Circulating mycobacterial-reactive CD4+ T cells with an immunosuppressive phenotype are higher in active tuberculosis than latent tuberculosis infection.
Identifieur interne : 003464 ( PubMed/Corpus ); précédent : 003463; suivant : 003465Circulating mycobacterial-reactive CD4+ T cells with an immunosuppressive phenotype are higher in active tuberculosis than latent tuberculosis infection.
Auteurs : K. Kim ; R. Perera ; D B A. Tan ; S. Fernandez ; N. Seddiki ; J. Waring ; M A FrenchSource :
- Tuberculosis (Edinburgh, Scotland) [ 1873-281X ] ; 2014.
English descriptors
- KwdEn :
- Adult, Antigens, Bacterial (immunology), Antigens, CD (immunology), Antigens, CD (metabolism), Apyrase (immunology), Apyrase (metabolism), Cells, Cultured, Coculture Techniques, Female, Humans, Immune Tolerance, Immunophenotyping, Interferon-gamma (immunology), Interferon-gamma (metabolism), Interleukin-10 (immunology), Interleukin-10 (metabolism), Latent Tuberculosis (blood), Latent Tuberculosis (diagnosis), Latent Tuberculosis (immunology), Latent Tuberculosis (microbiology), Lymphocyte Activation, Male, Mycobacterium tuberculosis (immunology), Mycobacterium tuberculosis (pathogenicity), Phenotype, Signal Transduction, T-Lymphocytes, Regulatory (immunology), T-Lymphocytes, Regulatory (metabolism), Tuberculosis (blood), Tuberculosis (immunology), Tuberculosis (microbiology), Tumor Necrosis Factor-alpha (immunology), Tumor Necrosis Factor-alpha (metabolism).
- MESH :
- chemical , immunology : Antigens, Bacterial, Antigens, CD, Apyrase, Interferon-gamma, Interleukin-10, Tumor Necrosis Factor-alpha.
- chemical , metabolism : Antigens, CD, Apyrase, Interferon-gamma, Interleukin-10, Tumor Necrosis Factor-alpha.
- blood : Latent Tuberculosis, Tuberculosis.
- diagnosis : Latent Tuberculosis.
- immunology : Latent Tuberculosis, Mycobacterium tuberculosis, T-Lymphocytes, Regulatory, Tuberculosis.
- metabolism : T-Lymphocytes, Regulatory.
- microbiology : Latent Tuberculosis, Tuberculosis.
- pathogenicity : Mycobacterium tuberculosis.
- Adult, Cells, Cultured, Coculture Techniques, Female, Humans, Immune Tolerance, Immunophenotyping, Lymphocyte Activation, Male, Phenotype, Signal Transduction.
Abstract
Previous studies suggest that control of Mycobacterium tuberculosis infection is compromised by the activity of regulatory T cells, including those that express CD39, an ectonucleotidase with immunosuppressive properties. Here, we examine the role of CD39 on CD4+ T cells reacting to M. tuberculosis antigens.
DOI: 10.1016/j.tube.2014.07.002
PubMed: 25095750
Links to Exploration step
pubmed:25095750Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Circulating mycobacterial-reactive CD4+ T cells with an immunosuppressive phenotype are higher in active tuberculosis than latent tuberculosis infection.</title><author><name sortKey="Kim, K" sort="Kim, K" uniqKey="Kim K" first="K" last="Kim">K. Kim</name><affiliation><nlm:affiliation>School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Perera, R" sort="Perera, R" uniqKey="Perera R" first="R" last="Perera">R. Perera</name><affiliation><nlm:affiliation>Tuberculosis Control Program, Health Department of Western Australia, Perth, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Tan, D B A" sort="Tan, D B A" uniqKey="Tan D" first="D B A" last="Tan">D B A. Tan</name><affiliation><nlm:affiliation>Centre for Asthma, Allergy and Respiratory Research, Lung Institute of Western Australia, Perth, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez, S" sort="Fernandez, S" uniqKey="Fernandez S" first="S" last="Fernandez">S. Fernandez</name><affiliation><nlm:affiliation>School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Seddiki, N" sort="Seddiki, N" uniqKey="Seddiki N" first="N" last="Seddiki">N. Seddiki</name><affiliation><nlm:affiliation>INSERM U955, Institut Mondor de Recherche Biomédicale, Créteil, France; Vaccine Research Institute (VRI) and Université Paris-Est Créteil, France.</nlm:affiliation></affiliation></author><author><name sortKey="Waring, J" sort="Waring, J" uniqKey="Waring J" first="J" last="Waring">J. Waring</name><affiliation><nlm:affiliation>Tuberculosis Control Program, Health Department of Western Australia, Perth, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="French, M A" sort="French, M A" uniqKey="French M" first="M A" last="French">M A French</name><affiliation><nlm:affiliation>School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia; Department of Clinical Immunology and PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Australia. Electronic address: martyn.french@uwa.edu.au.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25095750</idno><idno type="pmid">25095750</idno><idno type="doi">10.1016/j.tube.2014.07.002</idno><idno type="wicri:Area/PubMed/Corpus">003464</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003464</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Circulating mycobacterial-reactive CD4+ T cells with an immunosuppressive phenotype are higher in active tuberculosis than latent tuberculosis infection.</title><author><name sortKey="Kim, K" sort="Kim, K" uniqKey="Kim K" first="K" last="Kim">K. Kim</name><affiliation><nlm:affiliation>School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Perera, R" sort="Perera, R" uniqKey="Perera R" first="R" last="Perera">R. Perera</name><affiliation><nlm:affiliation>Tuberculosis Control Program, Health Department of Western Australia, Perth, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Tan, D B A" sort="Tan, D B A" uniqKey="Tan D" first="D B A" last="Tan">D B A. Tan</name><affiliation><nlm:affiliation>Centre for Asthma, Allergy and Respiratory Research, Lung Institute of Western Australia, Perth, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez, S" sort="Fernandez, S" uniqKey="Fernandez S" first="S" last="Fernandez">S. Fernandez</name><affiliation><nlm:affiliation>School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Seddiki, N" sort="Seddiki, N" uniqKey="Seddiki N" first="N" last="Seddiki">N. Seddiki</name><affiliation><nlm:affiliation>INSERM U955, Institut Mondor de Recherche Biomédicale, Créteil, France; Vaccine Research Institute (VRI) and Université Paris-Est Créteil, France.</nlm:affiliation></affiliation></author><author><name sortKey="Waring, J" sort="Waring, J" uniqKey="Waring J" first="J" last="Waring">J. Waring</name><affiliation><nlm:affiliation>Tuberculosis Control Program, Health Department of Western Australia, Perth, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="French, M A" sort="French, M A" uniqKey="French M" first="M A" last="French">M A French</name><affiliation><nlm:affiliation>School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia; Department of Clinical Immunology and PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Australia. Electronic address: martyn.french@uwa.edu.au.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Tuberculosis (Edinburgh, Scotland)</title><idno type="eISSN">1873-281X</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antigens, Bacterial (immunology)</term><term>Antigens, CD (immunology)</term><term>Antigens, CD (metabolism)</term><term>Apyrase (immunology)</term><term>Apyrase (metabolism)</term><term>Cells, Cultured</term><term>Coculture Techniques</term><term>Female</term><term>Humans</term><term>Immune Tolerance</term><term>Immunophenotyping</term><term>Interferon-gamma (immunology)</term><term>Interferon-gamma (metabolism)</term><term>Interleukin-10 (immunology)</term><term>Interleukin-10 (metabolism)</term><term>Latent Tuberculosis (blood)</term><term>Latent Tuberculosis (diagnosis)</term><term>Latent Tuberculosis (immunology)</term><term>Latent Tuberculosis (microbiology)</term><term>Lymphocyte Activation</term><term>Male</term><term>Mycobacterium tuberculosis (immunology)</term><term>Mycobacterium tuberculosis (pathogenicity)</term><term>Phenotype</term><term>Signal Transduction</term><term>T-Lymphocytes, Regulatory (immunology)</term><term>T-Lymphocytes, Regulatory (metabolism)</term><term>Tuberculosis (blood)</term><term>Tuberculosis (immunology)</term><term>Tuberculosis (microbiology)</term><term>Tumor Necrosis Factor-alpha (immunology)</term><term>Tumor Necrosis Factor-alpha (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Bacterial</term><term>Antigens, CD</term><term>Apyrase</term><term>Interferon-gamma</term><term>Interleukin-10</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, CD</term><term>Apyrase</term><term>Interferon-gamma</term><term>Interleukin-10</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Latent Tuberculosis</term><term>Tuberculosis</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Latent Tuberculosis</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Latent Tuberculosis</term><term>Mycobacterium tuberculosis</term><term>T-Lymphocytes, Regulatory</term><term>Tuberculosis</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>T-Lymphocytes, Regulatory</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Latent Tuberculosis</term><term>Tuberculosis</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Mycobacterium tuberculosis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cells, Cultured</term><term>Coculture Techniques</term><term>Female</term><term>Humans</term><term>Immune Tolerance</term><term>Immunophenotyping</term><term>Lymphocyte Activation</term><term>Male</term><term>Phenotype</term><term>Signal Transduction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous studies suggest that control of Mycobacterium tuberculosis infection is compromised by the activity of regulatory T cells, including those that express CD39, an ectonucleotidase with immunosuppressive properties. Here, we examine the role of CD39 on CD4+ T cells reacting to M. tuberculosis antigens.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25095750</PMID><DateCreated><Year>2014</Year><Month>09</Month><Day>22</Day></DateCreated><DateCompleted><Year>2015</Year><Month>11</Month><Day>03</Day></DateCompleted><DateRevised><Year>2014</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-281X</ISSN><JournalIssue CitedMedium="Internet"><Volume>94</Volume><Issue>5</Issue><PubDate><Year>2014</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Tuberculosis (Edinburgh, Scotland)</Title><ISOAbbreviation>Tuberculosis (Edinb)</ISOAbbreviation></Journal><ArticleTitle>Circulating mycobacterial-reactive CD4+ T cells with an immunosuppressive phenotype are higher in active tuberculosis than latent tuberculosis infection.</ArticleTitle><Pagination><MedlinePgn>494-501</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.tube.2014.07.002</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1472-9792(14)20461-6</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Previous studies suggest that control of Mycobacterium tuberculosis infection is compromised by the activity of regulatory T cells, including those that express CD39, an ectonucleotidase with immunosuppressive properties. Here, we examine the role of CD39 on CD4+ T cells reacting to M. tuberculosis antigens.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Cryopreserved PBMC from patients with active TB (n = 31) or individuals with LTBI (n = 30) were cultured with PPD, ESAT-6 or CFP-10 and antigen-reactive CD4+ T cells assessed by: A) intracellular expression of interferon-gamma (IFN-γ), tumour necrosis factor alpha (TNF-α) and interleukin (IL)-2, B) co-expression of CD25 and CD134 with or without CD39, and C) production of IFN-γ, TNF-α and IL-10 in culture supernatants.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Active TB patients were not differentiated from individuals with LTBI by intracellular expression of IFN-γ, TNF-α or IL-2 (alone or together), nor by co-expression of CD25 and CD134. However, active TB patients exhibited higher proportions of CD25+, CD134+, CD4+ T cells expressing CD39 in response to all antigens (p ≤ 0.022). Furthermore, in response to PPD, CD39 expression on CD25+, CD134+, CD4+ T cells correlated with IL-10 production (r = 0.41, p = 0.005) and inhibition of CD39 decreased IL-10 production.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Antigen-reactive CD4+ T cells expressing CD39 are more abundant in active TB than LTBI and are associated with production of the immunosuppressive cytokine IL-10. Modulating the effects of CD39 might enhance cellular immune responses against M. tuberculosis.</AbstractText><CopyrightInformation>Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perera</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Tuberculosis Control Program, Health Department of Western Australia, Perth, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>D B A</ForeName><Initials>DB</Initials><AffiliationInfo><Affiliation>Centre for Asthma, Allergy and Respiratory Research, Lung Institute of Western Australia, Perth, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernandez</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seddiki</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>INSERM U955, Institut Mondor de Recherche Biomédicale, Créteil, France; Vaccine Research Institute (VRI) and Université Paris-Est Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Waring</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Tuberculosis Control Program, Health Department of Western Australia, Perth, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>French</LastName><ForeName>M A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia; Department of Clinical Immunology and PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Australia. Electronic address: martyn.french@uwa.edu.au.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>07</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>Scotland</Country><MedlineTA>Tuberculosis (Edinb)</MedlineTA><NlmUniqueID>100971555</NlmUniqueID><ISSNLinking>1472-9792</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000942">Antigens, Bacterial</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015703">Antigens, CD</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C573415">IFNG protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C508609">IL10 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance></Chemical><Chemical><RegistryNumber>130068-27-8</RegistryNumber><NameOfSubstance UI="D016753">Interleukin-10</NameOfSubstance></Chemical><Chemical><RegistryNumber>82115-62-6</RegistryNumber><NameOfSubstance UI="D007371">Interferon-gamma</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.1.5</RegistryNumber><NameOfSubstance UI="D001081">Apyrase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.1.5</RegistryNumber><NameOfSubstance UI="C067869">CD39 antigen</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000942" MajorTopicYN="N">Antigens, Bacterial</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015703" MajorTopicYN="N">Antigens, CD</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001081" MajorTopicYN="N">Apyrase</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018920" MajorTopicYN="N">Coculture Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007108" MajorTopicYN="Y">Immune Tolerance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016130" MajorTopicYN="N">Immunophenotyping</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007371" MajorTopicYN="N">Interferon-gamma</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016753" MajorTopicYN="N">Interleukin-10</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055985" MajorTopicYN="N">Latent Tuberculosis</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008213" MajorTopicYN="N">Lymphocyte Activation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009169" MajorTopicYN="N">Mycobacterium tuberculosis</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010641" MajorTopicYN="N">Phenotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D050378" MajorTopicYN="N">T-Lymphocytes, Regulatory</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014376" MajorTopicYN="N">Tuberculosis</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antigen-reactive T cells</Keyword><Keyword MajorTopicYN="N">CD39</Keyword><Keyword MajorTopicYN="N">IL-10</Keyword><Keyword MajorTopicYN="N">Tuberculosis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>04</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>07</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>07</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>8</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>8</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>11</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25095750</ArticleId><ArticleId IdType="pii">S1472-9792(14)20461-6</ArticleId><ArticleId IdType="doi">10.1016/j.tube.2014.07.002</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003464 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 003464 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:25095750
|texte= Circulating mycobacterial-reactive CD4+ T cells with an immunosuppressive phenotype are higher in active tuberculosis than latent tuberculosis infection.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:25095750" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |