Mechanical clearance of red blood cells by the human spleen: Potential therapeutic applications of a biomimetic RBC filtration method.
Identifieur interne : 002A29 ( PubMed/Curation ); précédent : 002A28; suivant : 002A30Mechanical clearance of red blood cells by the human spleen: Potential therapeutic applications of a biomimetic RBC filtration method.
Auteurs : J. Duez [Australie] ; J P Holleran [Australie] ; P A Ndour [France] ; C. Pionneau [France] ; S. Diakité [France] ; C. Roussel [France] ; M. Dussiot [France] ; P. Amireault [France] ; V M Avery [Australie] ; P A Buffet [France]Source :
- Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine [ 1953-8022 ] ; 2015.
Descripteurs français
- KwdFr :
- Antipaludiques (pharmacologie), Antipaludiques (usage thérapeutique), Biomimétique, Conception d'appareillage, Conservation de sang (effets indésirables), Déformabilité érythrocytaire, Filtration (), Filtration (instrumentation), Humains, Index érythrocytaires, Microsphères, Paludisme (), Paludisme (sang), Paludisme (traitement médicamenteux), Parasitémie (), Parasitémie (sang), Parasitémie (traitement médicamenteux), Plasmodium (), Plasmodium (croissance et développement), Rate (physiologie), Transfusion sanguine, Vieillissement érythrocytaire, Érythrocytes (), Érythrocytes (parasitologie), Érythrocytes anormaux, Évaluation préclinique de médicament.
- MESH :
- croissance et développement : Plasmodium.
- effets indésirables : Conservation de sang.
- parasitologie : Érythrocytes.
- pharmacologie : Antipaludiques, Filtration.
- physiologie : Rate.
- sang : Paludisme, Parasitémie.
- traitement médicamenteux : Paludisme, Parasitémie.
- usage thérapeutique : Antipaludiques.
- Biomimétique, Conception d'appareillage, Déformabilité érythrocytaire, Filtration, Humains, Index érythrocytaires, Microsphères, Paludisme, Parasitémie, Plasmodium, Transfusion sanguine, Vieillissement érythrocytaire, Érythrocytes, Érythrocytes anormaux, Évaluation préclinique de médicament.
English descriptors
- KwdEn :
- Antimalarials (pharmacology), Antimalarials (therapeutic use), Biomimetics, Blood Preservation (adverse effects), Blood Transfusion, Drug Evaluation, Preclinical, Equipment Design, Erythrocyte Aging, Erythrocyte Deformability, Erythrocyte Indices, Erythrocytes (drug effects), Erythrocytes (parasitology), Erythrocytes, Abnormal, Filtration (instrumentation), Filtration (methods), Humans, Malaria (blood), Malaria (drug therapy), Malaria (therapy), Microspheres, Parasitemia (blood), Parasitemia (drug therapy), Parasitemia (therapy), Plasmodium (drug effects), Plasmodium (growth & development), Spleen (physiology).
- MESH :
- chemical , pharmacology : Antimalarials.
- chemical , therapeutic use : Antimalarials.
- adverse effects : Blood Preservation.
- blood : Malaria, Parasitemia.
- drug effects : Erythrocytes, Plasmodium.
- drug therapy : Malaria, Parasitemia.
- growth & development : Plasmodium.
- instrumentation : Filtration.
- methods : Filtration.
- parasitology : Erythrocytes.
- physiology : Spleen.
- therapy : Malaria, Parasitemia.
- Biomimetics, Blood Transfusion, Drug Evaluation, Preclinical, Equipment Design, Erythrocyte Aging, Erythrocyte Deformability, Erythrocyte Indices, Erythrocytes, Abnormal, Humans, Microspheres.
Abstract
During their lifespan, circulating RBC are frequently checked for their deformability. This mechanical quality control operates essentially in the human spleen. RBC unable to squeeze though narrow splenic slits are retained and cleared from the blood circulation. Under physiological conditions this prevents microvessels from being clogged by senescent, rigid RBC. Retention of poorly deformable RBC is an important determinant of pathogenesis in malaria and may also impact the clinical benefit of transfusion. Modulating the splenic retention of RBC has already been proposed to support therapeutic approaches in these research fields. To this aim, the development of microplates for high throughput filtration of RBC through microsphere layers (microplate-based microsphiltration) has been undertaken. This review focuses on potential therapeutic applications provided by this technology in malaria chemotherapy and transfusion.
DOI: 10.1016/j.tracli.2015.05.004
PubMed: 26138907
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Duez</name><affiliation wicri:level="1"><nlm:affiliation>CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France; HRA Pharma Laboratoires, 15, rue de Béranger, 75003 Paris, France; Eskitis Institute for Drug Discovery, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, QLD 4111, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France; HRA Pharma Laboratoires, 15, rue de Béranger, 75003 Paris, France; Eskitis Institute for Drug Discovery, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, QLD 4111</wicri:regionArea></affiliation></author><author><name sortKey="Holleran, J P" sort="Holleran, J P" uniqKey="Holleran J" first="J P" last="Holleran">J P Holleran</name><affiliation wicri:level="1"><nlm:affiliation>Eskitis Institute for Drug Discovery, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, QLD 4111, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Eskitis Institute for Drug Discovery, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, QLD 4111</wicri:regionArea></affiliation></author><author><name sortKey="Ndour, P A" sort="Ndour, P A" uniqKey="Ndour P" first="P A" last="Ndour">P A Ndour</name><affiliation wicri:level="1"><nlm:affiliation>CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Pionneau, C" sort="Pionneau, C" uniqKey="Pionneau C" first="C" last="Pionneau">C. 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Pionneau</name><affiliation wicri:level="1"><nlm:affiliation>CIMI-Paris Plateforme post-génomique de la Pitié Salpêtrière, P3S, hôpital La Pitié-Salpêtrière, 75013 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CIMI-Paris Plateforme post-génomique de la Pitié Salpêtrière, P3S, hôpital La Pitié-Salpêtrière, 75013 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Diakite, S" sort="Diakite, S" uniqKey="Diakite S" first="S" last="Diakité">S. Diakité</name><affiliation wicri:level="1"><nlm:affiliation>CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Roussel, C" sort="Roussel, C" uniqKey="Roussel C" first="C" last="Roussel">C. Roussel</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France; Inserm U1163/CNRS ERL 8254, Imagine Institute, Paris Descartes-Sorbonne Paris Cité University, 75015 Paris, France; Institut national de la transfusion sanguine (INTS), 75015 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France; Inserm U1163/CNRS ERL 8254, Imagine Institute, Paris Descartes-Sorbonne Paris Cité University, 75015 Paris, France; Institut national de la transfusion sanguine (INTS), 75015 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Dussiot, M" sort="Dussiot, M" uniqKey="Dussiot M" first="M" last="Dussiot">M. Dussiot</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France; Inserm U1163/CNRS ERL 8254, Imagine Institute, Paris Descartes-Sorbonne Paris Cité University, 75015 Paris, France; Institut national de la transfusion sanguine (INTS), 75015 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France; Inserm U1163/CNRS ERL 8254, Imagine Institute, Paris Descartes-Sorbonne Paris Cité University, 75015 Paris, France; Institut national de la transfusion sanguine (INTS), 75015 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Amireault, P" sort="Amireault, P" uniqKey="Amireault P" first="P" last="Amireault">P. Amireault</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France; Inserm U1163/CNRS ERL 8254, Imagine Institute, Paris Descartes-Sorbonne Paris Cité University, 75015 Paris, France; Institut national de la transfusion sanguine (INTS), 75015 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France; Inserm U1163/CNRS ERL 8254, Imagine Institute, Paris Descartes-Sorbonne Paris Cité University, 75015 Paris, France; Institut national de la transfusion sanguine (INTS), 75015 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Avery, V M" sort="Avery, V M" uniqKey="Avery V" first="V M" last="Avery">V M Avery</name><affiliation wicri:level="1"><nlm:affiliation>Eskitis Institute for Drug Discovery, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, QLD 4111, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Eskitis Institute for Drug Discovery, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, QLD 4111</wicri:regionArea></affiliation></author><author><name sortKey="Buffet, P A" sort="Buffet, P A" uniqKey="Buffet P" first="P A" last="Buffet">P A Buffet</name><affiliation wicri:level="1"><nlm:affiliation>CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France. Electronic address: pabuffet@gmail.com.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris</wicri:regionArea></affiliation></author></analytic><series><title level="j">Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine</title><idno type="eISSN">1953-8022</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antimalarials (pharmacology)</term><term>Antimalarials (therapeutic use)</term><term>Biomimetics</term><term>Blood Preservation (adverse effects)</term><term>Blood Transfusion</term><term>Drug Evaluation, Preclinical</term><term>Equipment Design</term><term>Erythrocyte Aging</term><term>Erythrocyte Deformability</term><term>Erythrocyte Indices</term><term>Erythrocytes (drug effects)</term><term>Erythrocytes (parasitology)</term><term>Erythrocytes, Abnormal</term><term>Filtration (instrumentation)</term><term>Filtration (methods)</term><term>Humans</term><term>Malaria (blood)</term><term>Malaria (drug therapy)</term><term>Malaria (therapy)</term><term>Microspheres</term><term>Parasitemia (blood)</term><term>Parasitemia (drug therapy)</term><term>Parasitemia (therapy)</term><term>Plasmodium (drug effects)</term><term>Plasmodium (growth & development)</term><term>Spleen (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antipaludiques (pharmacologie)</term><term>Antipaludiques (usage thérapeutique)</term><term>Biomimétique</term><term>Conception d'appareillage</term><term>Conservation de sang (effets indésirables)</term><term>Déformabilité érythrocytaire</term><term>Filtration ()</term><term>Filtration (instrumentation)</term><term>Humains</term><term>Index érythrocytaires</term><term>Microsphères</term><term>Paludisme ()</term><term>Paludisme (sang)</term><term>Paludisme (traitement médicamenteux)</term><term>Parasitémie ()</term><term>Parasitémie (sang)</term><term>Parasitémie (traitement médicamenteux)</term><term>Plasmodium ()</term><term>Plasmodium (croissance et développement)</term><term>Rate (physiologie)</term><term>Transfusion sanguine</term><term>Vieillissement érythrocytaire</term><term>Érythrocytes ()</term><term>Érythrocytes (parasitologie)</term><term>Érythrocytes anormaux</term><term>Évaluation préclinique de médicament</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antimalarials</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antimalarials</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Blood Preservation</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Malaria</term><term>Parasitemia</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Plasmodium</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Erythrocytes</term><term>Plasmodium</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Malaria</term><term>Parasitemia</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Conservation de sang</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Plasmodium</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Filtration</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Filtration</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Érythrocytes</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Erythrocytes</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antipaludiques</term><term>Filtration</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Rate</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Spleen</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Paludisme</term><term>Parasitémie</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Malaria</term><term>Parasitemia</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Paludisme</term><term>Parasitémie</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antipaludiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biomimetics</term><term>Blood Transfusion</term><term>Drug Evaluation, Preclinical</term><term>Equipment Design</term><term>Erythrocyte Aging</term><term>Erythrocyte Deformability</term><term>Erythrocyte Indices</term><term>Erythrocytes, Abnormal</term><term>Humans</term><term>Microspheres</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Biomimétique</term><term>Conception d'appareillage</term><term>Déformabilité érythrocytaire</term><term>Filtration</term><term>Humains</term><term>Index érythrocytaires</term><term>Microsphères</term><term>Paludisme</term><term>Parasitémie</term><term>Plasmodium</term><term>Transfusion sanguine</term><term>Vieillissement érythrocytaire</term><term>Érythrocytes</term><term>Érythrocytes anormaux</term><term>Évaluation préclinique de médicament</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During their lifespan, circulating RBC are frequently checked for their deformability. This mechanical quality control operates essentially in the human spleen. RBC unable to squeeze though narrow splenic slits are retained and cleared from the blood circulation. Under physiological conditions this prevents microvessels from being clogged by senescent, rigid RBC. Retention of poorly deformable RBC is an important determinant of pathogenesis in malaria and may also impact the clinical benefit of transfusion. Modulating the splenic retention of RBC has already been proposed to support therapeutic approaches in these research fields. To this aim, the development of microplates for high throughput filtration of RBC through microsphere layers (microplate-based microsphiltration) has been undertaken. This review focuses on potential therapeutic applications provided by this technology in malaria chemotherapy and transfusion.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26138907</PMID><DateCreated><Year>2015</Year><Month>08</Month><Day>10</Day></DateCreated><DateCompleted><Year>2016</Year><Month>06</Month><Day>10</Day></DateCompleted><DateRevised><Year>2015</Year><Month>08</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1953-8022</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><Issue>3</Issue><PubDate><Year>2015</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine</Title><ISOAbbreviation>Transfus Clin Biol</ISOAbbreviation></Journal><ArticleTitle>Mechanical clearance of red blood cells by the human spleen: Potential therapeutic applications of a biomimetic RBC filtration method.</ArticleTitle><Pagination><MedlinePgn>151-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.tracli.2015.05.004</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1246-7820(15)00053-1</ELocationID><Abstract><AbstractText>During their lifespan, circulating RBC are frequently checked for their deformability. This mechanical quality control operates essentially in the human spleen. RBC unable to squeeze though narrow splenic slits are retained and cleared from the blood circulation. Under physiological conditions this prevents microvessels from being clogged by senescent, rigid RBC. Retention of poorly deformable RBC is an important determinant of pathogenesis in malaria and may also impact the clinical benefit of transfusion. Modulating the splenic retention of RBC has already been proposed to support therapeutic approaches in these research fields. To this aim, the development of microplates for high throughput filtration of RBC through microsphere layers (microplate-based microsphiltration) has been undertaken. This review focuses on potential therapeutic applications provided by this technology in malaria chemotherapy and transfusion.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Masson SAS. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Duez</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France; HRA Pharma Laboratoires, 15, rue de Béranger, 75003 Paris, France; Eskitis Institute for Drug Discovery, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, QLD 4111, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holleran</LastName><ForeName>J P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Eskitis Institute for Drug Discovery, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, QLD 4111, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ndour</LastName><ForeName>P A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pionneau</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>CIMI-Paris Plateforme post-génomique de la Pitié Salpêtrière, P3S, hôpital La Pitié-Salpêtrière, 75013 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Diakité</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roussel</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France; Inserm U1163/CNRS ERL 8254, Imagine Institute, Paris Descartes-Sorbonne Paris Cité University, 75015 Paris, France; Institut national de la transfusion sanguine (INTS), 75015 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dussiot</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France; Inserm U1163/CNRS ERL 8254, Imagine Institute, Paris Descartes-Sorbonne Paris Cité University, 75015 Paris, France; Institut national de la transfusion sanguine (INTS), 75015 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amireault</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France; Inserm U1163/CNRS ERL 8254, Imagine Institute, Paris Descartes-Sorbonne Paris Cité University, 75015 Paris, France; Institut national de la transfusion sanguine (INTS), 75015 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Avery</LastName><ForeName>V M</ForeName><Initials>VM</Initials><AffiliationInfo><Affiliation>Eskitis Institute for Drug Discovery, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, QLD 4111, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buffet</LastName><ForeName>P A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France. Electronic address: pabuffet@gmail.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>06</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Transfus Clin Biol</MedlineTA><NlmUniqueID>9423846</NlmUniqueID><ISSNLinking>1246-7820</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000962">Antimalarials</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000962" MajorTopicYN="N">Antimalarials</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032701" MajorTopicYN="Y">Biomimetics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001793" MajorTopicYN="N">Blood Preservation</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001803" MajorTopicYN="N">Blood Transfusion</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004353" MajorTopicYN="N">Drug Evaluation, Preclinical</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004867" MajorTopicYN="N">Equipment Design</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004905" MajorTopicYN="N">Erythrocyte Aging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004907" MajorTopicYN="Y">Erythrocyte Deformability</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004909" MajorTopicYN="N">Erythrocyte Indices</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004912" MajorTopicYN="N">Erythrocytes</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004913" MajorTopicYN="N">Erythrocytes, Abnormal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005374" MajorTopicYN="N">Filtration</DescriptorName><QualifierName UI="Q000295" MajorTopicYN="N">instrumentation</QualifierName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008288" MajorTopicYN="N">Malaria</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008863" MajorTopicYN="N">Microspheres</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018512" MajorTopicYN="N">Parasitemia</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010961" MajorTopicYN="N">Plasmodium</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013154" MajorTopicYN="N">Spleen</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Applications</Keyword><Keyword MajorTopicYN="N">Applications thérapeutiques</Keyword><Keyword MajorTopicYN="N">Deformability</Keyword><Keyword MajorTopicYN="N">Déformabilité</Keyword><Keyword MajorTopicYN="N">Erythrocyte</Keyword><Keyword MajorTopicYN="N">Filtration</Keyword><Keyword MajorTopicYN="N">Malaria</Keyword><Keyword MajorTopicYN="N">Microspheres</Keyword><Keyword MajorTopicYN="N">Microsphères</Keyword><Keyword MajorTopicYN="N">Paludisme</Keyword><Keyword MajorTopicYN="N">Rate</Keyword><Keyword MajorTopicYN="N">Spleen</Keyword><Keyword MajorTopicYN="N">Transfusion</Keyword><Keyword MajorTopicYN="N">Érythrocyte</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>05</Month><Day>11</Day></PubMedPubDate><PubMedPubDate 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