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Differential expression of vitamin D-associated enzymes and receptors in brain cell subtypes.

Identifieur interne : 000604 ( PubMed/Corpus ); précédent : 000603; suivant : 000605

Differential expression of vitamin D-associated enzymes and receptors in brain cell subtypes.

Auteurs : Véréna Landel ; Delphine Stephan ; Xiaoying Cui ; Darryl Eyles ; François Feron

Source :

The Journal of steroid biochemistry and molecular biology [ 1879-1220 ] ; 2017.

RBID : pubmed:28893622

Abstract

Accumulating evidence indicates that the active form of vitamin D, 1,25(OH)2D3, can be considered as a neurosteroid. However, the cerebral expression of vitamin D-associated enzymes and receptors remains controversial. With the idea of carrying out a comparative study in mind, we compared the transcript expression of Cyp27a1, Cyp27b1, Cyp24a1, Vdr and Pdia3 in purified cultures of astrocytes, endothelial cells, microglia, neurons and oligodendrocytes. We observed that endothelial cells and neurons can possibly transform the inactive cholecalciferol into 25(OH)D3. It can then be metabolised into 1,25(OH)2D3, by neurons or microglia, before being transferred to astrocytes where it can bind to VDR and initiate gene transcription or be inactivated when in excess. Alternatively, 1,25(OH)2D3 can induce autocrine or paracrine rapid non-genomic actions via PDIA3 whose transcript is abundantly expressed in all cerebral cell types. Noticeably, brain endothelial cells appear as a singular subtype as they are potentially able to transform cholecalciferol into 25(OH)D3 and exhibit a variable expression of Pdia3, according to 1,25(OH)2D3 level. Altogether, our data indicate that, within the brain, vitamin D may trigger major auto-/paracrine non genomic actions, in addition to its well documented activities as a steroid hormone.

DOI: 10.1016/j.jsbmb.2017.09.008
PubMed: 28893622

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pubmed:28893622

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<author><name sortKey="Landel, Verena" sort="Landel, Verena" uniqKey="Landel V" first="Véréna" last="Landel">Véréna Landel</name>
<affiliation><nlm:affiliation>Aix Marseille Univ, CNRS, NICN, Marseille, France.</nlm:affiliation>
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<author><name sortKey="Stephan, Delphine" sort="Stephan, Delphine" uniqKey="Stephan D" first="Delphine" last="Stephan">Delphine Stephan</name>
<affiliation><nlm:affiliation>Aix Marseille Univ, CNRS, NICN, Marseille, France.</nlm:affiliation>
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<author><name sortKey="Cui, Xiaoying" sort="Cui, Xiaoying" uniqKey="Cui X" first="Xiaoying" last="Cui">Xiaoying Cui</name>
<affiliation><nlm:affiliation>Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Brisbane, Australia.</nlm:affiliation>
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<author><name sortKey="Eyles, Darryl" sort="Eyles, Darryl" uniqKey="Eyles D" first="Darryl" last="Eyles">Darryl Eyles</name>
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<author><name sortKey="Feron, Francois" sort="Feron, Francois" uniqKey="Feron F" first="François" last="Feron">François Feron</name>
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<front><div type="abstract" xml:lang="en">Accumulating evidence indicates that the active form of vitamin D, 1,25(OH)2D3, can be considered as a neurosteroid. However, the cerebral expression of vitamin D-associated enzymes and receptors remains controversial. With the idea of carrying out a comparative study in mind, we compared the transcript expression of Cyp27a1, Cyp27b1, Cyp24a1, Vdr and Pdia3 in purified cultures of astrocytes, endothelial cells, microglia, neurons and oligodendrocytes. We observed that endothelial cells and neurons can possibly transform the inactive cholecalciferol into 25(OH)D3. It can then be metabolised into 1,25(OH)2D3, by neurons or microglia, before being transferred to astrocytes where it can bind to VDR and initiate gene transcription or be inactivated when in excess. Alternatively, 1,25(OH)2D3 can induce autocrine or paracrine rapid non-genomic actions via PDIA3 whose transcript is abundantly expressed in all cerebral cell types. Noticeably, brain endothelial cells appear as a singular subtype as they are potentially able to transform cholecalciferol into 25(OH)D3 and exhibit a variable expression of Pdia3, according to 1,25(OH)2D3 level. Altogether, our data indicate that, within the brain, vitamin D may trigger major auto-/paracrine non genomic actions, in addition to its well documented activities as a steroid hormone.</div>
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<Abstract><AbstractText>Accumulating evidence indicates that the active form of vitamin D, 1,25(OH)2D3, can be considered as a neurosteroid. However, the cerebral expression of vitamin D-associated enzymes and receptors remains controversial. With the idea of carrying out a comparative study in mind, we compared the transcript expression of Cyp27a1, Cyp27b1, Cyp24a1, Vdr and Pdia3 in purified cultures of astrocytes, endothelial cells, microglia, neurons and oligodendrocytes. We observed that endothelial cells and neurons can possibly transform the inactive cholecalciferol into 25(OH)D3. It can then be metabolised into 1,25(OH)2D3, by neurons or microglia, before being transferred to astrocytes where it can bind to VDR and initiate gene transcription or be inactivated when in excess. Alternatively, 1,25(OH)2D3 can induce autocrine or paracrine rapid non-genomic actions via PDIA3 whose transcript is abundantly expressed in all cerebral cell types. Noticeably, brain endothelial cells appear as a singular subtype as they are potentially able to transform cholecalciferol into 25(OH)D3 and exhibit a variable expression of Pdia3, according to 1,25(OH)2D3 level. Altogether, our data indicate that, within the brain, vitamin D may trigger major auto-/paracrine non genomic actions, in addition to its well documented activities as a steroid hormone.</AbstractText>
<CopyrightInformation>Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.</CopyrightInformation>
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<Keyword MajorTopicYN="N">Brain</Keyword>
<Keyword MajorTopicYN="N">Cell types</Keyword>
<Keyword MajorTopicYN="N">Limiting enzymes</Keyword>
<Keyword MajorTopicYN="N">Rat</Keyword>
<Keyword MajorTopicYN="N">Receptors</Keyword>
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Differential expression of vitamin D-associated enzymes and receptors in brain cell subtypes.

Differential expression of vitamin D-associated enzymes and receptors in brain cell subtypes.

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Abstract

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