Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation.
Identifieur interne : 002525 ( PubMed/Curation ); précédent : 002524; suivant : 002526Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation.
Auteurs : Alerie Guzman De La Fuente [Royaume-Uni] ; Oihana Errea [Royaume-Uni] ; Peter Van Wijngaarden [Australie] ; Ginez A. Gonzalez [Royaume-Uni] ; Christophe Kerninon [France] ; Andrew A. Jarjour [Royaume-Uni] ; Hilary J. Lewis [Royaume-Uni] ; Clare A. Jones [Royaume-Uni] ; Brahim Nait-Oumesmar [France] ; Chao Zhao [Royaume-Uni] ; Jeffrey K. Huang [États-Unis] ; Charles Ffrench-Constant [Royaume-Uni] ; Robin J M. Franklin [Royaume-Uni]Source :
- The Journal of cell biology [ 1540-8140 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Animaux, Cellules souches (cytologie), Différenciation cellulaire, Femelle, Gaine de myéline (), Humains, Liaison aux protéines, Lignage cellulaire, Multimérisation de protéines, Mâle, Oligodendroglie (cytologie), Rat Sprague-Dawley, Rats, Récepteur X des rétinoïdes type gamma (métabolisme), Récepteur calcitriol (métabolisme), Régulation de l'expression des gènes, Sclérose en plaques (métabolisme), Sujet âgé, Sujet âgé de 80 ans ou plus, Transduction du signal, Vitamine D (métabolisme).
- MESH :
- cytologie : Cellules souches, Oligodendroglie.
- métabolisme : Récepteur X des rétinoïdes type gamma, Récepteur calcitriol, Sclérose en plaques, Vitamine D.
- Adulte, Adulte d'âge moyen, Animaux, Différenciation cellulaire, Femelle, Gaine de myéline, Humains, Liaison aux protéines, Lignage cellulaire, Multimérisation de protéines, Mâle, Rat Sprague-Dawley, Rats, Régulation de l'expression des gènes, Sujet âgé, Sujet âgé de 80 ans ou plus, Transduction du signal.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Animals, Cell Differentiation, Cell Lineage, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Multiple Sclerosis (metabolism), Myelin Sheath (chemistry), Oligodendroglia (cytology), Protein Binding, Protein Multimerization, Rats, Rats, Sprague-Dawley, Receptors, Calcitriol (metabolism), Retinoid X Receptor gamma (metabolism), Signal Transduction, Stem Cells (cytology), Vitamin D (metabolism).
- MESH :
- chemical , metabolism : Receptors, Calcitriol, Retinoid X Receptor gamma, Vitamin D.
- chemistry : Myelin Sheath.
- cytology : Oligodendroglia, Stem Cells.
- metabolism : Multiple Sclerosis.
- Adult, Aged, Aged, 80 and over, Animals, Cell Differentiation, Cell Lineage, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Protein Binding, Protein Multimerization, Rats, Rats, Sprague-Dawley, Signal Transduction.
Abstract
The mechanisms regulating differentiation of oligodendrocyte (OLG) progenitor cells (OPCs) into mature OLGs are key to understanding myelination and remyelination. Signaling via the retinoid X receptor γ (RXR-γ) has been shown to be a positive regulator of OPC differentiation. However, the nuclear receptor (NR) binding partner of RXR-γ has not been established. In this study we show that RXR-γ binds to several NRs in OPCs and OLGs, one of which is vitamin D receptor (VDR). Using pharmacological and knockdown approaches we show that RXR-VDR signaling induces OPC differentiation and that VDR agonist vitamin D enhances OPC differentiation. We also show expression of VDR in OLG lineage cells in multiple sclerosis. Our data reveal a role for vitamin D in the regenerative component of demyelinating disease and identify a new target for remyelination medicines.
DOI: 10.1083/jcb.201505119
PubMed: 26644513
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<author><name sortKey="Zhao, Chao" sort="Zhao, Chao" uniqKey="Zhao C" first="Chao" last="Zhao">Chao Zhao</name>
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<term>Aged</term>
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<term>Cell Differentiation</term>
<term>Cell Lineage</term>
<term>Female</term>
<term>Gene Expression Regulation</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multiple Sclerosis (metabolism)</term>
<term>Myelin Sheath (chemistry)</term>
<term>Oligodendroglia (cytology)</term>
<term>Protein Binding</term>
<term>Protein Multimerization</term>
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<term>Receptors, Calcitriol (metabolism)</term>
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<term>Adulte d'âge moyen</term>
<term>Animaux</term>
<term>Cellules souches (cytologie)</term>
<term>Différenciation cellulaire</term>
<term>Femelle</term>
<term>Gaine de myéline ()</term>
<term>Humains</term>
<term>Liaison aux protéines</term>
<term>Lignage cellulaire</term>
<term>Multimérisation de protéines</term>
<term>Mâle</term>
<term>Oligodendroglie (cytologie)</term>
<term>Rat Sprague-Dawley</term>
<term>Rats</term>
<term>Récepteur X des rétinoïdes type gamma (métabolisme)</term>
<term>Récepteur calcitriol (métabolisme)</term>
<term>Régulation de l'expression des gènes</term>
<term>Sclérose en plaques (métabolisme)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Transduction du signal</term>
<term>Vitamine D (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, Calcitriol</term>
<term>Retinoid X Receptor gamma</term>
<term>Vitamin D</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Myelin Sheath</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules souches</term>
<term>Oligodendroglie</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Oligodendroglia</term>
<term>Stem Cells</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Multiple Sclerosis</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Récepteur X des rétinoïdes type gamma</term>
<term>Récepteur calcitriol</term>
<term>Sclérose en plaques</term>
<term>Vitamine D</term>
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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Animals</term>
<term>Cell Differentiation</term>
<term>Cell Lineage</term>
<term>Female</term>
<term>Gene Expression Regulation</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Protein Binding</term>
<term>Protein Multimerization</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Animaux</term>
<term>Différenciation cellulaire</term>
<term>Femelle</term>
<term>Gaine de myéline</term>
<term>Humains</term>
<term>Liaison aux protéines</term>
<term>Lignage cellulaire</term>
<term>Multimérisation de protéines</term>
<term>Mâle</term>
<term>Rat Sprague-Dawley</term>
<term>Rats</term>
<term>Régulation de l'expression des gènes</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
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<front><div type="abstract" xml:lang="en">The mechanisms regulating differentiation of oligodendrocyte (OLG) progenitor cells (OPCs) into mature OLGs are key to understanding myelination and remyelination. Signaling via the retinoid X receptor γ (RXR-γ) has been shown to be a positive regulator of OPC differentiation. However, the nuclear receptor (NR) binding partner of RXR-γ has not been established. In this study we show that RXR-γ binds to several NRs in OPCs and OLGs, one of which is vitamin D receptor (VDR). Using pharmacological and knockdown approaches we show that RXR-VDR signaling induces OPC differentiation and that VDR agonist vitamin D enhances OPC differentiation. We also show expression of VDR in OLG lineage cells in multiple sclerosis. Our data reveal a role for vitamin D in the regenerative component of demyelinating disease and identify a new target for remyelination medicines.</div>
</front>
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<Day>22</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1540-8140</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>211</Volume>
<Issue>5</Issue>
<PubDate><Year>2015</Year>
<Month>Dec</Month>
<Day>07</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of cell biology</Title>
<ISOAbbreviation>J. Cell Biol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation.</ArticleTitle>
<Pagination><MedlinePgn>975-85</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1083/jcb.201505119</ELocationID>
<Abstract><AbstractText>The mechanisms regulating differentiation of oligodendrocyte (OLG) progenitor cells (OPCs) into mature OLGs are key to understanding myelination and remyelination. Signaling via the retinoid X receptor γ (RXR-γ) has been shown to be a positive regulator of OPC differentiation. However, the nuclear receptor (NR) binding partner of RXR-γ has not been established. In this study we show that RXR-γ binds to several NRs in OPCs and OLGs, one of which is vitamin D receptor (VDR). Using pharmacological and knockdown approaches we show that RXR-VDR signaling induces OPC differentiation and that VDR agonist vitamin D enhances OPC differentiation. We also show expression of VDR in OLG lineage cells in multiple sclerosis. Our data reveal a role for vitamin D in the regenerative component of demyelinating disease and identify a new target for remyelination medicines.</AbstractText>
<CopyrightInformation>© 2015 de la Fuente et al.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>de la Fuente</LastName>
<ForeName>Alerie Guzman</ForeName>
<Initials>AG</Initials>
<AffiliationInfo><Affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Errea</LastName>
<ForeName>Oihana</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van Wijngaarden</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK Centre for Eye Research, University of Melbourne, Royal Victorian Eye and Ear Hospital, Victoria 3002, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gonzalez</LastName>
<ForeName>Ginez A</ForeName>
<Initials>GA</Initials>
<AffiliationInfo><Affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kerninon</LastName>
<ForeName>Christophe</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Institut du Cerveau et de la Moelle Epinière, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1127, 75651 Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jarjour</LastName>
<ForeName>Andrew A</ForeName>
<Initials>AA</Initials>
<AffiliationInfo><Affiliation>Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lewis</LastName>
<ForeName>Hilary J</ForeName>
<Initials>HJ</Initials>
<AffiliationInfo><Affiliation>AstraZeneca, Great Abington CB21 6GH, England, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jones</LastName>
<ForeName>Clare A</ForeName>
<Initials>CA</Initials>
<AffiliationInfo><Affiliation>AstraZeneca, Great Abington CB21 6GH, England, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nait-Oumesmar</LastName>
<ForeName>Brahim</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Institut du Cerveau et de la Moelle Epinière, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1127, 75651 Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhao</LastName>
<ForeName>Chao</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Jeffrey K</ForeName>
<Initials>JK</Initials>
<AffiliationInfo><Affiliation>Department of Biology, Georgetown University, Washington, DC 20057.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>ffrench-Constant</LastName>
<ForeName>Charles</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Franklin</LastName>
<ForeName>Robin J M</ForeName>
<Initials>RJ</Initials>
<AffiliationInfo><Affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK rjf1000@cam.ac.uk.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>104783</GrantID>
<Agency>Wellcome Trust</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>MC_PC_12012</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><Agency>Wellcome Trust</Agency>
<Country>United Kingdom</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Cell Biol</MedlineTA>
<NlmUniqueID>0375356</NlmUniqueID>
<ISSNLinking>0021-9525</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018167">Receptors, Calcitriol</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D047491">Retinoid X Receptor gamma</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C579457">VDR protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>1406-16-2</RegistryNumber>
<NameOfSubstance UI="D014807">Vitamin D</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Expert Rev Neurother. 2013 Dec;13(12 Suppl):3-9</RefSource>
<PMID Version="1">24289836</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Sep 15;967:195-202</RefSource>
<PMID Version="1">25125396</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2006 Jan 4;26(1):328-32</RefSource>
<PMID Version="1">16399703</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Exp Mol Pathol. 2015 Apr;98(2):240-5</RefSource>
<PMID Version="1">25681066</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mult Scler. 2005 Jun;11(3):266-71</RefSource>
<PMID Version="1">15957505</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Glia. 1998 Mar;22(3):282-94</RefSource>
<PMID Version="1">9482214</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurosci Res. 2004 Oct 15;78(2):157-66</RefSource>
<PMID Version="1">15378614</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2000 Jun;47(6):707-17</RefSource>
<PMID Version="1">10852536</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Drug Discov. 2007 Oct;6(10):811-20</RefSource>
<PMID Version="1">17906643</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Glia. 2012 Jan;60(1):1-12</RefSource>
<PMID Version="1">21858876</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Neurosci. 2008 Sep;11(9):1024-34</RefSource>
<PMID Version="1">19160500</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Neurosci. 2011 Jan;14(1):45-53</RefSource>
<PMID Version="1">21131950</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Neurosci. 2013 Sep;16(9):1211-8</RefSource>
<PMID Version="1">23872599</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7861-4</RefSource>
<PMID Version="1">8755567</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Drug Discov. 2015 Apr;14(4):294</RefSource>
<PMID Version="1">25743082</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Glia. 1999 Feb 1;25(3):216-28</RefSource>
<PMID Version="1">9932868</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Brain. 2011 Jul;134(Pt 7):1882-900</RefSource>
<PMID Version="1">21507994</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>JAMA. 2006 Dec 20;296(23):2832-8</RefSource>
<PMID Version="1">17179460</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neuropathol Exp Neurol. 2013 Feb;72(2):91-105</RefSource>
<PMID Version="1">23334593</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Acta Neuropathol. 2003 May;105(5):438-48</RefSource>
<PMID Version="1">12677443</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 2008 Feb;79(2):152-7</RefSource>
<PMID Version="1">17578859</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell Mol Neurobiol. 2010 Mar;30(2):289-99</RefSource>
<PMID Version="1">19768531</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Cell Biol. 1980 Jun;85(3):890-902</RefSource>
<PMID Version="1">6248568</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell Stem Cell. 2010 Jun 4;6(6):578-90</RefSource>
<PMID Version="1">20569695</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2014 Sep 3;34(36):11929-47</RefSource>
<PMID Version="1">25186741</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Glia. 2000 Jul;31(1):59-68</RefSource>
<PMID Version="1">10816607</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Exp Cell Res. 2002 Jul 1;277(1):1-14</RefSource>
<PMID Version="1">12061813</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurosci. 2008 Nov;9(11):839-55</RefSource>
<PMID Version="1">18931697</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Med. 2015 Aug;12(8):e1001866</RefSource>
<PMID Version="1">26305103</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Alzheimers Dis. 2009;17(3):703-17</RefSource>
<PMID Version="1">19433889</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>APMIS. 2014 Dec;122(12):1178-86</RefSource>
<PMID Version="1">24862867</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Exp Neurol. 2011 Jul;230(1):138-48</RefSource>
<PMID Version="1">21515259</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 2009 Jun 2;72(22):1914-21</RefSource>
<PMID Version="1">19487649</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2013;8(5):e65034</RefSource>
<PMID Version="1">23741446</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 1991 Mar;87(3):1103-7</RefSource>
<PMID Version="1">1705564</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2000 Jun 2;275(22):16506-12</RefSource>
<PMID Version="1">10748178</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neuroophthalmol. 2015 Jun;35(2):194-200</RefSource>
<PMID Version="1">25985434</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Chem Neuroanat. 2005 Jan;29(1):21-30</RefSource>
<PMID Version="1">15589699</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Glia. 2000 Jan 1;29(1):102</RefSource>
<PMID Version="1">10594929</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Exp Neurol. 1999 Dec;160(2):333-47</RefSource>
<PMID Version="1">10619551</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Brain. 2008 Jul;131(Pt 7):1749-58</RefSource>
<PMID Version="1">18515322</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2011;6(10):e26262</RefSource>
<PMID Version="1">22028844</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biochim Biophys Acta. 2012 Jan;1821(1):57-69</RefSource>
<PMID Version="1">21515403</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Eur Arch Otorhinolaryngol. 2015 Oct;272(10):2815-23</RefSource>
<PMID Version="1">25261104</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurol. 2012 Nov 5;8(11):602-12</RefSource>
<PMID Version="1">23045241</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2002 Apr 1;22(7):2451-9</RefSource>
<PMID Version="1">11923409</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 1989 Dec 25;264(36):21760-9</RefSource>
<PMID Version="1">2480956</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 1998 Jan 15;18(2):601-9</RefSource>
<PMID Version="1">9425002</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2015 Jan 7;35(1):4-20</RefSource>
<PMID Version="1">25568099</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Cell Neurosci. 2004 Feb;25(2):252-62</RefSource>
<PMID Version="1">15019942</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neuropathol Exp Neurol. 1996 Aug;55(8):904-14</RefSource>
<PMID Version="1">8759780</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 2004 Jan 13;62(1):60-5</RefSource>
<PMID Version="1">14718698</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Rapid Commun Mass Spectrom. 2013 Jan 15;27(1):200-6</RefSource>
<PMID Version="1">23239334</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurosci Res. 2003 Apr 1;72(1):1-11</RefSource>
<PMID Version="1">12645074</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002454" MajorTopicYN="N">Cell Differentiation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019070" MajorTopicYN="N">Cell Lineage</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005786" MajorTopicYN="Y">Gene Expression Regulation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009103" MajorTopicYN="N">Multiple Sclerosis</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009186" MajorTopicYN="N">Myelin Sheath</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009836" MajorTopicYN="N">Oligodendroglia</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011485" MajorTopicYN="N">Protein Binding</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055503" MajorTopicYN="N">Protein Multimerization</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018167" MajorTopicYN="N">Receptors, Calcitriol</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D047491" MajorTopicYN="N">Retinoid X Receptor gamma</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013234" MajorTopicYN="N">Stem Cells</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014807" MajorTopicYN="N">Vitamin D</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<OtherID Source="NLM">PMC4674280</OtherID>
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<Day>9</Day>
<Hour>6</Hour>
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<PubMedPubDate PubStatus="medline"><Year>2016</Year>
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