Updated clinical classification of pulmonary hypertension.
Identifieur interne : 003A65 ( PubMed/Corpus ); précédent : 003A64; suivant : 003A66Updated clinical classification of pulmonary hypertension.
Auteurs : Gerald Simonneau ; Michael A. Gatzoulis ; Ian Adatia ; David Celermajer ; Chris Denton ; Ardeschir Ghofrani ; Miguel Angel Gomez Sanchez ; R. Krishna Kumar ; Michael Landzberg ; Roberto F. Machado ; Horst Olschewski ; Ivan M. Robbins ; Rogiero SouzaSource :
- Journal of the American College of Cardiology [ 1558-3597 ] ; 2013.
English descriptors
- KwdEn :
- Anemia, Hemolytic (classification), Anemia, Hemolytic (diagnosis), Anemia, Hemolytic (epidemiology), Animals, Connective Tissue Diseases (classification), Connective Tissue Diseases (diagnosis), Connective Tissue Diseases (epidemiology), Heart Defects, Congenital (classification), Heart Defects, Congenital (diagnosis), Heart Defects, Congenital (epidemiology), Humans, Hypertension, Pulmonary (classification), Hypertension, Pulmonary (diagnosis), Hypertension, Pulmonary (epidemiology).
- MESH :
- classification : Anemia, Hemolytic, Connective Tissue Diseases, Heart Defects, Congenital, Hypertension, Pulmonary.
- diagnosis : Anemia, Hemolytic, Connective Tissue Diseases, Heart Defects, Congenital, Hypertension, Pulmonary.
- epidemiology : Anemia, Hemolytic, Connective Tissue Diseases, Heart Defects, Congenital, Hypertension, Pulmonary.
- Animals, Humans.
Abstract
In 1998, a clinical classification of pulmonary hypertension (PH) was established, categorizing PH into groups which share similar pathological and hemodynamic characteristics and therapeutic approaches. During the 5th World Symposium held in Nice, France, in 2013, the consensus was reached to maintain the general scheme of previous clinical classifications. However, modifications and updates especially for Group 1 patients (pulmonary arterial hypertension [PAH]) were proposed. The main change was to withdraw persistent pulmonary hypertension of the newborn (PPHN) from Group 1 because this entity carries more differences than similarities with other PAH subgroups. In the current classification, PPHN is now designated number 1. Pulmonary hypertension associated with chronic hemolytic anemia has been moved from Group 1 PAH to Group 5, unclear/multifactorial mechanism. In addition, it was decided to add specific items related to pediatric pulmonary hypertension in order to create a comprehensive, common classification for both adults and children. Therefore, congenital or acquired left-heart inflow/outflow obstructive lesions and congenital cardiomyopathies have been added to Group 2, and segmental pulmonary hypertension has been added to Group 5. Last, there were no changes for Groups 2, 3, and 4.
DOI: 10.1016/j.jacc.2013.10.029
PubMed: 24355639
Links to Exploration step
pubmed:24355639Le document en format XML
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Gatzoulis</name><affiliation><nlm:affiliation>Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital and the National Heart and Lung Institute, Imperial College, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Adatia, Ian" sort="Adatia, Ian" uniqKey="Adatia I" first="Ian" last="Adatia">Ian Adatia</name><affiliation><nlm:affiliation>University of Alberta, Stollery Children's Hospital and Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Celermajer, David" sort="Celermajer, David" uniqKey="Celermajer D" first="David" last="Celermajer">David Celermajer</name><affiliation><nlm:affiliation>Heart Research Institute, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Denton, Chris" sort="Denton, Chris" uniqKey="Denton C" first="Chris" last="Denton">Chris Denton</name><affiliation><nlm:affiliation>Centre for Rheumatology and Connective Tissue Diseases, Division of Medicine, Royal Free Campus, UCL Medical School, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Ghofrani, Ardeschir" sort="Ghofrani, Ardeschir" uniqKey="Ghofrani A" first="Ardeschir" last="Ghofrani">Ardeschir Ghofrani</name><affiliation><nlm:affiliation>University of Giessen and Marburg Lung Center, Geissen, Hesse, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Gomez Sanchez, Miguel Angel" sort="Gomez Sanchez, Miguel Angel" uniqKey="Gomez Sanchez M" first="Miguel Angel" last="Gomez Sanchez">Miguel Angel Gomez Sanchez</name><affiliation><nlm:affiliation>Cardiology Service, Hospital Universitario 12 de Octubre, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Krishna Kumar, R" sort="Krishna Kumar, R" uniqKey="Krishna Kumar R" first="R" last="Krishna Kumar">R. 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Machado</name><affiliation><nlm:affiliation>University of Illinois, Chicago, Illinois.</nlm:affiliation></affiliation></author><author><name sortKey="Olschewski, Horst" sort="Olschewski, Horst" uniqKey="Olschewski H" first="Horst" last="Olschewski">Horst Olschewski</name><affiliation><nlm:affiliation>Institute for Lung and Vascular Research, Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Robbins, Ivan M" sort="Robbins, Ivan M" uniqKey="Robbins I" first="Ivan M" last="Robbins">Ivan M. Robbins</name><affiliation><nlm:affiliation>Vanderbilt University Medical Center, Nashville, Tennessee.</nlm:affiliation></affiliation></author><author><name sortKey="Souza, Rogiero" sort="Souza, Rogiero" uniqKey="Souza R" first="Rogiero" last="Souza">Rogiero Souza</name><affiliation><nlm:affiliation>Pulmonary Department, Heart Institute, University of São Paulo, Medical School, São Paulo, Brazil.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:24355639</idno><idno type="pmid">24355639</idno><idno type="doi">10.1016/j.jacc.2013.10.029</idno><idno type="wicri:Area/PubMed/Corpus">003A65</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003A65</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Updated clinical classification of pulmonary hypertension.</title><author><name sortKey="Simonneau, Gerald" sort="Simonneau, Gerald" uniqKey="Simonneau G" first="Gerald" last="Simonneau">Gerald Simonneau</name><affiliation><nlm:affiliation>Assistance publique-Hôpitaux de Paris, Service de Pneumologie, Hôpital Universitaire de Bicêtre, Université Paris-Sud, Laboratoire d'excellence en recherche sur le médicament et innovation thérapeutique, and INSERM, Unité 999, Le Kremlin Bicêtre, France. Electronic address: gerald.simonneau@bct.aphp.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Gatzoulis, Michael A" sort="Gatzoulis, Michael A" uniqKey="Gatzoulis M" first="Michael A" last="Gatzoulis">Michael A. Gatzoulis</name><affiliation><nlm:affiliation>Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital and the National Heart and Lung Institute, Imperial College, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Adatia, Ian" sort="Adatia, Ian" uniqKey="Adatia I" first="Ian" last="Adatia">Ian Adatia</name><affiliation><nlm:affiliation>University of Alberta, Stollery Children's Hospital and Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Celermajer, David" sort="Celermajer, David" uniqKey="Celermajer D" first="David" last="Celermajer">David Celermajer</name><affiliation><nlm:affiliation>Heart Research Institute, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Denton, Chris" sort="Denton, Chris" uniqKey="Denton C" first="Chris" last="Denton">Chris Denton</name><affiliation><nlm:affiliation>Centre for Rheumatology and Connective Tissue Diseases, Division of Medicine, Royal Free Campus, UCL Medical School, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Ghofrani, Ardeschir" sort="Ghofrani, Ardeschir" uniqKey="Ghofrani A" first="Ardeschir" last="Ghofrani">Ardeschir Ghofrani</name><affiliation><nlm:affiliation>University of Giessen and Marburg Lung Center, Geissen, Hesse, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Gomez Sanchez, Miguel Angel" sort="Gomez Sanchez, Miguel Angel" uniqKey="Gomez Sanchez M" first="Miguel Angel" last="Gomez Sanchez">Miguel Angel Gomez Sanchez</name><affiliation><nlm:affiliation>Cardiology Service, Hospital Universitario 12 de Octubre, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Krishna Kumar, R" sort="Krishna Kumar, R" uniqKey="Krishna Kumar R" first="R" last="Krishna Kumar">R. Krishna Kumar</name><affiliation><nlm:affiliation>Pediatric Cardiology, Amrita Institute of Medical Sciences, Cochin, Kerala, India.</nlm:affiliation></affiliation></author><author><name sortKey="Landzberg, Michael" sort="Landzberg, Michael" uniqKey="Landzberg M" first="Michael" last="Landzberg">Michael Landzberg</name><affiliation><nlm:affiliation>Childrens' Hospital, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Machado, Roberto F" sort="Machado, Roberto F" uniqKey="Machado R" first="Roberto F" last="Machado">Roberto F. Machado</name><affiliation><nlm:affiliation>University of Illinois, Chicago, Illinois.</nlm:affiliation></affiliation></author><author><name sortKey="Olschewski, Horst" sort="Olschewski, Horst" uniqKey="Olschewski H" first="Horst" last="Olschewski">Horst Olschewski</name><affiliation><nlm:affiliation>Institute for Lung and Vascular Research, Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Robbins, Ivan M" sort="Robbins, Ivan M" uniqKey="Robbins I" first="Ivan M" last="Robbins">Ivan M. Robbins</name><affiliation><nlm:affiliation>Vanderbilt University Medical Center, Nashville, Tennessee.</nlm:affiliation></affiliation></author><author><name sortKey="Souza, Rogiero" sort="Souza, Rogiero" uniqKey="Souza R" first="Rogiero" last="Souza">Rogiero Souza</name><affiliation><nlm:affiliation>Pulmonary Department, Heart Institute, University of São Paulo, Medical School, São Paulo, Brazil.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of the American College of Cardiology</title><idno type="eISSN">1558-3597</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anemia, Hemolytic (classification)</term><term>Anemia, Hemolytic (diagnosis)</term><term>Anemia, Hemolytic (epidemiology)</term><term>Animals</term><term>Connective Tissue Diseases (classification)</term><term>Connective Tissue Diseases (diagnosis)</term><term>Connective Tissue Diseases (epidemiology)</term><term>Heart Defects, Congenital (classification)</term><term>Heart Defects, Congenital (diagnosis)</term><term>Heart Defects, Congenital (epidemiology)</term><term>Humans</term><term>Hypertension, Pulmonary (classification)</term><term>Hypertension, Pulmonary (diagnosis)</term><term>Hypertension, Pulmonary (epidemiology)</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Anemia, Hemolytic</term><term>Connective Tissue Diseases</term><term>Heart Defects, Congenital</term><term>Hypertension, Pulmonary</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Anemia, Hemolytic</term><term>Connective Tissue Diseases</term><term>Heart Defects, Congenital</term><term>Hypertension, Pulmonary</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Anemia, Hemolytic</term><term>Connective Tissue Diseases</term><term>Heart Defects, Congenital</term><term>Hypertension, Pulmonary</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In 1998, a clinical classification of pulmonary hypertension (PH) was established, categorizing PH into groups which share similar pathological and hemodynamic characteristics and therapeutic approaches. During the 5th World Symposium held in Nice, France, in 2013, the consensus was reached to maintain the general scheme of previous clinical classifications. However, modifications and updates especially for Group 1 patients (pulmonary arterial hypertension [PAH]) were proposed. The main change was to withdraw persistent pulmonary hypertension of the newborn (PPHN) from Group 1 because this entity carries more differences than similarities with other PAH subgroups. In the current classification, PPHN is now designated number 1. Pulmonary hypertension associated with chronic hemolytic anemia has been moved from Group 1 PAH to Group 5, unclear/multifactorial mechanism. In addition, it was decided to add specific items related to pediatric pulmonary hypertension in order to create a comprehensive, common classification for both adults and children. Therefore, congenital or acquired left-heart inflow/outflow obstructive lesions and congenital cardiomyopathies have been added to Group 2, and segmental pulmonary hypertension has been added to Group 5. Last, there were no changes for Groups 2, 3, and 4.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24355639</PMID><DateCreated><Year>2013</Year><Month>12</Month><Day>20</Day></DateCreated><DateCompleted><Year>2014</Year><Month>03</Month><Day>12</Day></DateCompleted><DateRevised><Year>2015</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1558-3597</ISSN><JournalIssue CitedMedium="Internet"><Volume>62</Volume><Issue>25 Suppl</Issue><PubDate><Year>2013</Year><Month>Dec</Month><Day>24</Day></PubDate></JournalIssue><Title>Journal of the American College of Cardiology</Title><ISOAbbreviation>J. Am. Coll. Cardiol.</ISOAbbreviation></Journal><ArticleTitle>Updated clinical classification of pulmonary hypertension.</ArticleTitle><Pagination><MedlinePgn>D34-41</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jacc.2013.10.029</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0735-1097(13)05872-5</ELocationID><Abstract><AbstractText>In 1998, a clinical classification of pulmonary hypertension (PH) was established, categorizing PH into groups which share similar pathological and hemodynamic characteristics and therapeutic approaches. During the 5th World Symposium held in Nice, France, in 2013, the consensus was reached to maintain the general scheme of previous clinical classifications. However, modifications and updates especially for Group 1 patients (pulmonary arterial hypertension [PAH]) were proposed. The main change was to withdraw persistent pulmonary hypertension of the newborn (PPHN) from Group 1 because this entity carries more differences than similarities with other PAH subgroups. In the current classification, PPHN is now designated number 1. Pulmonary hypertension associated with chronic hemolytic anemia has been moved from Group 1 PAH to Group 5, unclear/multifactorial mechanism. In addition, it was decided to add specific items related to pediatric pulmonary hypertension in order to create a comprehensive, common classification for both adults and children. Therefore, congenital or acquired left-heart inflow/outflow obstructive lesions and congenital cardiomyopathies have been added to Group 2, and segmental pulmonary hypertension has been added to Group 5. Last, there were no changes for Groups 2, 3, and 4.</AbstractText><CopyrightInformation>Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Simonneau</LastName><ForeName>Gerald</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Assistance publique-Hôpitaux de Paris, Service de Pneumologie, Hôpital Universitaire de Bicêtre, Université Paris-Sud, Laboratoire d'excellence en recherche sur le médicament et innovation thérapeutique, and INSERM, Unité 999, Le Kremlin Bicêtre, France. Electronic address: gerald.simonneau@bct.aphp.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gatzoulis</LastName><ForeName>Michael A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital and the National Heart and Lung Institute, Imperial College, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adatia</LastName><ForeName>Ian</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>University of Alberta, Stollery Children's Hospital and Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Celermajer</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Heart Research Institute, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Denton</LastName><ForeName>Chris</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Centre for Rheumatology and Connective Tissue Diseases, Division of Medicine, Royal Free Campus, UCL Medical School, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghofrani</LastName><ForeName>Ardeschir</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>University of Giessen and Marburg Lung Center, Geissen, Hesse, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gomez Sanchez</LastName><ForeName>Miguel Angel</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Cardiology Service, Hospital Universitario 12 de Octubre, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krishna Kumar</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Pediatric Cardiology, Amrita Institute of Medical Sciences, Cochin, Kerala, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Landzberg</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Childrens' Hospital, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Machado</LastName><ForeName>Roberto F</ForeName><Initials>RF</Initials><AffiliationInfo><Affiliation>University of Illinois, Chicago, Illinois.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olschewski</LastName><ForeName>Horst</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute for Lung and Vascular Research, Medical University of Graz, Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robbins</LastName><ForeName>Ivan M</ForeName><Initials>IM</Initials><AffiliationInfo><Affiliation>Vanderbilt University Medical Center, Nashville, Tennessee.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Souza</LastName><ForeName>Rogiero</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Pulmonary Department, Heart Institute, University of São Paulo, Medical School, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Am Coll Cardiol</MedlineTA><NlmUniqueID>8301365</NlmUniqueID><ISSNLinking>0735-1097</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>J Am Coll Cardiol. 2014 Jul 1;63(25 Pt A):2881-2</RefSource><PMID Version="1">24794120</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>J Am Coll Cardiol. 2014 Jul 1;63(25 Pt A):2882-3</RefSource><PMID Version="1">24794124</PMID></CommentsCorrections><CommentsCorrections RefType="ErratumIn"><RefSource>J Am Coll Cardiol. 2014 Feb 25;63(7):746</RefSource></CommentsCorrections><CommentsCorrections RefType="ReprintIn"><RefSource>Turk Kardiyol Dern Ars. 2014 Oct;42 Suppl 1:45-54</RefSource><PMID Version="1">25697033</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000743" MajorTopicYN="N">Anemia, Hemolytic</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" 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MajorTopicYN="Y">classification</QualifierName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">CHD</Keyword><Keyword MajorTopicYN="N">HAART</Keyword><Keyword MajorTopicYN="N">HIV</Keyword><Keyword MajorTopicYN="N">IFN</Keyword><Keyword MajorTopicYN="N">PAH</Keyword><Keyword MajorTopicYN="N">PAP</Keyword><Keyword MajorTopicYN="N">PH</Keyword><Keyword MajorTopicYN="N">PH due to chronic lung diseases</Keyword><Keyword MajorTopicYN="N">PH due to left heart disease</Keyword><Keyword MajorTopicYN="N">POPH</Keyword><Keyword MajorTopicYN="N">PPHN</Keyword><Keyword MajorTopicYN="N">PVR</Keyword><Keyword MajorTopicYN="N">SCD</Keyword><Keyword MajorTopicYN="N">Sch-PAH</Keyword><Keyword MajorTopicYN="N">TGF</Keyword><Keyword MajorTopicYN="N">TKI</Keyword><Keyword MajorTopicYN="N">chronic thromboembolic pulmonary hypertension</Keyword><Keyword MajorTopicYN="N">congenital heart disease</Keyword><Keyword MajorTopicYN="N">highly active antiretroviral therapy</Keyword><Keyword MajorTopicYN="N">human immunodeficiency virus</Keyword><Keyword MajorTopicYN="N">interferon</Keyword><Keyword MajorTopicYN="N">persistent pulmonary hypertension of the newborn</Keyword><Keyword MajorTopicYN="N">portopulmonary hypertension</Keyword><Keyword MajorTopicYN="N">pulmonary arterial hypertension</Keyword><Keyword MajorTopicYN="N">pulmonary arterial pressure</Keyword><Keyword MajorTopicYN="N">pulmonary hypertension</Keyword><Keyword MajorTopicYN="N">pulmonary vascular resistance</Keyword><Keyword MajorTopicYN="N">schistosomiasis-associated PAH</Keyword><Keyword MajorTopicYN="N">sickle cell disease</Keyword><Keyword MajorTopicYN="N">tumor growth factor</Keyword><Keyword MajorTopicYN="N">tyrosine kinase inhibitor</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate 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