dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients.
Identifieur interne : 003A66 ( PubMed/Corpus ); précédent : 003A65; suivant : 003A67dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients.
Auteurs : C. Manitt ; C. Eng ; M. Pokinko ; R T Ryan ; A. Torres-Berrío ; J P Lopez ; S V Yogendran ; M J J. Daubaras ; A. Grant ; E R E. Schmidt ; F. Tronche ; P. Krimpenfort ; H M Cooper ; R J Pasterkamp ; B. Kolb ; G. Turecki ; T P Wong ; E J Nestler ; B. Giros ; C. FloresSource :
- Translational psychiatry [ 2158-3188 ] ; 2013.
English descriptors
- KwdEn :
- Adolescent, Adolescent Development (physiology), Animals, Case-Control Studies, Dopaminergic Neurons (metabolism), Genes, DCC (physiology), Genetic Predisposition to Disease, Haploinsufficiency, Humans, Male, Mental Disorders (genetics), Mice, Neural Pathways (growth & development), Neural Pathways (metabolism), Prefrontal Cortex (cytology), Prefrontal Cortex (growth & development), Prefrontal Cortex (metabolism), Self-Injurious Behavior (genetics), Suicide.
- MESH :
- cytology : Prefrontal Cortex.
- genetics : Mental Disorders, Self-Injurious Behavior.
- growth & development : Neural Pathways, Prefrontal Cortex.
- metabolism : Dopaminergic Neurons, Neural Pathways, Prefrontal Cortex.
- physiology : Adolescent Development, Genes, DCC.
- Adolescent, Animals, Case-Control Studies, Genetic Predisposition to Disease, Haploinsufficiency, Humans, Male, Mice, Suicide.
Abstract
Adolescence is a period of heightened susceptibility to psychiatric disorders of medial prefrontal cortex (mPFC) dysfunction and cognitive impairment. mPFC dopamine (DA) projections reach maturity only in early adulthood, when their control over cognition becomes fully functional. The mechanisms governing this protracted and unique development are unknown. Here we identify dcc as the first DA neuron gene to regulate mPFC connectivity during adolescence and dissect the mechanisms involved. Reduction or loss of dcc from DA neurons by Cre-lox recombination increased mPFC DA innervation. Underlying this was the presence of ectopic DA fibers that normally innervate non-cortical targets. Altered DA input changed the anatomy and electrophysiology of mPFC circuits, leading to enhanced cognitive flexibility. All phenotypes only emerged in adulthood. Using viral Cre, we demonstrated that dcc organizes mPFC wiring specifically during adolescence. Variations in DCC may determine differential predisposition to mPFC disorders in humans. Indeed, DCC expression is elevated in brains of antidepressant-free subjects who committed suicide.
DOI: 10.1038/tp.2013.105
PubMed: 24346136
Links to Exploration step
pubmed:24346136Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients.</title><author><name sortKey="Manitt, C" sort="Manitt, C" uniqKey="Manitt C" first="C" last="Manitt">C. Manitt</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Eng, C" sort="Eng, C" uniqKey="Eng C" first="C" last="Eng">C. Eng</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Pokinko, M" sort="Pokinko, M" uniqKey="Pokinko M" first="M" last="Pokinko">M. Pokinko</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Ryan, R T" sort="Ryan, R T" uniqKey="Ryan R" first="R T" last="Ryan">R T Ryan</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Torres Berrio, A" sort="Torres Berrio, A" uniqKey="Torres Berrio A" first="A" last="Torres-Berrío">A. Torres-Berrío</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Lopez, J P" sort="Lopez, J P" uniqKey="Lopez J" first="J P" last="Lopez">J P Lopez</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Yogendran, S V" sort="Yogendran, S V" uniqKey="Yogendran S" first="S V" last="Yogendran">S V Yogendran</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Daubaras, M J J" sort="Daubaras, M J J" uniqKey="Daubaras M" first="M J J" last="Daubaras">M J J. Daubaras</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Grant, A" sort="Grant, A" uniqKey="Grant A" first="A" last="Grant">A. Grant</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Schmidt, E R E" sort="Schmidt, E R E" uniqKey="Schmidt E" first="E R E" last="Schmidt">E R E. Schmidt</name><affiliation><nlm:affiliation>Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Tronche, F" sort="Tronche, F" uniqKey="Tronche F" first="F" last="Tronche">F. Tronche</name><affiliation><nlm:affiliation>UMR 7224 CNRS and Université Pierre et Marie Curie, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Krimpenfort, P" sort="Krimpenfort, P" uniqKey="Krimpenfort P" first="P" last="Krimpenfort">P. Krimpenfort</name><affiliation><nlm:affiliation>Division of Molecular Genetics, Centre for Biomedical Genetics, Cancer Genomics Centre, The Netherlands Cancer Institute, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Cooper, H M" sort="Cooper, H M" uniqKey="Cooper H" first="H M" last="Cooper">H M Cooper</name><affiliation><nlm:affiliation>The University of Queensland, Queensland Brain Institute, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Pasterkamp, R J" sort="Pasterkamp, R J" uniqKey="Pasterkamp R" first="R J" last="Pasterkamp">R J Pasterkamp</name><affiliation><nlm:affiliation>Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Kolb, B" sort="Kolb, B" uniqKey="Kolb B" first="B" last="Kolb">B. Kolb</name><affiliation><nlm:affiliation>Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Turecki, G" sort="Turecki, G" uniqKey="Turecki G" first="G" last="Turecki">G. Turecki</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Wong, T P" sort="Wong, T P" uniqKey="Wong T" first="T P" last="Wong">T P Wong</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Nestler, E J" sort="Nestler, E J" uniqKey="Nestler E" first="E J" last="Nestler">E J Nestler</name><affiliation><nlm:affiliation>Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Giros, B" sort="Giros, B" uniqKey="Giros B" first="B" last="Giros">B. Giros</name><affiliation><nlm:affiliation>1] Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada [2] UMR 7224 CNRS and Université Pierre et Marie Curie, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Flores, C" sort="Flores, C" uniqKey="Flores C" first="C" last="Flores">C. Flores</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:24346136</idno><idno type="pmid">24346136</idno><idno type="doi">10.1038/tp.2013.105</idno><idno type="wicri:Area/PubMed/Corpus">003A66</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003A66</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients.</title><author><name sortKey="Manitt, C" sort="Manitt, C" uniqKey="Manitt C" first="C" last="Manitt">C. Manitt</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Eng, C" sort="Eng, C" uniqKey="Eng C" first="C" last="Eng">C. Eng</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Pokinko, M" sort="Pokinko, M" uniqKey="Pokinko M" first="M" last="Pokinko">M. Pokinko</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Ryan, R T" sort="Ryan, R T" uniqKey="Ryan R" first="R T" last="Ryan">R T Ryan</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Torres Berrio, A" sort="Torres Berrio, A" uniqKey="Torres Berrio A" first="A" last="Torres-Berrío">A. Torres-Berrío</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Lopez, J P" sort="Lopez, J P" uniqKey="Lopez J" first="J P" last="Lopez">J P Lopez</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Yogendran, S V" sort="Yogendran, S V" uniqKey="Yogendran S" first="S V" last="Yogendran">S V Yogendran</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Daubaras, M J J" sort="Daubaras, M J J" uniqKey="Daubaras M" first="M J J" last="Daubaras">M J J. Daubaras</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Grant, A" sort="Grant, A" uniqKey="Grant A" first="A" last="Grant">A. Grant</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Schmidt, E R E" sort="Schmidt, E R E" uniqKey="Schmidt E" first="E R E" last="Schmidt">E R E. Schmidt</name><affiliation><nlm:affiliation>Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Tronche, F" sort="Tronche, F" uniqKey="Tronche F" first="F" last="Tronche">F. Tronche</name><affiliation><nlm:affiliation>UMR 7224 CNRS and Université Pierre et Marie Curie, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Krimpenfort, P" sort="Krimpenfort, P" uniqKey="Krimpenfort P" first="P" last="Krimpenfort">P. Krimpenfort</name><affiliation><nlm:affiliation>Division of Molecular Genetics, Centre for Biomedical Genetics, Cancer Genomics Centre, The Netherlands Cancer Institute, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Cooper, H M" sort="Cooper, H M" uniqKey="Cooper H" first="H M" last="Cooper">H M Cooper</name><affiliation><nlm:affiliation>The University of Queensland, Queensland Brain Institute, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Pasterkamp, R J" sort="Pasterkamp, R J" uniqKey="Pasterkamp R" first="R J" last="Pasterkamp">R J Pasterkamp</name><affiliation><nlm:affiliation>Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Kolb, B" sort="Kolb, B" uniqKey="Kolb B" first="B" last="Kolb">B. Kolb</name><affiliation><nlm:affiliation>Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Turecki, G" sort="Turecki, G" uniqKey="Turecki G" first="G" last="Turecki">G. Turecki</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Wong, T P" sort="Wong, T P" uniqKey="Wong T" first="T P" last="Wong">T P Wong</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Nestler, E J" sort="Nestler, E J" uniqKey="Nestler E" first="E J" last="Nestler">E J Nestler</name><affiliation><nlm:affiliation>Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Giros, B" sort="Giros, B" uniqKey="Giros B" first="B" last="Giros">B. Giros</name><affiliation><nlm:affiliation>1] Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada [2] UMR 7224 CNRS and Université Pierre et Marie Curie, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Flores, C" sort="Flores, C" uniqKey="Flores C" first="C" last="Flores">C. Flores</name><affiliation><nlm:affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Translational psychiatry</title><idno type="eISSN">2158-3188</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adolescent Development (physiology)</term><term>Animals</term><term>Case-Control Studies</term><term>Dopaminergic Neurons (metabolism)</term><term>Genes, DCC (physiology)</term><term>Genetic Predisposition to Disease</term><term>Haploinsufficiency</term><term>Humans</term><term>Male</term><term>Mental Disorders (genetics)</term><term>Mice</term><term>Neural Pathways (growth & development)</term><term>Neural Pathways (metabolism)</term><term>Prefrontal Cortex (cytology)</term><term>Prefrontal Cortex (growth & development)</term><term>Prefrontal Cortex (metabolism)</term><term>Self-Injurious Behavior (genetics)</term><term>Suicide</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mental Disorders</term><term>Self-Injurious Behavior</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Neural Pathways</term><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Dopaminergic Neurons</term><term>Neural Pathways</term><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Adolescent Development</term><term>Genes, DCC</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Animals</term><term>Case-Control Studies</term><term>Genetic Predisposition to Disease</term><term>Haploinsufficiency</term><term>Humans</term><term>Male</term><term>Mice</term><term>Suicide</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Adolescence is a period of heightened susceptibility to psychiatric disorders of medial prefrontal cortex (mPFC) dysfunction and cognitive impairment. mPFC dopamine (DA) projections reach maturity only in early adulthood, when their control over cognition becomes fully functional. The mechanisms governing this protracted and unique development are unknown. Here we identify dcc as the first DA neuron gene to regulate mPFC connectivity during adolescence and dissect the mechanisms involved. Reduction or loss of dcc from DA neurons by Cre-lox recombination increased mPFC DA innervation. Underlying this was the presence of ectopic DA fibers that normally innervate non-cortical targets. Altered DA input changed the anatomy and electrophysiology of mPFC circuits, leading to enhanced cognitive flexibility. All phenotypes only emerged in adulthood. Using viral Cre, we demonstrated that dcc organizes mPFC wiring specifically during adolescence. Variations in DCC may determine differential predisposition to mPFC disorders in humans. Indeed, DCC expression is elevated in brains of antidepressant-free subjects who committed suicide.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24346136</PMID><DateCreated><Year>2013</Year><Month>12</Month><Day>18</Day></DateCreated><DateCompleted><Year>2014</Year><Month>06</Month><Day>05</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>25</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2158-3188</ISSN><JournalIssue CitedMedium="Internet"><Volume>3</Volume><PubDate><Year>2013</Year><Month>Dec</Month><Day>17</Day></PubDate></JournalIssue><Title>Translational psychiatry</Title><ISOAbbreviation>Transl Psychiatry</ISOAbbreviation></Journal><ArticleTitle>dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients.</ArticleTitle><Pagination><MedlinePgn>e338</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/tp.2013.105</ELocationID><Abstract><AbstractText>Adolescence is a period of heightened susceptibility to psychiatric disorders of medial prefrontal cortex (mPFC) dysfunction and cognitive impairment. mPFC dopamine (DA) projections reach maturity only in early adulthood, when their control over cognition becomes fully functional. The mechanisms governing this protracted and unique development are unknown. Here we identify dcc as the first DA neuron gene to regulate mPFC connectivity during adolescence and dissect the mechanisms involved. Reduction or loss of dcc from DA neurons by Cre-lox recombination increased mPFC DA innervation. Underlying this was the presence of ectopic DA fibers that normally innervate non-cortical targets. Altered DA input changed the anatomy and electrophysiology of mPFC circuits, leading to enhanced cognitive flexibility. All phenotypes only emerged in adulthood. Using viral Cre, we demonstrated that dcc organizes mPFC wiring specifically during adolescence. Variations in DCC may determine differential predisposition to mPFC disorders in humans. Indeed, DCC expression is elevated in brains of antidepressant-free subjects who committed suicide.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Manitt</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eng</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pokinko</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ryan</LastName><ForeName>R T</ForeName><Initials>RT</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Torres-Berrío</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lopez</LastName><ForeName>J P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yogendran</LastName><ForeName>S V</ForeName><Initials>SV</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Daubaras</LastName><ForeName>M J J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grant</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>E R E</ForeName><Initials>ER</Initials><AffiliationInfo><Affiliation>Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tronche</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>UMR 7224 CNRS and Université Pierre et Marie Curie, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krimpenfort</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Division of Molecular Genetics, Centre for Biomedical Genetics, Cancer Genomics Centre, The Netherlands Cancer Institute, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cooper</LastName><ForeName>H M</ForeName><Initials>HM</Initials><AffiliationInfo><Affiliation>The University of Queensland, Queensland Brain Institute, Brisbane, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pasterkamp</LastName><ForeName>R J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kolb</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Turecki</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>T P</ForeName><Initials>TP</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nestler</LastName><ForeName>E J</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giros</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>1] Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada [2] UMR 7224 CNRS and Université Pierre et Marie Curie, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Flores</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P50 MH096890</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>12</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Transl Psychiatry</MedlineTA><NlmUniqueID>101562664</NlmUniqueID><ISSNLinking>2158-3188</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Eur J Pharmacol. 1995 Aug 25;282(1-3):157-67</RefSource><PMID Version="1">7498271</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Psychopharmacology (Berl). 1990;100(3):413-6</RefSource><PMID Version="1">2315438</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9235-40</RefSource><PMID Version="1">8799184</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Synapse. 1996 Aug;23(4):237-45</RefSource><PMID Version="1">8855508</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Behav Neurosci. 1996 Oct;110(5):872-86</RefSource><PMID Version="1">8918991</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 1997 Apr 24;386(6627):796-804</RefSource><PMID Version="1">9126737</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuron. 1997 Sep;19(3):575-89</RefSource><PMID Version="1">9331350</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 1998 May;4(5):635-7</RefSource><PMID Version="1">9585242</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Psychiatry. 1999 May;156(5):780-2</RefSource><PMID Version="1">10327916</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Anal Biochem. 1999 Jun 1;270(2):334-6</RefSource><PMID Version="1">10334853</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 1999 Jun 25;97(7):927-41</RefSource><PMID Version="1">10399920</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Psychiatry. 2005 Jun;10(6):606-12</RefSource><PMID Version="1">15534618</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Psychiatry. 2005 Aug;162(8):1403-13</RefSource><PMID Version="1">16055761</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2006 Feb 10;311(5762):864-8</RefSource><PMID Version="1">16469931</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Res. 2006 Dec 13;1125(1):9-16</RefSource><PMID Version="1">17112487</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>FEBS J. 2007 Jul;274(14):3568-77</RefSource><PMID Version="1">17565601</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2007 Oct 5;318(5847):103-6</RefSource><PMID Version="1">17916735</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Neurosci. 2007 Dec;26(11):3215-28</RefSource><PMID Version="1">18005074</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurotox Res. 2008 Oct;14(2-3):185-9</RefSource><PMID Version="1">19073425</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Psychiatry. 2009 Feb;14(2):175-89</RefSource><PMID Version="1">17938633</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Learn Mem. 2009 May;16(5):279-88</RefSource><PMID Version="1">19380710</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 2009 May 15;65(10):846-50</RefSource><PMID Version="1">19249751</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2009;4(8):e6585</RefSource><PMID Version="1">19668376</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2009 Sep 9;29(36):11065-77</RefSource><PMID Version="1">19741113</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Neurosci. 2009 Oct;30(7):1318-28</RefSource><PMID Version="1">19788579</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Neurosci. 2010 Apr;31(7):1292-302</RefSource><PMID Version="1">20345916</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2010 Apr 30;328(5978):592</RefSource><PMID Version="1">20431009</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2010;5(7):e11463</RefSource><PMID Version="1">20628609</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2011 Jan 18;76(3):260-4</RefSource><PMID Version="1">21242494</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Schizophr Bull. 2011 May;37(3):484-92</RefSource><PMID Version="1">21505115</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropsychologia. 2011 Jun;49(7):1660-9</RefSource><PMID Version="1">21392517</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2011 Jun 8;31(23):8381-94</RefSource><PMID Version="1">21653843</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Psychiatry Neurosci. 2011 Sep;36(5):296-310</RefSource><PMID Version="1">21481303</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurosci. 2011 Nov;12(11):652-69</RefSource><PMID Version="1">22011681</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Dis. 2012 Jan;45(1):14-22</RefSource><PMID Version="1">21081163</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2012 Feb 23;482(7386):538-41</RefSource><PMID Version="1">22358843</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Behav Brain Res. 2012 Apr 1;229(1):202-7</RefSource><PMID Version="1">22249134</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Schizophr Res. 2012 May;137(1-3):26-31</RefSource><PMID Version="1">22418395</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurosci. 2012 Sep;13(9):636-50</RefSource><PMID Version="1">22903221</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurophysiol. 2012 Sep;108(6):1620-30</RefSource><PMID Version="1">22723669</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2012 Nov 14;32(46):16223-32</RefSource><PMID Version="1">23152606</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Rep. 2013 Jan 31;3(1):173-85</RefSource><PMID Version="1">23291093</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Neurosci. 2013 Sep;38(6):2853-63</RefSource><PMID Version="1">23738838</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Neuropsychopharmacol. 2014 Jan;17(1):23-32</RefSource><PMID Version="1">24025154</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Comp Neurol. 2014 Apr 1;522(5):1031-47</RefSource><PMID Version="1">23983069</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Psychiatry. 2014 Apr;19(4):417-26</RefSource><PMID Version="1">23752244</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Comp Neurol. 1995 Jul 31;358(3):383-400</RefSource><PMID Version="1">7560293</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Dev Biol. 2000 Jan 15;217(2):244-53</RefSource><PMID Version="1">10625550</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurosci Biobehav Rev. 2000 Jun;24(4):417-63</RefSource><PMID Version="1">10817843</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2000 Jun 1;20(11):4320-4</RefSource><PMID Version="1">10818167</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cereb Cortex. 2000 Oct;10(10):1014-27</RefSource><PMID Version="1">11007552</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroscience. 2002;110(2):245-56</RefSource><PMID Version="1">11958867</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Gen Psychiatry. 2002 May;59(5):409-16</RefSource><PMID Version="1">11982444</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Comp Neurol. 2003 Nov 24;466(4):478-94</RefSource><PMID Version="1">14566944</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropsychopharmacology. 2004 Jan;29(1):72-80</RefSource><PMID Version="1">12968132</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2004 Mar 24;24(12):3040-50</RefSource><PMID Version="1">15044543</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Res. 1979 Feb 23;162(2):243-59</RefSource><PMID Version="1">761089</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroscience. 1980;5(2):207-27</RefSource><PMID Version="1">6990293</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroscience. 1987 Sep;22(3):849-62</RefSource><PMID Version="1">3683852</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Comp Neurol. 1988 Mar 1;269(1):58-72</RefSource><PMID Version="1">3361004</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Gen Psychiatry. 1988 Jul;45(7):609-15</RefSource><PMID Version="1">3382320</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroscience. 1988 Jun;25(3):857-87</RefSource><PMID Version="1">3405431</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Res. 1996 Apr 9;715(1-2):86-97</RefSource><PMID Version="1">8739626</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D041923" MajorTopicYN="N">Adolescent Development</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059290" MajorTopicYN="N">Dopaminergic Neurons</DescriptorName><QualifierName 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