A collaborative sequential meta-analysis of individual patient data from randomized trials of endovascular therapy and tPA vs. tPA alone for acute ischemic stroke: ThRombEctomy And tPA (TREAT) analysis: statistical analysis plan for a sequential meta-analysis performed within the VISTA-Endovascular collaboration.
Identifieur interne : 002772 ( PubMed/Curation ); précédent : 002771; suivant : 002773A collaborative sequential meta-analysis of individual patient data from randomized trials of endovascular therapy and tPA vs. tPA alone for acute ischemic stroke: ThRombEctomy And tPA (TREAT) analysis: statistical analysis plan for a sequential meta-analysis performed within the VISTA-Endovascular collaboration.
Auteurs : Rachael L. Macisaac [Royaume-Uni] ; Pooja Khatri [États-Unis] ; Martin Bendszus [Allemagne] ; Serge Bracard [France] ; Joseph Broderick [États-Unis] ; Bruce Campbell [Australie] ; Alfonso Ciccone [Italie] ; Antoni Dávalos [Espagne] ; Stephen M. Davis [Australie] ; Andrew Demchuk [Canada] ; Hans-Christoph Diener [Allemagne] ; Diederik Dippel [Pays-Bas] ; Geoffrey A. Donnan [Australie] ; Jens Fiehler [Allemagne] ; David Fiorella [États-Unis] ; Mayank Goyal [Canada] ; Werner Hacke [Allemagne] ; Michael D. Hill [Canada] ; Reza Jahan [États-Unis] ; Edward Jauch [États-Unis] ; Tudor Jovin [États-Unis] ; Chelsea S. Kidwell [États-Unis] ; David Liebeskind [États-Unis] ; Charles B. Majoie [Pays-Bas] ; Sheila Cristina Ouriques Martins [Brésil] ; Peter Mitchell [Australie] ; J. Mocco [États-Unis] ; Keith W. Muir [Royaume-Uni] ; Raul Nogueira [États-Unis] ; Jeffrey L. Saver [États-Unis] ; Wouter J. Schonewille [Pays-Bas] ; Adnan H. Siddiqui [États-Unis] ; Götz Thomalla [Allemagne] ; Thomas A. Tomsick [États-Unis] ; Aquilla S. Turk [États-Unis] ; Philip White [Royaume-Uni] ; Osama Zaidat [États-Unis] ; Kennedy R. Lees [Royaume-Uni]Source :
- International journal of stroke : official journal of the International Stroke Society [ 1747-4949 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Tissue Plasminogen Activator.
- methods : Endovascular Procedures.
- therapy : Stroke.
- Analysis of Variance, Cooperative Behavior, Female, Humans, Male, Meta-Analysis as Topic, Randomized Controlled Trials as Topic, Treatment Outcome.
Abstract
Endovascular treatment has been shown to restore blood flow effectively. Second-generation medical devices such as stent retrievers are now showing overwhelming efficacy in clinical trials, particularly in conjunction with intravenous recombinant tissue plasminogen activator.
DOI: 10.1111/ijs.12622
PubMed: 26352438
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Macisaac</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea></affiliation></author><author><name sortKey="Khatri, Pooja" sort="Khatri, Pooja" uniqKey="Khatri P" first="Pooja" last="Khatri">Pooja Khatri</name><affiliation wicri:level="1"><nlm:affiliation>University of Cincinnati, Cincinnati, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Cincinnati, Cincinnati, OH</wicri:regionArea></affiliation></author><author><name sortKey="Bendszus, Martin" sort="Bendszus, Martin" uniqKey="Bendszus M" first="Martin" last="Bendszus">Martin Bendszus</name><affiliation wicri:level="1"><nlm:affiliation>Heidelberg University Hospital, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Heidelberg University Hospital, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Bracard, Serge" sort="Bracard, Serge" uniqKey="Bracard S" first="Serge" last="Bracard">Serge Bracard</name><affiliation wicri:level="1"><nlm:affiliation>CHRU NANCY, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHRU NANCY, Nancy</wicri:regionArea></affiliation></author><author><name sortKey="Broderick, Joseph" sort="Broderick, Joseph" uniqKey="Broderick J" first="Joseph" last="Broderick">Joseph Broderick</name><affiliation wicri:level="1"><nlm:affiliation>University of Cincinnati, Cincinnati, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Cincinnati, Cincinnati, OH</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, Bruce" sort="Campbell, Bruce" uniqKey="Campbell B" first="Bruce" last="Campbell">Bruce Campbell</name><affiliation wicri:level="1"><nlm:affiliation>Royal Melbourne Hospital, Parkville, Vic., Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Melbourne Hospital, Parkville, Vic.</wicri:regionArea></affiliation></author><author><name sortKey="Ciccone, Alfonso" sort="Ciccone, Alfonso" uniqKey="Ciccone A" first="Alfonso" last="Ciccone">Alfonso Ciccone</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardio-Thoracic-Vascular, Azienda Ospedaliera Carlo Poma Mantova, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Cardio-Thoracic-Vascular, Azienda Ospedaliera Carlo Poma Mantova</wicri:regionArea></affiliation></author><author><name sortKey="Davalos, Antoni" sort="Davalos, Antoni" uniqKey="Davalos A" first="Antoni" last="Dávalos">Antoni Dávalos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Universitari Germans Trias i Pujol, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Davis, Stephen M" sort="Davis, Stephen M" uniqKey="Davis S" first="Stephen M" last="Davis">Stephen M. 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Hill</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Clinical Neurosciences, University of Calgary, Calgary, AB</wicri:regionArea></affiliation></author><author><name sortKey="Jahan, Reza" sort="Jahan, Reza" uniqKey="Jahan R" first="Reza" last="Jahan">Reza Jahan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, UCLA, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, UCLA, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Jauch, Edward" sort="Jauch, Edward" uniqKey="Jauch E" first="Edward" last="Jauch">Edward Jauch</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Medical University of South Carolina, Charleston, SC</wicri:regionArea></affiliation></author><author><name sortKey="Jovin, Tudor" sort="Jovin, Tudor" uniqKey="Jovin T" first="Tudor" last="Jovin">Tudor Jovin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, UPMC Stroke Institute, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, UPMC Stroke Institute, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea></affiliation></author><author><name sortKey="Kidwell, Chelsea S" sort="Kidwell, Chelsea S" uniqKey="Kidwell C" first="Chelsea S" last="Kidwell">Chelsea S. Kidwell</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Arizona, Tucson, AZ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Arizona, Tucson, AZ</wicri:regionArea></affiliation></author><author><name sortKey="Liebeskind, David" sort="Liebeskind, David" uniqKey="Liebeskind D" first="David" last="Liebeskind">David Liebeskind</name><affiliation wicri:level="1"><nlm:affiliation>UCLA Stroke Center, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>UCLA Stroke Center, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Majoie, Charles B" sort="Majoie, Charles B" uniqKey="Majoie C" first="Charles B" last="Majoie">Charles B. Majoie</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Academic Medical Centre, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Martins, Sheila Cristina Ouriques" sort="Martins, Sheila Cristina Ouriques" uniqKey="Martins S" first="Sheila Cristina Ouriques" last="Martins">Sheila Cristina Ouriques Martins</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Neurology, Hospital de Clínicas de Porto Alegre, Porto Alegre</wicri:regionArea></affiliation></author><author><name sortKey="Mitchell, Peter" sort="Mitchell, Peter" uniqKey="Mitchell P" first="Peter" last="Mitchell">Peter Mitchell</name><affiliation wicri:level="1"><nlm:affiliation>Melbourne Health, University of Melbourne and the Royal Melbourne Subject, Melbourne, Vic., Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne Health, University of Melbourne and the Royal Melbourne Subject, Melbourne, Vic.</wicri:regionArea></affiliation></author><author><name sortKey="Mocco, J" sort="Mocco, J" uniqKey="Mocco J" first="J" last="Mocco">J. Mocco</name><affiliation wicri:level="1"><nlm:affiliation>Mount Sinai Hospital, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mount Sinai Hospital, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Muir, Keith W" sort="Muir, Keith W" uniqKey="Muir K" first="Keith W" last="Muir">Keith W. Muir</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Stroke and Brain Imaging Research, Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Stroke and Brain Imaging Research, Institute of Neuroscience and Psychology, University of Glasgow, Glasgow</wicri:regionArea></affiliation></author><author><name sortKey="Nogueira, Raul" sort="Nogueira, Raul" uniqKey="Nogueira R" first="Raul" last="Nogueira">Raul Nogueira</name><affiliation wicri:level="1"><nlm:affiliation>Massachussetts General Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachussetts General Hospital, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Saver, Jeffrey L" sort="Saver, Jeffrey L" uniqKey="Saver J" first="Jeffrey L" last="Saver">Jeffrey L. Saver</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, UCLA, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, UCLA, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Schonewille, Wouter J" sort="Schonewille, Wouter J" uniqKey="Schonewille W" first="Wouter J" last="Schonewille">Wouter J. Schonewille</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, St. Antonius Hospital, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, St. Antonius Hospital, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Siddiqui, Adnan H" sort="Siddiqui, Adnan H" uniqKey="Siddiqui A" first="Adnan H" last="Siddiqui">Adnan H. Siddiqui</name><affiliation wicri:level="1"><nlm:affiliation>University of Buffalo, Buffalo, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Buffalo, Buffalo, NY</wicri:regionArea></affiliation></author><author><name sortKey="Thomalla, Gotz" sort="Thomalla, Gotz" uniqKey="Thomalla G" first="Götz" last="Thomalla">Götz Thomalla</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Tomsick, Thomas A" sort="Tomsick, Thomas A" uniqKey="Tomsick T" first="Thomas A" last="Tomsick">Thomas A. Tomsick</name><affiliation wicri:level="1"><nlm:affiliation>University of Cincinnati, Cincinnati, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Cincinnati, Cincinnati, OH</wicri:regionArea></affiliation></author><author><name sortKey="Turk, Aquilla S" sort="Turk, Aquilla S" uniqKey="Turk A" first="Aquilla S" last="Turk">Aquilla S. Turk</name><affiliation wicri:level="1"><nlm:affiliation>Medical University of South Carolina, Charleston, SC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Medical University of South Carolina, Charleston, SC</wicri:regionArea></affiliation></author><author><name sortKey="White, Philip" sort="White, Philip" uniqKey="White P" first="Philip" last="White">Philip White</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neuroscience, Newcastle University, Newcastle upon Tyne</wicri:regionArea></affiliation></author><author><name sortKey="Zaidat, Osama" sort="Zaidat, Osama" uniqKey="Zaidat O" first="Osama" last="Zaidat">Osama Zaidat</name><affiliation wicri:level="1"><nlm:affiliation>Medical College of Wisconsin, Milwaukee, WI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Medical College of Wisconsin, Milwaukee, WI</wicri:regionArea></affiliation></author><author><name sortKey="Lees, Kennedy R" sort="Lees, Kennedy R" uniqKey="Lees K" first="Kennedy R" last="Lees">Kennedy R. Lees</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26352438</idno><idno type="pmid">26352438</idno><idno type="doi">10.1111/ijs.12622</idno><idno type="wicri:Area/PubMed/Corpus">002841</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002841</idno><idno type="wicri:Area/PubMed/Curation">002772</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002772</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A collaborative sequential meta-analysis of individual patient data from randomized trials of endovascular therapy and tPA vs. tPA alone for acute ischemic stroke: ThRombEctomy And tPA (TREAT) analysis: statistical analysis plan for a sequential meta-analysis performed within the VISTA-Endovascular collaboration.</title><author><name sortKey="Macisaac, Rachael L" sort="Macisaac, Rachael L" uniqKey="Macisaac R" first="Rachael L" last="Macisaac">Rachael L. Macisaac</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea></affiliation></author><author><name sortKey="Khatri, Pooja" sort="Khatri, Pooja" uniqKey="Khatri P" first="Pooja" last="Khatri">Pooja Khatri</name><affiliation wicri:level="1"><nlm:affiliation>University of Cincinnati, Cincinnati, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Cincinnati, Cincinnati, OH</wicri:regionArea></affiliation></author><author><name sortKey="Bendszus, Martin" sort="Bendszus, Martin" uniqKey="Bendszus M" first="Martin" last="Bendszus">Martin Bendszus</name><affiliation wicri:level="1"><nlm:affiliation>Heidelberg University Hospital, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Heidelberg University Hospital, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Bracard, Serge" sort="Bracard, Serge" uniqKey="Bracard S" first="Serge" last="Bracard">Serge Bracard</name><affiliation wicri:level="1"><nlm:affiliation>CHRU NANCY, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHRU NANCY, Nancy</wicri:regionArea></affiliation></author><author><name sortKey="Broderick, Joseph" sort="Broderick, Joseph" uniqKey="Broderick J" first="Joseph" last="Broderick">Joseph Broderick</name><affiliation wicri:level="1"><nlm:affiliation>University of Cincinnati, Cincinnati, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Cincinnati, Cincinnati, OH</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, Bruce" sort="Campbell, Bruce" uniqKey="Campbell B" first="Bruce" last="Campbell">Bruce Campbell</name><affiliation wicri:level="1"><nlm:affiliation>Royal Melbourne Hospital, Parkville, Vic., Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Melbourne Hospital, Parkville, Vic.</wicri:regionArea></affiliation></author><author><name sortKey="Ciccone, Alfonso" sort="Ciccone, Alfonso" uniqKey="Ciccone A" first="Alfonso" last="Ciccone">Alfonso Ciccone</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardio-Thoracic-Vascular, Azienda Ospedaliera Carlo Poma Mantova, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Cardio-Thoracic-Vascular, Azienda Ospedaliera Carlo Poma Mantova</wicri:regionArea></affiliation></author><author><name sortKey="Davalos, Antoni" sort="Davalos, Antoni" uniqKey="Davalos A" first="Antoni" last="Dávalos">Antoni Dávalos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Universitari Germans Trias i Pujol, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Davis, Stephen M" sort="Davis, Stephen M" uniqKey="Davis S" first="Stephen M" last="Davis">Stephen M. Davis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, The Royal Melbourne Hospital, Parkville, Vic., Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, The Royal Melbourne Hospital, Parkville, Vic.</wicri:regionArea></affiliation></author><author><name sortKey="Demchuk, Andrew" sort="Demchuk, Andrew" uniqKey="Demchuk A" first="Andrew" last="Demchuk">Andrew Demchuk</name><affiliation wicri:level="1"><nlm:affiliation>University of Calgary, Calgary, AB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Calgary, Calgary, AB</wicri:regionArea></affiliation></author><author><name sortKey="Diener, Hans Christoph" sort="Diener, Hans Christoph" uniqKey="Diener H" first="Hans-Christoph" last="Diener">Hans-Christoph Diener</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Hospital Essen, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital Essen, Essen</wicri:regionArea></affiliation></author><author><name sortKey="Dippel, Diederik" sort="Dippel, Diederik" uniqKey="Dippel D" first="Diederik" last="Dippel">Diederik Dippel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Erasmus MC, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Erasmus MC, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Donnan, Geoffrey A" sort="Donnan, Geoffrey A" uniqKey="Donnan G" first="Geoffrey A" last="Donnan">Geoffrey A. Donnan</name><affiliation wicri:level="1"><nlm:affiliation>Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Vic., Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Vic.</wicri:regionArea></affiliation></author><author><name sortKey="Fiehler, Jens" sort="Fiehler, Jens" uniqKey="Fiehler J" first="Jens" last="Fiehler">Jens Fiehler</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Fiorella, David" sort="Fiorella, David" uniqKey="Fiorella D" first="David" last="Fiorella">David Fiorella</name><affiliation wicri:level="1"><nlm:affiliation>Stony Brook University, Stony Brook, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stony Brook University, Stony Brook, NY</wicri:regionArea></affiliation></author><author><name sortKey="Goyal, Mayank" sort="Goyal, Mayank" uniqKey="Goyal M" first="Mayank" last="Goyal">Mayank Goyal</name><affiliation wicri:level="1"><nlm:affiliation>Hotchkiss Brain Institute, Calgary, AB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Hotchkiss Brain Institute, Calgary, AB</wicri:regionArea></affiliation></author><author><name sortKey="Hacke, Werner" sort="Hacke, Werner" uniqKey="Hacke W" first="Werner" last="Hacke">Werner Hacke</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Ruprecht-Karls-University of Heidelberg, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Hill, Michael D" sort="Hill, Michael D" uniqKey="Hill M" first="Michael D" last="Hill">Michael D. Hill</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Clinical Neurosciences, University of Calgary, Calgary, AB</wicri:regionArea></affiliation></author><author><name sortKey="Jahan, Reza" sort="Jahan, Reza" uniqKey="Jahan R" first="Reza" last="Jahan">Reza Jahan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, UCLA, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, UCLA, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Jauch, Edward" sort="Jauch, Edward" uniqKey="Jauch E" first="Edward" last="Jauch">Edward Jauch</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Medical University of South Carolina, Charleston, SC</wicri:regionArea></affiliation></author><author><name sortKey="Jovin, Tudor" sort="Jovin, Tudor" uniqKey="Jovin T" first="Tudor" last="Jovin">Tudor Jovin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, UPMC Stroke Institute, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, UPMC Stroke Institute, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea></affiliation></author><author><name sortKey="Kidwell, Chelsea S" sort="Kidwell, Chelsea S" uniqKey="Kidwell C" first="Chelsea S" last="Kidwell">Chelsea S. Kidwell</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Arizona, Tucson, AZ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Arizona, Tucson, AZ</wicri:regionArea></affiliation></author><author><name sortKey="Liebeskind, David" sort="Liebeskind, David" uniqKey="Liebeskind D" first="David" last="Liebeskind">David Liebeskind</name><affiliation wicri:level="1"><nlm:affiliation>UCLA Stroke Center, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>UCLA Stroke Center, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Majoie, Charles B" sort="Majoie, Charles B" uniqKey="Majoie C" first="Charles B" last="Majoie">Charles B. Majoie</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Academic Medical Centre, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Martins, Sheila Cristina Ouriques" sort="Martins, Sheila Cristina Ouriques" uniqKey="Martins S" first="Sheila Cristina Ouriques" last="Martins">Sheila Cristina Ouriques Martins</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Neurology, Hospital de Clínicas de Porto Alegre, Porto Alegre</wicri:regionArea></affiliation></author><author><name sortKey="Mitchell, Peter" sort="Mitchell, Peter" uniqKey="Mitchell P" first="Peter" last="Mitchell">Peter Mitchell</name><affiliation wicri:level="1"><nlm:affiliation>Melbourne Health, University of Melbourne and the Royal Melbourne Subject, Melbourne, Vic., Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne Health, University of Melbourne and the Royal Melbourne Subject, Melbourne, Vic.</wicri:regionArea></affiliation></author><author><name sortKey="Mocco, J" sort="Mocco, J" uniqKey="Mocco J" first="J" last="Mocco">J. Mocco</name><affiliation wicri:level="1"><nlm:affiliation>Mount Sinai Hospital, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mount Sinai Hospital, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Muir, Keith W" sort="Muir, Keith W" uniqKey="Muir K" first="Keith W" last="Muir">Keith W. Muir</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Stroke and Brain Imaging Research, Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Stroke and Brain Imaging Research, Institute of Neuroscience and Psychology, University of Glasgow, Glasgow</wicri:regionArea></affiliation></author><author><name sortKey="Nogueira, Raul" sort="Nogueira, Raul" uniqKey="Nogueira R" first="Raul" last="Nogueira">Raul Nogueira</name><affiliation wicri:level="1"><nlm:affiliation>Massachussetts General Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachussetts General Hospital, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Saver, Jeffrey L" sort="Saver, Jeffrey L" uniqKey="Saver J" first="Jeffrey L" last="Saver">Jeffrey L. Saver</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, UCLA, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, UCLA, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Schonewille, Wouter J" sort="Schonewille, Wouter J" uniqKey="Schonewille W" first="Wouter J" last="Schonewille">Wouter J. Schonewille</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, St. Antonius Hospital, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, St. Antonius Hospital, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Siddiqui, Adnan H" sort="Siddiqui, Adnan H" uniqKey="Siddiqui A" first="Adnan H" last="Siddiqui">Adnan H. Siddiqui</name><affiliation wicri:level="1"><nlm:affiliation>University of Buffalo, Buffalo, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Buffalo, Buffalo, NY</wicri:regionArea></affiliation></author><author><name sortKey="Thomalla, Gotz" sort="Thomalla, Gotz" uniqKey="Thomalla G" first="Götz" last="Thomalla">Götz Thomalla</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Tomsick, Thomas A" sort="Tomsick, Thomas A" uniqKey="Tomsick T" first="Thomas A" last="Tomsick">Thomas A. Tomsick</name><affiliation wicri:level="1"><nlm:affiliation>University of Cincinnati, Cincinnati, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Cincinnati, Cincinnati, OH</wicri:regionArea></affiliation></author><author><name sortKey="Turk, Aquilla S" sort="Turk, Aquilla S" uniqKey="Turk A" first="Aquilla S" last="Turk">Aquilla S. Turk</name><affiliation wicri:level="1"><nlm:affiliation>Medical University of South Carolina, Charleston, SC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Medical University of South Carolina, Charleston, SC</wicri:regionArea></affiliation></author><author><name sortKey="White, Philip" sort="White, Philip" uniqKey="White P" first="Philip" last="White">Philip White</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neuroscience, Newcastle University, Newcastle upon Tyne</wicri:regionArea></affiliation></author><author><name sortKey="Zaidat, Osama" sort="Zaidat, Osama" uniqKey="Zaidat O" first="Osama" last="Zaidat">Osama Zaidat</name><affiliation wicri:level="1"><nlm:affiliation>Medical College of Wisconsin, Milwaukee, WI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Medical College of Wisconsin, Milwaukee, WI</wicri:regionArea></affiliation></author><author><name sortKey="Lees, Kennedy R" sort="Lees, Kennedy R" uniqKey="Lees K" first="Kennedy R" last="Lees">Kennedy R. Lees</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea></affiliation></author></analytic><series><title level="j">International journal of stroke : official journal of the International Stroke Society</title><idno type="eISSN">1747-4949</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term><term>Cooperative Behavior</term><term>Endovascular Procedures (methods)</term><term>Female</term><term>Humans</term><term>Male</term><term>Meta-Analysis as Topic</term><term>Randomized Controlled Trials as Topic</term><term>Stroke (therapy)</term><term>Tissue Plasminogen Activator (therapeutic use)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Accident vasculaire cérébral ()</term><term>Activateur tissulaire du plasminogène (usage thérapeutique)</term><term>Analyse de variance</term><term>Comportement coopératif</term><term>Essais contrôlés randomisés comme sujet</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Méta-analyse comme sujet</term><term>Procédures endovasculaires ()</term><term>Résultat thérapeutique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Tissue Plasminogen Activator</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Endovascular Procedures</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Activateur tissulaire du plasminogène</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Cooperative Behavior</term><term>Female</term><term>Humans</term><term>Male</term><term>Meta-Analysis as Topic</term><term>Randomized Controlled Trials as Topic</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Accident vasculaire cérébral</term><term>Analyse de variance</term><term>Comportement coopératif</term><term>Essais contrôlés randomisés comme sujet</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Méta-analyse comme sujet</term><term>Procédures endovasculaires</term><term>Résultat thérapeutique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Endovascular treatment has been shown to restore blood flow effectively. Second-generation medical devices such as stent retrievers are now showing overwhelming efficacy in clinical trials, particularly in conjunction with intravenous recombinant tissue plasminogen activator.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26352438</PMID><DateCreated><Year>2015</Year><Month>10</Month><Day>27</Day></DateCreated><DateCompleted><Year>2016</Year><Month>07</Month><Day>29</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1747-4949</ISSN><JournalIssue CitedMedium="Internet"><Volume>10 Suppl A100</Volume><PubDate><Year>2015</Year><Month>Oct</Month></PubDate></JournalIssue><Title>International journal of stroke : official journal of the International Stroke Society</Title><ISOAbbreviation>Int J Stroke</ISOAbbreviation></Journal><ArticleTitle>A collaborative sequential meta-analysis of individual patient data from randomized trials of endovascular therapy and tPA vs. tPA alone for acute ischemic stroke: ThRombEctomy And tPA (TREAT) analysis: statistical analysis plan for a sequential meta-analysis performed within the VISTA-Endovascular collaboration.</ArticleTitle><Pagination><MedlinePgn>136-44</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/ijs.12622</ELocationID><Abstract><AbstractText Label="RATIONALE" NlmCategory="BACKGROUND">Endovascular treatment has been shown to restore blood flow effectively. Second-generation medical devices such as stent retrievers are now showing overwhelming efficacy in clinical trials, particularly in conjunction with intravenous recombinant tissue plasminogen activator.</AbstractText><AbstractText Label="AIMS AND DESIGN" NlmCategory="OBJECTIVE">This statistical analysis plan utilizing a novel, sequential approach describes a prospective, individual patient data analysis of endovascular therapy in conjunction with intravenous recombinant tissue plasminogen activator agreed upon by the Thrombectomy and Tissue Plasminogen Activator Collaborative Group.</AbstractText><AbstractText Label="STUDY OUTCOMES" NlmCategory="RESULTS">This protocol will specify the primary outcome for efficacy, as 'favorable' outcome defined by the ordinal distribution of the modified Rankin Scale measured at three-months poststroke, but with modified Rankin Scales 5 and 6 collapsed into a single category. The primary analysis will aim to answer the questions: 'what is the treatment effect of endovascular therapy with intravenous recombinant tissue plasminogen activator compared to intravenous tissue plasminogen activator alone on full scale modified Rankin Scale at 3 months?' and 'to what extent do key patient characteristics influence the treatment effect of endovascular therapy?'. Key secondary outcomes include effect of endovascular therapy on death within 90 days; analyses of modified Rankin Scale using dichotomized methods; and effects of endovascular therapy on symptomatic intracranial hemorrhage. Several secondary analyses will be considered as well as expanding patient cohorts to intravenous recombinant tissue plasminogen activator-ineligible patients, should data allow.</AbstractText><AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">This collaborative meta-analysis of individual participant data from randomized trials of endovascular therapy vs. control in conjunction with intravenous thrombolysis will demonstrate the efficacy and generalizability of endovascular therapy with intravenous thrombolysis as a concomitant medication.</AbstractText><CopyrightInformation>© 2015 World Stroke Organization.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>MacIsaac</LastName><ForeName>Rachael L</ForeName><Initials>RL</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khatri</LastName><ForeName>Pooja</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>University of Cincinnati, Cincinnati, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bendszus</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Heidelberg University Hospital, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bracard</LastName><ForeName>Serge</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>CHRU NANCY, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Broderick</LastName><ForeName>Joseph</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>University of Cincinnati, Cincinnati, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Campbell</LastName><ForeName>Bruce</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Royal Melbourne Hospital, Parkville, Vic., Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ciccone</LastName><ForeName>Alfonso</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Cardio-Thoracic-Vascular, Azienda Ospedaliera Carlo Poma Mantova, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dávalos</LastName><ForeName>Antoni</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Davis</LastName><ForeName>Stephen M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Department of Neurology, The Royal Melbourne Hospital, Parkville, Vic., Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Demchuk</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>University of Calgary, Calgary, AB, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Diener</LastName><ForeName>Hans-Christoph</ForeName><Initials>HC</Initials><AffiliationInfo><Affiliation>Department of Neurology, University Hospital Essen, Essen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dippel</LastName><ForeName>Diederik</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Neurology, Erasmus MC, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Donnan</LastName><ForeName>Geoffrey A</ForeName><Initials>GA</Initials><AffiliationInfo><Affiliation>Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Vic., Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fiehler</LastName><ForeName>Jens</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fiorella</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Stony Brook University, Stony Brook, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goyal</LastName><ForeName>Mayank</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Hotchkiss Brain Institute, Calgary, AB, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hacke</LastName><ForeName>Werner</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Neurology, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hill</LastName><ForeName>Michael D</ForeName><Initials>MD</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-6269-1543</Identifier><AffiliationInfo><Affiliation>Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jahan</LastName><ForeName>Reza</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Radiology, UCLA, Los Angeles, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jauch</LastName><ForeName>Edward</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jovin</LastName><ForeName>Tudor</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Neurology, UPMC Stroke Institute, University of Pittsburgh, Pittsburgh, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kidwell</LastName><ForeName>Chelsea S</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Arizona, Tucson, AZ, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Imaging, University of Arizona, Tucson, AZ, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liebeskind</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>UCLA Stroke Center, Los Angeles, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Majoie</LastName><ForeName>Charles B</ForeName><Initials>CB</Initials><AffiliationInfo><Affiliation>Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martins</LastName><ForeName>Sheila Cristina Ouriques</ForeName><Initials>SC</Initials><AffiliationInfo><Affiliation>Department of Neurology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mitchell</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Melbourne Health, University of Melbourne and the Royal Melbourne Subject, Melbourne, Vic., Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mocco</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Mount Sinai Hospital, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muir</LastName><ForeName>Keith W</ForeName><Initials>KW</Initials><AffiliationInfo><Affiliation>Centre for Stroke and Brain Imaging Research, Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nogueira</LastName><ForeName>Raul</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Massachussetts General Hospital, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saver</LastName><ForeName>Jeffrey L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Department of Neurology, UCLA, Los Angeles, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schonewille</LastName><ForeName>Wouter J</ForeName><Initials>WJ</Initials><AffiliationInfo><Affiliation>Department of Neurology, St. Antonius Hospital, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Siddiqui</LastName><ForeName>Adnan H</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>University of Buffalo, Buffalo, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thomalla</LastName><ForeName>Götz</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tomsick</LastName><ForeName>Thomas A</ForeName><Initials>TA</Initials><AffiliationInfo><Affiliation>University of Cincinnati, Cincinnati, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Turk</LastName><ForeName>Aquilla S</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Medical University of South Carolina, Charleston, SC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>White</LastName><ForeName>Philip</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zaidat</LastName><ForeName>Osama</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Medical College of Wisconsin, Milwaukee, WI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lees</LastName><ForeName>Kennedy R</ForeName><Initials>KR</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>VISTA Endovascular collaboration</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>HTA/14/08/47</GrantID><Agency>Department of Health</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>09</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Int J Stroke</MedlineTA><NlmUniqueID>101274068</NlmUniqueID><ISSNLinking>1747-4930</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>EC 3.4.21.68</RegistryNumber><NameOfSubstance UI="D010959">Tissue Plasminogen Activator</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003299" MajorTopicYN="Y">Cooperative Behavior</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057510" MajorTopicYN="N">Endovascular Procedures</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015201" MajorTopicYN="Y">Meta-Analysis as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020521" MajorTopicYN="N">Stroke</DescriptorName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010959" MajorTopicYN="N">Tissue Plasminogen Activator</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">acute</Keyword><Keyword MajorTopicYN="N">endovascular</Keyword><Keyword MajorTopicYN="N">ischemic stroke</Keyword><Keyword MajorTopicYN="N">meta-analysis</Keyword><Keyword MajorTopicYN="N">protocols</Keyword><Keyword MajorTopicYN="N">treatment</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>05</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>07</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>9</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>9</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26352438</ArticleId><ArticleId IdType="doi">10.1111/ijs.12622</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler 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