Host range of the potential biopesticide Pea Albumin 1b (PA1b) is limited to insects.
Identifieur interne : 003439 ( PubMed/Corpus ); précédent : 003438; suivant : 003440Host range of the potential biopesticide Pea Albumin 1b (PA1b) is limited to insects.
Auteurs : Isabelle Rahioui ; Vanessa Eyraud ; Lamis Karaki ; Florenz Sasse ; Maïté Carre-Pierrat ; An Qin ; Ming H. Zheng ; Stefan Toepfer ; Catherine Sivignon ; Corinne Royer ; Pedro Da Silva ; Frédéric GressentSource :
- Toxicon : official journal of the International Society on Toxinology [ 1879-3150 ] ; 2014.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Beetles (drug effects), Cell Differentiation (drug effects), Cell Line, Tumor, Drosophila melanogaster (drug effects), Fabaceae (chemistry), Humans, Insect Proteins (chemistry), Insecticide Resistance, Insects (drug effects), MCF-7 Cells, Mice, Molecular Sequence Data, Osteoclasts (drug effects), Pesticides (chemistry), Pesticides (toxicity), Plant Proteins (chemistry), Plant Proteins (toxicity), Seeds (chemistry), Toxicity Tests, Vacuolar Proton-Translocating ATPases (chemistry).
- MESH :
- chemical , chemistry : Insect Proteins, Pesticides, Plant Proteins, Vacuolar Proton-Translocating ATPases.
- chemistry : Fabaceae, Seeds.
- drug effects : Beetles, Cell Differentiation, Drosophila melanogaster, Insects, Osteoclasts.
- chemical , toxicity : Pesticides, Plant Proteins.
- Amino Acid Sequence, Animals, Cell Line, Tumor, Humans, Insecticide Resistance, MCF-7 Cells, Mice, Molecular Sequence Data, Toxicity Tests.
Abstract
The Pea Albumin 1 subunit b (PA1b) peptide is an entomotoxin extracted from legume seeds with lethal activity towards several insect pests. Its toxic activity occurs after the perception of PA1b by a plasmalemmic proton pump (V-ATPase) in the insects. Assays revealed that PA1b showed no activity towards mammalian cells displaying high V-ATPase activity. Similarly, PA1b displayed no binding activity and no biological activity towards other non-insect organisms. We demonstrate here that binding to labelled PA1b was found in all the insect families tested, regardless of the sensitivity or insensitivity of the individual species. The coleopteran Bruchidae, which are mainly legume seed pests, were found to be fully resistant. A number of insect species were seen to be insensitive to the toxin although they exhibited binding activity for the labelled PA1b. The fruit fly, Drosophila melanogaster (Diptera), was generally insensitive when maintained on an agar diet, but the fly appeared to be sensitive to PA1b in bioassays using a different diet. In conclusion, the PA1b toxin provides legumes with a major source of resistance to insects, and insects feeding on legume seeds need to overcome this plant resistance by disrupting the PA1b - V-ATPase interaction.
DOI: 10.1016/j.toxicon.2014.07.004
PubMed: 25064271
Links to Exploration step
pubmed:25064271Le document en format XML
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Albert Einstein, F-69621 Villeurbanne, France.</nlm:affiliation></affiliation></author><author><name sortKey="Karaki, Lamis" sort="Karaki, Lamis" uniqKey="Karaki L" first="Lamis" last="Karaki">Lamis Karaki</name><affiliation><nlm:affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. 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Albert Einstein, F-69621 Villeurbanne, France.</nlm:affiliation></affiliation></author><author><name sortKey="Royer, Corinne" sort="Royer, Corinne" uniqKey="Royer C" first="Corinne" last="Royer">Corinne Royer</name><affiliation><nlm:affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France.</nlm:affiliation></affiliation></author><author><name sortKey="Da Silva, Pedro" sort="Da Silva, Pedro" uniqKey="Da Silva P" first="Pedro" last="Da Silva">Pedro Da Silva</name><affiliation><nlm:affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gressent, Frederic" sort="Gressent, Frederic" uniqKey="Gressent F" first="Frédéric" last="Gressent">Frédéric Gressent</name><affiliation><nlm:affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France. Electronic address: Frederic.Gressent@supagro.inra.fr.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25064271</idno><idno type="pmid">25064271</idno><idno type="doi">10.1016/j.toxicon.2014.07.004</idno><idno type="wicri:Area/PubMed/Corpus">003439</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003439</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Host range of the potential biopesticide Pea Albumin 1b (PA1b) is limited to insects.</title><author><name sortKey="Rahioui, Isabelle" sort="Rahioui, Isabelle" uniqKey="Rahioui I" first="Isabelle" last="Rahioui">Isabelle Rahioui</name><affiliation><nlm:affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France.</nlm:affiliation></affiliation></author><author><name sortKey="Eyraud, Vanessa" sort="Eyraud, Vanessa" uniqKey="Eyraud V" first="Vanessa" last="Eyraud">Vanessa Eyraud</name><affiliation><nlm:affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France.</nlm:affiliation></affiliation></author><author><name sortKey="Karaki, Lamis" sort="Karaki, Lamis" uniqKey="Karaki L" first="Lamis" last="Karaki">Lamis Karaki</name><affiliation><nlm:affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sasse, Florenz" sort="Sasse, Florenz" uniqKey="Sasse F" first="Florenz" last="Sasse">Florenz Sasse</name><affiliation><nlm:affiliation>Department of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124 Braunschweig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Carre Pierrat, Maite" sort="Carre Pierrat, Maite" uniqKey="Carre Pierrat M" first="Maïté" last="Carre-Pierrat">Maïté Carre-Pierrat</name><affiliation><nlm:affiliation>Biology of Caenorhabditis elegans Facility, CNRS UMS 3421, Campus de la Doua, 16 rue Dubois, 69622 Villeurbanne, France; Université Claude Bernard Lyon 1, 43 bd du 11 Novembre, F-69622 Villeurbanne, France.</nlm:affiliation></affiliation></author><author><name sortKey="Qin, An" sort="Qin, An" uniqKey="Qin A" first="An" last="Qin">An Qin</name><affiliation><nlm:affiliation>Centre for Orthopaedic Research, School of Surgery, University of Western Australia, Perth, Australia; Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Zheng, Ming H" sort="Zheng, Ming H" uniqKey="Zheng M" first="Ming H" last="Zheng">Ming H. Zheng</name><affiliation><nlm:affiliation>Centre for Orthopaedic Research, School of Surgery, University of Western Australia, Perth, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Toepfer, Stefan" sort="Toepfer, Stefan" uniqKey="Toepfer S" first="Stefan" last="Toepfer">Stefan Toepfer</name><affiliation><nlm:affiliation>Chinese Ministry of Agriculture - CABI Joint Laboratory for Biosafety, Yuanmingyuan Western Road 2, CN - 100193 Beijing, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Sivignon, Catherine" sort="Sivignon, Catherine" uniqKey="Sivignon C" first="Catherine" last="Sivignon">Catherine Sivignon</name><affiliation><nlm:affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France.</nlm:affiliation></affiliation></author><author><name sortKey="Royer, Corinne" sort="Royer, Corinne" uniqKey="Royer C" first="Corinne" last="Royer">Corinne Royer</name><affiliation><nlm:affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France.</nlm:affiliation></affiliation></author><author><name sortKey="Da Silva, Pedro" sort="Da Silva, Pedro" uniqKey="Da Silva P" first="Pedro" last="Da Silva">Pedro Da Silva</name><affiliation><nlm:affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gressent, Frederic" sort="Gressent, Frederic" uniqKey="Gressent F" first="Frédéric" last="Gressent">Frédéric Gressent</name><affiliation><nlm:affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France. Electronic address: Frederic.Gressent@supagro.inra.fr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Toxicon : official journal of the International Society on Toxinology</title><idno type="eISSN">1879-3150</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Beetles (drug effects)</term><term>Cell Differentiation (drug effects)</term><term>Cell Line, Tumor</term><term>Drosophila melanogaster (drug effects)</term><term>Fabaceae (chemistry)</term><term>Humans</term><term>Insect Proteins (chemistry)</term><term>Insecticide Resistance</term><term>Insects (drug effects)</term><term>MCF-7 Cells</term><term>Mice</term><term>Molecular Sequence Data</term><term>Osteoclasts (drug effects)</term><term>Pesticides (chemistry)</term><term>Pesticides (toxicity)</term><term>Plant Proteins (chemistry)</term><term>Plant Proteins (toxicity)</term><term>Seeds (chemistry)</term><term>Toxicity Tests</term><term>Vacuolar Proton-Translocating ATPases (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Insect Proteins</term><term>Pesticides</term><term>Plant Proteins</term><term>Vacuolar Proton-Translocating ATPases</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Fabaceae</term><term>Seeds</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Beetles</term><term>Cell Differentiation</term><term>Drosophila melanogaster</term><term>Insects</term><term>Osteoclasts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Pesticides</term><term>Plant Proteins</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Cell Line, Tumor</term><term>Humans</term><term>Insecticide Resistance</term><term>MCF-7 Cells</term><term>Mice</term><term>Molecular Sequence Data</term><term>Toxicity Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Pea Albumin 1 subunit b (PA1b) peptide is an entomotoxin extracted from legume seeds with lethal activity towards several insect pests. Its toxic activity occurs after the perception of PA1b by a plasmalemmic proton pump (V-ATPase) in the insects. Assays revealed that PA1b showed no activity towards mammalian cells displaying high V-ATPase activity. Similarly, PA1b displayed no binding activity and no biological activity towards other non-insect organisms. We demonstrate here that binding to labelled PA1b was found in all the insect families tested, regardless of the sensitivity or insensitivity of the individual species. The coleopteran Bruchidae, which are mainly legume seed pests, were found to be fully resistant. A number of insect species were seen to be insensitive to the toxin although they exhibited binding activity for the labelled PA1b. The fruit fly, Drosophila melanogaster (Diptera), was generally insensitive when maintained on an agar diet, but the fly appeared to be sensitive to PA1b in bioassays using a different diet. In conclusion, the PA1b toxin provides legumes with a major source of resistance to insects, and insects feeding on legume seeds need to overcome this plant resistance by disrupting the PA1b - V-ATPase interaction.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25064271</PMID><DateCreated><Year>2014</Year><Month>08</Month><Day>18</Day></DateCreated><DateCompleted><Year>2015</Year><Month>04</Month><Day>23</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-3150</ISSN><JournalIssue CitedMedium="Internet"><Volume>89</Volume><PubDate><Year>2014</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Toxicon : official journal of the International Society on Toxinology</Title><ISOAbbreviation>Toxicon</ISOAbbreviation></Journal><ArticleTitle>Host range of the potential biopesticide Pea Albumin 1b (PA1b) is limited to insects.</ArticleTitle><Pagination><MedlinePgn>67-76</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.toxicon.2014.07.004</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0041-0101(14)00194-9</ELocationID><Abstract><AbstractText>The Pea Albumin 1 subunit b (PA1b) peptide is an entomotoxin extracted from legume seeds with lethal activity towards several insect pests. Its toxic activity occurs after the perception of PA1b by a plasmalemmic proton pump (V-ATPase) in the insects. Assays revealed that PA1b showed no activity towards mammalian cells displaying high V-ATPase activity. Similarly, PA1b displayed no binding activity and no biological activity towards other non-insect organisms. We demonstrate here that binding to labelled PA1b was found in all the insect families tested, regardless of the sensitivity or insensitivity of the individual species. The coleopteran Bruchidae, which are mainly legume seed pests, were found to be fully resistant. A number of insect species were seen to be insensitive to the toxin although they exhibited binding activity for the labelled PA1b. The fruit fly, Drosophila melanogaster (Diptera), was generally insensitive when maintained on an agar diet, but the fly appeared to be sensitive to PA1b in bioassays using a different diet. In conclusion, the PA1b toxin provides legumes with a major source of resistance to insects, and insects feeding on legume seeds need to overcome this plant resistance by disrupting the PA1b - V-ATPase interaction.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rahioui</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eyraud</LastName><ForeName>Vanessa</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karaki</LastName><ForeName>Lamis</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sasse</LastName><ForeName>Florenz</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124 Braunschweig, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carre-Pierrat</LastName><ForeName>Maïté</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Biology of Caenorhabditis elegans Facility, CNRS UMS 3421, Campus de la Doua, 16 rue Dubois, 69622 Villeurbanne, France; Université Claude Bernard Lyon 1, 43 bd du 11 Novembre, F-69622 Villeurbanne, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qin</LastName><ForeName>An</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Centre for Orthopaedic Research, School of Surgery, University of Western Australia, Perth, Australia; Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Ming H</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Centre for Orthopaedic Research, School of Surgery, University of Western Australia, Perth, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Toepfer</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Chinese Ministry of Agriculture - CABI Joint Laboratory for Biosafety, Yuanmingyuan Western Road 2, CN - 100193 Beijing, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sivignon</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Royer</LastName><ForeName>Corinne</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Da Silva</LastName><ForeName>Pedro</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gressent</LastName><ForeName>Frédéric</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France. 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MajorTopicYN="N">Fabaceae</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019476" MajorTopicYN="N">Insect Proteins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007305" MajorTopicYN="N">Insecticide Resistance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007313" MajorTopicYN="N">Insects</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D061986" MajorTopicYN="N">MCF-7 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010010" MajorTopicYN="N">Osteoclasts</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010575" MajorTopicYN="N">Pesticides</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010940" MajorTopicYN="N">Plant Proteins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012639" MajorTopicYN="N">Seeds</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018675" MajorTopicYN="N">Toxicity Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D025262" MajorTopicYN="N">Vacuolar Proton-Translocating ATPases</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Biopesticide</Keyword><Keyword MajorTopicYN="N">Insect</Keyword><Keyword MajorTopicYN="N">Non-target effects</Keyword><Keyword MajorTopicYN="N">PA1b</Keyword><Keyword MajorTopicYN="N">Pea Albumin 1 subunit b</Keyword><Keyword MajorTopicYN="N">V-ATPase</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>03</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>06</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>07</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>7</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>4</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25064271</ArticleId><ArticleId IdType="pii">S0041-0101(14)00194-9</ArticleId><ArticleId IdType="doi">10.1016/j.toxicon.2014.07.004</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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