Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
Identifieur interne : 002B94 ( PubMed/Corpus ); précédent : 002B93; suivant : 002B95Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
Auteurs : Fredrick R. Schumacher ; Stephanie L. Schmit ; Shuo Jiao ; Christopher K. Edlund ; Hansong Wang ; Ben Zhang ; Li Hsu ; Shu-Chen Huang ; Christopher P. Fischer ; John F. Harju ; Gregory E. Idos ; Flavio Lejbkowicz ; Frank J. Manion ; Kevin Mcdonnell ; Caroline E. Mcneil ; Marilena Melas ; Hedy S. Rennert ; Wei Shi ; Duncan C. Thomas ; David J. Van Den Berg ; Carolyn M. Hutter ; Aaron K. Aragaki ; Katja Butterbach ; Bette J. Caan ; Christopher S. Carlson ; Stephen J. Chanock ; Keith R. Curtis ; Charles S. Fuchs ; Manish Gala ; Edward L. Giovannucc ; Edward L. Giocannucci ; Stephanie M. Gogarten ; Richard B. Hayes ; Brian Henderson ; David J. Hunter ; Rebecca D. Jackson ; Laurence N. Kolonel ; Charles Kooperberg ; Sébastien Küry ; Sebastian Kury ; Andrea Lacroix ; Cathy C. Laurie ; Cecelia A. Laurie ; Mathieu Lemire ; Mathiew Lemire ; David Levine ; Jing Ma ; Karen W. Makar ; Conghui Qu ; Darin Taverna ; Cornelia M. Ulrich ; Kana Wu ; Suminori Kono ; Dee W. West ; Sonja I. Berndt ; Stéphane Bezieau ; Hermann Brenner ; Peter T. Campbell ; Andrew T. Chan ; Jenny Chang-Claude ; Gerhard A. Coetzee ; David V. Conti ; David Duggan ; Jane C. Figueiredo ; Barbara K. Fortini ; Steven J. Gallinger ; W James Gauderman ; Graham Giles ; Roger Green ; Robert Haile ; Tabitha A. Harrison ; Michael Hoffmeister ; John L. Hopper ; Thomas J. Hudson ; Eric Jacobs ; Motoki Iwasaki ; Sun Ha Jee ; Mark Jenkins ; Wei-Hua Jia ; Amit Joshi ; Li Li ; Noralene M. Lindor ; Keitaro Matsuo ; Victor Moreno ; Bhramar Mukherjee ; Polly A. Newcomb ; John D. Potter ; Leon Raskin ; Gad Rennert ; Stephanie Rosse ; Gianluca Severi ; Robert E. Schoen ; Daniela Seminara ; Xiao-Ou Shu ; Martha L. Slattery ; Shoichiro Tsugane ; Emily White ; Yong-Bing Xiang ; Brent W. Zanke ; Wei Zheng ; Loic Le Marchand ; Graham Casey ; Stephen B. Gruber ; Ulrike PetersSource :
- Nature communications [ 2041-1723 ] ; 2015.
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Abstract
Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.
DOI: 10.1038/ncomms8138
PubMed: 26151821
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genome-wide association study of colorectal cancer identifies six new susceptibility loci.</title><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R" last="Schumacher">Fredrick R. Schumacher</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Schmit, Stephanie L" sort="Schmit, Stephanie L" uniqKey="Schmit S" first="Stephanie L" last="Schmit">Stephanie L. Schmit</name><affiliation><nlm:affiliation>1] Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA [2] Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jiao, Shuo" sort="Jiao, Shuo" uniqKey="Jiao S" first="Shuo" last="Jiao">Shuo Jiao</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Edlund, Christopher K" sort="Edlund, Christopher K" uniqKey="Edlund C" first="Christopher K" last="Edlund">Christopher K. Edlund</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Hansong" sort="Wang, Hansong" uniqKey="Wang H" first="Hansong" last="Wang">Hansong Wang</name><affiliation><nlm:affiliation>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Ben" sort="Zhang, Ben" uniqKey="Zhang B" first="Ben" last="Zhang">Ben Zhang</name><affiliation><nlm:affiliation>Department of General Surgery, Third Military Medical University Southwest Hospital, Chongqing 400038, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hsu, Li" sort="Hsu, Li" uniqKey="Hsu L" first="Li" last="Hsu">Li Hsu</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Shu Chen" sort="Huang, Shu Chen" uniqKey="Huang S" first="Shu-Chen" last="Huang">Shu-Chen Huang</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Fischer, Christopher P" sort="Fischer, Christopher P" uniqKey="Fischer C" first="Christopher P" last="Fischer">Christopher P. Fischer</name><affiliation><nlm:affiliation>University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Harju, John F" sort="Harju, John F" uniqKey="Harju J" first="John F" last="Harju">John F. Harju</name><affiliation><nlm:affiliation>University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Idos, Gregory E" sort="Idos, Gregory E" uniqKey="Idos G" first="Gregory E" last="Idos">Gregory E. Idos</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lejbkowicz, Flavio" sort="Lejbkowicz, Flavio" uniqKey="Lejbkowicz F" first="Flavio" last="Lejbkowicz">Flavio Lejbkowicz</name><affiliation><nlm:affiliation>1] Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361, Israel [2] Clalit Health Services National Cancer Control Center, Haifa 34361, Israel.</nlm:affiliation></affiliation></author><author><name sortKey="Manion, Frank J" sort="Manion, Frank J" uniqKey="Manion F" first="Frank J" last="Manion">Frank J. Manion</name><affiliation><nlm:affiliation>University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mcdonnell, Kevin" sort="Mcdonnell, Kevin" uniqKey="Mcdonnell K" first="Kevin" last="Mcdonnell">Kevin Mcdonnell</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mcneil, Caroline E" sort="Mcneil, Caroline E" uniqKey="Mcneil C" first="Caroline E" last="Mcneil">Caroline E. Mcneil</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Melas, Marilena" sort="Melas, Marilena" uniqKey="Melas M" first="Marilena" last="Melas">Marilena Melas</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rennert, Hedy S" sort="Rennert, Hedy S" uniqKey="Rennert H" first="Hedy S" last="Rennert">Hedy S. Rennert</name><affiliation><nlm:affiliation>1] Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361, Israel [2] Clalit Health Services National Cancer Control Center, Haifa 34361, Israel.</nlm:affiliation></affiliation></author><author><name sortKey="Shi, Wei" sort="Shi, Wei" uniqKey="Shi W" first="Wei" last="Shi">Wei Shi</name><affiliation><nlm:affiliation>Department of Surgery, Children's Hospital Los Angeles, Los Angeles, California 90027, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Thomas, Duncan C" sort="Thomas, Duncan C" uniqKey="Thomas D" first="Duncan C" last="Thomas">Duncan C. Thomas</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Van Den Berg, David J" sort="Van Den Berg, David J" uniqKey="Van Den Berg D" first="David J" last="Van Den Berg">David J. Van Den Berg</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hutter, Carolyn M" sort="Hutter, Carolyn M" uniqKey="Hutter C" first="Carolyn M" last="Hutter">Carolyn M. Hutter</name><affiliation><nlm:affiliation>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Aragaki, Aaron K" sort="Aragaki, Aaron K" uniqKey="Aragaki A" first="Aaron K" last="Aragaki">Aaron K. Aragaki</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Butterbach, Katja" sort="Butterbach, Katja" uniqKey="Butterbach K" first="Katja" last="Butterbach">Katja Butterbach</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Caan, Bette J" sort="Caan, Bette J" uniqKey="Caan B" first="Bette J" last="Caan">Bette J. Caan</name><affiliation><nlm:affiliation>Division of Research, Kaiser Permanente Medical Care Program of Northern California, Oakland, California 94612, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Carlson, Christopher S" sort="Carlson, Christopher S" uniqKey="Carlson C" first="Christopher S" last="Carlson">Christopher S. Carlson</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-9776, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Curtis, Keith R" sort="Curtis, Keith R" uniqKey="Curtis K" first="Keith R" last="Curtis">Keith R. Curtis</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Fuchs, Charles S" sort="Fuchs, Charles S" uniqKey="Fuchs C" first="Charles S" last="Fuchs">Charles S. Fuchs</name><affiliation><nlm:affiliation>1] Department of Medicine, Brigham and Women's Hospital, Brookline, Massachusetts 02115, USA [2] Department of Medical Oncology, Dana-Farber Cancer Institute, Brookline, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gala, Manish" sort="Gala, Manish" uniqKey="Gala M" first="Manish" last="Gala">Manish Gala</name><affiliation><nlm:affiliation>Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Giovannucc, Edward L" sort="Giovannucc, Edward L" uniqKey="Giovannucc E" first="Edward L" last="Giovannucc">Edward L. Giovannucc</name></author><author><name sortKey="Giocannucci, Edward L" sort="Giocannucci, Edward L" uniqKey="Giocannucci E" first="Edward L" last="Giocannucci">Edward L. Giocannucci</name><affiliation><nlm:affiliation>1] Harvard Medical School, Boston, Massachusetts 02114, USA [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gogarten, Stephanie M" sort="Gogarten, Stephanie M" uniqKey="Gogarten S" first="Stephanie M" last="Gogarten">Stephanie M. Gogarten</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B" last="Hayes">Richard B. Hayes</name><affiliation><nlm:affiliation>Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, New York 10016, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Henderson, Brian" sort="Henderson, Brian" uniqKey="Henderson B" first="Brian" last="Henderson">Brian Henderson</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation><nlm:affiliation>Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jackson, Rebecca D" sort="Jackson, Rebecca D" uniqKey="Jackson R" first="Rebecca D" last="Jackson">Rebecca D. Jackson</name><affiliation><nlm:affiliation>Department of Medicine, Ohio State University, Columbus, Ohio 43210, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N" last="Kolonel">Laurence N. Kolonel</name><affiliation><nlm:affiliation>Office of Public Health Studies, University of Hawaii Manoa, Honolulu, Hawaii 96822, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kury, Sebastien" sort="Kury, Sebastien" uniqKey="Kury S" first="Sébastien" last="Küry">Sébastien Küry</name></author><author><name sortKey="Kury, Sebastian" sort="Kury, Sebastian" uniqKey="Kury S" first="Sebastian" last="Kury">Sebastian Kury</name><affiliation><nlm:affiliation>Service de Génétique Médicale, CHU Nantes, Nantes 44093, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lacroix, Andrea" sort="Lacroix, Andrea" uniqKey="Lacroix A" first="Andrea" last="Lacroix">Andrea Lacroix</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Laurie, Cathy C" sort="Laurie, Cathy C" uniqKey="Laurie C" first="Cathy C" last="Laurie">Cathy C. Laurie</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Laurie, Cecelia A" sort="Laurie, Cecelia A" uniqKey="Laurie C" first="Cecelia A" last="Laurie">Cecelia A. Laurie</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name></author><author><name sortKey="Lemire, Mathiew" sort="Lemire, Mathiew" uniqKey="Lemire M" first="Mathiew" last="Lemire">Mathiew Lemire</name><affiliation><nlm:affiliation>Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Levine, David" sort="Levine, David" uniqKey="Levine D" first="David" last="Levine">David Levine</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation><nlm:affiliation>Harvard School of Public Health, Boston, Massachusetts 02114, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Makar, Karen W" sort="Makar, Karen W" uniqKey="Makar K" first="Karen W" last="Makar">Karen W. Makar</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Qu, Conghui" sort="Qu, Conghui" uniqKey="Qu C" first="Conghui" last="Qu">Conghui Qu</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Taverna, Darin" sort="Taverna, Darin" uniqKey="Taverna D" first="Darin" last="Taverna">Darin Taverna</name><affiliation><nlm:affiliation>Phoenix College, Phoenix, Arizona 85013, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ulrich, Cornelia M" sort="Ulrich, Cornelia M" uniqKey="Ulrich C" first="Cornelia M" last="Ulrich">Cornelia M. Ulrich</name><affiliation><nlm:affiliation>1] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA [2] Division of Preventive Oncology, German Cancer Research Center, Heidelberg 69120, Germany [3] Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington 98195, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Kana" sort="Wu, Kana" uniqKey="Wu K" first="Kana" last="Wu">Kana Wu</name><affiliation><nlm:affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kono, Suminori" sort="Kono, Suminori" uniqKey="Kono S" first="Suminori" last="Kono">Suminori Kono</name><affiliation><nlm:affiliation>Department of Preventive Medicine, Kyushu University, Fukuoka 812-8582, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="West, Dee W" sort="West, Dee W" uniqKey="West D" first="Dee W" last="West">Dee W. West</name><affiliation><nlm:affiliation>Cancer Registry of Greater California, Public Health Institute, Sacramento, California 95825, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-9776, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stéphane" last="Bezieau">Stéphane Bezieau</name><affiliation><nlm:affiliation>Centre Hospitalier Universitaire Hotel-Dieu, Nantes, 44093, France.</nlm:affiliation></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Campbell, Peter T" sort="Campbell, Peter T" uniqKey="Campbell P" first="Peter T" last="Campbell">Peter T. Campbell</name><affiliation><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30329-4251, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T" last="Chan">Andrew T. 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Figueiredo</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Fortini, Barbara K" sort="Fortini, Barbara K" uniqKey="Fortini B" first="Barbara K" last="Fortini">Barbara K. Fortini</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gallinger, Steven J" sort="Gallinger, Steven J" uniqKey="Gallinger S" first="Steven J" last="Gallinger">Steven J. Gallinger</name><affiliation><nlm:affiliation>Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Gauderman, W James" sort="Gauderman, W James" uniqKey="Gauderman W" first="W James" last="Gauderman">W James Gauderman</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Giles, Graham" sort="Giles, Graham" uniqKey="Giles G" first="Graham" last="Giles">Graham Giles</name><affiliation><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Green, Roger" sort="Green, Roger" uniqKey="Green R" first="Roger" last="Green">Roger Green</name><affiliation><nlm:affiliation>Discipline of Genetics, Memorial University of Newfoundland, St. John's, Newfoundland A1B 3V6, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Haile, Robert" sort="Haile, Robert" uniqKey="Haile R" first="Robert" last="Haile">Robert Haile</name><affiliation><nlm:affiliation>Department of Medicine, Division of Oncology, Stanford University, Stanford, California 94305, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Harrison, Tabitha A" sort="Harrison, Tabitha A" uniqKey="Harrison T" first="Tabitha A" last="Harrison">Tabitha A. Harrison</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation><nlm:affiliation>Centre for MEGA Epidemiology, The University of Melbourne, Carlton, Victoria 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J" last="Hudson">Thomas J. Hudson</name><affiliation><nlm:affiliation>Department of Genomics, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Jacobs, Eric" sort="Jacobs, Eric" uniqKey="Jacobs E" first="Eric" last="Jacobs">Eric Jacobs</name><affiliation><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30329-4251, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Iwasaki, Motoki" sort="Iwasaki, Motoki" uniqKey="Iwasaki M" first="Motoki" last="Iwasaki">Motoki Iwasaki</name><affiliation><nlm:affiliation>Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Jee, Sun Ha" sort="Jee, Sun Ha" uniqKey="Jee S" first="Sun Ha" last="Jee">Sun Ha Jee</name><affiliation><nlm:affiliation>Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 120-749, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Jenkins, Mark" sort="Jenkins, Mark" uniqKey="Jenkins M" first="Mark" last="Jenkins">Mark Jenkins</name><affiliation><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Jia, Wei Hua" sort="Jia, Wei Hua" uniqKey="Jia W" first="Wei-Hua" last="Jia">Wei-Hua Jia</name><affiliation><nlm:affiliation>State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China.</nlm:affiliation></affiliation></author><author><name sortKey="Joshi, Amit" sort="Joshi, Amit" uniqKey="Joshi A" first="Amit" last="Joshi">Amit Joshi</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name><affiliation><nlm:affiliation>Department of Family Medicine and Community Health, Case Western Reserve University, Cleveland, Ohio 44106, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lindor, Noralene M" sort="Lindor, Noralene M" uniqKey="Lindor N" first="Noralene M" last="Lindor">Noralene M. Lindor</name><affiliation><nlm:affiliation>Department of Health Science Research, Mayo Clinic, Scottsdale, Arizona 85259, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name><affiliation><nlm:affiliation>Department of Preventive Medicine, Kyushu University, Fukuoka 812-8582, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Moreno, Victor" sort="Moreno, Victor" uniqKey="Moreno V" first="Victor" last="Moreno">Victor Moreno</name><affiliation><nlm:affiliation>Cancer Epidemiology Service, Catalan Institute of Oncology, IDIBELL, 08908, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Mukherjee, Bhramar" sort="Mukherjee, Bhramar" uniqKey="Mukherjee B" first="Bhramar" last="Mukherjee">Bhramar Mukherjee</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A" last="Newcomb">Polly A. Newcomb</name><affiliation><nlm:affiliation>Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D" last="Potter">John D. Potter</name><affiliation><nlm:affiliation>Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Raskin, Leon" sort="Raskin, Leon" uniqKey="Raskin L" first="Leon" last="Raskin">Leon Raskin</name><affiliation><nlm:affiliation>1] Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA [2] Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA [3] Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation><nlm:affiliation>1] Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA [2] Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361, Israel [3] Clalit Health Services National Cancer Control Center, Haifa 34361, Israel [4] Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3200003, Israel.</nlm:affiliation></affiliation></author><author><name sortKey="Rosse, Stephanie" sort="Rosse, Stephanie" uniqKey="Rosse S" first="Stephanie" last="Rosse">Stephanie Rosse</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:affiliation>1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia [2] Human Genetics Foundation (HuGeF), Torino 10126, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E" last="Schoen">Robert E. Schoen</name><affiliation><nlm:affiliation>Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation><nlm:affiliation>Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:affiliation>1] Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738, USA [2] Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L" last="Slattery">Martha L. Slattery</name><affiliation><nlm:affiliation>Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Tsugane, Shoichiro" sort="Tsugane, Shoichiro" uniqKey="Tsugane S" first="Shoichiro" last="Tsugane">Shoichiro Tsugane</name><affiliation><nlm:affiliation>Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Xiang, Yong Bing" sort="Xiang, Yong Bing" uniqKey="Xiang Y" first="Yong-Bing" last="Xiang">Yong-Bing Xiang</name><affiliation><nlm:affiliation>Department of Epidemiology, Shanghai Cancer Institute, Shanghai 2200-25, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zanke, Brent W" sort="Zanke, Brent W" uniqKey="Zanke B" first="Brent W" last="Zanke">Brent W. Zanke</name><affiliation><nlm:affiliation>1] The University of Ottawa, Ottawa, Ontario K1N 6N5, Canada [2] Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario K1Y 4E9, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:affiliation>1] Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA [2] Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:affiliation>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B" last="Gruber">Stephen B. Gruber</name><affiliation><nlm:affiliation>1] Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA [2] Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26151821</idno><idno type="pmid">26151821</idno><idno type="doi">10.1038/ncomms8138</idno><idno type="wicri:Area/PubMed/Corpus">002B94</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002B94</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genome-wide association study of colorectal cancer identifies six new susceptibility loci.</title><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R" last="Schumacher">Fredrick R. Schumacher</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Schmit, Stephanie L" sort="Schmit, Stephanie L" uniqKey="Schmit S" first="Stephanie L" last="Schmit">Stephanie L. Schmit</name><affiliation><nlm:affiliation>1] Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA [2] Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jiao, Shuo" sort="Jiao, Shuo" uniqKey="Jiao S" first="Shuo" last="Jiao">Shuo Jiao</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Edlund, Christopher K" sort="Edlund, Christopher K" uniqKey="Edlund C" first="Christopher K" last="Edlund">Christopher K. Edlund</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Hansong" sort="Wang, Hansong" uniqKey="Wang H" first="Hansong" last="Wang">Hansong Wang</name><affiliation><nlm:affiliation>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Ben" sort="Zhang, Ben" uniqKey="Zhang B" first="Ben" last="Zhang">Ben Zhang</name><affiliation><nlm:affiliation>Department of General Surgery, Third Military Medical University Southwest Hospital, Chongqing 400038, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hsu, Li" sort="Hsu, Li" uniqKey="Hsu L" first="Li" last="Hsu">Li Hsu</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Shu Chen" sort="Huang, Shu Chen" uniqKey="Huang S" first="Shu-Chen" last="Huang">Shu-Chen Huang</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Fischer, Christopher P" sort="Fischer, Christopher P" uniqKey="Fischer C" first="Christopher P" last="Fischer">Christopher P. Fischer</name><affiliation><nlm:affiliation>University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Harju, John F" sort="Harju, John F" uniqKey="Harju J" first="John F" last="Harju">John F. Harju</name><affiliation><nlm:affiliation>University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Idos, Gregory E" sort="Idos, Gregory E" uniqKey="Idos G" first="Gregory E" last="Idos">Gregory E. Idos</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lejbkowicz, Flavio" sort="Lejbkowicz, Flavio" uniqKey="Lejbkowicz F" first="Flavio" last="Lejbkowicz">Flavio Lejbkowicz</name><affiliation><nlm:affiliation>1] Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361, Israel [2] Clalit Health Services National Cancer Control Center, Haifa 34361, Israel.</nlm:affiliation></affiliation></author><author><name sortKey="Manion, Frank J" sort="Manion, Frank J" uniqKey="Manion F" first="Frank J" last="Manion">Frank J. Manion</name><affiliation><nlm:affiliation>University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mcdonnell, Kevin" sort="Mcdonnell, Kevin" uniqKey="Mcdonnell K" first="Kevin" last="Mcdonnell">Kevin Mcdonnell</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mcneil, Caroline E" sort="Mcneil, Caroline E" uniqKey="Mcneil C" first="Caroline E" last="Mcneil">Caroline E. Mcneil</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Melas, Marilena" sort="Melas, Marilena" uniqKey="Melas M" first="Marilena" last="Melas">Marilena Melas</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rennert, Hedy S" sort="Rennert, Hedy S" uniqKey="Rennert H" first="Hedy S" last="Rennert">Hedy S. Rennert</name><affiliation><nlm:affiliation>1] Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361, Israel [2] Clalit Health Services National Cancer Control Center, Haifa 34361, Israel.</nlm:affiliation></affiliation></author><author><name sortKey="Shi, Wei" sort="Shi, Wei" uniqKey="Shi W" first="Wei" last="Shi">Wei Shi</name><affiliation><nlm:affiliation>Department of Surgery, Children's Hospital Los Angeles, Los Angeles, California 90027, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Thomas, Duncan C" sort="Thomas, Duncan C" uniqKey="Thomas D" first="Duncan C" last="Thomas">Duncan C. Thomas</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Van Den Berg, David J" sort="Van Den Berg, David J" uniqKey="Van Den Berg D" first="David J" last="Van Den Berg">David J. Van Den Berg</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hutter, Carolyn M" sort="Hutter, Carolyn M" uniqKey="Hutter C" first="Carolyn M" last="Hutter">Carolyn M. Hutter</name><affiliation><nlm:affiliation>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Aragaki, Aaron K" sort="Aragaki, Aaron K" uniqKey="Aragaki A" first="Aaron K" last="Aragaki">Aaron K. Aragaki</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Butterbach, Katja" sort="Butterbach, Katja" uniqKey="Butterbach K" first="Katja" last="Butterbach">Katja Butterbach</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Caan, Bette J" sort="Caan, Bette J" uniqKey="Caan B" first="Bette J" last="Caan">Bette J. Caan</name><affiliation><nlm:affiliation>Division of Research, Kaiser Permanente Medical Care Program of Northern California, Oakland, California 94612, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Carlson, Christopher S" sort="Carlson, Christopher S" uniqKey="Carlson C" first="Christopher S" last="Carlson">Christopher S. Carlson</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-9776, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Curtis, Keith R" sort="Curtis, Keith R" uniqKey="Curtis K" first="Keith R" last="Curtis">Keith R. Curtis</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Fuchs, Charles S" sort="Fuchs, Charles S" uniqKey="Fuchs C" first="Charles S" last="Fuchs">Charles S. Fuchs</name><affiliation><nlm:affiliation>1] Department of Medicine, Brigham and Women's Hospital, Brookline, Massachusetts 02115, USA [2] Department of Medical Oncology, Dana-Farber Cancer Institute, Brookline, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gala, Manish" sort="Gala, Manish" uniqKey="Gala M" first="Manish" last="Gala">Manish Gala</name><affiliation><nlm:affiliation>Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Giovannucc, Edward L" sort="Giovannucc, Edward L" uniqKey="Giovannucc E" first="Edward L" last="Giovannucc">Edward L. Giovannucc</name></author><author><name sortKey="Giocannucci, Edward L" sort="Giocannucci, Edward L" uniqKey="Giocannucci E" first="Edward L" last="Giocannucci">Edward L. Giocannucci</name><affiliation><nlm:affiliation>1] Harvard Medical School, Boston, Massachusetts 02114, USA [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gogarten, Stephanie M" sort="Gogarten, Stephanie M" uniqKey="Gogarten S" first="Stephanie M" last="Gogarten">Stephanie M. Gogarten</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B" last="Hayes">Richard B. Hayes</name><affiliation><nlm:affiliation>Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, New York 10016, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Henderson, Brian" sort="Henderson, Brian" uniqKey="Henderson B" first="Brian" last="Henderson">Brian Henderson</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation><nlm:affiliation>Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jackson, Rebecca D" sort="Jackson, Rebecca D" uniqKey="Jackson R" first="Rebecca D" last="Jackson">Rebecca D. Jackson</name><affiliation><nlm:affiliation>Department of Medicine, Ohio State University, Columbus, Ohio 43210, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N" last="Kolonel">Laurence N. Kolonel</name><affiliation><nlm:affiliation>Office of Public Health Studies, University of Hawaii Manoa, Honolulu, Hawaii 96822, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kury, Sebastien" sort="Kury, Sebastien" uniqKey="Kury S" first="Sébastien" last="Küry">Sébastien Küry</name></author><author><name sortKey="Kury, Sebastian" sort="Kury, Sebastian" uniqKey="Kury S" first="Sebastian" last="Kury">Sebastian Kury</name><affiliation><nlm:affiliation>Service de Génétique Médicale, CHU Nantes, Nantes 44093, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lacroix, Andrea" sort="Lacroix, Andrea" uniqKey="Lacroix A" first="Andrea" last="Lacroix">Andrea Lacroix</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Laurie, Cathy C" sort="Laurie, Cathy C" uniqKey="Laurie C" first="Cathy C" last="Laurie">Cathy C. Laurie</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Laurie, Cecelia A" sort="Laurie, Cecelia A" uniqKey="Laurie C" first="Cecelia A" last="Laurie">Cecelia A. Laurie</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name></author><author><name sortKey="Lemire, Mathiew" sort="Lemire, Mathiew" uniqKey="Lemire M" first="Mathiew" last="Lemire">Mathiew Lemire</name><affiliation><nlm:affiliation>Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Levine, David" sort="Levine, David" uniqKey="Levine D" first="David" last="Levine">David Levine</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation><nlm:affiliation>Harvard School of Public Health, Boston, Massachusetts 02114, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Makar, Karen W" sort="Makar, Karen W" uniqKey="Makar K" first="Karen W" last="Makar">Karen W. Makar</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Qu, Conghui" sort="Qu, Conghui" uniqKey="Qu C" first="Conghui" last="Qu">Conghui Qu</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Taverna, Darin" sort="Taverna, Darin" uniqKey="Taverna D" first="Darin" last="Taverna">Darin Taverna</name><affiliation><nlm:affiliation>Phoenix College, Phoenix, Arizona 85013, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ulrich, Cornelia M" sort="Ulrich, Cornelia M" uniqKey="Ulrich C" first="Cornelia M" last="Ulrich">Cornelia M. Ulrich</name><affiliation><nlm:affiliation>1] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA [2] Division of Preventive Oncology, German Cancer Research Center, Heidelberg 69120, Germany [3] Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington 98195, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Kana" sort="Wu, Kana" uniqKey="Wu K" first="Kana" last="Wu">Kana Wu</name><affiliation><nlm:affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kono, Suminori" sort="Kono, Suminori" uniqKey="Kono S" first="Suminori" last="Kono">Suminori Kono</name><affiliation><nlm:affiliation>Department of Preventive Medicine, Kyushu University, Fukuoka 812-8582, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="West, Dee W" sort="West, Dee W" uniqKey="West D" first="Dee W" last="West">Dee W. West</name><affiliation><nlm:affiliation>Cancer Registry of Greater California, Public Health Institute, Sacramento, California 95825, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-9776, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stéphane" last="Bezieau">Stéphane Bezieau</name><affiliation><nlm:affiliation>Centre Hospitalier Universitaire Hotel-Dieu, Nantes, 44093, France.</nlm:affiliation></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Campbell, Peter T" sort="Campbell, Peter T" uniqKey="Campbell P" first="Peter T" last="Campbell">Peter T. Campbell</name><affiliation><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30329-4251, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T" last="Chan">Andrew T. Chan</name><affiliation><nlm:affiliation>1] Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA [2] Harvard Medical School, Boston, Massachusetts 02114, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:affiliation>Unit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Coetzee, Gerhard A" sort="Coetzee, Gerhard A" uniqKey="Coetzee G" first="Gerhard A" last="Coetzee">Gerhard A. Coetzee</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V" last="Conti">David V. Conti</name><affiliation><nlm:affiliation>1] Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA [2] Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Duggan, David" sort="Duggan, David" uniqKey="Duggan D" first="David" last="Duggan">David Duggan</name><affiliation><nlm:affiliation>Genetic Basis of Human Disease Division, Translational Genomics Research Institute, Phoenix, Arizona 85004, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Figueiredo, Jane C" sort="Figueiredo, Jane C" uniqKey="Figueiredo J" first="Jane C" last="Figueiredo">Jane C. Figueiredo</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Fortini, Barbara K" sort="Fortini, Barbara K" uniqKey="Fortini B" first="Barbara K" last="Fortini">Barbara K. Fortini</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gallinger, Steven J" sort="Gallinger, Steven J" uniqKey="Gallinger S" first="Steven J" last="Gallinger">Steven J. Gallinger</name><affiliation><nlm:affiliation>Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Gauderman, W James" sort="Gauderman, W James" uniqKey="Gauderman W" first="W James" last="Gauderman">W James Gauderman</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Giles, Graham" sort="Giles, Graham" uniqKey="Giles G" first="Graham" last="Giles">Graham Giles</name><affiliation><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Green, Roger" sort="Green, Roger" uniqKey="Green R" first="Roger" last="Green">Roger Green</name><affiliation><nlm:affiliation>Discipline of Genetics, Memorial University of Newfoundland, St. John's, Newfoundland A1B 3V6, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Haile, Robert" sort="Haile, Robert" uniqKey="Haile R" first="Robert" last="Haile">Robert Haile</name><affiliation><nlm:affiliation>Department of Medicine, Division of Oncology, Stanford University, Stanford, California 94305, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Harrison, Tabitha A" sort="Harrison, Tabitha A" uniqKey="Harrison T" first="Tabitha A" last="Harrison">Tabitha A. Harrison</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation><nlm:affiliation>Centre for MEGA Epidemiology, The University of Melbourne, Carlton, Victoria 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J" last="Hudson">Thomas J. Hudson</name><affiliation><nlm:affiliation>Department of Genomics, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Jacobs, Eric" sort="Jacobs, Eric" uniqKey="Jacobs E" first="Eric" last="Jacobs">Eric Jacobs</name><affiliation><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30329-4251, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Iwasaki, Motoki" sort="Iwasaki, Motoki" uniqKey="Iwasaki M" first="Motoki" last="Iwasaki">Motoki Iwasaki</name><affiliation><nlm:affiliation>Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Jee, Sun Ha" sort="Jee, Sun Ha" uniqKey="Jee S" first="Sun Ha" last="Jee">Sun Ha Jee</name><affiliation><nlm:affiliation>Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 120-749, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Jenkins, Mark" sort="Jenkins, Mark" uniqKey="Jenkins M" first="Mark" last="Jenkins">Mark Jenkins</name><affiliation><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Jia, Wei Hua" sort="Jia, Wei Hua" uniqKey="Jia W" first="Wei-Hua" last="Jia">Wei-Hua Jia</name><affiliation><nlm:affiliation>State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China.</nlm:affiliation></affiliation></author><author><name sortKey="Joshi, Amit" sort="Joshi, Amit" uniqKey="Joshi A" first="Amit" last="Joshi">Amit Joshi</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name><affiliation><nlm:affiliation>Department of Family Medicine and Community Health, Case Western Reserve University, Cleveland, Ohio 44106, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lindor, Noralene M" sort="Lindor, Noralene M" uniqKey="Lindor N" first="Noralene M" last="Lindor">Noralene M. Lindor</name><affiliation><nlm:affiliation>Department of Health Science Research, Mayo Clinic, Scottsdale, Arizona 85259, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name><affiliation><nlm:affiliation>Department of Preventive Medicine, Kyushu University, Fukuoka 812-8582, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Moreno, Victor" sort="Moreno, Victor" uniqKey="Moreno V" first="Victor" last="Moreno">Victor Moreno</name><affiliation><nlm:affiliation>Cancer Epidemiology Service, Catalan Institute of Oncology, IDIBELL, 08908, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Mukherjee, Bhramar" sort="Mukherjee, Bhramar" uniqKey="Mukherjee B" first="Bhramar" last="Mukherjee">Bhramar Mukherjee</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A" last="Newcomb">Polly A. Newcomb</name><affiliation><nlm:affiliation>Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D" last="Potter">John D. Potter</name><affiliation><nlm:affiliation>Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Raskin, Leon" sort="Raskin, Leon" uniqKey="Raskin L" first="Leon" last="Raskin">Leon Raskin</name><affiliation><nlm:affiliation>1] Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA [2] Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA [3] Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation><nlm:affiliation>1] Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA [2] Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361, Israel [3] Clalit Health Services National Cancer Control Center, Haifa 34361, Israel [4] Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3200003, Israel.</nlm:affiliation></affiliation></author><author><name sortKey="Rosse, Stephanie" sort="Rosse, Stephanie" uniqKey="Rosse S" first="Stephanie" last="Rosse">Stephanie Rosse</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:affiliation>1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia [2] Human Genetics Foundation (HuGeF), Torino 10126, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E" last="Schoen">Robert E. Schoen</name><affiliation><nlm:affiliation>Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation><nlm:affiliation>Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:affiliation>1] Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738, USA [2] Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L" last="Slattery">Martha L. Slattery</name><affiliation><nlm:affiliation>Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Tsugane, Shoichiro" sort="Tsugane, Shoichiro" uniqKey="Tsugane S" first="Shoichiro" last="Tsugane">Shoichiro Tsugane</name><affiliation><nlm:affiliation>Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Xiang, Yong Bing" sort="Xiang, Yong Bing" uniqKey="Xiang Y" first="Yong-Bing" last="Xiang">Yong-Bing Xiang</name><affiliation><nlm:affiliation>Department of Epidemiology, Shanghai Cancer Institute, Shanghai 2200-25, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zanke, Brent W" sort="Zanke, Brent W" uniqKey="Zanke B" first="Brent W" last="Zanke">Brent W. Zanke</name><affiliation><nlm:affiliation>1] The University of Ottawa, Ottawa, Ontario K1N 6N5, Canada [2] Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario K1Y 4E9, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:affiliation>1] Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA [2] Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:affiliation>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B" last="Gruber">Stephen B. Gruber</name><affiliation><nlm:affiliation>1] Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA [2] Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Nature communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Case-Control Studies</term><term>Colorectal Neoplasms (genetics)</term><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Odds Ratio</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Colorectal Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Odds Ratio</term><term>Polymorphism, Single Nucleotide</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26151821</PMID><DateCreated><Year>2015</Year><Month>07</Month><Day>08</Day></DateCreated><DateCompleted><Year>2016</Year><Month>04</Month><Day>18</Day></DateCompleted><DateRevised><Year>2017</Year><Month>07</Month><Day>26</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2041-1723</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><PubDate><Year>2015</Year><Month>Jul</Month><Day>07</Day></PubDate></JournalIssue><Title>Nature communications</Title><ISOAbbreviation>Nat Commun</ISOAbbreviation></Journal><ArticleTitle>Genome-wide association study of colorectal cancer identifies six new susceptibility loci.</ArticleTitle><Pagination><MedlinePgn>7138</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/ncomms8138</ELocationID><Abstract><AbstractText>Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schumacher</LastName><ForeName>Fredrick R</ForeName><Initials>FR</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmit</LastName><ForeName>Stephanie L</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>1] Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA [2] Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiao</LastName><ForeName>Shuo</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Edlund</LastName><ForeName>Christopher K</ForeName><Initials>CK</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Hansong</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Ben</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of General Surgery, Third Military Medical University Southwest Hospital, Chongqing 400038, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hsu</LastName><ForeName>Li</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Shu-Chen</ForeName><Initials>SC</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fischer</LastName><ForeName>Christopher P</ForeName><Initials>CP</Initials><AffiliationInfo><Affiliation>University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harju</LastName><ForeName>John F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Idos</LastName><ForeName>Gregory E</ForeName><Initials>GE</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lejbkowicz</LastName><ForeName>Flavio</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>1] Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361, Israel [2] Clalit Health Services National Cancer Control Center, Haifa 34361, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manion</LastName><ForeName>Frank J</ForeName><Initials>FJ</Initials><Identifier Source="ORCID">0000000310306348</Identifier><AffiliationInfo><Affiliation>University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McDonnell</LastName><ForeName>Kevin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McNeil</LastName><ForeName>Caroline E</ForeName><Initials>CE</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Melas</LastName><ForeName>Marilena</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rennert</LastName><ForeName>Hedy S</ForeName><Initials>HS</Initials><AffiliationInfo><Affiliation>1] Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361, Israel [2] Clalit Health Services National Cancer Control Center, Haifa 34361, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Surgery, Children's Hospital Los Angeles, Los Angeles, California 90027, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thomas</LastName><ForeName>Duncan C</ForeName><Initials>DC</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van Den Berg</LastName><ForeName>David J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hutter</LastName><ForeName>Carolyn M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aragaki</LastName><ForeName>Aaron K</ForeName><Initials>AK</Initials><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Butterbach</LastName><ForeName>Katja</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caan</LastName><ForeName>Bette J</ForeName><Initials>BJ</Initials><AffiliationInfo><Affiliation>Division of Research, Kaiser Permanente Medical Care Program of Northern California, Oakland, California 94612, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carlson</LastName><ForeName>Christopher S</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chanock</LastName><ForeName>Stephen J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-9776, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Curtis</LastName><ForeName>Keith R</ForeName><Initials>KR</Initials><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fuchs</LastName><ForeName>Charles S</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>1] Department of Medicine, Brigham and Women's Hospital, Brookline, Massachusetts 02115, USA [2] Department of Medical Oncology, Dana-Farber Cancer Institute, Brookline, Massachusetts 02115, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gala</LastName><ForeName>Manish</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giovannucc</LastName><ForeName>Edward L</ForeName><Initials>EL</Initials></Author><Author ValidYN="N"><LastName>Giocannucci</LastName><ForeName>Edward L</ForeName><Initials>EL</Initials><AffiliationInfo><Affiliation>1] Harvard Medical School, Boston, Massachusetts 02114, USA [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gogarten</LastName><ForeName>Stephanie M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hayes</LastName><ForeName>Richard B</ForeName><Initials>RB</Initials><AffiliationInfo><Affiliation>Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, New York 10016, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Henderson</LastName><ForeName>Brian</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hunter</LastName><ForeName>David J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jackson</LastName><ForeName>Rebecca D</ForeName><Initials>RD</Initials><AffiliationInfo><Affiliation>Department of Medicine, Ohio State University, Columbus, Ohio 43210, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kolonel</LastName><ForeName>Laurence N</ForeName><Initials>LN</Initials><AffiliationInfo><Affiliation>Office of Public Health Studies, University of Hawaii Manoa, Honolulu, Hawaii 96822, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kooperberg</LastName><ForeName>Charles</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Küry</LastName><ForeName>Sébastien</ForeName><Initials>S</Initials></Author><Author ValidYN="N"><LastName>Kury</LastName><ForeName>Sebastian</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Service de Génétique Médicale, CHU Nantes, Nantes 44093, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>LaCroix</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laurie</LastName><ForeName>Cathy C</ForeName><Initials>CC</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laurie</LastName><ForeName>Cecelia A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lemire</LastName><ForeName>Mathieu</ForeName><Initials>M</Initials></Author><Author ValidYN="N"><LastName>Lemire</LastName><ForeName>Mathiew</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Levine</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Jing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Harvard School of Public Health, Boston, Massachusetts 02114, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Makar</LastName><ForeName>Karen W</ForeName><Initials>KW</Initials><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qu</LastName><ForeName>Conghui</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taverna</LastName><ForeName>Darin</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Phoenix College, Phoenix, Arizona 85013, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ulrich</LastName><ForeName>Cornelia M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>1] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA [2] Division of Preventive Oncology, German Cancer Research Center, Heidelberg 69120, Germany [3] Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Kana</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kono</LastName><ForeName>Suminori</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, Kyushu University, Fukuoka 812-8582, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>West</LastName><ForeName>Dee W</ForeName><Initials>DW</Initials><AffiliationInfo><Affiliation>Cancer Registry of Greater California, Public Health Institute, Sacramento, California 95825, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berndt</LastName><ForeName>Sonja I</ForeName><Initials>SI</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-9776, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bezieau</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Centre Hospitalier Universitaire Hotel-Dieu, Nantes, 44093, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brenner</LastName><ForeName>Hermann</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Campbell</LastName><ForeName>Peter T</ForeName><Initials>PT</Initials><AffiliationInfo><Affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30329-4251, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Andrew T</ForeName><Initials>AT</Initials><AffiliationInfo><Affiliation>1] Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA [2] Harvard Medical School, Boston, Massachusetts 02114, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chang-Claude</LastName><ForeName>Jenny</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Unit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coetzee</LastName><ForeName>Gerhard A</ForeName><Initials>GA</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Conti</LastName><ForeName>David V</ForeName><Initials>DV</Initials><AffiliationInfo><Affiliation>1] Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA [2] Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duggan</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Genetic Basis of Human Disease Division, Translational Genomics Research Institute, Phoenix, Arizona 85004, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Figueiredo</LastName><ForeName>Jane C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fortini</LastName><ForeName>Barbara K</ForeName><Initials>BK</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gallinger</LastName><ForeName>Steven J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gauderman</LastName><ForeName>W James</ForeName><Initials>WJ</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giles</LastName><ForeName>Graham</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Green</LastName><ForeName>Roger</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Discipline of Genetics, Memorial University of Newfoundland, St. John's, Newfoundland A1B 3V6, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haile</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Oncology, Stanford University, Stanford, California 94305, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harrison</LastName><ForeName>Tabitha A</ForeName><Initials>TA</Initials><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoffmeister</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hopper</LastName><ForeName>John L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Centre for MEGA Epidemiology, The University of Melbourne, Carlton, Victoria 3010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hudson</LastName><ForeName>Thomas J</ForeName><Initials>TJ</Initials><Identifier Source="ORCID">0000000213764849</Identifier><AffiliationInfo><Affiliation>Department of Genomics, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jacobs</LastName><ForeName>Eric</ForeName><Initials>E</Initials><Identifier Source="ORCID">0000000284587659</Identifier><AffiliationInfo><Affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30329-4251, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Iwasaki</LastName><ForeName>Motoki</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jee</LastName><ForeName>Sun Ha</ForeName><Initials>SH</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 120-749, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jenkins</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria 3010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jia</LastName><ForeName>Wei-Hua</ForeName><Initials>WH</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Joshi</LastName><ForeName>Amit</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Li</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Family Medicine and Community Health, Case Western Reserve University, Cleveland, Ohio 44106, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lindor</LastName><ForeName>Noralene M</ForeName><Initials>NM</Initials><AffiliationInfo><Affiliation>Department of Health Science Research, Mayo Clinic, Scottsdale, Arizona 85259, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matsuo</LastName><ForeName>Keitaro</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, Kyushu University, Fukuoka 812-8582, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moreno</LastName><ForeName>Victor</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Service, Catalan Institute of Oncology, IDIBELL, 08908, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mukherjee</LastName><ForeName>Bhramar</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Newcomb</LastName><ForeName>Polly A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Potter</LastName><ForeName>John D</ForeName><Initials>JD</Initials><AffiliationInfo><Affiliation>Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raskin</LastName><ForeName>Leon</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>1] Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA [2] Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA [3] Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rennert</LastName><ForeName>Gad</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>1] Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA [2] Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361, Israel [3] Clalit Health Services National Cancer Control Center, Haifa 34361, Israel [4] Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3200003, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rosse</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Severi</LastName><ForeName>Gianluca</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia [2] Human Genetics Foundation (HuGeF), Torino 10126, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schoen</LastName><ForeName>Robert E</ForeName><Initials>RE</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seminara</LastName><ForeName>Daniela</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shu</LastName><ForeName>Xiao-Ou</ForeName><Initials>XO</Initials><AffiliationInfo><Affiliation>1] Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738, USA [2] Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Slattery</LastName><ForeName>Martha L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsugane</LastName><ForeName>Shoichiro</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>White</LastName><ForeName>Emily</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiang</LastName><ForeName>Yong-Bing</ForeName><Initials>YB</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Shanghai Cancer Institute, Shanghai 2200-25, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zanke</LastName><ForeName>Brent W</ForeName><Initials>BW</Initials><AffiliationInfo><Affiliation>1] The University of Ottawa, Ottawa, Ontario K1N 6N5, Canada [2] Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario K1Y 4E9, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>1] Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA [2] Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Marchand</LastName><ForeName>Loic</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Casey</LastName><ForeName>Graham</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gruber</LastName><ForeName>Stephen B</ForeName><Initials>SB</Initials><AffiliationInfo><Affiliation>1] Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA [2] Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peters</LastName><ForeName>Ulrike</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 CA059045</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA074799</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 CA015704</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 CA055075</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA048998</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA137088</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 HG000040</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 CA173640</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA074794</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 ES019876</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 CA014089</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA081488</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA097735</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 ES013678</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 CA167552</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 CA167551</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA-09-002</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA122839</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>S10 OD020069</GrantID><Acronym>OD</Acronym><Agency>NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA074783</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA074806</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 CA182910</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 CA071789</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA074800</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U19 CA148107</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017418">Meta-Analysis</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>07</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nat Commun</MedlineTA><NlmUniqueID>101528555</NlmUniqueID><ISSNLinking>2041-1723</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="ErratumIn"><RefSource>Nat Commun. 2015;6:8739</RefSource><PMID Version="1">26498495</PMID><Note>Kury, Sebastian; Giocannucci, Edward L. 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