A collaborative sequential meta-analysis of individual patient data from randomized trials of endovascular therapy and tPA vs. tPA alone for acute ischemic stroke: ThRombEctomy And tPA (TREAT) analysis: statistical analysis plan for a sequential meta-analysis performed within the VISTA-Endovascular collaboration.
Identifieur interne : 002841 ( PubMed/Corpus ); précédent : 002840; suivant : 002842A collaborative sequential meta-analysis of individual patient data from randomized trials of endovascular therapy and tPA vs. tPA alone for acute ischemic stroke: ThRombEctomy And tPA (TREAT) analysis: statistical analysis plan for a sequential meta-analysis performed within the VISTA-Endovascular collaboration.
Auteurs : Rachael L. Macisaac ; Pooja Khatri ; Martin Bendszus ; Serge Bracard ; Joseph Broderick ; Bruce Campbell ; Alfonso Ciccone ; Antoni Dávalos ; Stephen M. Davis ; Andrew Demchuk ; Hans-Christoph Diener ; Diederik Dippel ; Geoffrey A. Donnan ; Jens Fiehler ; David Fiorella ; Mayank Goyal ; Werner Hacke ; Michael D. Hill ; Reza Jahan ; Edward Jauch ; Tudor Jovin ; Chelsea S. Kidwell ; David Liebeskind ; Charles B. Majoie ; Sheila Cristina Ouriques Martins ; Peter Mitchell ; J. Mocco ; Keith W. Muir ; Raul Nogueira ; Jeffrey L. Saver ; Wouter J. Schonewille ; Adnan H. Siddiqui ; Götz Thomalla ; Thomas A. Tomsick ; Aquilla S. Turk ; Philip White ; Osama Zaidat ; Kennedy R. LeesSource :
- International journal of stroke : official journal of the International Stroke Society [ 1747-4949 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Tissue Plasminogen Activator.
- methods : Endovascular Procedures.
- therapy : Stroke.
- Analysis of Variance, Cooperative Behavior, Female, Humans, Male, Meta-Analysis as Topic, Randomized Controlled Trials as Topic, Treatment Outcome.
Abstract
Endovascular treatment has been shown to restore blood flow effectively. Second-generation medical devices such as stent retrievers are now showing overwhelming efficacy in clinical trials, particularly in conjunction with intravenous recombinant tissue plasminogen activator.
DOI: 10.1111/ijs.12622
PubMed: 26352438
Links to Exploration step
pubmed:26352438Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A collaborative sequential meta-analysis of individual patient data from randomized trials of endovascular therapy and tPA vs. tPA alone for acute ischemic stroke: ThRombEctomy And tPA (TREAT) analysis: statistical analysis plan for a sequential meta-analysis performed within the VISTA-Endovascular collaboration.</title><author><name sortKey="Macisaac, Rachael L" sort="Macisaac, Rachael L" uniqKey="Macisaac R" first="Rachael L" last="Macisaac">Rachael L. Macisaac</name><affiliation><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Khatri, Pooja" sort="Khatri, Pooja" uniqKey="Khatri P" first="Pooja" last="Khatri">Pooja Khatri</name><affiliation><nlm:affiliation>University of Cincinnati, Cincinnati, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bendszus, Martin" sort="Bendszus, Martin" uniqKey="Bendszus M" first="Martin" last="Bendszus">Martin Bendszus</name><affiliation><nlm:affiliation>Heidelberg University Hospital, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bracard, Serge" sort="Bracard, Serge" uniqKey="Bracard S" first="Serge" last="Bracard">Serge Bracard</name><affiliation><nlm:affiliation>CHRU NANCY, Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Broderick, Joseph" sort="Broderick, Joseph" uniqKey="Broderick J" first="Joseph" last="Broderick">Joseph Broderick</name><affiliation><nlm:affiliation>University of Cincinnati, Cincinnati, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Campbell, Bruce" sort="Campbell, Bruce" uniqKey="Campbell B" first="Bruce" last="Campbell">Bruce Campbell</name><affiliation><nlm:affiliation>Royal Melbourne Hospital, Parkville, Vic., Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ciccone, Alfonso" sort="Ciccone, Alfonso" uniqKey="Ciccone A" first="Alfonso" last="Ciccone">Alfonso Ciccone</name><affiliation><nlm:affiliation>Department of Cardio-Thoracic-Vascular, Azienda Ospedaliera Carlo Poma Mantova, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Davalos, Antoni" sort="Davalos, Antoni" uniqKey="Davalos A" first="Antoni" last="Dávalos">Antoni Dávalos</name><affiliation><nlm:affiliation>Department of Neurology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Davis, Stephen M" sort="Davis, Stephen M" uniqKey="Davis S" first="Stephen M" last="Davis">Stephen M. Davis</name><affiliation><nlm:affiliation>Department of Neurology, The Royal Melbourne Hospital, Parkville, Vic., Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Demchuk, Andrew" sort="Demchuk, Andrew" uniqKey="Demchuk A" first="Andrew" last="Demchuk">Andrew Demchuk</name><affiliation><nlm:affiliation>University of Calgary, Calgary, AB, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Diener, Hans Christoph" sort="Diener, Hans Christoph" uniqKey="Diener H" first="Hans-Christoph" last="Diener">Hans-Christoph Diener</name><affiliation><nlm:affiliation>Department of Neurology, University Hospital Essen, Essen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Dippel, Diederik" sort="Dippel, Diederik" uniqKey="Dippel D" first="Diederik" last="Dippel">Diederik Dippel</name><affiliation><nlm:affiliation>Department of Neurology, Erasmus MC, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Donnan, Geoffrey A" sort="Donnan, Geoffrey A" uniqKey="Donnan G" first="Geoffrey A" last="Donnan">Geoffrey A. Donnan</name><affiliation><nlm:affiliation>Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Vic., Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Fiehler, Jens" sort="Fiehler, Jens" uniqKey="Fiehler J" first="Jens" last="Fiehler">Jens Fiehler</name><affiliation><nlm:affiliation>Department of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Fiorella, David" sort="Fiorella, David" uniqKey="Fiorella D" first="David" last="Fiorella">David Fiorella</name><affiliation><nlm:affiliation>Stony Brook University, Stony Brook, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Goyal, Mayank" sort="Goyal, Mayank" uniqKey="Goyal M" first="Mayank" last="Goyal">Mayank Goyal</name><affiliation><nlm:affiliation>Hotchkiss Brain Institute, Calgary, AB, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Hacke, Werner" sort="Hacke, Werner" uniqKey="Hacke W" first="Werner" last="Hacke">Werner Hacke</name><affiliation><nlm:affiliation>Department of Neurology, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hill, Michael D" sort="Hill, Michael D" uniqKey="Hill M" first="Michael D" last="Hill">Michael D. Hill</name><affiliation><nlm:affiliation>Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Jahan, Reza" sort="Jahan, Reza" uniqKey="Jahan R" first="Reza" last="Jahan">Reza Jahan</name><affiliation><nlm:affiliation>Department of Radiology, UCLA, Los Angeles, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jauch, Edward" sort="Jauch, Edward" uniqKey="Jauch E" first="Edward" last="Jauch">Edward Jauch</name><affiliation><nlm:affiliation>Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jovin, Tudor" sort="Jovin, Tudor" uniqKey="Jovin T" first="Tudor" last="Jovin">Tudor Jovin</name><affiliation><nlm:affiliation>Department of Neurology, UPMC Stroke Institute, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kidwell, Chelsea S" sort="Kidwell, Chelsea S" uniqKey="Kidwell C" first="Chelsea S" last="Kidwell">Chelsea S. Kidwell</name><affiliation><nlm:affiliation>Department of Neurology, University of Arizona, Tucson, AZ, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Liebeskind, David" sort="Liebeskind, David" uniqKey="Liebeskind D" first="David" last="Liebeskind">David Liebeskind</name><affiliation><nlm:affiliation>UCLA Stroke Center, Los Angeles, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Majoie, Charles B" sort="Majoie, Charles B" uniqKey="Majoie C" first="Charles B" last="Majoie">Charles B. Majoie</name><affiliation><nlm:affiliation>Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Martins, Sheila Cristina Ouriques" sort="Martins, Sheila Cristina Ouriques" uniqKey="Martins S" first="Sheila Cristina Ouriques" last="Martins">Sheila Cristina Ouriques Martins</name><affiliation><nlm:affiliation>Department of Neurology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Mitchell, Peter" sort="Mitchell, Peter" uniqKey="Mitchell P" first="Peter" last="Mitchell">Peter Mitchell</name><affiliation><nlm:affiliation>Melbourne Health, University of Melbourne and the Royal Melbourne Subject, Melbourne, Vic., Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mocco, J" sort="Mocco, J" uniqKey="Mocco J" first="J" last="Mocco">J. Mocco</name><affiliation><nlm:affiliation>Mount Sinai Hospital, New York, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Muir, Keith W" sort="Muir, Keith W" uniqKey="Muir K" first="Keith W" last="Muir">Keith W. Muir</name><affiliation><nlm:affiliation>Centre for Stroke and Brain Imaging Research, Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Nogueira, Raul" sort="Nogueira, Raul" uniqKey="Nogueira R" first="Raul" last="Nogueira">Raul Nogueira</name><affiliation><nlm:affiliation>Massachussetts General Hospital, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Saver, Jeffrey L" sort="Saver, Jeffrey L" uniqKey="Saver J" first="Jeffrey L" last="Saver">Jeffrey L. Saver</name><affiliation><nlm:affiliation>Department of Neurology, UCLA, Los Angeles, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Schonewille, Wouter J" sort="Schonewille, Wouter J" uniqKey="Schonewille W" first="Wouter J" last="Schonewille">Wouter J. Schonewille</name><affiliation><nlm:affiliation>Department of Neurology, St. Antonius Hospital, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Siddiqui, Adnan H" sort="Siddiqui, Adnan H" uniqKey="Siddiqui A" first="Adnan H" last="Siddiqui">Adnan H. Siddiqui</name><affiliation><nlm:affiliation>University of Buffalo, Buffalo, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Thomalla, Gotz" sort="Thomalla, Gotz" uniqKey="Thomalla G" first="Götz" last="Thomalla">Götz Thomalla</name><affiliation><nlm:affiliation>Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Tomsick, Thomas A" sort="Tomsick, Thomas A" uniqKey="Tomsick T" first="Thomas A" last="Tomsick">Thomas A. Tomsick</name><affiliation><nlm:affiliation>University of Cincinnati, Cincinnati, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Turk, Aquilla S" sort="Turk, Aquilla S" uniqKey="Turk A" first="Aquilla S" last="Turk">Aquilla S. Turk</name><affiliation><nlm:affiliation>Medical University of South Carolina, Charleston, SC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="White, Philip" sort="White, Philip" uniqKey="White P" first="Philip" last="White">Philip White</name><affiliation><nlm:affiliation>Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Zaidat, Osama" sort="Zaidat, Osama" uniqKey="Zaidat O" first="Osama" last="Zaidat">Osama Zaidat</name><affiliation><nlm:affiliation>Medical College of Wisconsin, Milwaukee, WI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lees, Kennedy R" sort="Lees, Kennedy R" uniqKey="Lees K" first="Kennedy R" last="Lees">Kennedy R. Lees</name><affiliation><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26352438</idno><idno type="pmid">26352438</idno><idno type="doi">10.1111/ijs.12622</idno><idno type="wicri:Area/PubMed/Corpus">002841</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002841</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A collaborative sequential meta-analysis of individual patient data from randomized trials of endovascular therapy and tPA vs. tPA alone for acute ischemic stroke: ThRombEctomy And tPA (TREAT) analysis: statistical analysis plan for a sequential meta-analysis performed within the VISTA-Endovascular collaboration.</title><author><name sortKey="Macisaac, Rachael L" sort="Macisaac, Rachael L" uniqKey="Macisaac R" first="Rachael L" last="Macisaac">Rachael L. Macisaac</name><affiliation><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Khatri, Pooja" sort="Khatri, Pooja" uniqKey="Khatri P" first="Pooja" last="Khatri">Pooja Khatri</name><affiliation><nlm:affiliation>University of Cincinnati, Cincinnati, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bendszus, Martin" sort="Bendszus, Martin" uniqKey="Bendszus M" first="Martin" last="Bendszus">Martin Bendszus</name><affiliation><nlm:affiliation>Heidelberg University Hospital, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bracard, Serge" sort="Bracard, Serge" uniqKey="Bracard S" first="Serge" last="Bracard">Serge Bracard</name><affiliation><nlm:affiliation>CHRU NANCY, Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Broderick, Joseph" sort="Broderick, Joseph" uniqKey="Broderick J" first="Joseph" last="Broderick">Joseph Broderick</name><affiliation><nlm:affiliation>University of Cincinnati, Cincinnati, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Campbell, Bruce" sort="Campbell, Bruce" uniqKey="Campbell B" first="Bruce" last="Campbell">Bruce Campbell</name><affiliation><nlm:affiliation>Royal Melbourne Hospital, Parkville, Vic., Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ciccone, Alfonso" sort="Ciccone, Alfonso" uniqKey="Ciccone A" first="Alfonso" last="Ciccone">Alfonso Ciccone</name><affiliation><nlm:affiliation>Department of Cardio-Thoracic-Vascular, Azienda Ospedaliera Carlo Poma Mantova, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Davalos, Antoni" sort="Davalos, Antoni" uniqKey="Davalos A" first="Antoni" last="Dávalos">Antoni Dávalos</name><affiliation><nlm:affiliation>Department of Neurology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Davis, Stephen M" sort="Davis, Stephen M" uniqKey="Davis S" first="Stephen M" last="Davis">Stephen M. Davis</name><affiliation><nlm:affiliation>Department of Neurology, The Royal Melbourne Hospital, Parkville, Vic., Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Demchuk, Andrew" sort="Demchuk, Andrew" uniqKey="Demchuk A" first="Andrew" last="Demchuk">Andrew Demchuk</name><affiliation><nlm:affiliation>University of Calgary, Calgary, AB, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Diener, Hans Christoph" sort="Diener, Hans Christoph" uniqKey="Diener H" first="Hans-Christoph" last="Diener">Hans-Christoph Diener</name><affiliation><nlm:affiliation>Department of Neurology, University Hospital Essen, Essen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Dippel, Diederik" sort="Dippel, Diederik" uniqKey="Dippel D" first="Diederik" last="Dippel">Diederik Dippel</name><affiliation><nlm:affiliation>Department of Neurology, Erasmus MC, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Donnan, Geoffrey A" sort="Donnan, Geoffrey A" uniqKey="Donnan G" first="Geoffrey A" last="Donnan">Geoffrey A. Donnan</name><affiliation><nlm:affiliation>Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Vic., Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Fiehler, Jens" sort="Fiehler, Jens" uniqKey="Fiehler J" first="Jens" last="Fiehler">Jens Fiehler</name><affiliation><nlm:affiliation>Department of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Fiorella, David" sort="Fiorella, David" uniqKey="Fiorella D" first="David" last="Fiorella">David Fiorella</name><affiliation><nlm:affiliation>Stony Brook University, Stony Brook, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Goyal, Mayank" sort="Goyal, Mayank" uniqKey="Goyal M" first="Mayank" last="Goyal">Mayank Goyal</name><affiliation><nlm:affiliation>Hotchkiss Brain Institute, Calgary, AB, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Hacke, Werner" sort="Hacke, Werner" uniqKey="Hacke W" first="Werner" last="Hacke">Werner Hacke</name><affiliation><nlm:affiliation>Department of Neurology, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hill, Michael D" sort="Hill, Michael D" uniqKey="Hill M" first="Michael D" last="Hill">Michael D. Hill</name><affiliation><nlm:affiliation>Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Jahan, Reza" sort="Jahan, Reza" uniqKey="Jahan R" first="Reza" last="Jahan">Reza Jahan</name><affiliation><nlm:affiliation>Department of Radiology, UCLA, Los Angeles, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jauch, Edward" sort="Jauch, Edward" uniqKey="Jauch E" first="Edward" last="Jauch">Edward Jauch</name><affiliation><nlm:affiliation>Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jovin, Tudor" sort="Jovin, Tudor" uniqKey="Jovin T" first="Tudor" last="Jovin">Tudor Jovin</name><affiliation><nlm:affiliation>Department of Neurology, UPMC Stroke Institute, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kidwell, Chelsea S" sort="Kidwell, Chelsea S" uniqKey="Kidwell C" first="Chelsea S" last="Kidwell">Chelsea S. Kidwell</name><affiliation><nlm:affiliation>Department of Neurology, University of Arizona, Tucson, AZ, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Liebeskind, David" sort="Liebeskind, David" uniqKey="Liebeskind D" first="David" last="Liebeskind">David Liebeskind</name><affiliation><nlm:affiliation>UCLA Stroke Center, Los Angeles, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Majoie, Charles B" sort="Majoie, Charles B" uniqKey="Majoie C" first="Charles B" last="Majoie">Charles B. Majoie</name><affiliation><nlm:affiliation>Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Martins, Sheila Cristina Ouriques" sort="Martins, Sheila Cristina Ouriques" uniqKey="Martins S" first="Sheila Cristina Ouriques" last="Martins">Sheila Cristina Ouriques Martins</name><affiliation><nlm:affiliation>Department of Neurology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Mitchell, Peter" sort="Mitchell, Peter" uniqKey="Mitchell P" first="Peter" last="Mitchell">Peter Mitchell</name><affiliation><nlm:affiliation>Melbourne Health, University of Melbourne and the Royal Melbourne Subject, Melbourne, Vic., Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mocco, J" sort="Mocco, J" uniqKey="Mocco J" first="J" last="Mocco">J. Mocco</name><affiliation><nlm:affiliation>Mount Sinai Hospital, New York, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Muir, Keith W" sort="Muir, Keith W" uniqKey="Muir K" first="Keith W" last="Muir">Keith W. Muir</name><affiliation><nlm:affiliation>Centre for Stroke and Brain Imaging Research, Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Nogueira, Raul" sort="Nogueira, Raul" uniqKey="Nogueira R" first="Raul" last="Nogueira">Raul Nogueira</name><affiliation><nlm:affiliation>Massachussetts General Hospital, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Saver, Jeffrey L" sort="Saver, Jeffrey L" uniqKey="Saver J" first="Jeffrey L" last="Saver">Jeffrey L. Saver</name><affiliation><nlm:affiliation>Department of Neurology, UCLA, Los Angeles, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Schonewille, Wouter J" sort="Schonewille, Wouter J" uniqKey="Schonewille W" first="Wouter J" last="Schonewille">Wouter J. Schonewille</name><affiliation><nlm:affiliation>Department of Neurology, St. Antonius Hospital, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Siddiqui, Adnan H" sort="Siddiqui, Adnan H" uniqKey="Siddiqui A" first="Adnan H" last="Siddiqui">Adnan H. Siddiqui</name><affiliation><nlm:affiliation>University of Buffalo, Buffalo, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Thomalla, Gotz" sort="Thomalla, Gotz" uniqKey="Thomalla G" first="Götz" last="Thomalla">Götz Thomalla</name><affiliation><nlm:affiliation>Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Tomsick, Thomas A" sort="Tomsick, Thomas A" uniqKey="Tomsick T" first="Thomas A" last="Tomsick">Thomas A. Tomsick</name><affiliation><nlm:affiliation>University of Cincinnati, Cincinnati, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Turk, Aquilla S" sort="Turk, Aquilla S" uniqKey="Turk A" first="Aquilla S" last="Turk">Aquilla S. Turk</name><affiliation><nlm:affiliation>Medical University of South Carolina, Charleston, SC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="White, Philip" sort="White, Philip" uniqKey="White P" first="Philip" last="White">Philip White</name><affiliation><nlm:affiliation>Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Zaidat, Osama" sort="Zaidat, Osama" uniqKey="Zaidat O" first="Osama" last="Zaidat">Osama Zaidat</name><affiliation><nlm:affiliation>Medical College of Wisconsin, Milwaukee, WI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lees, Kennedy R" sort="Lees, Kennedy R" uniqKey="Lees K" first="Kennedy R" last="Lees">Kennedy R. Lees</name><affiliation><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author></analytic><series><title level="j">International journal of stroke : official journal of the International Stroke Society</title><idno type="eISSN">1747-4949</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term><term>Cooperative Behavior</term><term>Endovascular Procedures (methods)</term><term>Female</term><term>Humans</term><term>Male</term><term>Meta-Analysis as Topic</term><term>Randomized Controlled Trials as Topic</term><term>Stroke (therapy)</term><term>Tissue Plasminogen Activator (therapeutic use)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Tissue Plasminogen Activator</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Endovascular Procedures</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Stroke</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Cooperative Behavior</term><term>Female</term><term>Humans</term><term>Male</term><term>Meta-Analysis as Topic</term><term>Randomized Controlled Trials as Topic</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Endovascular treatment has been shown to restore blood flow effectively. Second-generation medical devices such as stent retrievers are now showing overwhelming efficacy in clinical trials, particularly in conjunction with intravenous recombinant tissue plasminogen activator.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26352438</PMID><DateCreated><Year>2015</Year><Month>10</Month><Day>27</Day></DateCreated><DateCompleted><Year>2016</Year><Month>07</Month><Day>29</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1747-4949</ISSN><JournalIssue CitedMedium="Internet"><Volume>10 Suppl A100</Volume><PubDate><Year>2015</Year><Month>Oct</Month></PubDate></JournalIssue><Title>International journal of stroke : official journal of the International Stroke Society</Title><ISOAbbreviation>Int J Stroke</ISOAbbreviation></Journal><ArticleTitle>A collaborative sequential meta-analysis of individual patient data from randomized trials of endovascular therapy and tPA vs. tPA alone for acute ischemic stroke: ThRombEctomy And tPA (TREAT) analysis: statistical analysis plan for a sequential meta-analysis performed within the VISTA-Endovascular collaboration.</ArticleTitle><Pagination><MedlinePgn>136-44</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/ijs.12622</ELocationID><Abstract><AbstractText Label="RATIONALE" NlmCategory="BACKGROUND">Endovascular treatment has been shown to restore blood flow effectively. Second-generation medical devices such as stent retrievers are now showing overwhelming efficacy in clinical trials, particularly in conjunction with intravenous recombinant tissue plasminogen activator.</AbstractText><AbstractText Label="AIMS AND DESIGN" NlmCategory="OBJECTIVE">This statistical analysis plan utilizing a novel, sequential approach describes a prospective, individual patient data analysis of endovascular therapy in conjunction with intravenous recombinant tissue plasminogen activator agreed upon by the Thrombectomy and Tissue Plasminogen Activator Collaborative Group.</AbstractText><AbstractText Label="STUDY OUTCOMES" NlmCategory="RESULTS">This protocol will specify the primary outcome for efficacy, as 'favorable' outcome defined by the ordinal distribution of the modified Rankin Scale measured at three-months poststroke, but with modified Rankin Scales 5 and 6 collapsed into a single category. The primary analysis will aim to answer the questions: 'what is the treatment effect of endovascular therapy with intravenous recombinant tissue plasminogen activator compared to intravenous tissue plasminogen activator alone on full scale modified Rankin Scale at 3 months?' and 'to what extent do key patient characteristics influence the treatment effect of endovascular therapy?'. Key secondary outcomes include effect of endovascular therapy on death within 90 days; analyses of modified Rankin Scale using dichotomized methods; and effects of endovascular therapy on symptomatic intracranial hemorrhage. Several secondary analyses will be considered as well as expanding patient cohorts to intravenous recombinant tissue plasminogen activator-ineligible patients, should data allow.</AbstractText><AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">This collaborative meta-analysis of individual participant data from randomized trials of endovascular therapy vs. control in conjunction with intravenous thrombolysis will demonstrate the efficacy and generalizability of endovascular therapy with intravenous thrombolysis as a concomitant medication.</AbstractText><CopyrightInformation>© 2015 World Stroke Organization.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>MacIsaac</LastName><ForeName>Rachael L</ForeName><Initials>RL</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khatri</LastName><ForeName>Pooja</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>University of Cincinnati, Cincinnati, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bendszus</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Heidelberg University Hospital, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bracard</LastName><ForeName>Serge</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>CHRU NANCY, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Broderick</LastName><ForeName>Joseph</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>University of Cincinnati, Cincinnati, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Campbell</LastName><ForeName>Bruce</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Royal Melbourne Hospital, Parkville, Vic., Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ciccone</LastName><ForeName>Alfonso</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Cardio-Thoracic-Vascular, Azienda Ospedaliera Carlo Poma Mantova, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dávalos</LastName><ForeName>Antoni</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Davis</LastName><ForeName>Stephen M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Department of Neurology, The Royal Melbourne Hospital, Parkville, Vic., Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Demchuk</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>University of Calgary, Calgary, AB, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Diener</LastName><ForeName>Hans-Christoph</ForeName><Initials>HC</Initials><AffiliationInfo><Affiliation>Department of Neurology, University Hospital Essen, Essen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dippel</LastName><ForeName>Diederik</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Neurology, Erasmus MC, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Donnan</LastName><ForeName>Geoffrey A</ForeName><Initials>GA</Initials><AffiliationInfo><Affiliation>Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Vic., Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fiehler</LastName><ForeName>Jens</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fiorella</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Stony Brook University, Stony Brook, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goyal</LastName><ForeName>Mayank</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Hotchkiss Brain Institute, Calgary, AB, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hacke</LastName><ForeName>Werner</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Neurology, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hill</LastName><ForeName>Michael D</ForeName><Initials>MD</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-6269-1543</Identifier><AffiliationInfo><Affiliation>Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jahan</LastName><ForeName>Reza</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Radiology, UCLA, Los Angeles, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jauch</LastName><ForeName>Edward</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jovin</LastName><ForeName>Tudor</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Neurology, UPMC Stroke Institute, University of Pittsburgh, Pittsburgh, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kidwell</LastName><ForeName>Chelsea S</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Arizona, Tucson, AZ, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Imaging, University of Arizona, Tucson, AZ, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liebeskind</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>UCLA Stroke Center, Los Angeles, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Majoie</LastName><ForeName>Charles B</ForeName><Initials>CB</Initials><AffiliationInfo><Affiliation>Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martins</LastName><ForeName>Sheila Cristina Ouriques</ForeName><Initials>SC</Initials><AffiliationInfo><Affiliation>Department of Neurology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mitchell</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Melbourne Health, University of Melbourne and the Royal Melbourne Subject, Melbourne, Vic., Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mocco</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Mount Sinai Hospital, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muir</LastName><ForeName>Keith W</ForeName><Initials>KW</Initials><AffiliationInfo><Affiliation>Centre for Stroke and Brain Imaging Research, Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nogueira</LastName><ForeName>Raul</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Massachussetts General Hospital, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saver</LastName><ForeName>Jeffrey L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Department of Neurology, UCLA, Los Angeles, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schonewille</LastName><ForeName>Wouter J</ForeName><Initials>WJ</Initials><AffiliationInfo><Affiliation>Department of Neurology, St. Antonius Hospital, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Siddiqui</LastName><ForeName>Adnan H</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>University of Buffalo, Buffalo, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thomalla</LastName><ForeName>Götz</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tomsick</LastName><ForeName>Thomas A</ForeName><Initials>TA</Initials><AffiliationInfo><Affiliation>University of Cincinnati, Cincinnati, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Turk</LastName><ForeName>Aquilla S</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Medical University of South Carolina, Charleston, SC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>White</LastName><ForeName>Philip</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zaidat</LastName><ForeName>Osama</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Medical College of Wisconsin, Milwaukee, WI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lees</LastName><ForeName>Kennedy R</ForeName><Initials>KR</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>VISTA Endovascular collaboration</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>HTA/14/08/47</GrantID><Agency>Department of Health</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>09</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Int J Stroke</MedlineTA><NlmUniqueID>101274068</NlmUniqueID><ISSNLinking>1747-4930</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>EC 3.4.21.68</RegistryNumber><NameOfSubstance UI="D010959">Tissue Plasminogen Activator</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003299" MajorTopicYN="Y">Cooperative Behavior</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057510" MajorTopicYN="N">Endovascular Procedures</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015201" MajorTopicYN="Y">Meta-Analysis as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020521" MajorTopicYN="N">Stroke</DescriptorName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010959" MajorTopicYN="N">Tissue Plasminogen Activator</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">acute</Keyword><Keyword MajorTopicYN="N">endovascular</Keyword><Keyword MajorTopicYN="N">ischemic stroke</Keyword><Keyword MajorTopicYN="N">meta-analysis</Keyword><Keyword MajorTopicYN="N">protocols</Keyword><Keyword MajorTopicYN="N">treatment</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>05</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>07</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>9</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>9</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26352438</ArticleId><ArticleId IdType="doi">10.1111/ijs.12622</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler 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