Complementarity and redundancy of IL-22-producing innate lymphoid cells.
Identifieur interne : 002267 ( PubMed/Corpus ); précédent : 002266; suivant : 002268Complementarity and redundancy of IL-22-producing innate lymphoid cells.
Auteurs : Lucille C. Rankin ; Mathilde J H. Girard-Madoux ; Cyril Seillet ; Lisa A. Mielke ; Yann Kerdiles ; Aurore Fenis ; Elisabeth Wieduwild ; Tracy Putoczki ; Stanislas Mondot ; Olivier Lantz ; Dieter Demon ; Anthony T. Papenfuss ; Gordon K. Smyth ; Mohamed Lamkanfi ; Sebastian Carotta ; Jean-Christophe Renauld ; Wei Shi ; Sabrina Carpentier ; Tim Soos ; Christopher Arendt ; Sophie Ugolini ; Nicholas D. Huntington ; Gabrielle T. Belz ; Eric VivierSource :
- Nature immunology [ 1529-2916 ] ; 2016.
English descriptors
- KwdEn :
- Animals, Citrobacter rodentium (immunology), Cluster Analysis, Disease Models, Animal, Enterobacteriaceae Infections (genetics), Enterobacteriaceae Infections (immunology), Enterobacteriaceae Infections (metabolism), Enterobacteriaceae Infections (mortality), Enterobacteriaceae Infections (pathology), Female, Gene Expression Profiling, Gene Expression Regulation, Homeostasis, Immunity, Innate, Interleukins (biosynthesis), Lymphocyte Subsets (immunology), Lymphocyte Subsets (metabolism), Lymphocytes (immunology), Lymphocytes (metabolism), Male, Mice, Mice, Knockout, Mice, Transgenic, Myeloid Cell Leukemia Sequence 1 Protein (deficiency), Myeloid Cell Leukemia Sequence 1 Protein (genetics), Myeloid Cell Leukemia Sequence 1 Protein (metabolism), Natural Cytotoxicity Triggering Receptor 1 (metabolism), Signal Transduction, T-Box Domain Proteins (deficiency), T-Box Domain Proteins (genetics), T-Box Domain Proteins (metabolism), Transcriptome.
- MESH :
- chemical , biosynthesis : Interleukins.
- chemical , deficiency : Myeloid Cell Leukemia Sequence 1 Protein, T-Box Domain Proteins.
- genetics : Enterobacteriaceae Infections, Myeloid Cell Leukemia Sequence 1 Protein, T-Box Domain Proteins.
- immunology : Citrobacter rodentium, Enterobacteriaceae Infections, Lymphocyte Subsets, Lymphocytes.
- metabolism : Enterobacteriaceae Infections, Lymphocyte Subsets, Lymphocytes, Myeloid Cell Leukemia Sequence 1 Protein, Natural Cytotoxicity Triggering Receptor 1, T-Box Domain Proteins.
- mortality : Enterobacteriaceae Infections.
- pathology : Enterobacteriaceae Infections.
- Animals, Cluster Analysis, Disease Models, Animal, Female, Gene Expression Profiling, Gene Expression Regulation, Homeostasis, Immunity, Innate, Male, Mice, Mice, Knockout, Mice, Transgenic, Signal Transduction, Transcriptome.
Abstract
Intestinal T cells and group 3 innate lymphoid cells (ILC3 cells) control the composition of the microbiota and gut immune responses. Within the gut, ILC3 subsets coexist that either express or lack the natural cytoxicity receptor (NCR) NKp46. We identified here the transcriptional signature associated with the transcription factor T-bet-dependent differentiation of NCR(-) ILC3 cells into NCR(+) ILC3 cells. Contrary to the prevailing view, we found by conditional deletion of the key ILC3 genes Stat3, Il22, Tbx21 and Mcl1 that NCR(+) ILC3 cells were redundant for the control of mouse colonic infection with Citrobacter rodentium in the presence of T cells. However, NCR(+) ILC3 cells were essential for cecal homeostasis. Our data show that interplay between intestinal ILC3 cells and adaptive lymphocytes results in robust complementary failsafe mechanisms that ensure gut homeostasis.
DOI: 10.1038/ni.3332
PubMed: 26595889
Links to Exploration step
pubmed:26595889Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Complementarity and redundancy of IL-22-producing innate lymphoid cells.</title><author><name sortKey="Rankin, Lucille C" sort="Rankin, Lucille C" uniqKey="Rankin L" first="Lucille C" last="Rankin">Lucille C. Rankin</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Girard Madoux, Mathilde J H" sort="Girard Madoux, Mathilde J H" uniqKey="Girard Madoux M" first="Mathilde J H" last="Girard-Madoux">Mathilde J H. Girard-Madoux</name><affiliation><nlm:affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Seillet, Cyril" sort="Seillet, Cyril" uniqKey="Seillet C" first="Cyril" last="Seillet">Cyril Seillet</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mielke, Lisa A" sort="Mielke, Lisa A" uniqKey="Mielke L" first="Lisa A" last="Mielke">Lisa A. Mielke</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Kerdiles, Yann" sort="Kerdiles, Yann" uniqKey="Kerdiles Y" first="Yann" last="Kerdiles">Yann Kerdiles</name><affiliation><nlm:affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fenis, Aurore" sort="Fenis, Aurore" uniqKey="Fenis A" first="Aurore" last="Fenis">Aurore Fenis</name><affiliation><nlm:affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Wieduwild, Elisabeth" sort="Wieduwild, Elisabeth" uniqKey="Wieduwild E" first="Elisabeth" last="Wieduwild">Elisabeth Wieduwild</name><affiliation><nlm:affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Putoczki, Tracy" sort="Putoczki, Tracy" uniqKey="Putoczki T" first="Tracy" last="Putoczki">Tracy Putoczki</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mondot, Stanislas" sort="Mondot, Stanislas" uniqKey="Mondot S" first="Stanislas" last="Mondot">Stanislas Mondot</name><affiliation><nlm:affiliation>Labex Milieu Intérieur, Institut Pasteur, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lantz, Olivier" sort="Lantz, Olivier" uniqKey="Lantz O" first="Olivier" last="Lantz">Olivier Lantz</name><affiliation><nlm:affiliation>Laboratoire d'Immunologie and Inserm U932, Institut Curie, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Demon, Dieter" sort="Demon, Dieter" uniqKey="Demon D" first="Dieter" last="Demon">Dieter Demon</name><affiliation><nlm:affiliation>Inflammation Research Center, VIB, Ghent University, Ghent, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Papenfuss, Anthony T" sort="Papenfuss, Anthony T" uniqKey="Papenfuss A" first="Anthony T" last="Papenfuss">Anthony T. Papenfuss</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Smyth, Gordon K" sort="Smyth, Gordon K" uniqKey="Smyth G" first="Gordon K" last="Smyth">Gordon K. Smyth</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Lamkanfi, Mohamed" sort="Lamkanfi, Mohamed" uniqKey="Lamkanfi M" first="Mohamed" last="Lamkanfi">Mohamed Lamkanfi</name><affiliation><nlm:affiliation>Inflammation Research Center, VIB, Ghent University, Ghent, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Carotta, Sebastian" sort="Carotta, Sebastian" uniqKey="Carotta S" first="Sebastian" last="Carotta">Sebastian Carotta</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Renauld, Jean Christophe" sort="Renauld, Jean Christophe" uniqKey="Renauld J" first="Jean-Christophe" last="Renauld">Jean-Christophe Renauld</name><affiliation><nlm:affiliation>Ludwig Institute for Cancer Research and Experimental Medicine Unit, Catholic University of Louvain, Brussels, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Shi, Wei" sort="Shi, Wei" uniqKey="Shi W" first="Wei" last="Shi">Wei Shi</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Carpentier, Sabrina" sort="Carpentier, Sabrina" uniqKey="Carpentier S" first="Sabrina" last="Carpentier">Sabrina Carpentier</name><affiliation><nlm:affiliation>MI-mAbs consortium Aix-Marseille University, Centre d'Immunologie de Marseille-Luminy, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Soos, Tim" sort="Soos, Tim" uniqKey="Soos T" first="Tim" last="Soos">Tim Soos</name><affiliation><nlm:affiliation>Bioinnovation, SANOFI, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Arendt, Christopher" sort="Arendt, Christopher" uniqKey="Arendt C" first="Christopher" last="Arendt">Christopher Arendt</name><affiliation><nlm:affiliation>Bioinnovation, SANOFI, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ugolini, Sophie" sort="Ugolini, Sophie" uniqKey="Ugolini S" first="Sophie" last="Ugolini">Sophie Ugolini</name><affiliation><nlm:affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Huntington, Nicholas D" sort="Huntington, Nicholas D" uniqKey="Huntington N" first="Nicholas D" last="Huntington">Nicholas D. Huntington</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Belz, Gabrielle T" sort="Belz, Gabrielle T" uniqKey="Belz G" first="Gabrielle T" last="Belz">Gabrielle T. Belz</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Vivier, Eric" sort="Vivier, Eric" uniqKey="Vivier E" first="Eric" last="Vivier">Eric Vivier</name><affiliation><nlm:affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26595889</idno><idno type="pmid">26595889</idno><idno type="doi">10.1038/ni.3332</idno><idno type="wicri:Area/PubMed/Corpus">002267</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002267</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Complementarity and redundancy of IL-22-producing innate lymphoid cells.</title><author><name sortKey="Rankin, Lucille C" sort="Rankin, Lucille C" uniqKey="Rankin L" first="Lucille C" last="Rankin">Lucille C. Rankin</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Girard Madoux, Mathilde J H" sort="Girard Madoux, Mathilde J H" uniqKey="Girard Madoux M" first="Mathilde J H" last="Girard-Madoux">Mathilde J H. Girard-Madoux</name><affiliation><nlm:affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Seillet, Cyril" sort="Seillet, Cyril" uniqKey="Seillet C" first="Cyril" last="Seillet">Cyril Seillet</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mielke, Lisa A" sort="Mielke, Lisa A" uniqKey="Mielke L" first="Lisa A" last="Mielke">Lisa A. Mielke</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Kerdiles, Yann" sort="Kerdiles, Yann" uniqKey="Kerdiles Y" first="Yann" last="Kerdiles">Yann Kerdiles</name><affiliation><nlm:affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fenis, Aurore" sort="Fenis, Aurore" uniqKey="Fenis A" first="Aurore" last="Fenis">Aurore Fenis</name><affiliation><nlm:affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Wieduwild, Elisabeth" sort="Wieduwild, Elisabeth" uniqKey="Wieduwild E" first="Elisabeth" last="Wieduwild">Elisabeth Wieduwild</name><affiliation><nlm:affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Putoczki, Tracy" sort="Putoczki, Tracy" uniqKey="Putoczki T" first="Tracy" last="Putoczki">Tracy Putoczki</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mondot, Stanislas" sort="Mondot, Stanislas" uniqKey="Mondot S" first="Stanislas" last="Mondot">Stanislas Mondot</name><affiliation><nlm:affiliation>Labex Milieu Intérieur, Institut Pasteur, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lantz, Olivier" sort="Lantz, Olivier" uniqKey="Lantz O" first="Olivier" last="Lantz">Olivier Lantz</name><affiliation><nlm:affiliation>Laboratoire d'Immunologie and Inserm U932, Institut Curie, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Demon, Dieter" sort="Demon, Dieter" uniqKey="Demon D" first="Dieter" last="Demon">Dieter Demon</name><affiliation><nlm:affiliation>Inflammation Research Center, VIB, Ghent University, Ghent, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Papenfuss, Anthony T" sort="Papenfuss, Anthony T" uniqKey="Papenfuss A" first="Anthony T" last="Papenfuss">Anthony T. Papenfuss</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Smyth, Gordon K" sort="Smyth, Gordon K" uniqKey="Smyth G" first="Gordon K" last="Smyth">Gordon K. Smyth</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Lamkanfi, Mohamed" sort="Lamkanfi, Mohamed" uniqKey="Lamkanfi M" first="Mohamed" last="Lamkanfi">Mohamed Lamkanfi</name><affiliation><nlm:affiliation>Inflammation Research Center, VIB, Ghent University, Ghent, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Carotta, Sebastian" sort="Carotta, Sebastian" uniqKey="Carotta S" first="Sebastian" last="Carotta">Sebastian Carotta</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Renauld, Jean Christophe" sort="Renauld, Jean Christophe" uniqKey="Renauld J" first="Jean-Christophe" last="Renauld">Jean-Christophe Renauld</name><affiliation><nlm:affiliation>Ludwig Institute for Cancer Research and Experimental Medicine Unit, Catholic University of Louvain, Brussels, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Shi, Wei" sort="Shi, Wei" uniqKey="Shi W" first="Wei" last="Shi">Wei Shi</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Carpentier, Sabrina" sort="Carpentier, Sabrina" uniqKey="Carpentier S" first="Sabrina" last="Carpentier">Sabrina Carpentier</name><affiliation><nlm:affiliation>MI-mAbs consortium Aix-Marseille University, Centre d'Immunologie de Marseille-Luminy, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Soos, Tim" sort="Soos, Tim" uniqKey="Soos T" first="Tim" last="Soos">Tim Soos</name><affiliation><nlm:affiliation>Bioinnovation, SANOFI, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Arendt, Christopher" sort="Arendt, Christopher" uniqKey="Arendt C" first="Christopher" last="Arendt">Christopher Arendt</name><affiliation><nlm:affiliation>Bioinnovation, SANOFI, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ugolini, Sophie" sort="Ugolini, Sophie" uniqKey="Ugolini S" first="Sophie" last="Ugolini">Sophie Ugolini</name><affiliation><nlm:affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Huntington, Nicholas D" sort="Huntington, Nicholas D" uniqKey="Huntington N" first="Nicholas D" last="Huntington">Nicholas D. Huntington</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Belz, Gabrielle T" sort="Belz, Gabrielle T" uniqKey="Belz G" first="Gabrielle T" last="Belz">Gabrielle T. Belz</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Vivier, Eric" sort="Vivier, Eric" uniqKey="Vivier E" first="Eric" last="Vivier">Eric Vivier</name><affiliation><nlm:affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Nature immunology</title><idno type="eISSN">1529-2916</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Citrobacter rodentium (immunology)</term><term>Cluster Analysis</term><term>Disease Models, Animal</term><term>Enterobacteriaceae Infections (genetics)</term><term>Enterobacteriaceae Infections (immunology)</term><term>Enterobacteriaceae Infections (metabolism)</term><term>Enterobacteriaceae Infections (mortality)</term><term>Enterobacteriaceae Infections (pathology)</term><term>Female</term><term>Gene Expression Profiling</term><term>Gene Expression Regulation</term><term>Homeostasis</term><term>Immunity, Innate</term><term>Interleukins (biosynthesis)</term><term>Lymphocyte Subsets (immunology)</term><term>Lymphocyte Subsets (metabolism)</term><term>Lymphocytes (immunology)</term><term>Lymphocytes (metabolism)</term><term>Male</term><term>Mice</term><term>Mice, Knockout</term><term>Mice, Transgenic</term><term>Myeloid Cell Leukemia Sequence 1 Protein (deficiency)</term><term>Myeloid Cell Leukemia Sequence 1 Protein (genetics)</term><term>Myeloid Cell Leukemia Sequence 1 Protein (metabolism)</term><term>Natural Cytotoxicity Triggering Receptor 1 (metabolism)</term><term>Signal Transduction</term><term>T-Box Domain Proteins (deficiency)</term><term>T-Box Domain Proteins (genetics)</term><term>T-Box Domain Proteins (metabolism)</term><term>Transcriptome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interleukins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Myeloid Cell Leukemia Sequence 1 Protein</term><term>T-Box Domain Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Enterobacteriaceae Infections</term><term>Myeloid Cell Leukemia Sequence 1 Protein</term><term>T-Box Domain Proteins</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Citrobacter rodentium</term><term>Enterobacteriaceae Infections</term><term>Lymphocyte Subsets</term><term>Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Enterobacteriaceae Infections</term><term>Lymphocyte Subsets</term><term>Lymphocytes</term><term>Myeloid Cell Leukemia Sequence 1 Protein</term><term>Natural Cytotoxicity Triggering Receptor 1</term><term>T-Box Domain Proteins</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Enterobacteriaceae Infections</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Enterobacteriaceae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cluster Analysis</term><term>Disease Models, Animal</term><term>Female</term><term>Gene Expression Profiling</term><term>Gene Expression Regulation</term><term>Homeostasis</term><term>Immunity, Innate</term><term>Male</term><term>Mice</term><term>Mice, Knockout</term><term>Mice, Transgenic</term><term>Signal Transduction</term><term>Transcriptome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Intestinal T cells and group 3 innate lymphoid cells (ILC3 cells) control the composition of the microbiota and gut immune responses. Within the gut, ILC3 subsets coexist that either express or lack the natural cytoxicity receptor (NCR) NKp46. We identified here the transcriptional signature associated with the transcription factor T-bet-dependent differentiation of NCR(-) ILC3 cells into NCR(+) ILC3 cells. Contrary to the prevailing view, we found by conditional deletion of the key ILC3 genes Stat3, Il22, Tbx21 and Mcl1 that NCR(+) ILC3 cells were redundant for the control of mouse colonic infection with Citrobacter rodentium in the presence of T cells. However, NCR(+) ILC3 cells were essential for cecal homeostasis. Our data show that interplay between intestinal ILC3 cells and adaptive lymphocytes results in robust complementary failsafe mechanisms that ensure gut homeostasis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26595889</PMID><DateCreated><Year>2016</Year><Month>01</Month><Day>20</Day></DateCreated><DateCompleted><Year>2016</Year><Month>06</Month><Day>06</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1529-2916</ISSN><JournalIssue CitedMedium="Internet"><Volume>17</Volume><Issue>2</Issue><PubDate><Year>2016</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Nature immunology</Title><ISOAbbreviation>Nat. Immunol.</ISOAbbreviation></Journal><ArticleTitle>Complementarity and redundancy of IL-22-producing innate lymphoid cells.</ArticleTitle><Pagination><MedlinePgn>179-86</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/ni.3332</ELocationID><Abstract><AbstractText>Intestinal T cells and group 3 innate lymphoid cells (ILC3 cells) control the composition of the microbiota and gut immune responses. Within the gut, ILC3 subsets coexist that either express or lack the natural cytoxicity receptor (NCR) NKp46. We identified here the transcriptional signature associated with the transcription factor T-bet-dependent differentiation of NCR(-) ILC3 cells into NCR(+) ILC3 cells. Contrary to the prevailing view, we found by conditional deletion of the key ILC3 genes Stat3, Il22, Tbx21 and Mcl1 that NCR(+) ILC3 cells were redundant for the control of mouse colonic infection with Citrobacter rodentium in the presence of T cells. However, NCR(+) ILC3 cells were essential for cecal homeostasis. Our data show that interplay between intestinal ILC3 cells and adaptive lymphocytes results in robust complementary failsafe mechanisms that ensure gut homeostasis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rankin</LastName><ForeName>Lucille C</ForeName><Initials>LC</Initials><AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Girard-Madoux</LastName><ForeName>Mathilde J H</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seillet</LastName><ForeName>Cyril</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mielke</LastName><ForeName>Lisa A</ForeName><Initials>LA</Initials><AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kerdiles</LastName><ForeName>Yann</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fenis</LastName><ForeName>Aurore</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wieduwild</LastName><ForeName>Elisabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Putoczki</LastName><ForeName>Tracy</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mondot</LastName><ForeName>Stanislas</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Labex Milieu Intérieur, Institut Pasteur, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lantz</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Laboratoire d'Immunologie and Inserm U932, Institut Curie, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Demon</LastName><ForeName>Dieter</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Inflammation Research Center, VIB, Ghent University, Ghent, Belgium.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biochemistry, Ghent University, Ghent, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Papenfuss</LastName><ForeName>Anthony T</ForeName><Initials>AT</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-1102-8506</Identifier><AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smyth</LastName><ForeName>Gordon K</ForeName><Initials>GK</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-9221-2892</Identifier><AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Mathematics and Statistics, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lamkanfi</LastName><ForeName>Mohamed</ForeName><Initials>M</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-4898-7663</Identifier><AffiliationInfo><Affiliation>Inflammation Research Center, VIB, Ghent University, Ghent, Belgium.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biochemistry, Ghent University, Ghent, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carotta</LastName><ForeName>Sebastian</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Boehringer-Ingelheim RCV, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Renauld</LastName><ForeName>Jean-Christophe</ForeName><Initials>JC</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-1736-2131</Identifier><AffiliationInfo><Affiliation>Ludwig Institute for Cancer Research and Experimental Medicine Unit, Catholic University of Louvain, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Computing and Information Systems, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carpentier</LastName><ForeName>Sabrina</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>MI-mAbs consortium Aix-Marseille University, Centre d'Immunologie de Marseille-Luminy, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soos</LastName><ForeName>Tim</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Bioinnovation, SANOFI, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arendt</LastName><ForeName>Christopher</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Bioinnovation, SANOFI, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ugolini</LastName><ForeName>Sophie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huntington</LastName><ForeName>Nicholas D</ForeName><Initials>ND</Initials><AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Belz</LastName><ForeName>Gabrielle T</ForeName><Initials>GT</Initials><AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vivier</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Immunologie, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, Marseille, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>268537</GrantID><Agency>European Research Council</Agency><Country>International</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>11</Month><Day>30</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Nat Immunol</MedlineTA><NlmUniqueID>100941354</NlmUniqueID><ISSNLinking>1529-2908</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007378">Interleukins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D064549">Myeloid Cell Leukemia Sequence 1 Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D055627">Natural Cytotoxicity Triggering Receptor 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020825">T-Box Domain Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C406820">T-box transcription factor TBX21</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C415368">interleukin-22</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Immunity. 2014 Jan 16;40(1):25-39</RefSource><PMID Version="1">24412612</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunology. 2004 Jul;112(3):364-8</RefSource><PMID Version="1">15196203</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int Immunol. 2016 Jan;28(1):35-42</RefSource><PMID Version="1">26374472</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Evol Biol. 2009 Oct;22(10):1984-99</RefSource><PMID Version="1">19678866</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Microbiol. 2004 Oct;6(10):963-72</RefSource><PMID Version="1">15339271</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunity. 1997 Oct;7(4):493-504</RefSource><PMID Version="1">9354470</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16951-6</RefSource><PMID Version="1">12482940</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gene. 2014 Feb 10;535(2):218-24</RefSource><PMID Version="1">24309373</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2013 Jun 6;498(7452):113-7</RefSource><PMID Version="1">23698371</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunity. 2015 Apr 21;42(4):731-43</RefSource><PMID Version="1">25902484</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunity. 2014 Sep 18;41(3):366-74</RefSource><PMID Version="1">25238094</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Immunol. 2014 Sep;14(9):631-9</RefSource><PMID Version="1">25132095</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Immunol. 2015;33:747-85</RefSource><PMID Version="1">25706098</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2011 Apr 14;117(15):4052-5</RefSource><PMID Version="1">21310921</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunity. 2013 Aug 22;39(2):386-99</RefSource><PMID Version="1">23954130</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Cell Biol. 2001 Mar;21(5):1621-32</RefSource><PMID Version="1">11238899</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2015 May 22;348(6237):aaa6566</RefSource><PMID Version="1">25999512</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunity. 2011 Jan 28;34(1):122-34</RefSource><PMID Version="1">21194981</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2013 Feb 14;494(7436):261-5</RefSource><PMID Version="1">23334414</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Adv Immunol. 2010;107:1-29</RefSource><PMID Version="1">21034969</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunity. 2008 Dec 19;29(6):958-70</RefSource><PMID Version="1">19084435</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Virol. 2010 Aug;84(15):7750-9</RefSource><PMID Version="1">20504940</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2014 Nov 1;193(9):4602-13</RefSource><PMID Version="1">25261485</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2009 Feb 5;457(7230):722-5</RefSource><PMID Version="1">18978771</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mucosal Immunol. 2015 Mar;8(2):403-13</RefSource><PMID Version="1">25183367</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bioinformatics. 2009 Mar 15;25(6):765-71</RefSource><PMID Version="1">19176553</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2012 Jun 8;336(6086):1321-5</RefSource><PMID Version="1">22674331</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Immunol. 2013 Apr;14(4):389-95</RefSource><PMID Version="1">23455676</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunity. 2012 Dec 14;37(6):1061-75</RefSource><PMID Version="1">23200827</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Stat Appl Genet Mol Biol. 2004;3:Article3</RefSource><PMID Version="1">16646809</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2015 Apr 20;43(7):e47</RefSource><PMID Version="1">25605792</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5123-8</RefSource><PMID Version="1">25838284</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2015 Jan 15;517(7534):293-301</RefSource><PMID Version="1">25592534</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18324-9</RefSource><PMID Version="1">22021440</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2008 Mar;14(3):282-9</RefSource><PMID Version="1">18264109</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunity. 2010 Nov 24;33(5):736-51</RefSource><PMID Version="1">21093318</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2012 Dec 17;209(13):2331-8</RefSource><PMID Version="1">23209316</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Immunol. 2013 Feb;13(2):145-9</RefSource><PMID Version="1">23348417</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bioinformatics. 2014 Apr 1;30(7):923-30</RefSource><PMID Version="1">24227677</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Commun. 2014;5:4539</RefSource><PMID Version="1">25119382</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMJ. 2009;338:b716</RefSource><PMID Version="1">19273506</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Immunol. 2015 Jan;16(1):1-5</RefSource><PMID Version="1">25521670</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2013 May 6;210(5):917-31</RefSource><PMID Version="1">23589566</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunity. 2014 Nov 20;41(5):776-88</RefSource><PMID Version="1">25456160</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunity. 2014 Sep 18;41(3):354-65</RefSource><PMID Version="1">25238093</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2009 Nov 15;183(10):6639-45</RefSource><PMID Version="1">19864591</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Immunol. 2015 Mar;16(3):306-17</RefSource><PMID Version="1">25621825</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2010 Oct 1;185(7):3913-8</RefSource><PMID Version="1">20802153</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2014 Feb 15;192(4):1778-86</RefSource><PMID Version="1">24442439</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Immunol. 2015 Aug;45(8):2171-82</RefSource><PMID Version="1">26031799</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044082" MajorTopicYN="N">Citrobacter rodentium</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016000" MajorTopicYN="N">Cluster Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004756" MajorTopicYN="N">Enterobacteriaceae Infections</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020869" MajorTopicYN="N">Gene Expression Profiling</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005786" MajorTopicYN="N">Gene Expression Regulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006706" MajorTopicYN="N">Homeostasis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007113" MajorTopicYN="Y">Immunity, Innate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007378" MajorTopicYN="N">Interleukins</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016131" MajorTopicYN="N">Lymphocyte Subsets</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008214" MajorTopicYN="N">Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008822" MajorTopicYN="N">Mice, Transgenic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064549" MajorTopicYN="N">Myeloid Cell Leukemia Sequence 1 Protein</DescriptorName><QualifierName UI="Q000172" MajorTopicYN="N">deficiency</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055627" MajorTopicYN="N">Natural Cytotoxicity Triggering Receptor 1</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020825" MajorTopicYN="N">T-Box Domain Proteins</DescriptorName><QualifierName UI="Q000172" MajorTopicYN="N">deficiency</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059467" MajorTopicYN="N">Transcriptome</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">EMS65743</OtherID><OtherID Source="NLM">PMC4720992</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>10</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>10</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>11</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>11</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>6</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26595889</ArticleId><ArticleId IdType="pii">ni.3332</ArticleId><ArticleId IdType="doi">10.1038/ni.3332</ArticleId><ArticleId IdType="pmc">PMC4720992</ArticleId><ArticleId IdType="mid">EMS65743</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002267 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 002267 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:26595889
|texte= Complementarity and redundancy of IL-22-producing innate lymphoid cells.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:26595889" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |