Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation.
Identifieur interne : 002594 ( PubMed/Corpus ); précédent : 002593; suivant : 002595Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation.
Auteurs : Alerie Guzman De La Fuente ; Oihana Errea ; Peter Van Wijngaarden ; Ginez A. Gonzalez ; Christophe Kerninon ; Andrew A. Jarjour ; Hilary J. Lewis ; Clare A. Jones ; Brahim Nait-Oumesmar ; Chao Zhao ; Jeffrey K. Huang ; Charles Ffrench-Constant ; Robin J M. FranklinSource :
- The Journal of cell biology [ 1540-8140 ] ; 2015.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Animals, Cell Differentiation, Cell Lineage, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Multiple Sclerosis (metabolism), Myelin Sheath (chemistry), Oligodendroglia (cytology), Protein Binding, Protein Multimerization, Rats, Rats, Sprague-Dawley, Receptors, Calcitriol (metabolism), Retinoid X Receptor gamma (metabolism), Signal Transduction, Stem Cells (cytology), Vitamin D (metabolism).
- MESH :
- chemical , metabolism : Receptors, Calcitriol, Retinoid X Receptor gamma, Vitamin D.
- chemistry : Myelin Sheath.
- cytology : Oligodendroglia, Stem Cells.
- metabolism : Multiple Sclerosis.
- Adult, Aged, Aged, 80 and over, Animals, Cell Differentiation, Cell Lineage, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Protein Binding, Protein Multimerization, Rats, Rats, Sprague-Dawley, Signal Transduction.
Abstract
The mechanisms regulating differentiation of oligodendrocyte (OLG) progenitor cells (OPCs) into mature OLGs are key to understanding myelination and remyelination. Signaling via the retinoid X receptor γ (RXR-γ) has been shown to be a positive regulator of OPC differentiation. However, the nuclear receptor (NR) binding partner of RXR-γ has not been established. In this study we show that RXR-γ binds to several NRs in OPCs and OLGs, one of which is vitamin D receptor (VDR). Using pharmacological and knockdown approaches we show that RXR-VDR signaling induces OPC differentiation and that VDR agonist vitamin D enhances OPC differentiation. We also show expression of VDR in OLG lineage cells in multiple sclerosis. Our data reveal a role for vitamin D in the regenerative component of demyelinating disease and identify a new target for remyelination medicines.
DOI: 10.1083/jcb.201505119
PubMed: 26644513
Links to Exploration step
pubmed:26644513Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation.</title><author><name sortKey="De La Fuente, Alerie Guzman" sort="De La Fuente, Alerie Guzman" uniqKey="De La Fuente A" first="Alerie Guzman" last="De La Fuente">Alerie Guzman De La Fuente</name><affiliation><nlm:affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Errea, Oihana" sort="Errea, Oihana" uniqKey="Errea O" first="Oihana" last="Errea">Oihana Errea</name><affiliation><nlm:affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Van Wijngaarden, Peter" sort="Van Wijngaarden, Peter" uniqKey="Van Wijngaarden P" first="Peter" last="Van Wijngaarden">Peter Van Wijngaarden</name><affiliation><nlm:affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK Centre for Eye Research, University of Melbourne, Royal Victorian Eye and Ear Hospital, Victoria 3002, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Gonzalez, Ginez A" sort="Gonzalez, Ginez A" uniqKey="Gonzalez G" first="Ginez A" last="Gonzalez">Ginez A. Gonzalez</name><affiliation><nlm:affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kerninon, Christophe" sort="Kerninon, Christophe" uniqKey="Kerninon C" first="Christophe" last="Kerninon">Christophe Kerninon</name><affiliation><nlm:affiliation>Institut du Cerveau et de la Moelle Epinière, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1127, 75651 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Jarjour, Andrew A" sort="Jarjour, Andrew A" uniqKey="Jarjour A" first="Andrew A" last="Jarjour">Andrew A. Jarjour</name><affiliation><nlm:affiliation>Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lewis, Hilary J" sort="Lewis, Hilary J" uniqKey="Lewis H" first="Hilary J" last="Lewis">Hilary J. Lewis</name><affiliation><nlm:affiliation>AstraZeneca, Great Abington CB21 6GH, England, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Jones, Clare A" sort="Jones, Clare A" uniqKey="Jones C" first="Clare A" last="Jones">Clare A. Jones</name><affiliation><nlm:affiliation>AstraZeneca, Great Abington CB21 6GH, England, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Nait Oumesmar, Brahim" sort="Nait Oumesmar, Brahim" uniqKey="Nait Oumesmar B" first="Brahim" last="Nait-Oumesmar">Brahim Nait-Oumesmar</name><affiliation><nlm:affiliation>Institut du Cerveau et de la Moelle Epinière, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1127, 75651 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, Chao" sort="Zhao, Chao" uniqKey="Zhao C" first="Chao" last="Zhao">Chao Zhao</name><affiliation><nlm:affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Jeffrey K" sort="Huang, Jeffrey K" uniqKey="Huang J" first="Jeffrey K" last="Huang">Jeffrey K. Huang</name><affiliation><nlm:affiliation>Department of Biology, Georgetown University, Washington, DC 20057.</nlm:affiliation></affiliation></author><author><name sortKey="Ffrench Constant, Charles" sort="Ffrench Constant, Charles" uniqKey="Ffrench Constant C" first="Charles" last="Ffrench-Constant">Charles Ffrench-Constant</name><affiliation><nlm:affiliation>Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Franklin, Robin J M" sort="Franklin, Robin J M" uniqKey="Franklin R" first="Robin J M" last="Franklin">Robin J M. Franklin</name><affiliation><nlm:affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK rjf1000@cam.ac.uk.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26644513</idno><idno type="pmid">26644513</idno><idno type="doi">10.1083/jcb.201505119</idno><idno type="wicri:Area/PubMed/Corpus">002594</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002594</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation.</title><author><name sortKey="De La Fuente, Alerie Guzman" sort="De La Fuente, Alerie Guzman" uniqKey="De La Fuente A" first="Alerie Guzman" last="De La Fuente">Alerie Guzman De La Fuente</name><affiliation><nlm:affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Errea, Oihana" sort="Errea, Oihana" uniqKey="Errea O" first="Oihana" last="Errea">Oihana Errea</name><affiliation><nlm:affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Van Wijngaarden, Peter" sort="Van Wijngaarden, Peter" uniqKey="Van Wijngaarden P" first="Peter" last="Van Wijngaarden">Peter Van Wijngaarden</name><affiliation><nlm:affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK Centre for Eye Research, University of Melbourne, Royal Victorian Eye and Ear Hospital, Victoria 3002, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Gonzalez, Ginez A" sort="Gonzalez, Ginez A" uniqKey="Gonzalez G" first="Ginez A" last="Gonzalez">Ginez A. Gonzalez</name><affiliation><nlm:affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kerninon, Christophe" sort="Kerninon, Christophe" uniqKey="Kerninon C" first="Christophe" last="Kerninon">Christophe Kerninon</name><affiliation><nlm:affiliation>Institut du Cerveau et de la Moelle Epinière, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1127, 75651 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Jarjour, Andrew A" sort="Jarjour, Andrew A" uniqKey="Jarjour A" first="Andrew A" last="Jarjour">Andrew A. Jarjour</name><affiliation><nlm:affiliation>Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lewis, Hilary J" sort="Lewis, Hilary J" uniqKey="Lewis H" first="Hilary J" last="Lewis">Hilary J. Lewis</name><affiliation><nlm:affiliation>AstraZeneca, Great Abington CB21 6GH, England, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Jones, Clare A" sort="Jones, Clare A" uniqKey="Jones C" first="Clare A" last="Jones">Clare A. Jones</name><affiliation><nlm:affiliation>AstraZeneca, Great Abington CB21 6GH, England, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Nait Oumesmar, Brahim" sort="Nait Oumesmar, Brahim" uniqKey="Nait Oumesmar B" first="Brahim" last="Nait-Oumesmar">Brahim Nait-Oumesmar</name><affiliation><nlm:affiliation>Institut du Cerveau et de la Moelle Epinière, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1127, 75651 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, Chao" sort="Zhao, Chao" uniqKey="Zhao C" first="Chao" last="Zhao">Chao Zhao</name><affiliation><nlm:affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Jeffrey K" sort="Huang, Jeffrey K" uniqKey="Huang J" first="Jeffrey K" last="Huang">Jeffrey K. Huang</name><affiliation><nlm:affiliation>Department of Biology, Georgetown University, Washington, DC 20057.</nlm:affiliation></affiliation></author><author><name sortKey="Ffrench Constant, Charles" sort="Ffrench Constant, Charles" uniqKey="Ffrench Constant C" first="Charles" last="Ffrench-Constant">Charles Ffrench-Constant</name><affiliation><nlm:affiliation>Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Franklin, Robin J M" sort="Franklin, Robin J M" uniqKey="Franklin R" first="Robin J M" last="Franklin">Robin J M. Franklin</name><affiliation><nlm:affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK rjf1000@cam.ac.uk.</nlm:affiliation></affiliation></author></analytic><series><title level="j">The Journal of cell biology</title><idno type="eISSN">1540-8140</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Animals</term><term>Cell Differentiation</term><term>Cell Lineage</term><term>Female</term><term>Gene Expression Regulation</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multiple Sclerosis (metabolism)</term><term>Myelin Sheath (chemistry)</term><term>Oligodendroglia (cytology)</term><term>Protein Binding</term><term>Protein Multimerization</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Receptors, Calcitriol (metabolism)</term><term>Retinoid X Receptor gamma (metabolism)</term><term>Signal Transduction</term><term>Stem Cells (cytology)</term><term>Vitamin D (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, Calcitriol</term><term>Retinoid X Receptor gamma</term><term>Vitamin D</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Myelin Sheath</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Oligodendroglia</term><term>Stem Cells</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Multiple Sclerosis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Animals</term><term>Cell Differentiation</term><term>Cell Lineage</term><term>Female</term><term>Gene Expression Regulation</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Protein Binding</term><term>Protein Multimerization</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Signal Transduction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The mechanisms regulating differentiation of oligodendrocyte (OLG) progenitor cells (OPCs) into mature OLGs are key to understanding myelination and remyelination. Signaling via the retinoid X receptor γ (RXR-γ) has been shown to be a positive regulator of OPC differentiation. However, the nuclear receptor (NR) binding partner of RXR-γ has not been established. In this study we show that RXR-γ binds to several NRs in OPCs and OLGs, one of which is vitamin D receptor (VDR). Using pharmacological and knockdown approaches we show that RXR-VDR signaling induces OPC differentiation and that VDR agonist vitamin D enhances OPC differentiation. We also show expression of VDR in OLG lineage cells in multiple sclerosis. Our data reveal a role for vitamin D in the regenerative component of demyelinating disease and identify a new target for remyelination medicines.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26644513</PMID><DateCreated><Year>2015</Year><Month>12</Month><Day>08</Day></DateCreated><DateCompleted><Year>2016</Year><Month>04</Month><Day>05</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1540-8140</ISSN><JournalIssue CitedMedium="Internet"><Volume>211</Volume><Issue>5</Issue><PubDate><Year>2015</Year><Month>Dec</Month><Day>07</Day></PubDate></JournalIssue><Title>The Journal of cell biology</Title><ISOAbbreviation>J. Cell Biol.</ISOAbbreviation></Journal><ArticleTitle>Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation.</ArticleTitle><Pagination><MedlinePgn>975-85</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1083/jcb.201505119</ELocationID><Abstract><AbstractText>The mechanisms regulating differentiation of oligodendrocyte (OLG) progenitor cells (OPCs) into mature OLGs are key to understanding myelination and remyelination. Signaling via the retinoid X receptor γ (RXR-γ) has been shown to be a positive regulator of OPC differentiation. However, the nuclear receptor (NR) binding partner of RXR-γ has not been established. In this study we show that RXR-γ binds to several NRs in OPCs and OLGs, one of which is vitamin D receptor (VDR). Using pharmacological and knockdown approaches we show that RXR-VDR signaling induces OPC differentiation and that VDR agonist vitamin D enhances OPC differentiation. We also show expression of VDR in OLG lineage cells in multiple sclerosis. Our data reveal a role for vitamin D in the regenerative component of demyelinating disease and identify a new target for remyelination medicines.</AbstractText><CopyrightInformation>© 2015 de la Fuente et al.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>de la Fuente</LastName><ForeName>Alerie Guzman</ForeName><Initials>AG</Initials><AffiliationInfo><Affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Errea</LastName><ForeName>Oihana</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Wijngaarden</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK Centre for Eye Research, University of Melbourne, Royal Victorian Eye and Ear Hospital, Victoria 3002, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gonzalez</LastName><ForeName>Ginez A</ForeName><Initials>GA</Initials><AffiliationInfo><Affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kerninon</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institut du Cerveau et de la Moelle Epinière, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1127, 75651 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jarjour</LastName><ForeName>Andrew A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lewis</LastName><ForeName>Hilary J</ForeName><Initials>HJ</Initials><AffiliationInfo><Affiliation>AstraZeneca, Great Abington CB21 6GH, England, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jones</LastName><ForeName>Clare A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>AstraZeneca, Great Abington CB21 6GH, England, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nait-Oumesmar</LastName><ForeName>Brahim</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Institut du Cerveau et de la Moelle Epinière, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1127, 75651 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Chao</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Jeffrey K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Department of Biology, Georgetown University, Washington, DC 20057.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>ffrench-Constant</LastName><ForeName>Charles</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Franklin</LastName><ForeName>Robin J M</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK rjf1000@cam.ac.uk.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>104783</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MC_PC_12012</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Cell Biol</MedlineTA><NlmUniqueID>0375356</NlmUniqueID><ISSNLinking>0021-9525</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018167">Receptors, Calcitriol</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D047491">Retinoid X Receptor gamma</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C579457">VDR protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>1406-16-2</RegistryNumber><NameOfSubstance UI="D014807">Vitamin D</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Expert Rev Neurother. 2013 Dec;13(12 Suppl):3-9</RefSource><PMID Version="1">24289836</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Sep 15;967:195-202</RefSource><PMID Version="1">25125396</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2006 Jan 4;26(1):328-32</RefSource><PMID Version="1">16399703</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Mol Pathol. 2015 Apr;98(2):240-5</RefSource><PMID Version="1">25681066</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mult Scler. 2005 Jun;11(3):266-71</RefSource><PMID Version="1">15957505</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Glia. 1998 Mar;22(3):282-94</RefSource><PMID Version="1">9482214</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci Res. 2004 Oct 15;78(2):157-66</RefSource><PMID Version="1">15378614</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2000 Jun;47(6):707-17</RefSource><PMID Version="1">10852536</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Drug Discov. 2007 Oct;6(10):811-20</RefSource><PMID Version="1">17906643</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Glia. 2012 Jan;60(1):1-12</RefSource><PMID Version="1">21858876</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Neurosci. 2008 Sep;11(9):1024-34</RefSource><PMID Version="1">19160500</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Neurosci. 2011 Jan;14(1):45-53</RefSource><PMID Version="1">21131950</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Neurosci. 2013 Sep;16(9):1211-8</RefSource><PMID Version="1">23872599</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7861-4</RefSource><PMID Version="1">8755567</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Drug Discov. 2015 Apr;14(4):294</RefSource><PMID Version="1">25743082</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Glia. 1999 Feb 1;25(3):216-28</RefSource><PMID Version="1">9932868</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2011 Jul;134(Pt 7):1882-900</RefSource><PMID Version="1">21507994</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>JAMA. 2006 Dec 20;296(23):2832-8</RefSource><PMID Version="1">17179460</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neuropathol Exp Neurol. 2013 Feb;72(2):91-105</RefSource><PMID Version="1">23334593</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Neuropathol. 2003 May;105(5):438-48</RefSource><PMID Version="1">12677443</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 2008 Feb;79(2):152-7</RefSource><PMID Version="1">17578859</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Mol Neurobiol. 2010 Mar;30(2):289-99</RefSource><PMID Version="1">19768531</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cell Biol. 1980 Jun;85(3):890-902</RefSource><PMID Version="1">6248568</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Stem Cell. 2010 Jun 4;6(6):578-90</RefSource><PMID Version="1">20569695</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2014 Sep 3;34(36):11929-47</RefSource><PMID Version="1">25186741</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Glia. 2000 Jul;31(1):59-68</RefSource><PMID Version="1">10816607</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Cell Res. 2002 Jul 1;277(1):1-14</RefSource><PMID Version="1">12061813</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurosci. 2008 Nov;9(11):839-55</RefSource><PMID Version="1">18931697</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Med. 2015 Aug;12(8):e1001866</RefSource><PMID Version="1">26305103</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Alzheimers Dis. 2009;17(3):703-17</RefSource><PMID Version="1">19433889</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>APMIS. 2014 Dec;122(12):1178-86</RefSource><PMID Version="1">24862867</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Neurol. 2011 Jul;230(1):138-48</RefSource><PMID Version="1">21515259</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2009 Jun 2;72(22):1914-21</RefSource><PMID Version="1">19487649</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2013;8(5):e65034</RefSource><PMID Version="1">23741446</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 1991 Mar;87(3):1103-7</RefSource><PMID Version="1">1705564</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2000 Jun 2;275(22):16506-12</RefSource><PMID Version="1">10748178</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neuroophthalmol. 2015 Jun;35(2):194-200</RefSource><PMID Version="1">25985434</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Chem Neuroanat. 2005 Jan;29(1):21-30</RefSource><PMID Version="1">15589699</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Glia. 2000 Jan 1;29(1):102</RefSource><PMID Version="1">10594929</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Neurol. 1999 Dec;160(2):333-47</RefSource><PMID Version="1">10619551</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2008 Jul;131(Pt 7):1749-58</RefSource><PMID Version="1">18515322</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2011;6(10):e26262</RefSource><PMID Version="1">22028844</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochim Biophys Acta. 2012 Jan;1821(1):57-69</RefSource><PMID Version="1">21515403</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur Arch Otorhinolaryngol. 2015 Oct;272(10):2815-23</RefSource><PMID Version="1">25261104</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurol. 2012 Nov 5;8(11):602-12</RefSource><PMID Version="1">23045241</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2002 Apr 1;22(7):2451-9</RefSource><PMID Version="1">11923409</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 1989 Dec 25;264(36):21760-9</RefSource><PMID Version="1">2480956</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 1998 Jan 15;18(2):601-9</RefSource><PMID Version="1">9425002</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2015 Jan 7;35(1):4-20</RefSource><PMID Version="1">25568099</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Cell Neurosci. 2004 Feb;25(2):252-62</RefSource><PMID Version="1">15019942</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neuropathol Exp Neurol. 1996 Aug;55(8):904-14</RefSource><PMID Version="1">8759780</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2004 Jan 13;62(1):60-5</RefSource><PMID Version="1">14718698</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Rapid Commun Mass Spectrom. 2013 Jan 15;27(1):200-6</RefSource><PMID Version="1">23239334</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci Res. 2003 Apr 1;72(1):1-11</RefSource><PMID Version="1">12645074</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002454" MajorTopicYN="N">Cell Differentiation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019070" MajorTopicYN="N">Cell Lineage</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005786" MajorTopicYN="Y">Gene Expression Regulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009103" MajorTopicYN="N">Multiple Sclerosis</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009186" MajorTopicYN="N">Myelin Sheath</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009836" MajorTopicYN="N">Oligodendroglia</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011485" MajorTopicYN="N">Protein Binding</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055503" MajorTopicYN="N">Protein Multimerization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018167" MajorTopicYN="N">Receptors, Calcitriol</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D047491" MajorTopicYN="N">Retinoid X Receptor gamma</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013234" MajorTopicYN="N">Stem Cells</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014807" MajorTopicYN="N">Vitamin D</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4674280</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>12</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>12</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>4</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26644513</ArticleId><ArticleId IdType="pii">jcb.201505119</ArticleId><ArticleId IdType="doi">10.1083/jcb.201505119</ArticleId><ArticleId IdType="pmc">PMC4674280</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002594 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 002594 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:26644513
|texte= Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:26644513" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |