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Complementarity and redundancy of IL-22-producing innate lymphoid cells.

Identifieur interne : 002241 ( PubMed/Curation ); précédent : 002240; suivant : 002242

Complementarity and redundancy of IL-22-producing innate lymphoid cells.

Auteurs : Lucille C. Rankin [Australie] ; Mathilde J H. Girard-Madoux [France] ; Cyril Seillet [Australie] ; Lisa A. Mielke [Australie] ; Yann Kerdiles [France] ; Aurore Fenis [France] ; Elisabeth Wieduwild [France] ; Tracy Putoczki [Australie] ; Stanislas Mondot [France] ; Olivier Lantz [France] ; Dieter Demon [Belgique] ; Anthony T. Papenfuss [Australie] ; Gordon K. Smyth [Australie] ; Mohamed Lamkanfi [Belgique] ; Sebastian Carotta [Australie] ; Jean-Christophe Renauld [Belgique] ; Wei Shi [Australie] ; Sabrina Carpentier [France] ; Tim Soos [États-Unis] ; Christopher Arendt [États-Unis] ; Sophie Ugolini [France] ; Nicholas D. Huntington [Australie] ; Gabrielle T. Belz [Australie] ; Eric Vivier [France]

Source :

Nature immunology [ 1529-2916 ] ; 2016.

RBID : pubmed:26595889

Descripteurs français

English descriptors

KwdEn :
- Animals, Citrobacter rodentium (immunology), Cluster Analysis, Disease Models, Animal, Enterobacteriaceae Infections (genetics), Enterobacteriaceae Infections (immunology), Enterobacteriaceae Infections (metabolism), Enterobacteriaceae Infections (mortality), Enterobacteriaceae Infections (pathology), Female, Gene Expression Profiling, Gene Expression Regulation, Homeostasis, Immunity, Innate, Interleukins (biosynthesis), Lymphocyte Subsets (immunology), Lymphocyte Subsets (metabolism), Lymphocytes (immunology), Lymphocytes (metabolism), Male, Mice, Mice, Knockout, Mice, Transgenic, Myeloid Cell Leukemia Sequence 1 Protein (deficiency), Myeloid Cell Leukemia Sequence 1 Protein (genetics), Myeloid Cell Leukemia Sequence 1 Protein (metabolism), Natural Cytotoxicity Triggering Receptor 1 (metabolism), Signal Transduction, T-Box Domain Proteins (deficiency), T-Box Domain Proteins (genetics), T-Box Domain Proteins (metabolism), Transcriptome.
MESH :
- chemical , biosynthesis : Interleukins.
- chemical , deficiency : Myeloid Cell Leukemia Sequence 1 Protein, T-Box Domain Proteins.
- genetics : Enterobacteriaceae Infections, Myeloid Cell Leukemia Sequence 1 Protein, T-Box Domain Proteins.
- immunology : Citrobacter rodentium, Enterobacteriaceae Infections, Lymphocyte Subsets, Lymphocytes.
- metabolism : Enterobacteriaceae Infections, Lymphocyte Subsets, Lymphocytes, Myeloid Cell Leukemia Sequence 1 Protein, Natural Cytotoxicity Triggering Receptor 1, T-Box Domain Proteins.
- mortality : Enterobacteriaceae Infections.
- pathology : Enterobacteriaceae Infections.
- Animals, Cluster Analysis, Disease Models, Animal, Female, Gene Expression Profiling, Gene Expression Regulation, Homeostasis, Immunity, Innate, Male, Mice, Mice, Knockout, Mice, Transgenic, Signal Transduction, Transcriptome.

Abstract

Intestinal T cells and group 3 innate lymphoid cells (ILC3 cells) control the composition of the microbiota and gut immune responses. Within the gut, ILC3 subsets coexist that either express or lack the natural cytoxicity receptor (NCR) NKp46. We identified here the transcriptional signature associated with the transcription factor T-bet-dependent differentiation of NCR(-) ILC3 cells into NCR(+) ILC3 cells. Contrary to the prevailing view, we found by conditional deletion of the key ILC3 genes Stat3, Il22, Tbx21 and Mcl1 that NCR(+) ILC3 cells were redundant for the control of mouse colonic infection with Citrobacter rodentium in the presence of T cells. However, NCR(+) ILC3 cells were essential for cecal homeostasis. Our data show that interplay between intestinal ILC3 cells and adaptive lymphocytes results in robust complementary failsafe mechanisms that ensure gut homeostasis.

DOI: 10.1038/ni.3332
PubMed: 26595889

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<author><name sortKey="Demon, Dieter" sort="Demon, Dieter" uniqKey="Demon D" first="Dieter" last="Demon">Dieter Demon</name>
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<author><name sortKey="Carotta, Sebastian" sort="Carotta, Sebastian" uniqKey="Carotta S" first="Sebastian" last="Carotta">Sebastian Carotta</name>
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<author><name sortKey="Renauld, Jean Christophe" sort="Renauld, Jean Christophe" uniqKey="Renauld J" first="Jean-Christophe" last="Renauld">Jean-Christophe Renauld</name>
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<author><name sortKey="Shi, Wei" sort="Shi, Wei" uniqKey="Shi W" first="Wei" last="Shi">Wei Shi</name>
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<author><name sortKey="Carpentier, Sabrina" sort="Carpentier, Sabrina" uniqKey="Carpentier S" first="Sabrina" last="Carpentier">Sabrina Carpentier</name>
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<author><name sortKey="Soos, Tim" sort="Soos, Tim" uniqKey="Soos T" first="Tim" last="Soos">Tim Soos</name>
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<author><name sortKey="Ugolini, Sophie" sort="Ugolini, Sophie" uniqKey="Ugolini S" first="Sophie" last="Ugolini">Sophie Ugolini</name>
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<author><name sortKey="Huntington, Nicholas D" sort="Huntington, Nicholas D" uniqKey="Huntington N" first="Nicholas D" last="Huntington">Nicholas D. Huntington</name>
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<author><name sortKey="Belz, Gabrielle T" sort="Belz, Gabrielle T" uniqKey="Belz G" first="Gabrielle T" last="Belz">Gabrielle T. Belz</name>
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<author><name sortKey="Vivier, Eric" sort="Vivier, Eric" uniqKey="Vivier E" first="Eric" last="Vivier">Eric Vivier</name>
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<country xml:lang="fr">France</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Complementarity and redundancy of IL-22-producing innate lymphoid cells.</title>
<author><name sortKey="Rankin, Lucille C" sort="Rankin, Lucille C" uniqKey="Rankin L" first="Lucille C" last="Rankin">Lucille C. Rankin</name>
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</author>
<author><name sortKey="Girard Madoux, Mathilde J H" sort="Girard Madoux, Mathilde J H" uniqKey="Girard Madoux M" first="Mathilde J H" last="Girard-Madoux">Mathilde J H. Girard-Madoux</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Seillet, Cyril" sort="Seillet, Cyril" uniqKey="Seillet C" first="Cyril" last="Seillet">Cyril Seillet</name>
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<author><name sortKey="Mielke, Lisa A" sort="Mielke, Lisa A" uniqKey="Mielke L" first="Lisa A" last="Mielke">Lisa A. Mielke</name>
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<author><name sortKey="Kerdiles, Yann" sort="Kerdiles, Yann" uniqKey="Kerdiles Y" first="Yann" last="Kerdiles">Yann Kerdiles</name>
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<author><name sortKey="Fenis, Aurore" sort="Fenis, Aurore" uniqKey="Fenis A" first="Aurore" last="Fenis">Aurore Fenis</name>
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<author><name sortKey="Wieduwild, Elisabeth" sort="Wieduwild, Elisabeth" uniqKey="Wieduwild E" first="Elisabeth" last="Wieduwild">Elisabeth Wieduwild</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Putoczki, Tracy" sort="Putoczki, Tracy" uniqKey="Putoczki T" first="Tracy" last="Putoczki">Tracy Putoczki</name>
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<author><name sortKey="Mondot, Stanislas" sort="Mondot, Stanislas" uniqKey="Mondot S" first="Stanislas" last="Mondot">Stanislas Mondot</name>
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<author><name sortKey="Lantz, Olivier" sort="Lantz, Olivier" uniqKey="Lantz O" first="Olivier" last="Lantz">Olivier Lantz</name>
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<author><name sortKey="Demon, Dieter" sort="Demon, Dieter" uniqKey="Demon D" first="Dieter" last="Demon">Dieter Demon</name>
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<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Inflammation Research Center, VIB, Ghent University, Ghent</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Papenfuss, Anthony T" sort="Papenfuss, Anthony T" uniqKey="Papenfuss A" first="Anthony T" last="Papenfuss">Anthony T. Papenfuss</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smyth, Gordon K" sort="Smyth, Gordon K" uniqKey="Smyth G" first="Gordon K" last="Smyth">Gordon K. Smyth</name>
<affiliation wicri:level="1"><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lamkanfi, Mohamed" sort="Lamkanfi, Mohamed" uniqKey="Lamkanfi M" first="Mohamed" last="Lamkanfi">Mohamed Lamkanfi</name>
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<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Inflammation Research Center, VIB, Ghent University, Ghent</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Carotta, Sebastian" sort="Carotta, Sebastian" uniqKey="Carotta S" first="Sebastian" last="Carotta">Sebastian Carotta</name>
<affiliation wicri:level="1"><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Renauld, Jean Christophe" sort="Renauld, Jean Christophe" uniqKey="Renauld J" first="Jean-Christophe" last="Renauld">Jean-Christophe Renauld</name>
<affiliation wicri:level="1"><nlm:affiliation>Ludwig Institute for Cancer Research and Experimental Medicine Unit, Catholic University of Louvain, Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Ludwig Institute for Cancer Research and Experimental Medicine Unit, Catholic University of Louvain, Brussels</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shi, Wei" sort="Shi, Wei" uniqKey="Shi W" first="Wei" last="Shi">Wei Shi</name>
<affiliation wicri:level="1"><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Carpentier, Sabrina" sort="Carpentier, Sabrina" uniqKey="Carpentier S" first="Sabrina" last="Carpentier">Sabrina Carpentier</name>
<affiliation wicri:level="1"><nlm:affiliation>MI-mAbs consortium Aix-Marseille University, Centre d'Immunologie de Marseille-Luminy, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>MI-mAbs consortium Aix-Marseille University, Centre d'Immunologie de Marseille-Luminy, Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Soos, Tim" sort="Soos, Tim" uniqKey="Soos T" first="Tim" last="Soos">Tim Soos</name>
<affiliation wicri:level="1"><nlm:affiliation>Bioinnovation, SANOFI, Boston, Massachusetts, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Bioinnovation, SANOFI, Boston, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arendt, Christopher" sort="Arendt, Christopher" uniqKey="Arendt C" first="Christopher" last="Arendt">Christopher Arendt</name>
<affiliation wicri:level="1"><nlm:affiliation>Bioinnovation, SANOFI, Boston, Massachusetts, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Bioinnovation, SANOFI, Boston, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ugolini, Sophie" sort="Ugolini, Sophie" uniqKey="Ugolini S" first="Sophie" last="Ugolini">Sophie Ugolini</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huntington, Nicholas D" sort="Huntington, Nicholas D" uniqKey="Huntington N" first="Nicholas D" last="Huntington">Nicholas D. Huntington</name>
<affiliation wicri:level="1"><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Belz, Gabrielle T" sort="Belz, Gabrielle T" uniqKey="Belz G" first="Gabrielle T" last="Belz">Gabrielle T. Belz</name>
<affiliation wicri:level="1"><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vivier, Eric" sort="Vivier, Eric" uniqKey="Vivier E" first="Eric" last="Vivier">Eric Vivier</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature immunology</title>
<idno type="eISSN">1529-2916</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Citrobacter rodentium (immunology)</term>
<term>Cluster Analysis</term>
<term>Disease Models, Animal</term>
<term>Enterobacteriaceae Infections (genetics)</term>
<term>Enterobacteriaceae Infections (immunology)</term>
<term>Enterobacteriaceae Infections (metabolism)</term>
<term>Enterobacteriaceae Infections (mortality)</term>
<term>Enterobacteriaceae Infections (pathology)</term>
<term>Female</term>
<term>Gene Expression Profiling</term>
<term>Gene Expression Regulation</term>
<term>Homeostasis</term>
<term>Immunity, Innate</term>
<term>Interleukins (biosynthesis)</term>
<term>Lymphocyte Subsets (immunology)</term>
<term>Lymphocyte Subsets (metabolism)</term>
<term>Lymphocytes (immunology)</term>
<term>Lymphocytes (metabolism)</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Knockout</term>
<term>Mice, Transgenic</term>
<term>Myeloid Cell Leukemia Sequence 1 Protein (deficiency)</term>
<term>Myeloid Cell Leukemia Sequence 1 Protein (genetics)</term>
<term>Myeloid Cell Leukemia Sequence 1 Protein (metabolism)</term>
<term>Natural Cytotoxicity Triggering Receptor 1 (metabolism)</term>
<term>Signal Transduction</term>
<term>T-Box Domain Proteins (deficiency)</term>
<term>T-Box Domain Proteins (genetics)</term>
<term>T-Box Domain Proteins (metabolism)</term>
<term>Transcriptome</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term>
<term>Analyse de regroupements</term>
<term>Animaux</term>
<term>Citrobacter rodentium (immunologie)</term>
<term>Femelle</term>
<term>Homéostasie</term>
<term>Immunité innée</term>
<term>Infections à Enterobacteriaceae (anatomopathologie)</term>
<term>Infections à Enterobacteriaceae (génétique)</term>
<term>Infections à Enterobacteriaceae (immunologie)</term>
<term>Infections à Enterobacteriaceae (mortalité)</term>
<term>Infections à Enterobacteriaceae (métabolisme)</term>
<term>Interleukines (biosynthèse)</term>
<term>Lymphocytes (immunologie)</term>
<term>Lymphocytes (métabolisme)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Protéine Mcl-1 (déficit)</term>
<term>Protéine Mcl-1 (génétique)</term>
<term>Protéine Mcl-1 (métabolisme)</term>
<term>Protéines à domaine boîte-T (déficit)</term>
<term>Protéines à domaine boîte-T (génétique)</term>
<term>Protéines à domaine boîte-T (métabolisme)</term>
<term>Récepteur-1 de déclenchement de cytotoxicité naturelle (métabolisme)</term>
<term>Régulation de l'expression des gènes</term>
<term>Souris</term>
<term>Souris knockout</term>
<term>Souris transgéniques</term>
<term>Sous-populations de lymphocytes (immunologie)</term>
<term>Sous-populations de lymphocytes (métabolisme)</term>
<term>Transcriptome</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interleukins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Myeloid Cell Leukemia Sequence 1 Protein</term>
<term>T-Box Domain Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à Enterobacteriaceae</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Interleukines</term>
</keywords>
<keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Protéine Mcl-1</term>
<term>Protéines à domaine boîte-T</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Enterobacteriaceae Infections</term>
<term>Myeloid Cell Leukemia Sequence 1 Protein</term>
<term>T-Box Domain Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Infections à Enterobacteriaceae</term>
<term>Protéine Mcl-1</term>
<term>Protéines à domaine boîte-T</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Citrobacter rodentium</term>
<term>Infections à Enterobacteriaceae</term>
<term>Lymphocytes</term>
<term>Sous-populations de lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Citrobacter rodentium</term>
<term>Enterobacteriaceae Infections</term>
<term>Lymphocyte Subsets</term>
<term>Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Enterobacteriaceae Infections</term>
<term>Lymphocyte Subsets</term>
<term>Lymphocytes</term>
<term>Myeloid Cell Leukemia Sequence 1 Protein</term>
<term>Natural Cytotoxicity Triggering Receptor 1</term>
<term>T-Box Domain Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Enterobacteriaceae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à Enterobacteriaceae</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Infections à Enterobacteriaceae</term>
<term>Lymphocytes</term>
<term>Protéine Mcl-1</term>
<term>Protéines à domaine boîte-T</term>
<term>Récepteur-1 de déclenchement de cytotoxicité naturelle</term>
<term>Sous-populations de lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Enterobacteriaceae Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cluster Analysis</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Gene Expression Profiling</term>
<term>Gene Expression Regulation</term>
<term>Homeostasis</term>
<term>Immunity, Innate</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Knockout</term>
<term>Mice, Transgenic</term>
<term>Signal Transduction</term>
<term>Transcriptome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term>
<term>Analyse de regroupements</term>
<term>Animaux</term>
<term>Femelle</term>
<term>Homéostasie</term>
<term>Immunité innée</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Régulation de l'expression des gènes</term>
<term>Souris</term>
<term>Souris knockout</term>
<term>Souris transgéniques</term>
<term>Transcriptome</term>
<term>Transduction du signal</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Intestinal T cells and group 3 innate lymphoid cells (ILC3 cells) control the composition of the microbiota and gut immune responses. Within the gut, ILC3 subsets coexist that either express or lack the natural cytoxicity receptor (NCR) NKp46. We identified here the transcriptional signature associated with the transcription factor T-bet-dependent differentiation of NCR(-) ILC3 cells into NCR(+) ILC3 cells. Contrary to the prevailing view, we found by conditional deletion of the key ILC3 genes Stat3, Il22, Tbx21 and Mcl1 that NCR(+) ILC3 cells were redundant for the control of mouse colonic infection with Citrobacter rodentium in the presence of T cells. However, NCR(+) ILC3 cells were essential for cecal homeostasis. Our data show that interplay between intestinal ILC3 cells and adaptive lymphocytes results in robust complementary failsafe mechanisms that ensure gut homeostasis.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26595889</PMID>
<DateCreated><Year>2016</Year>
<Month>01</Month>
<Day>20</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>06</Month>
<Day>06</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1529-2916</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>17</Volume>
<Issue>2</Issue>
<PubDate><Year>2016</Year>
<Month>Feb</Month>
</PubDate>
</JournalIssue>
<Title>Nature immunology</Title>
<ISOAbbreviation>Nat. Immunol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Complementarity and redundancy of IL-22-producing innate lymphoid cells.</ArticleTitle>
<Pagination><MedlinePgn>179-86</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/ni.3332</ELocationID>
<Abstract><AbstractText>Intestinal T cells and group 3 innate lymphoid cells (ILC3 cells) control the composition of the microbiota and gut immune responses. Within the gut, ILC3 subsets coexist that either express or lack the natural cytoxicity receptor (NCR) NKp46. We identified here the transcriptional signature associated with the transcription factor T-bet-dependent differentiation of NCR(-) ILC3 cells into NCR(+) ILC3 cells. Contrary to the prevailing view, we found by conditional deletion of the key ILC3 genes Stat3, Il22, Tbx21 and Mcl1 that NCR(+) ILC3 cells were redundant for the control of mouse colonic infection with Citrobacter rodentium in the presence of T cells. However, NCR(+) ILC3 cells were essential for cecal homeostasis. Our data show that interplay between intestinal ILC3 cells and adaptive lymphocytes results in robust complementary failsafe mechanisms that ensure gut homeostasis.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rankin</LastName>
<ForeName>Lucille C</ForeName>
<Initials>LC</Initials>
<AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Girard-Madoux</LastName>
<ForeName>Mathilde J H</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Seillet</LastName>
<ForeName>Cyril</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mielke</LastName>
<ForeName>Lisa A</ForeName>
<Initials>LA</Initials>
<AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kerdiles</LastName>
<ForeName>Yann</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fenis</LastName>
<ForeName>Aurore</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wieduwild</LastName>
<ForeName>Elisabeth</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Putoczki</LastName>
<ForeName>Tracy</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mondot</LastName>
<ForeName>Stanislas</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Labex Milieu Intérieur, Institut Pasteur, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lantz</LastName>
<ForeName>Olivier</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Laboratoire d'Immunologie and Inserm U932, Institut Curie, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Demon</LastName>
<ForeName>Dieter</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Inflammation Research Center, VIB, Ghent University, Ghent, Belgium.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Biochemistry, Ghent University, Ghent, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Papenfuss</LastName>
<ForeName>Anthony T</ForeName>
<Initials>AT</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-1102-8506</Identifier>
<AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Smyth</LastName>
<ForeName>Gordon K</ForeName>
<Initials>GK</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0001-9221-2892</Identifier>
<AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Mathematics and Statistics, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lamkanfi</LastName>
<ForeName>Mohamed</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-4898-7663</Identifier>
<AffiliationInfo><Affiliation>Inflammation Research Center, VIB, Ghent University, Ghent, Belgium.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Biochemistry, Ghent University, Ghent, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Carotta</LastName>
<ForeName>Sebastian</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Boehringer-Ingelheim RCV, Vienna, Austria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Renauld</LastName>
<ForeName>Jean-Christophe</ForeName>
<Initials>JC</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-1736-2131</Identifier>
<AffiliationInfo><Affiliation>Ludwig Institute for Cancer Research and Experimental Medicine Unit, Catholic University of Louvain, Brussels, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shi</LastName>
<ForeName>Wei</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Computing and Information Systems, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Carpentier</LastName>
<ForeName>Sabrina</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>MI-mAbs consortium Aix-Marseille University, Centre d'Immunologie de Marseille-Luminy, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Soos</LastName>
<ForeName>Tim</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Bioinnovation, SANOFI, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Arendt</LastName>
<ForeName>Christopher</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Bioinnovation, SANOFI, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ugolini</LastName>
<ForeName>Sophie</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huntington</LastName>
<ForeName>Nicholas D</ForeName>
<Initials>ND</Initials>
<AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Belz</LastName>
<ForeName>Gabrielle T</ForeName>
<Initials>GT</Initials>
<AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vivier</LastName>
<ForeName>Eric</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Immunologie, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>268537</GrantID>
<Agency>European Research Council</Agency>
<Country>International</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>11</Month>
<Day>30</Day>
</ArticleDate>
</Article>
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   |texte=   Complementarity and redundancy of IL-22-producing innate lymphoid cells.
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Complementarity and redundancy of IL-22-producing innate lymphoid cells.

Complementarity and redundancy of IL-22-producing innate lymphoid cells.

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