in active tuberculosis than latent tuberculosis infection.
Auteurs : K. Kim [Australie] ; R. Perera [Australie] ; D B A. Tan [Australie] ; S. Fernandez [Australie] ; N. Seddiki [France] ; J. Waring [Australie] ; M A French [Australie]Source :
- Tuberculosis (Edinburgh, Scotland) [ 1873-281X ] ; 2014.
Descripteurs français
- KwdFr :
- Activation des lymphocytes, Adulte, Antigènes CD (immunologie), Antigènes CD (métabolisme), Antigènes bactériens (immunologie), Apyrase (immunologie), Apyrase (métabolisme), Cellules cultivées, Facteur de nécrose tumorale alpha (immunologie), Facteur de nécrose tumorale alpha (métabolisme), Femelle, Humains, Immunophénotypage, Interféron gamma (immunologie), Interféron gamma (métabolisme), Interleukine-10 (immunologie), Interleukine-10 (métabolisme), Lymphocytes T régulateurs (immunologie), Lymphocytes T régulateurs (métabolisme), Mycobacterium tuberculosis (immunologie), Mycobacterium tuberculosis (pathogénicité), Mâle, Phénotype, Techniques de coculture, Tolérance immunitaire, Transduction du signal, Tuberculose (immunologie), Tuberculose (microbiologie), Tuberculose (sang), Tuberculose latente (diagnostic), Tuberculose latente (immunologie), Tuberculose latente (microbiologie), Tuberculose latente (sang).
- MESH :
- diagnostic : Tuberculose latente.
- immunologie : Antigènes CD, Antigènes bactériens, Apyrase, Facteur de nécrose tumorale alpha, Interféron gamma, Interleukine-10, Lymphocytes T régulateurs, Mycobacterium tuberculosis, Tuberculose, Tuberculose latente.
- microbiologie : Tuberculose, Tuberculose latente.
- métabolisme : Antigènes CD, Apyrase, Facteur de nécrose tumorale alpha, Interféron gamma, Interleukine-10, Lymphocytes T régulateurs.
- pathogénicité : Mycobacterium tuberculosis.
- sang : Tuberculose, Tuberculose latente.
- Activation des lymphocytes, Adulte, Cellules cultivées, Femelle, Humains, Immunophénotypage, Mâle, Phénotype, Techniques de coculture, Tolérance immunitaire, Transduction du signal.
English descriptors
- KwdEn :
- Adult, Antigens, Bacterial (immunology), Antigens, CD (immunology), Antigens, CD (metabolism), Apyrase (immunology), Apyrase (metabolism), Cells, Cultured, Coculture Techniques, Female, Humans, Immune Tolerance, Immunophenotyping, Interferon-gamma (immunology), Interferon-gamma (metabolism), Interleukin-10 (immunology), Interleukin-10 (metabolism), Latent Tuberculosis (blood), Latent Tuberculosis (diagnosis), Latent Tuberculosis (immunology), Latent Tuberculosis (microbiology), Lymphocyte Activation, Male, Mycobacterium tuberculosis (immunology), Mycobacterium tuberculosis (pathogenicity), Phenotype, Signal Transduction, T-Lymphocytes, Regulatory (immunology), T-Lymphocytes, Regulatory (metabolism), Tuberculosis (blood), Tuberculosis (immunology), Tuberculosis (microbiology), Tumor Necrosis Factor-alpha (immunology), Tumor Necrosis Factor-alpha (metabolism).
- MESH :
- chemical , immunology : Antigens, Bacterial, Antigens, CD, Apyrase, Interferon-gamma, Interleukin-10, Tumor Necrosis Factor-alpha.
- chemical , metabolism : Antigens, CD, Apyrase, Interferon-gamma, Interleukin-10, Tumor Necrosis Factor-alpha.
- blood : Latent Tuberculosis, Tuberculosis.
- diagnosis : Latent Tuberculosis.
- immunology : Latent Tuberculosis, Mycobacterium tuberculosis, T-Lymphocytes, Regulatory, Tuberculosis.
- metabolism : T-Lymphocytes, Regulatory.
- microbiology : Latent Tuberculosis, Tuberculosis.
- pathogenicity : Mycobacterium tuberculosis.
- Adult, Cells, Cultured, Coculture Techniques, Female, Humans, Immune Tolerance, Immunophenotyping, Lymphocyte Activation, Male, Phenotype, Signal Transduction.
Abstract
Previous studies suggest that control of Mycobacterium tuberculosis infection is compromised by the activity of regulatory T cells, including those that express CD39, an ectonucleotidase with immunosuppressive properties. Here, we examine the role of CD39 on CD4+ T cells reacting to M. tuberculosis antigens.
DOI: 10.1016/j.tube.2014.07.002
PubMed: 25095750
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<term>Antigens, CD (immunology)</term>
<term>Antigens, CD (metabolism)</term>
<term>Apyrase (immunology)</term>
<term>Apyrase (metabolism)</term>
<term>Cells, Cultured</term>
<term>Coculture Techniques</term>
<term>Female</term>
<term>Humans</term>
<term>Immune Tolerance</term>
<term>Immunophenotyping</term>
<term>Interferon-gamma (immunology)</term>
<term>Interferon-gamma (metabolism)</term>
<term>Interleukin-10 (immunology)</term>
<term>Interleukin-10 (metabolism)</term>
<term>Latent Tuberculosis (blood)</term>
<term>Latent Tuberculosis (diagnosis)</term>
<term>Latent Tuberculosis (immunology)</term>
<term>Latent Tuberculosis (microbiology)</term>
<term>Lymphocyte Activation</term>
<term>Male</term>
<term>Mycobacterium tuberculosis (immunology)</term>
<term>Mycobacterium tuberculosis (pathogenicity)</term>
<term>Phenotype</term>
<term>Signal Transduction</term>
<term>T-Lymphocytes, Regulatory (immunology)</term>
<term>T-Lymphocytes, Regulatory (metabolism)</term>
<term>Tuberculosis (blood)</term>
<term>Tuberculosis (immunology)</term>
<term>Tuberculosis (microbiology)</term>
<term>Tumor Necrosis Factor-alpha (immunology)</term>
<term>Tumor Necrosis Factor-alpha (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Adulte</term>
<term>Antigènes CD (immunologie)</term>
<term>Antigènes CD (métabolisme)</term>
<term>Antigènes bactériens (immunologie)</term>
<term>Apyrase (immunologie)</term>
<term>Apyrase (métabolisme)</term>
<term>Cellules cultivées</term>
<term>Facteur de nécrose tumorale alpha (immunologie)</term>
<term>Facteur de nécrose tumorale alpha (métabolisme)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunophénotypage</term>
<term>Interféron gamma (immunologie)</term>
<term>Interféron gamma (métabolisme)</term>
<term>Interleukine-10 (immunologie)</term>
<term>Interleukine-10 (métabolisme)</term>
<term>Lymphocytes T régulateurs (immunologie)</term>
<term>Lymphocytes T régulateurs (métabolisme)</term>
<term>Mycobacterium tuberculosis (immunologie)</term>
<term>Mycobacterium tuberculosis (pathogénicité)</term>
<term>Mâle</term>
<term>Phénotype</term>
<term>Techniques de coculture</term>
<term>Tolérance immunitaire</term>
<term>Transduction du signal</term>
<term>Tuberculose (immunologie)</term>
<term>Tuberculose (microbiologie)</term>
<term>Tuberculose (sang)</term>
<term>Tuberculose latente (diagnostic)</term>
<term>Tuberculose latente (immunologie)</term>
<term>Tuberculose latente (microbiologie)</term>
<term>Tuberculose latente (sang)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Bacterial</term>
<term>Antigens, CD</term>
<term>Apyrase</term>
<term>Interferon-gamma</term>
<term>Interleukin-10</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, CD</term>
<term>Apyrase</term>
<term>Interferon-gamma</term>
<term>Interleukin-10</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Latent Tuberculosis</term>
<term>Tuberculosis</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Latent Tuberculosis</term>
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<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Tuberculose latente</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes CD</term>
<term>Antigènes bactériens</term>
<term>Apyrase</term>
<term>Facteur de nécrose tumorale alpha</term>
<term>Interféron gamma</term>
<term>Interleukine-10</term>
<term>Lymphocytes T régulateurs</term>
<term>Mycobacterium tuberculosis</term>
<term>Tuberculose</term>
<term>Tuberculose latente</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Latent Tuberculosis</term>
<term>Mycobacterium tuberculosis</term>
<term>T-Lymphocytes, Regulatory</term>
<term>Tuberculosis</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>T-Lymphocytes, Regulatory</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Tuberculose</term>
<term>Tuberculose latente</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Latent Tuberculosis</term>
<term>Tuberculosis</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigènes CD</term>
<term>Apyrase</term>
<term>Facteur de nécrose tumorale alpha</term>
<term>Interféron gamma</term>
<term>Interleukine-10</term>
<term>Lymphocytes T régulateurs</term>
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<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Mycobacterium tuberculosis</term>
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<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Mycobacterium tuberculosis</term>
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<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Tuberculose</term>
<term>Tuberculose latente</term>
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<term>Cells, Cultured</term>
<term>Coculture Techniques</term>
<term>Female</term>
<term>Humans</term>
<term>Immune Tolerance</term>
<term>Immunophenotyping</term>
<term>Lymphocyte Activation</term>
<term>Male</term>
<term>Phenotype</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Adulte</term>
<term>Cellules cultivées</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunophénotypage</term>
<term>Mâle</term>
<term>Phénotype</term>
<term>Techniques de coculture</term>
<term>Tolérance immunitaire</term>
<term>Transduction du signal</term>
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<front><div type="abstract" xml:lang="en">Previous studies suggest that control of Mycobacterium tuberculosis infection is compromised by the activity of regulatory T cells, including those that express CD39, an ectonucleotidase with immunosuppressive properties. Here, we examine the role of CD39 on CD4+ T cells reacting to M. tuberculosis antigens.</div>
</front>
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<DateCreated><Year>2014</Year>
<Month>09</Month>
<Day>22</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>11</Month>
<Day>03</Day>
</DateCompleted>
<DateRevised><Year>2014</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-281X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>94</Volume>
<Issue>5</Issue>
<PubDate><Year>2014</Year>
<Month>Sep</Month>
</PubDate>
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<Title>Tuberculosis (Edinburgh, Scotland)</Title>
<ISOAbbreviation>Tuberculosis (Edinb)</ISOAbbreviation>
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<ArticleTitle>Circulating mycobacterial-reactive CD4+ T cells with an immunosuppressive phenotype are higher in active tuberculosis than latent tuberculosis infection.</ArticleTitle>
<Pagination><MedlinePgn>494-501</MedlinePgn>
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<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.tube.2014.07.002</ELocationID>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Previous studies suggest that control of Mycobacterium tuberculosis infection is compromised by the activity of regulatory T cells, including those that express CD39, an ectonucleotidase with immunosuppressive properties. Here, we examine the role of CD39 on CD4+ T cells reacting to M. tuberculosis antigens.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Cryopreserved PBMC from patients with active TB (n = 31) or individuals with LTBI (n = 30) were cultured with PPD, ESAT-6 or CFP-10 and antigen-reactive CD4+ T cells assessed by: A) intracellular expression of interferon-gamma (IFN-γ), tumour necrosis factor alpha (TNF-α) and interleukin (IL)-2, B) co-expression of CD25 and CD134 with or without CD39, and C) production of IFN-γ, TNF-α and IL-10 in culture supernatants.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Active TB patients were not differentiated from individuals with LTBI by intracellular expression of IFN-γ, TNF-α or IL-2 (alone or together), nor by co-expression of CD25 and CD134. However, active TB patients exhibited higher proportions of CD25+, CD134+, CD4+ T cells expressing CD39 in response to all antigens (p ≤ 0.022). Furthermore, in response to PPD, CD39 expression on CD25+, CD134+, CD4+ T cells correlated with IL-10 production (r = 0.41, p = 0.005) and inhibition of CD39 decreased IL-10 production.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Antigen-reactive CD4+ T cells expressing CD39 are more abundant in active TB than LTBI and are associated with production of the immunosuppressive cytokine IL-10. Modulating the effects of CD39 might enhance cellular immune responses against M. tuberculosis.</AbstractText>
<CopyrightInformation>Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>K</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Perera</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Tuberculosis Control Program, Health Department of Western Australia, Perth, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tan</LastName>
<ForeName>D B A</ForeName>
<Initials>DB</Initials>
<AffiliationInfo><Affiliation>Centre for Asthma, Allergy and Respiratory Research, Lung Institute of Western Australia, Perth, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fernandez</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Seddiki</LastName>
<ForeName>N</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>INSERM U955, Institut Mondor de Recherche Biomédicale, Créteil, France; Vaccine Research Institute (VRI) and Université Paris-Est Créteil, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Waring</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Tuberculosis Control Program, Health Department of Western Australia, Perth, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>French</LastName>
<ForeName>M A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia; Department of Clinical Immunology and PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Australia. Electronic address: martyn.french@uwa.edu.au.</Affiliation>
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<Country>United Kingdom</Country>
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<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>07</Month>
<Day>17</Day>
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<NameOfSubstance UI="D000942">Antigens, Bacterial</NameOfSubstance>
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<NameOfSubstance UI="D015703">Antigens, CD</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C573415">IFNG protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C508609">IL10 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>130068-27-8</RegistryNumber>
<NameOfSubstance UI="D016753">Interleukin-10</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>82115-62-6</RegistryNumber>
<NameOfSubstance UI="D007371">Interferon-gamma</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.6.1.5</RegistryNumber>
<NameOfSubstance UI="D001081">Apyrase</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.6.1.5</RegistryNumber>
<NameOfSubstance UI="C067869">CD39 antigen</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000942" MajorTopicYN="N">Antigens, Bacterial</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015703" MajorTopicYN="N">Antigens, CD</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001081" MajorTopicYN="N">Apyrase</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018920" MajorTopicYN="N">Coculture Techniques</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007108" MajorTopicYN="Y">Immune Tolerance</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016130" MajorTopicYN="N">Immunophenotyping</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007371" MajorTopicYN="N">Interferon-gamma</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016753" MajorTopicYN="N">Interleukin-10</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055985" MajorTopicYN="N">Latent Tuberculosis</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008213" MajorTopicYN="N">Lymphocyte Activation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009169" MajorTopicYN="N">Mycobacterium tuberculosis</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010641" MajorTopicYN="N">Phenotype</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050378" MajorTopicYN="N">T-Lymphocytes, Regulatory</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014376" MajorTopicYN="N">Tuberculosis</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antigen-reactive T cells</Keyword>
<Keyword MajorTopicYN="N">CD39</Keyword>
<Keyword MajorTopicYN="N">IL-10</Keyword>
<Keyword MajorTopicYN="N">Tuberculosis</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year>
<Month>04</Month>
<Day>24</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2014</Year>
<Month>07</Month>
<Day>01</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2014</Year>
<Month>07</Month>
<Day>08</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2014</Year>
<Month>8</Month>
<Day>7</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2014</Year>
<Month>8</Month>
<Day>7</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2015</Year>
<Month>11</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">25095750</ArticleId>
<ArticleId IdType="pii">S1472-9792(14)20461-6</ArticleId>
<ArticleId IdType="doi">10.1016/j.tube.2014.07.002</ArticleId>
</ArticleIdList>
</PubmedData>
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