Characterization of a novel PXR isoform with potential dominant-negative properties.
Identifieur interne : 003477 ( PubMed/Corpus ); précédent : 003476; suivant : 003478Characterization of a novel PXR isoform with potential dominant-negative properties.
Auteurs : Cyril Breuker ; Chris Planque ; Fatemeh Rajabi ; Jean-Charles Nault ; Gabrielle Couchy ; Jessica Zucman-Rossi ; Alexandre Evrard ; Jovana Kantar ; Eric Chevet ; Paulette Bioulac-Sage ; Jeanne Ramos ; Eric Assenat ; Dominique Joubert ; Julie Pannequin ; Frédéric Hollande ; Jean Marc PascussiSource :
- Journal of hepatology [ 1600-0641 ] ; 2014.
English descriptors
- KwdEn :
- Adenoma, Liver Cell (metabolism), Adenoma, Liver Cell (pathology), Adenoma, Liver Cell (surgery), Carcinoma, Hepatocellular (metabolism), Carcinoma, Hepatocellular (pathology), Carcinoma, Hepatocellular (surgery), Cell Line, Tumor, Cells, Cultured, DNA Methylation, Hepatectomy, Humans, In Vitro Techniques, Liver (metabolism), Liver (pathology), Liver Neoplasms (metabolism), Liver Neoplasms (pathology), Liver Neoplasms (surgery), Protein Isoforms (genetics), Protein Isoforms (metabolism), RNA, Messenger (genetics), RNA, Messenger (metabolism), Receptors, Steroid (genetics), Receptors, Steroid (metabolism), Treatment Outcome.
- MESH :
- chemical , genetics : Protein Isoforms, RNA, Messenger, Receptors, Steroid.
- metabolism : Adenoma, Liver Cell, Carcinoma, Hepatocellular, Liver, Liver Neoplasms, Protein Isoforms, RNA, Messenger, Receptors, Steroid.
- pathology : Adenoma, Liver Cell, Carcinoma, Hepatocellular, Liver, Liver Neoplasms.
- surgery : Adenoma, Liver Cell, Carcinoma, Hepatocellular, Liver Neoplasms.
- Cell Line, Tumor, Cells, Cultured, DNA Methylation, Hepatectomy, Humans, In Vitro Techniques, Treatment Outcome.
Abstract
The nuclear Pregnane X Receptor (PXR, NR1I2) plays a pivotal role in xenobiotic metabolism. Here, we sought to characterize a new PXR isoform (hereafter called small PXR or sPXR) stemming from alternative transcription starting sites downstream of a CpG Island located near exon 3 of the human PXR gene.
DOI: 10.1016/j.jhep.2014.04.030
PubMed: 24798619
Links to Exploration step
pubmed:24798619Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characterization of a novel PXR isoform with potential dominant-negative properties.</title><author><name sortKey="Breuker, Cyril" sort="Breuker, Cyril" uniqKey="Breuker C" first="Cyril" last="Breuker">Cyril Breuker</name><affiliation><nlm:affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France; Service de Pharmacie, Centre Hospitalier Universitaire Lapeyronie, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Planque, Chris" sort="Planque, Chris" uniqKey="Planque C" first="Chris" last="Planque">Chris Planque</name><affiliation><nlm:affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rajabi, Fatemeh" sort="Rajabi, Fatemeh" uniqKey="Rajabi F" first="Fatemeh" last="Rajabi">Fatemeh Rajabi</name><affiliation><nlm:affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Nault, Jean Charles" sort="Nault, Jean Charles" uniqKey="Nault J" first="Jean-Charles" last="Nault">Jean-Charles Nault</name><affiliation><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale, U674, Paris, France; Université Paris Descartes, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Couchy, Gabrielle" sort="Couchy, Gabrielle" uniqKey="Couchy G" first="Gabrielle" last="Couchy">Gabrielle Couchy</name><affiliation><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale, U674, Paris, France; Université Paris Descartes, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Zucman Rossi, Jessica" sort="Zucman Rossi, Jessica" uniqKey="Zucman Rossi J" first="Jessica" last="Zucman-Rossi">Jessica Zucman-Rossi</name><affiliation><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale, U674, Paris, France; Université Paris Descartes, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Evrard, Alexandre" sort="Evrard, Alexandre" uniqKey="Evrard A" first="Alexandre" last="Evrard">Alexandre Evrard</name><affiliation><nlm:affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France; Laboratoire de Biochimie, Centre Hospitalier Universitaire, Nîmes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kantar, Jovana" sort="Kantar, Jovana" uniqKey="Kantar J" first="Jovana" last="Kantar">Jovana Kantar</name><affiliation><nlm:affiliation>Laboratoire de Biochimie, Centre Hospitalier Universitaire, Nîmes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Chevet, Eric" sort="Chevet, Eric" uniqKey="Chevet E" first="Eric" last="Chevet">Eric Chevet</name><affiliation><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale, U1053, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bioulac Sage, Paulette" sort="Bioulac Sage, Paulette" uniqKey="Bioulac Sage P" first="Paulette" last="Bioulac-Sage">Paulette Bioulac-Sage</name><affiliation><nlm:affiliation>Service d'anatomie pathologique, Centre Hospitalier Universitaire Gui de Chauliac, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ramos, Jeanne" sort="Ramos, Jeanne" uniqKey="Ramos J" first="Jeanne" last="Ramos">Jeanne Ramos</name><affiliation><nlm:affiliation>Service d'anatomie pathologique, Centre Hospitalier Universitaire Gui de Chauliac, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Assenat, Eric" sort="Assenat, Eric" uniqKey="Assenat E" first="Eric" last="Assenat">Eric Assenat</name><affiliation><nlm:affiliation>Service d'anatomie pathologique, Centre Hospitalier Universitaire Gui de Chauliac, Montpellier, France; Centre Val d'Aurelle, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Joubert, Dominique" sort="Joubert, Dominique" uniqKey="Joubert D" first="Dominique" last="Joubert">Dominique Joubert</name><affiliation><nlm:affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pannequin, Julie" sort="Pannequin, Julie" uniqKey="Pannequin J" first="Julie" last="Pannequin">Julie Pannequin</name><affiliation><nlm:affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hollande, Frederic" sort="Hollande, Frederic" uniqKey="Hollande F" first="Frédéric" last="Hollande">Frédéric Hollande</name><affiliation><nlm:affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France; Department of Pathology, University of Melbourne, Parkville, VIC 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Pascussi, Jean Marc" sort="Pascussi, Jean Marc" uniqKey="Pascussi J" first="Jean Marc" last="Pascussi">Jean Marc Pascussi</name><affiliation><nlm:affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France. Electronic address: jean-marc.pascussi@inserm.fr.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24798619</idno><idno type="pmid">24798619</idno><idno type="doi">10.1016/j.jhep.2014.04.030</idno><idno type="wicri:Area/PubMed/Corpus">003477</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003477</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Characterization of a novel PXR isoform with potential dominant-negative properties.</title><author><name sortKey="Breuker, Cyril" sort="Breuker, Cyril" uniqKey="Breuker C" first="Cyril" last="Breuker">Cyril Breuker</name><affiliation><nlm:affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France; Service de Pharmacie, Centre Hospitalier Universitaire Lapeyronie, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Planque, Chris" sort="Planque, Chris" uniqKey="Planque C" first="Chris" last="Planque">Chris Planque</name><affiliation><nlm:affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rajabi, Fatemeh" sort="Rajabi, Fatemeh" uniqKey="Rajabi F" first="Fatemeh" last="Rajabi">Fatemeh Rajabi</name><affiliation><nlm:affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Nault, Jean Charles" sort="Nault, Jean Charles" uniqKey="Nault J" first="Jean-Charles" last="Nault">Jean-Charles Nault</name><affiliation><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale, U674, Paris, France; Université Paris Descartes, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Couchy, Gabrielle" sort="Couchy, Gabrielle" uniqKey="Couchy G" first="Gabrielle" last="Couchy">Gabrielle Couchy</name><affiliation><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale, U674, Paris, France; Université Paris Descartes, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Zucman Rossi, Jessica" sort="Zucman Rossi, Jessica" uniqKey="Zucman Rossi J" first="Jessica" last="Zucman-Rossi">Jessica Zucman-Rossi</name><affiliation><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale, U674, Paris, France; Université Paris Descartes, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Evrard, Alexandre" sort="Evrard, Alexandre" uniqKey="Evrard A" first="Alexandre" last="Evrard">Alexandre Evrard</name><affiliation><nlm:affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France; Laboratoire de Biochimie, Centre Hospitalier Universitaire, Nîmes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kantar, Jovana" sort="Kantar, Jovana" uniqKey="Kantar J" first="Jovana" last="Kantar">Jovana Kantar</name><affiliation><nlm:affiliation>Laboratoire de Biochimie, Centre Hospitalier Universitaire, Nîmes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Chevet, Eric" sort="Chevet, Eric" uniqKey="Chevet E" first="Eric" last="Chevet">Eric Chevet</name><affiliation><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale, U1053, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bioulac Sage, Paulette" sort="Bioulac Sage, Paulette" uniqKey="Bioulac Sage P" first="Paulette" last="Bioulac-Sage">Paulette Bioulac-Sage</name><affiliation><nlm:affiliation>Service d'anatomie pathologique, Centre Hospitalier Universitaire Gui de Chauliac, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ramos, Jeanne" sort="Ramos, Jeanne" uniqKey="Ramos J" first="Jeanne" last="Ramos">Jeanne Ramos</name><affiliation><nlm:affiliation>Service d'anatomie pathologique, Centre Hospitalier Universitaire Gui de Chauliac, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Assenat, Eric" sort="Assenat, Eric" uniqKey="Assenat E" first="Eric" last="Assenat">Eric Assenat</name><affiliation><nlm:affiliation>Service d'anatomie pathologique, Centre Hospitalier Universitaire Gui de Chauliac, Montpellier, France; Centre Val d'Aurelle, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Joubert, Dominique" sort="Joubert, Dominique" uniqKey="Joubert D" first="Dominique" last="Joubert">Dominique Joubert</name><affiliation><nlm:affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pannequin, Julie" sort="Pannequin, Julie" uniqKey="Pannequin J" first="Julie" last="Pannequin">Julie Pannequin</name><affiliation><nlm:affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hollande, Frederic" sort="Hollande, Frederic" uniqKey="Hollande F" first="Frédéric" last="Hollande">Frédéric Hollande</name><affiliation><nlm:affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France; Department of Pathology, University of Melbourne, Parkville, VIC 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Pascussi, Jean Marc" sort="Pascussi, Jean Marc" uniqKey="Pascussi J" first="Jean Marc" last="Pascussi">Jean Marc Pascussi</name><affiliation><nlm:affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France. Electronic address: jean-marc.pascussi@inserm.fr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of hepatology</title><idno type="eISSN">1600-0641</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoma, Liver Cell (metabolism)</term><term>Adenoma, Liver Cell (pathology)</term><term>Adenoma, Liver Cell (surgery)</term><term>Carcinoma, Hepatocellular (metabolism)</term><term>Carcinoma, Hepatocellular (pathology)</term><term>Carcinoma, Hepatocellular (surgery)</term><term>Cell Line, Tumor</term><term>Cells, Cultured</term><term>DNA Methylation</term><term>Hepatectomy</term><term>Humans</term><term>In Vitro Techniques</term><term>Liver (metabolism)</term><term>Liver (pathology)</term><term>Liver Neoplasms (metabolism)</term><term>Liver Neoplasms (pathology)</term><term>Liver Neoplasms (surgery)</term><term>Protein Isoforms (genetics)</term><term>Protein Isoforms (metabolism)</term><term>RNA, Messenger (genetics)</term><term>RNA, Messenger (metabolism)</term><term>Receptors, Steroid (genetics)</term><term>Receptors, Steroid (metabolism)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Protein Isoforms</term><term>RNA, Messenger</term><term>Receptors, Steroid</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Adenoma, Liver Cell</term><term>Carcinoma, Hepatocellular</term><term>Liver</term><term>Liver Neoplasms</term><term>Protein Isoforms</term><term>RNA, Messenger</term><term>Receptors, Steroid</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Adenoma, Liver Cell</term><term>Carcinoma, Hepatocellular</term><term>Liver</term><term>Liver Neoplasms</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Adenoma, Liver Cell</term><term>Carcinoma, Hepatocellular</term><term>Liver Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term><term>Cells, Cultured</term><term>DNA Methylation</term><term>Hepatectomy</term><term>Humans</term><term>In Vitro Techniques</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The nuclear Pregnane X Receptor (PXR, NR1I2) plays a pivotal role in xenobiotic metabolism. Here, we sought to characterize a new PXR isoform (hereafter called small PXR or sPXR) stemming from alternative transcription starting sites downstream of a CpG Island located near exon 3 of the human PXR gene.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24798619</PMID><DateCreated><Year>2014</Year><Month>08</Month><Day>19</Day></DateCreated><DateCompleted><Year>2015</Year><Month>07</Month><Day>20</Day></DateCompleted><DateRevised><Year>2014</Year><Month>08</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-0641</ISSN><JournalIssue CitedMedium="Internet"><Volume>61</Volume><Issue>3</Issue><PubDate><Year>2014</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Journal of hepatology</Title><ISOAbbreviation>J. Hepatol.</ISOAbbreviation></Journal><ArticleTitle>Characterization of a novel PXR isoform with potential dominant-negative properties.</ArticleTitle><Pagination><MedlinePgn>609-16</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jhep.2014.04.030</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0168-8278(14)00293-1</ELocationID><Abstract><AbstractText Label="BACKGROUND & AIMS" NlmCategory="OBJECTIVE">The nuclear Pregnane X Receptor (PXR, NR1I2) plays a pivotal role in xenobiotic metabolism. Here, we sought to characterize a new PXR isoform (hereafter called small PXR or sPXR) stemming from alternative transcription starting sites downstream of a CpG Island located near exon 3 of the human PXR gene.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Quantitative RT-PCR, western blot, methylation-specific PCR, luciferase reporter assays, electro-mobility shift assays, and stable sPXR overexpression were used to examine sPXR expression and function in hepatocellular cell lines, healthy human liver (n=99), hepatocellular adenomas (HCA, n=91) and hepatocellular carcinoma samples (HCC, n=213).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Liver sPXR mRNA expression varied importantly among individuals and encodes a 37kDa nuclear protein consisting of the ligand-binding domain of PXR that behaves as a dominant-negative of PXR transactivation properties. In vitro methylation of the sPXR upstream promoter abolished its activity, while the demethylation agent 5-aza-2-deoxycytidine increased sPXR mRNA expression in several cell lines. Finally, we observed that sPXR mRNA expression displayed significant differences related to HCA or HCC biology.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This novel PXR isoform, displaying a dominant-negative activity and regulated by DNA methylation, is associated with outcomes of patients with HCC treated by resection, suggesting that it represents a key modulator of PXR.</AbstractText><CopyrightInformation>Copyright © 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Breuker</LastName><ForeName>Cyril</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France; Service de Pharmacie, Centre Hospitalier Universitaire Lapeyronie, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Planque</LastName><ForeName>Chris</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rajabi</LastName><ForeName>Fatemeh</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nault</LastName><ForeName>Jean-Charles</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale, U674, Paris, France; Université Paris Descartes, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Couchy</LastName><ForeName>Gabrielle</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale, U674, Paris, France; Université Paris Descartes, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zucman-Rossi</LastName><ForeName>Jessica</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale, U674, Paris, France; Université Paris Descartes, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Evrard</LastName><ForeName>Alexandre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France; Laboratoire de Biochimie, Centre Hospitalier Universitaire, Nîmes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kantar</LastName><ForeName>Jovana</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Laboratoire de Biochimie, Centre Hospitalier Universitaire, Nîmes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chevet</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale, U1053, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bioulac-Sage</LastName><ForeName>Paulette</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Service d'anatomie pathologique, Centre Hospitalier Universitaire Gui de Chauliac, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ramos</LastName><ForeName>Jeanne</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Service d'anatomie pathologique, Centre Hospitalier Universitaire Gui de Chauliac, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Assenat</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Service d'anatomie pathologique, Centre Hospitalier Universitaire Gui de Chauliac, Montpellier, France; Centre Val d'Aurelle, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Joubert</LastName><ForeName>Dominique</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pannequin</LastName><ForeName>Julie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hollande</LastName><ForeName>Frédéric</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France; Department of Pathology, University of Melbourne, Parkville, VIC 3010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pascussi</LastName><ForeName>Jean Marc</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France. Electronic address: jean-marc.pascussi@inserm.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>05</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Hepatol</MedlineTA><NlmUniqueID>8503886</NlmUniqueID><ISSNLinking>0168-8278</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020033">Protein Isoforms</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011987">Receptors, Steroid</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C110809">pregnane X receptor</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D018248" MajorTopicYN="N">Adenoma, Liver Cell</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006528" MajorTopicYN="N">Carcinoma, Hepatocellular</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019175" MajorTopicYN="N">DNA Methylation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006498" MajorTopicYN="N">Hepatectomy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D066298" MajorTopicYN="N">In Vitro Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008113" MajorTopicYN="N">Liver Neoplasms</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020033" MajorTopicYN="N">Protein Isoforms</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011987" MajorTopicYN="N">Receptors, Steroid</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Drug metabolism</Keyword><Keyword MajorTopicYN="N">Epigenetic regulation</Keyword><Keyword MajorTopicYN="N">Hepatocyte</Keyword><Keyword MajorTopicYN="N">Nuclear receptor</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>05</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>04</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>04</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>5</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>5</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>7</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24798619</ArticleId><ArticleId IdType="pii">S0168-8278(14)00293-1</ArticleId><ArticleId IdType="doi">10.1016/j.jhep.2014.04.030</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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