Differential expression of vitamin D-associated enzymes and receptors in brain cell subtypes.
Identifieur interne : 000602 ( PubMed/Curation ); précédent : 000601; suivant : 000603Differential expression of vitamin D-associated enzymes and receptors in brain cell subtypes.
Auteurs : Véréna Landel [France] ; Delphine Stephan [France] ; Xiaoying Cui [Australie] ; Darryl Eyles [Australie] ; François Feron [France]Source :
- The Journal of steroid biochemistry and molecular biology [ 1879-1220 ] ; 2017.
Abstract
Accumulating evidence indicates that the active form of vitamin D, 1,25(OH)2D3, can be considered as a neurosteroid. However, the cerebral expression of vitamin D-associated enzymes and receptors remains controversial. With the idea of carrying out a comparative study in mind, we compared the transcript expression of Cyp27a1, Cyp27b1, Cyp24a1, Vdr and Pdia3 in purified cultures of astrocytes, endothelial cells, microglia, neurons and oligodendrocytes. We observed that endothelial cells and neurons can possibly transform the inactive cholecalciferol into 25(OH)D3. It can then be metabolised into 1,25(OH)2D3, by neurons or microglia, before being transferred to astrocytes where it can bind to VDR and initiate gene transcription or be inactivated when in excess. Alternatively, 1,25(OH)2D3 can induce autocrine or paracrine rapid non-genomic actions via PDIA3 whose transcript is abundantly expressed in all cerebral cell types. Noticeably, brain endothelial cells appear as a singular subtype as they are potentially able to transform cholecalciferol into 25(OH)D3 and exhibit a variable expression of Pdia3, according to 1,25(OH)2D3 level. Altogether, our data indicate that, within the brain, vitamin D may trigger major auto-/paracrine non genomic actions, in addition to its well documented activities as a steroid hormone.
DOI: 10.1016/j.jsbmb.2017.09.008
PubMed: 28893622
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000604
Links to Exploration step
pubmed:28893622Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differential expression of vitamin D-associated enzymes and receptors in brain cell subtypes.</title>
<author><name sortKey="Landel, Verena" sort="Landel, Verena" uniqKey="Landel V" first="Véréna" last="Landel">Véréna Landel</name>
<affiliation wicri:level="1"><nlm:affiliation>Aix Marseille Univ, CNRS, NICN, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Univ, CNRS, NICN, Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stephan, Delphine" sort="Stephan, Delphine" uniqKey="Stephan D" first="Delphine" last="Stephan">Delphine Stephan</name>
<affiliation wicri:level="1"><nlm:affiliation>Aix Marseille Univ, CNRS, NICN, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Univ, CNRS, NICN, Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cui, Xiaoying" sort="Cui, Xiaoying" uniqKey="Cui X" first="Xiaoying" last="Cui">Xiaoying Cui</name>
<affiliation wicri:level="1"><nlm:affiliation>Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eyles, Darryl" sort="Eyles, Darryl" uniqKey="Eyles D" first="Darryl" last="Eyles">Darryl Eyles</name>
<affiliation wicri:level="1"><nlm:affiliation>Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Brisbane, Australia; Queensland Centre for Mental Health Research, Brisbane, QLD, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Brisbane, Australia; Queensland Centre for Mental Health Research, Brisbane, QLD, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Feron, Francois" sort="Feron, Francois" uniqKey="Feron F" first="François" last="Feron">François Feron</name>
<affiliation wicri:level="1"><nlm:affiliation>Aix Marseille Univ, CNRS, NICN, Marseille, France. Electronic address: francois.feron@univ-amu.fr.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Univ, CNRS, NICN, Marseille</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:28893622</idno>
<idno type="pmid">28893622</idno>
<idno type="doi">10.1016/j.jsbmb.2017.09.008</idno>
<idno type="wicri:Area/PubMed/Corpus">000604</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000604</idno>
<idno type="wicri:Area/PubMed/Curation">000602</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000602</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Differential expression of vitamin D-associated enzymes and receptors in brain cell subtypes.</title>
<author><name sortKey="Landel, Verena" sort="Landel, Verena" uniqKey="Landel V" first="Véréna" last="Landel">Véréna Landel</name>
<affiliation wicri:level="1"><nlm:affiliation>Aix Marseille Univ, CNRS, NICN, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Univ, CNRS, NICN, Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stephan, Delphine" sort="Stephan, Delphine" uniqKey="Stephan D" first="Delphine" last="Stephan">Delphine Stephan</name>
<affiliation wicri:level="1"><nlm:affiliation>Aix Marseille Univ, CNRS, NICN, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Univ, CNRS, NICN, Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cui, Xiaoying" sort="Cui, Xiaoying" uniqKey="Cui X" first="Xiaoying" last="Cui">Xiaoying Cui</name>
<affiliation wicri:level="1"><nlm:affiliation>Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eyles, Darryl" sort="Eyles, Darryl" uniqKey="Eyles D" first="Darryl" last="Eyles">Darryl Eyles</name>
<affiliation wicri:level="1"><nlm:affiliation>Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Brisbane, Australia; Queensland Centre for Mental Health Research, Brisbane, QLD, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Brisbane, Australia; Queensland Centre for Mental Health Research, Brisbane, QLD, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Feron, Francois" sort="Feron, Francois" uniqKey="Feron F" first="François" last="Feron">François Feron</name>
<affiliation wicri:level="1"><nlm:affiliation>Aix Marseille Univ, CNRS, NICN, Marseille, France. Electronic address: francois.feron@univ-amu.fr.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Univ, CNRS, NICN, Marseille</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of steroid biochemistry and molecular biology</title>
<idno type="eISSN">1879-1220</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Accumulating evidence indicates that the active form of vitamin D, 1,25(OH)2D3, can be considered as a neurosteroid. However, the cerebral expression of vitamin D-associated enzymes and receptors remains controversial. With the idea of carrying out a comparative study in mind, we compared the transcript expression of Cyp27a1, Cyp27b1, Cyp24a1, Vdr and Pdia3 in purified cultures of astrocytes, endothelial cells, microglia, neurons and oligodendrocytes. We observed that endothelial cells and neurons can possibly transform the inactive cholecalciferol into 25(OH)D3. It can then be metabolised into 1,25(OH)2D3, by neurons or microglia, before being transferred to astrocytes where it can bind to VDR and initiate gene transcription or be inactivated when in excess. Alternatively, 1,25(OH)2D3 can induce autocrine or paracrine rapid non-genomic actions via PDIA3 whose transcript is abundantly expressed in all cerebral cell types. Noticeably, brain endothelial cells appear as a singular subtype as they are potentially able to transform cholecalciferol into 25(OH)D3 and exhibit a variable expression of Pdia3, according to 1,25(OH)2D3 level. Altogether, our data indicate that, within the brain, vitamin D may trigger major auto-/paracrine non genomic actions, in addition to its well documented activities as a steroid hormone.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">28893622</PMID>
<DateCreated><Year>2017</Year>
<Month>09</Month>
<Day>12</Day>
</DateCreated>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-1220</ISSN>
<JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year>
<Month>Sep</Month>
<Day>08</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of steroid biochemistry and molecular biology</Title>
<ISOAbbreviation>J. Steroid Biochem. Mol. Biol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Differential expression of vitamin D-associated enzymes and receptors in brain cell subtypes.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">S0960-0760(17)30256-X</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jsbmb.2017.09.008</ELocationID>
<Abstract><AbstractText>Accumulating evidence indicates that the active form of vitamin D, 1,25(OH)2D3, can be considered as a neurosteroid. However, the cerebral expression of vitamin D-associated enzymes and receptors remains controversial. With the idea of carrying out a comparative study in mind, we compared the transcript expression of Cyp27a1, Cyp27b1, Cyp24a1, Vdr and Pdia3 in purified cultures of astrocytes, endothelial cells, microglia, neurons and oligodendrocytes. We observed that endothelial cells and neurons can possibly transform the inactive cholecalciferol into 25(OH)D3. It can then be metabolised into 1,25(OH)2D3, by neurons or microglia, before being transferred to astrocytes where it can bind to VDR and initiate gene transcription or be inactivated when in excess. Alternatively, 1,25(OH)2D3 can induce autocrine or paracrine rapid non-genomic actions via PDIA3 whose transcript is abundantly expressed in all cerebral cell types. Noticeably, brain endothelial cells appear as a singular subtype as they are potentially able to transform cholecalciferol into 25(OH)D3 and exhibit a variable expression of Pdia3, according to 1,25(OH)2D3 level. Altogether, our data indicate that, within the brain, vitamin D may trigger major auto-/paracrine non genomic actions, in addition to its well documented activities as a steroid hormone.</AbstractText>
<CopyrightInformation>Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Landel</LastName>
<ForeName>Véréna</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Aix Marseille Univ, CNRS, NICN, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stephan</LastName>
<ForeName>Delphine</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Aix Marseille Univ, CNRS, NICN, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cui</LastName>
<ForeName>Xiaoying</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Brisbane, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Eyles</LastName>
<ForeName>Darryl</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Brisbane, Australia; Queensland Centre for Mental Health Research, Brisbane, QLD, Brisbane, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Feron</LastName>
<ForeName>François</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Aix Marseille Univ, CNRS, NICN, Marseille, France. Electronic address: francois.feron@univ-amu.fr.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>09</Month>
<Day>08</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Steroid Biochem Mol Biol</MedlineTA>
<NlmUniqueID>9015483</NlmUniqueID>
<ISSNLinking>0960-0760</ISSNLinking>
</MedlineJournalInfo>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">1,25(OH)2D3</Keyword>
<Keyword MajorTopicYN="N">Brain</Keyword>
<Keyword MajorTopicYN="N">Cell types</Keyword>
<Keyword MajorTopicYN="N">Limiting enzymes</Keyword>
<Keyword MajorTopicYN="N">Rat</Keyword>
<Keyword MajorTopicYN="N">Receptors</Keyword>
<Keyword MajorTopicYN="N">Vitamin D</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>05</Month>
<Day>08</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2017</Year>
<Month>09</Month>
<Day>01</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>09</Month>
<Day>08</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>9</Month>
<Day>13</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>9</Month>
<Day>13</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>9</Month>
<Day>13</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>aheadofprint</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">28893622</ArticleId>
<ArticleId IdType="pii">S0960-0760(17)30256-X</ArticleId>
<ArticleId IdType="doi">10.1016/j.jsbmb.2017.09.008</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000602 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 000602 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= PubMed |étape= Curation |type= RBID |clé= pubmed:28893622 |texte= Differential expression of vitamin D-associated enzymes and receptors in brain cell subtypes. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:28893622" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |