Mechanical clearance of red blood cells by the human spleen: Potential therapeutic applications of a biomimetic RBC filtration method.
Identifieur interne : 002B00 ( PubMed/Corpus ); précédent : 002A99; suivant : 002B01Mechanical clearance of red blood cells by the human spleen: Potential therapeutic applications of a biomimetic RBC filtration method.
Auteurs : J. Duez ; J P Holleran ; P A Ndour ; C. Pionneau ; S. Diakité ; C. Roussel ; M. Dussiot ; P. Amireault ; V M Avery ; P A BuffetSource :
- Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine [ 1953-8022 ] ; 2015.
English descriptors
- KwdEn :
- Antimalarials (pharmacology), Antimalarials (therapeutic use), Biomimetics, Blood Preservation (adverse effects), Blood Transfusion, Drug Evaluation, Preclinical, Equipment Design, Erythrocyte Aging, Erythrocyte Deformability, Erythrocyte Indices, Erythrocytes (drug effects), Erythrocytes (parasitology), Erythrocytes, Abnormal, Filtration (instrumentation), Filtration (methods), Humans, Malaria (blood), Malaria (drug therapy), Malaria (therapy), Microspheres, Parasitemia (blood), Parasitemia (drug therapy), Parasitemia (therapy), Plasmodium (drug effects), Plasmodium (growth & development), Spleen (physiology).
- MESH :
- chemical , pharmacology : Antimalarials.
- chemical , therapeutic use : Antimalarials.
- adverse effects : Blood Preservation.
- blood : Malaria, Parasitemia.
- drug effects : Erythrocytes, Plasmodium.
- drug therapy : Malaria, Parasitemia.
- growth & development : Plasmodium.
- instrumentation : Filtration.
- methods : Filtration.
- parasitology : Erythrocytes.
- physiology : Spleen.
- therapy : Malaria, Parasitemia.
- Biomimetics, Blood Transfusion, Drug Evaluation, Preclinical, Equipment Design, Erythrocyte Aging, Erythrocyte Deformability, Erythrocyte Indices, Erythrocytes, Abnormal, Humans, Microspheres.
Abstract
During their lifespan, circulating RBC are frequently checked for their deformability. This mechanical quality control operates essentially in the human spleen. RBC unable to squeeze though narrow splenic slits are retained and cleared from the blood circulation. Under physiological conditions this prevents microvessels from being clogged by senescent, rigid RBC. Retention of poorly deformable RBC is an important determinant of pathogenesis in malaria and may also impact the clinical benefit of transfusion. Modulating the splenic retention of RBC has already been proposed to support therapeutic approaches in these research fields. To this aim, the development of microplates for high throughput filtration of RBC through microsphere layers (microplate-based microsphiltration) has been undertaken. This review focuses on potential therapeutic applications provided by this technology in malaria chemotherapy and transfusion.
DOI: 10.1016/j.tracli.2015.05.004
PubMed: 26138907
Links to Exploration step
pubmed:26138907Le document en format XML
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Duez</name><affiliation><nlm:affiliation>CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France; HRA Pharma Laboratoires, 15, rue de Béranger, 75003 Paris, France; Eskitis Institute for Drug Discovery, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, QLD 4111, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Holleran, J P" sort="Holleran, J P" uniqKey="Holleran J" first="J P" last="Holleran">J P Holleran</name><affiliation><nlm:affiliation>Eskitis Institute for Drug Discovery, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, QLD 4111, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ndour, P A" sort="Ndour, P A" uniqKey="Ndour P" first="P A" last="Ndour">P A Ndour</name><affiliation><nlm:affiliation>CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pionneau, C" sort="Pionneau, C" uniqKey="Pionneau C" first="C" last="Pionneau">C. 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Duez</name><affiliation><nlm:affiliation>CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France; HRA Pharma Laboratoires, 15, rue de Béranger, 75003 Paris, France; Eskitis Institute for Drug Discovery, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, QLD 4111, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Holleran, J P" sort="Holleran, J P" uniqKey="Holleran J" first="J P" last="Holleran">J P Holleran</name><affiliation><nlm:affiliation>Eskitis Institute for Drug Discovery, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, QLD 4111, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ndour, P A" sort="Ndour, P A" uniqKey="Ndour P" first="P A" last="Ndour">P A Ndour</name><affiliation><nlm:affiliation>CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pionneau, C" sort="Pionneau, C" uniqKey="Pionneau C" first="C" last="Pionneau">C. Pionneau</name><affiliation><nlm:affiliation>CIMI-Paris Plateforme post-génomique de la Pitié Salpêtrière, P3S, hôpital La Pitié-Salpêtrière, 75013 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Diakite, S" sort="Diakite, S" uniqKey="Diakite S" first="S" last="Diakité">S. Diakité</name><affiliation><nlm:affiliation>CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Roussel, C" sort="Roussel, C" uniqKey="Roussel C" first="C" last="Roussel">C. Roussel</name><affiliation><nlm:affiliation>Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France; Inserm U1163/CNRS ERL 8254, Imagine Institute, Paris Descartes-Sorbonne Paris Cité University, 75015 Paris, France; Institut national de la transfusion sanguine (INTS), 75015 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Dussiot, M" sort="Dussiot, M" uniqKey="Dussiot M" first="M" last="Dussiot">M. Dussiot</name><affiliation><nlm:affiliation>Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France; Inserm U1163/CNRS ERL 8254, Imagine Institute, Paris Descartes-Sorbonne Paris Cité University, 75015 Paris, France; Institut national de la transfusion sanguine (INTS), 75015 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Amireault, P" sort="Amireault, P" uniqKey="Amireault P" first="P" last="Amireault">P. Amireault</name><affiliation><nlm:affiliation>Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France; Inserm U1163/CNRS ERL 8254, Imagine Institute, Paris Descartes-Sorbonne Paris Cité University, 75015 Paris, France; Institut national de la transfusion sanguine (INTS), 75015 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Avery, V M" sort="Avery, V M" uniqKey="Avery V" first="V M" last="Avery">V M Avery</name><affiliation><nlm:affiliation>Eskitis Institute for Drug Discovery, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, QLD 4111, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Buffet, P A" sort="Buffet, P A" uniqKey="Buffet P" first="P A" last="Buffet">P A Buffet</name><affiliation><nlm:affiliation>CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France. Electronic address: pabuffet@gmail.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine</title><idno type="eISSN">1953-8022</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antimalarials (pharmacology)</term><term>Antimalarials (therapeutic use)</term><term>Biomimetics</term><term>Blood Preservation (adverse effects)</term><term>Blood Transfusion</term><term>Drug Evaluation, Preclinical</term><term>Equipment Design</term><term>Erythrocyte Aging</term><term>Erythrocyte Deformability</term><term>Erythrocyte Indices</term><term>Erythrocytes (drug effects)</term><term>Erythrocytes (parasitology)</term><term>Erythrocytes, Abnormal</term><term>Filtration (instrumentation)</term><term>Filtration (methods)</term><term>Humans</term><term>Malaria (blood)</term><term>Malaria (drug therapy)</term><term>Malaria (therapy)</term><term>Microspheres</term><term>Parasitemia (blood)</term><term>Parasitemia (drug therapy)</term><term>Parasitemia (therapy)</term><term>Plasmodium (drug effects)</term><term>Plasmodium (growth & development)</term><term>Spleen (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antimalarials</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antimalarials</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Blood Preservation</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Malaria</term><term>Parasitemia</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Erythrocytes</term><term>Plasmodium</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Malaria</term><term>Parasitemia</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Plasmodium</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Filtration</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Filtration</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Erythrocytes</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Spleen</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Malaria</term><term>Parasitemia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biomimetics</term><term>Blood Transfusion</term><term>Drug Evaluation, Preclinical</term><term>Equipment Design</term><term>Erythrocyte Aging</term><term>Erythrocyte Deformability</term><term>Erythrocyte Indices</term><term>Erythrocytes, Abnormal</term><term>Humans</term><term>Microspheres</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During their lifespan, circulating RBC are frequently checked for their deformability. This mechanical quality control operates essentially in the human spleen. RBC unable to squeeze though narrow splenic slits are retained and cleared from the blood circulation. Under physiological conditions this prevents microvessels from being clogged by senescent, rigid RBC. Retention of poorly deformable RBC is an important determinant of pathogenesis in malaria and may also impact the clinical benefit of transfusion. Modulating the splenic retention of RBC has already been proposed to support therapeutic approaches in these research fields. To this aim, the development of microplates for high throughput filtration of RBC through microsphere layers (microplate-based microsphiltration) has been undertaken. This review focuses on potential therapeutic applications provided by this technology in malaria chemotherapy and transfusion.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26138907</PMID><DateCreated><Year>2015</Year><Month>08</Month><Day>10</Day></DateCreated><DateCompleted><Year>2016</Year><Month>06</Month><Day>10</Day></DateCompleted><DateRevised><Year>2015</Year><Month>08</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1953-8022</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><Issue>3</Issue><PubDate><Year>2015</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine</Title><ISOAbbreviation>Transfus Clin Biol</ISOAbbreviation></Journal><ArticleTitle>Mechanical clearance of red blood cells by the human spleen: Potential therapeutic applications of a biomimetic RBC filtration method.</ArticleTitle><Pagination><MedlinePgn>151-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.tracli.2015.05.004</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1246-7820(15)00053-1</ELocationID><Abstract><AbstractText>During their lifespan, circulating RBC are frequently checked for their deformability. This mechanical quality control operates essentially in the human spleen. RBC unable to squeeze though narrow splenic slits are retained and cleared from the blood circulation. Under physiological conditions this prevents microvessels from being clogged by senescent, rigid RBC. Retention of poorly deformable RBC is an important determinant of pathogenesis in malaria and may also impact the clinical benefit of transfusion. Modulating the splenic retention of RBC has already been proposed to support therapeutic approaches in these research fields. To this aim, the development of microplates for high throughput filtration of RBC through microsphere layers (microplate-based microsphiltration) has been undertaken. This review focuses on potential therapeutic applications provided by this technology in malaria chemotherapy and transfusion.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Masson SAS. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Duez</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France; HRA Pharma Laboratoires, 15, rue de Béranger, 75003 Paris, France; Eskitis Institute for Drug Discovery, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, QLD 4111, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holleran</LastName><ForeName>J P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Eskitis Institute for Drug Discovery, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, QLD 4111, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ndour</LastName><ForeName>P A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pionneau</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>CIMI-Paris Plateforme post-génomique de la Pitié Salpêtrière, P3S, hôpital La Pitié-Salpêtrière, 75013 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Diakité</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roussel</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France; Inserm U1163/CNRS ERL 8254, Imagine Institute, Paris Descartes-Sorbonne Paris Cité University, 75015 Paris, France; Institut national de la transfusion sanguine (INTS), 75015 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dussiot</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France; Inserm U1163/CNRS ERL 8254, Imagine Institute, Paris Descartes-Sorbonne Paris Cité University, 75015 Paris, France; Institut national de la transfusion sanguine (INTS), 75015 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amireault</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France; Inserm U1163/CNRS ERL 8254, Imagine Institute, Paris Descartes-Sorbonne Paris Cité University, 75015 Paris, France; Institut national de la transfusion sanguine (INTS), 75015 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Avery</LastName><ForeName>V M</ForeName><Initials>VM</Initials><AffiliationInfo><Affiliation>Eskitis Institute for Drug Discovery, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, QLD 4111, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buffet</LastName><ForeName>P A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France. Electronic address: pabuffet@gmail.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>06</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Transfus Clin Biol</MedlineTA><NlmUniqueID>9423846</NlmUniqueID><ISSNLinking>1246-7820</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000962">Antimalarials</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000962" MajorTopicYN="N">Antimalarials</DescriptorName><QualifierName UI="Q000494" 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MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008863" MajorTopicYN="N">Microspheres</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018512" MajorTopicYN="N">Parasitemia</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010961" MajorTopicYN="N">Plasmodium</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013154" MajorTopicYN="N">Spleen</DescriptorName><QualifierName UI="Q000502" 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