Short-term risk of colorectal cancer in individuals with lynch syndrome: a meta-analysis.
Identifieur interne : 003019 ( PubMed/Corpus ); précédent : 003018; suivant : 003020Short-term risk of colorectal cancer in individuals with lynch syndrome: a meta-analysis.
Auteurs : Mark A. Jenkins ; James G. Dowty ; Driss Ait Ouakrim ; John D. Mathews ; John L. Hopper ; Youenn Drouet ; Christine Lasset ; Valérie Bonadona ; Aung Ko WinSource :
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology [ 1527-7755 ] ; 2015.
English descriptors
- KwdEn :
- Adaptor Proteins, Signal Transducing (genetics), Adult, Age Factors, Aged, Colonoscopy, Colorectal Neoplasms (diagnosis), Colorectal Neoplasms (genetics), Colorectal Neoplasms, Hereditary Nonpolyposis (genetics), Family Health, Female, Genetic Predisposition to Disease (genetics), Heterozygote, Humans, Male, Middle Aged, MutL Protein Homolog 1, MutS Homolog 2 Protein (genetics), Mutation, Nuclear Proteins (genetics), Risk Assessment (methods), Risk Assessment (statistics & numerical data), Risk Factors, Sex Factors, Time Factors.
- MESH :
- chemical , genetics : Adaptor Proteins, Signal Transducing, MutS Homolog 2 Protein, Nuclear Proteins.
- diagnosis : Colorectal Neoplasms.
- genetics : Colorectal Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Genetic Predisposition to Disease.
- methods : Risk Assessment.
- statistics & numerical data : Risk Assessment.
- Adult, Age Factors, Aged, Colonoscopy, Family Health, Female, Heterozygote, Humans, Male, Middle Aged, MutL Protein Homolog 1, Mutation, Risk Factors, Sex Factors, Time Factors.
Abstract
For carriers of germline mutations in DNA mismatch repair genes, the most relevant statistic for cancer prevention is colorectal cancer (Lynch syndrome) risk, particularly in the short term.
DOI: 10.1200/JCO.2014.55.8536
PubMed: 25534380
Links to Exploration step
pubmed:25534380Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Short-term risk of colorectal cancer in individuals with lynch syndrome: a meta-analysis.</title><author><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A" last="Jenkins">Mark A. Jenkins</name><affiliation><nlm:affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France. m.jenkins@unimelb.edu.au.</nlm:affiliation></affiliation></author><author><name sortKey="Dowty, James G" sort="Dowty, James G" uniqKey="Dowty J" first="James G" last="Dowty">James G. Dowty</name><affiliation><nlm:affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ait Ouakrim, Driss" sort="Ait Ouakrim, Driss" uniqKey="Ait Ouakrim D" first="Driss" last="Ait Ouakrim">Driss Ait Ouakrim</name><affiliation><nlm:affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mathews, John D" sort="Mathews, John D" uniqKey="Mathews J" first="John D" last="Mathews">John D. Mathews</name><affiliation><nlm:affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation><nlm:affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Drouet, Youenn" sort="Drouet, Youenn" uniqKey="Drouet Y" first="Youenn" last="Drouet">Youenn Drouet</name><affiliation><nlm:affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lasset, Christine" sort="Lasset, Christine" uniqKey="Lasset C" first="Christine" last="Lasset">Christine Lasset</name><affiliation><nlm:affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bonadona, Valerie" sort="Bonadona, Valerie" uniqKey="Bonadona V" first="Valérie" last="Bonadona">Valérie Bonadona</name><affiliation><nlm:affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Win, Aung Ko" sort="Win, Aung Ko" uniqKey="Win A" first="Aung Ko" last="Win">Aung Ko Win</name><affiliation><nlm:affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25534380</idno><idno type="pmid">25534380</idno><idno type="doi">10.1200/JCO.2014.55.8536</idno><idno type="wicri:Area/PubMed/Corpus">003019</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003019</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Short-term risk of colorectal cancer in individuals with lynch syndrome: a meta-analysis.</title><author><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A" last="Jenkins">Mark A. Jenkins</name><affiliation><nlm:affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France. m.jenkins@unimelb.edu.au.</nlm:affiliation></affiliation></author><author><name sortKey="Dowty, James G" sort="Dowty, James G" uniqKey="Dowty J" first="James G" last="Dowty">James G. Dowty</name><affiliation><nlm:affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ait Ouakrim, Driss" sort="Ait Ouakrim, Driss" uniqKey="Ait Ouakrim D" first="Driss" last="Ait Ouakrim">Driss Ait Ouakrim</name><affiliation><nlm:affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mathews, John D" sort="Mathews, John D" uniqKey="Mathews J" first="John D" last="Mathews">John D. Mathews</name><affiliation><nlm:affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation><nlm:affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Drouet, Youenn" sort="Drouet, Youenn" uniqKey="Drouet Y" first="Youenn" last="Drouet">Youenn Drouet</name><affiliation><nlm:affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lasset, Christine" sort="Lasset, Christine" uniqKey="Lasset C" first="Christine" last="Lasset">Christine Lasset</name><affiliation><nlm:affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bonadona, Valerie" sort="Bonadona, Valerie" uniqKey="Bonadona V" first="Valérie" last="Bonadona">Valérie Bonadona</name><affiliation><nlm:affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Win, Aung Ko" sort="Win, Aung Ko" uniqKey="Win A" first="Aung Ko" last="Win">Aung Ko Win</name><affiliation><nlm:affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of clinical oncology : official journal of the American Society of Clinical Oncology</title><idno type="eISSN">1527-7755</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptor Proteins, Signal Transducing (genetics)</term><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Colonoscopy</term><term>Colorectal Neoplasms (diagnosis)</term><term>Colorectal Neoplasms (genetics)</term><term>Colorectal Neoplasms, Hereditary Nonpolyposis (genetics)</term><term>Family Health</term><term>Female</term><term>Genetic Predisposition to Disease (genetics)</term><term>Heterozygote</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>MutL Protein Homolog 1</term><term>MutS Homolog 2 Protein (genetics)</term><term>Mutation</term><term>Nuclear Proteins (genetics)</term><term>Risk Assessment (methods)</term><term>Risk Assessment (statistics & numerical data)</term><term>Risk Factors</term><term>Sex Factors</term><term>Time Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Adaptor Proteins, Signal Transducing</term><term>MutS Homolog 2 Protein</term><term>Nuclear Proteins</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Colorectal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Colorectal Neoplasms</term><term>Colorectal Neoplasms, Hereditary Nonpolyposis</term><term>Genetic Predisposition to Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Risk Assessment</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Risk Assessment</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Colonoscopy</term><term>Family Health</term><term>Female</term><term>Heterozygote</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>MutL Protein Homolog 1</term><term>Mutation</term><term>Risk Factors</term><term>Sex Factors</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">For carriers of germline mutations in DNA mismatch repair genes, the most relevant statistic for cancer prevention is colorectal cancer (Lynch syndrome) risk, particularly in the short term.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25534380</PMID><DateCreated><Year>2015</Year><Month>01</Month><Day>30</Day></DateCreated><DateCompleted><Year>2015</Year><Month>04</Month><Day>20</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1527-7755</ISSN><JournalIssue CitedMedium="Internet"><Volume>33</Volume><Issue>4</Issue><PubDate><Year>2015</Year><Month>Feb</Month><Day>01</Day></PubDate></JournalIssue><Title>Journal of clinical oncology : official journal of the American Society of Clinical Oncology</Title><ISOAbbreviation>J. Clin. Oncol.</ISOAbbreviation></Journal><ArticleTitle>Short-term risk of colorectal cancer in individuals with lynch syndrome: a meta-analysis.</ArticleTitle><Pagination><MedlinePgn>326-31</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1200/JCO.2014.55.8536</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">For carriers of germline mutations in DNA mismatch repair genes, the most relevant statistic for cancer prevention is colorectal cancer (Lynch syndrome) risk, particularly in the short term.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We conducted a meta-analysis of all independent published Lynch syndrome studies reporting age- and sex-dependent colorectal cancer risks. We estimated 5-year colorectal cancer risk over different age groups, separately for male and female mutation carriers, and number needed to screen to prevent one death.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We pooled estimates from analyses of 1,114 Lynch syndrome families (508 with MLH1 mutations and 606 with MSH2 mutations). On average, one in 71 male and one in 102 female MLH1 or MSH2 mutation carriers in their 20s will be diagnosed with colorectal cancer in the next 5 years. These colorectal cancer risks increase with age, peaking in the 50s (one in seven males and one in 12 females), and then decrease with age (one in 13 males and one in 19 females in their 70s). Annual colonoscopy in 16 males or 25 females in their 50s would prevent one death from colorectal cancer over 5 years while resulting in almost no serious complications. In comparison, annual colonoscopy in 155 males or 217 females in their 20s would prevent one death while resulting in approximately one serious complication.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">For MLH1 or MSH2 mutation carriers, current guidelines recommend colonoscopy every 1 to 2 years starting in their 20s. Our findings support this regimen from age 30 years; however, it might not be justifiable for carriers who are in their 20s.</AbstractText><CopyrightInformation>© 2014 by American Society of Clinical Oncology.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jenkins</LastName><ForeName>Mark A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France. m.jenkins@unimelb.edu.au.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dowty</LastName><ForeName>James G</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ait Ouakrim</LastName><ForeName>Driss</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mathews</LastName><ForeName>John D</ForeName><Initials>JD</Initials><AffiliationInfo><Affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hopper</LastName><ForeName>John L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Drouet</LastName><ForeName>Youenn</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lasset</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bonadona</LastName><ForeName>Valérie</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Win</LastName><ForeName>Aung Ko</ForeName><Initials>AK</Initials><AffiliationInfo><Affiliation>Mark A. Jenkins, James G. Dowty, Driss Ait Ouakrim, John D. Mathews, John L. Hopper, and Aung Ko Win, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; John L. Hopper, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea; Youenn Drouet, Christine Lasset, and Valérie Bonadona, Université Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne; and Youenn Drouet, Christine Lasset, and Valérie Bonadona, Centre Léon Bérard, Lyon, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017418">Meta-Analysis</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>12</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Clin Oncol</MedlineTA><NlmUniqueID>8309333</NlmUniqueID><ISSNLinking>0732-183X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D048868">Adaptor Proteins, Signal Transducing</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C501486">MLH1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009687">Nuclear Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.1.3</RegistryNumber><NameOfSubstance UI="C497172">MSH2 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.1.3</RegistryNumber><NameOfSubstance UI="D000070957">MutL Protein Homolog 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.1.3</RegistryNumber><NameOfSubstance UI="D051718">MutS Homolog 2 Protein</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D048868" MajorTopicYN="N">Adaptor Proteins, Signal Transducing</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003113" MajorTopicYN="N">Colonoscopy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015179" MajorTopicYN="N">Colorectal Neoplasms</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003123" MajorTopicYN="N">Colorectal Neoplasms, Hereditary Nonpolyposis</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005192" MajorTopicYN="N">Family Health</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020022" MajorTopicYN="N">Genetic Predisposition to Disease</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006579" MajorTopicYN="N">Heterozygote</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000070957" MajorTopicYN="N">MutL Protein Homolog 1</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051718" MajorTopicYN="N">MutS Homolog 2 Protein</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="Y">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009687" MajorTopicYN="N">Nuclear Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012737" MajorTopicYN="N">Sex Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>12</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>12</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>4</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25534380</ArticleId><ArticleId IdType="pii">JCO.2014.55.8536</ArticleId><ArticleId IdType="doi">10.1200/JCO.2014.55.8536</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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