Imputation of KIR Types from SNP Variation Data.
Identifieur interne : 002831 ( PubMed/Corpus ); précédent : 002830; suivant : 002832Imputation of KIR Types from SNP Variation Data.
Auteurs : Damjan Vukcevic ; James A. Traherne ; Sigrid N Ss ; Eva Ellinghaus ; Yoichiro Kamatani ; Alexander Dilthey ; Mark Lathrop ; Tom H. Karlsen ; Andre Franke ; Miriam Moffatt ; William Cookson ; John Trowsdale ; Gil Mcvean ; Stephen Sawcer ; Stephen LeslieSource :
- American journal of human genetics [ 1537-6605 ] ; 2015.
English descriptors
- KwdEn :
- Asthma (genetics), Case-Control Studies, Cohort Studies, DNA Copy Number Variations (genetics), Dermatitis, Atopic (genetics), Europe, Family, Female, Genetic Predisposition to Disease, Genotype, High-Throughput Nucleotide Sequencing, Humans, Male, Polymorphism, Single Nucleotide (genetics), Receptors, KIR (classification), Receptors, KIR (genetics), Sequence Analysis, DNA.
- MESH :
- chemical , classification : Receptors, KIR.
- chemical , genetics : Receptors, KIR.
- geographic : Europe.
- genetics : Asthma, DNA Copy Number Variations, Dermatitis, Atopic, Polymorphism, Single Nucleotide.
- Case-Control Studies, Cohort Studies, Family, Female, Genetic Predisposition to Disease, Genotype, High-Throughput Nucleotide Sequencing, Humans, Male, Sequence Analysis, DNA.
Abstract
Large population studies of immune system genes are essential for characterizing their role in diseases, including autoimmune conditions. Of key interest are a group of genes encoding the killer cell immunoglobulin-like receptors (KIRs), which have known and hypothesized roles in autoimmune diseases, resistance to viruses, reproductive conditions, and cancer. These genes are highly polymorphic, which makes typing expensive and time consuming. Consequently, despite their importance, KIRs have been little studied in large cohorts. Statistical imputation methods developed for other complex loci (e.g., human leukocyte antigen [HLA]) on the basis of SNP data provide an inexpensive high-throughput alternative to direct laboratory typing of these loci and have enabled important findings and insights for many diseases. We present KIR∗IMP, a method for imputation of KIR copy number. We show that KIR∗IMP is highly accurate and thus allows the study of KIRs in large cohorts and enables detailed investigation of the role of KIRs in human disease.
DOI: 10.1016/j.ajhg.2015.09.005
PubMed: 26430804
Links to Exploration step
pubmed:26430804Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Imputation of KIR Types from SNP Variation Data.</title><author><name sortKey="Vukcevic, Damjan" sort="Vukcevic, Damjan" uniqKey="Vukcevic D" first="Damjan" last="Vukcevic">Damjan Vukcevic</name><affiliation><nlm:affiliation>Statistical Genetics, Murdoch Childrens Research Institute, Parkville, VIC 3052, Australia; School of Mathematics and Statistics, University of Melbourne, Parkville, VIC 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Traherne, James A" sort="Traherne, James A" uniqKey="Traherne J" first="James A" last="Traherne">James A. Traherne</name><affiliation><nlm:affiliation>Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK; Division of Immunology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.</nlm:affiliation></affiliation></author><author><name sortKey="N Ss, Sigrid" sort="N Ss, Sigrid" uniqKey="N Ss S" first="Sigrid" last="N Ss">Sigrid N Ss</name><affiliation><nlm:affiliation>Research Institute of Internal Medicine, Department of Cancer Medicine, Surgery, and Transplantation, Oslo University Hospital Rikshospitalet, Postboks 4950, Nydalen, 0424 Oslo, Norway; Norwegian PSC Research Center, Division of Cancer, Surgery, and Transplantation, Oslo University Hospital, Postboks 4950, Nydalen, 0424 Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Ellinghaus, Eva" sort="Ellinghaus, Eva" uniqKey="Ellinghaus E" first="Eva" last="Ellinghaus">Eva Ellinghaus</name><affiliation><nlm:affiliation>Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel, Schittenhelmstraße 12, 24105 Kiel, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kamatani, Yoichiro" sort="Kamatani, Yoichiro" uniqKey="Kamatani Y" first="Yoichiro" last="Kamatani">Yoichiro Kamatani</name><affiliation><nlm:affiliation>Fondation Jean Dausset, Centre d'Etude du Polymorphisme Humain, 27 Rue Juliette Dodu, 75010 Paris, France; RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Dilthey, Alexander" sort="Dilthey, Alexander" uniqKey="Dilthey A" first="Alexander" last="Dilthey">Alexander Dilthey</name><affiliation><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation><nlm:affiliation>McGill University and Génome Québec Innovation Centre, Montreal, 740 Dr. Penfield Avenue, Room 7104, Montreal, QC H3A 0G1, Canada; Fondation Jean Dausset, Centre d'Etude du Polymorphisme Humain, 27 Rue Juliette Dodu, 75010 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Karlsen, Tom H" sort="Karlsen, Tom H" uniqKey="Karlsen T" first="Tom H" last="Karlsen">Tom H. Karlsen</name><affiliation><nlm:affiliation>Research Institute of Internal Medicine, Department of Cancer Medicine, Surgery, and Transplantation, Oslo University Hospital Rikshospitalet, Postboks 4950, Nydalen, 0424 Oslo, Norway; K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Postboks 1171, Blindern, 0318 Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name><affiliation><nlm:affiliation>Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel, Schittenhelmstraße 12, 24105 Kiel, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Moffatt, Miriam" sort="Moffatt, Miriam" uniqKey="Moffatt M" first="Miriam" last="Moffatt">Miriam Moffatt</name><affiliation><nlm:affiliation>National Heart and Lung Institute, Imperial College London, Royal Brompton Campus, Dovehouse Street, London SW3 6LY, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Cookson, William" sort="Cookson, William" uniqKey="Cookson W" first="William" last="Cookson">William Cookson</name><affiliation><nlm:affiliation>National Heart and Lung Institute, Imperial College London, Royal Brompton Campus, Dovehouse Street, London SW3 6LY, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Trowsdale, John" sort="Trowsdale, John" uniqKey="Trowsdale J" first="John" last="Trowsdale">John Trowsdale</name><affiliation><nlm:affiliation>Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK; Division of Immunology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Mcvean, Gil" sort="Mcvean, Gil" uniqKey="Mcvean G" first="Gil" last="Mcvean">Gil Mcvean</name><affiliation><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sawcer, Stephen" sort="Sawcer, Stephen" uniqKey="Sawcer S" first="Stephen" last="Sawcer">Stephen Sawcer</name><affiliation><nlm:affiliation>Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Leslie, Stephen" sort="Leslie, Stephen" uniqKey="Leslie S" first="Stephen" last="Leslie">Stephen Leslie</name><affiliation><nlm:affiliation>Statistical Genetics, Murdoch Childrens Research Institute, Parkville, VIC 3052, Australia; School of Mathematics and Statistics, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: stephen.leslie@mcri.edu.au.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26430804</idno><idno type="pmid">26430804</idno><idno type="doi">10.1016/j.ajhg.2015.09.005</idno><idno type="wicri:Area/PubMed/Corpus">002831</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002831</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Imputation of KIR Types from SNP Variation Data.</title><author><name sortKey="Vukcevic, Damjan" sort="Vukcevic, Damjan" uniqKey="Vukcevic D" first="Damjan" last="Vukcevic">Damjan Vukcevic</name><affiliation><nlm:affiliation>Statistical Genetics, Murdoch Childrens Research Institute, Parkville, VIC 3052, Australia; School of Mathematics and Statistics, University of Melbourne, Parkville, VIC 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Traherne, James A" sort="Traherne, James A" uniqKey="Traherne J" first="James A" last="Traherne">James A. Traherne</name><affiliation><nlm:affiliation>Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK; Division of Immunology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.</nlm:affiliation></affiliation></author><author><name sortKey="N Ss, Sigrid" sort="N Ss, Sigrid" uniqKey="N Ss S" first="Sigrid" last="N Ss">Sigrid N Ss</name><affiliation><nlm:affiliation>Research Institute of Internal Medicine, Department of Cancer Medicine, Surgery, and Transplantation, Oslo University Hospital Rikshospitalet, Postboks 4950, Nydalen, 0424 Oslo, Norway; Norwegian PSC Research Center, Division of Cancer, Surgery, and Transplantation, Oslo University Hospital, Postboks 4950, Nydalen, 0424 Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Ellinghaus, Eva" sort="Ellinghaus, Eva" uniqKey="Ellinghaus E" first="Eva" last="Ellinghaus">Eva Ellinghaus</name><affiliation><nlm:affiliation>Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel, Schittenhelmstraße 12, 24105 Kiel, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kamatani, Yoichiro" sort="Kamatani, Yoichiro" uniqKey="Kamatani Y" first="Yoichiro" last="Kamatani">Yoichiro Kamatani</name><affiliation><nlm:affiliation>Fondation Jean Dausset, Centre d'Etude du Polymorphisme Humain, 27 Rue Juliette Dodu, 75010 Paris, France; RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Dilthey, Alexander" sort="Dilthey, Alexander" uniqKey="Dilthey A" first="Alexander" last="Dilthey">Alexander Dilthey</name><affiliation><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation><nlm:affiliation>McGill University and Génome Québec Innovation Centre, Montreal, 740 Dr. Penfield Avenue, Room 7104, Montreal, QC H3A 0G1, Canada; Fondation Jean Dausset, Centre d'Etude du Polymorphisme Humain, 27 Rue Juliette Dodu, 75010 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Karlsen, Tom H" sort="Karlsen, Tom H" uniqKey="Karlsen T" first="Tom H" last="Karlsen">Tom H. Karlsen</name><affiliation><nlm:affiliation>Research Institute of Internal Medicine, Department of Cancer Medicine, Surgery, and Transplantation, Oslo University Hospital Rikshospitalet, Postboks 4950, Nydalen, 0424 Oslo, Norway; K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Postboks 1171, Blindern, 0318 Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name><affiliation><nlm:affiliation>Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel, Schittenhelmstraße 12, 24105 Kiel, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Moffatt, Miriam" sort="Moffatt, Miriam" uniqKey="Moffatt M" first="Miriam" last="Moffatt">Miriam Moffatt</name><affiliation><nlm:affiliation>National Heart and Lung Institute, Imperial College London, Royal Brompton Campus, Dovehouse Street, London SW3 6LY, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Cookson, William" sort="Cookson, William" uniqKey="Cookson W" first="William" last="Cookson">William Cookson</name><affiliation><nlm:affiliation>National Heart and Lung Institute, Imperial College London, Royal Brompton Campus, Dovehouse Street, London SW3 6LY, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Trowsdale, John" sort="Trowsdale, John" uniqKey="Trowsdale J" first="John" last="Trowsdale">John Trowsdale</name><affiliation><nlm:affiliation>Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK; Division of Immunology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Mcvean, Gil" sort="Mcvean, Gil" uniqKey="Mcvean G" first="Gil" last="Mcvean">Gil Mcvean</name><affiliation><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sawcer, Stephen" sort="Sawcer, Stephen" uniqKey="Sawcer S" first="Stephen" last="Sawcer">Stephen Sawcer</name><affiliation><nlm:affiliation>Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Leslie, Stephen" sort="Leslie, Stephen" uniqKey="Leslie S" first="Stephen" last="Leslie">Stephen Leslie</name><affiliation><nlm:affiliation>Statistical Genetics, Murdoch Childrens Research Institute, Parkville, VIC 3052, Australia; School of Mathematics and Statistics, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: stephen.leslie@mcri.edu.au.</nlm:affiliation></affiliation></author></analytic><series><title level="j">American journal of human genetics</title><idno type="eISSN">1537-6605</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Asthma (genetics)</term><term>Case-Control Studies</term><term>Cohort Studies</term><term>DNA Copy Number Variations (genetics)</term><term>Dermatitis, Atopic (genetics)</term><term>Europe</term><term>Family</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>High-Throughput Nucleotide Sequencing</term><term>Humans</term><term>Male</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>Receptors, KIR (classification)</term><term>Receptors, KIR (genetics)</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="MESH" type="chemical" qualifier="classification" xml:lang="en"><term>Receptors, KIR</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptors, KIR</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Europe</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Asthma</term><term>DNA Copy Number Variations</term><term>Dermatitis, Atopic</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>Cohort Studies</term><term>Family</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>High-Throughput Nucleotide Sequencing</term><term>Humans</term><term>Male</term><term>Sequence Analysis, DNA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Large population studies of immune system genes are essential for characterizing their role in diseases, including autoimmune conditions. Of key interest are a group of genes encoding the killer cell immunoglobulin-like receptors (KIRs), which have known and hypothesized roles in autoimmune diseases, resistance to viruses, reproductive conditions, and cancer. These genes are highly polymorphic, which makes typing expensive and time consuming. Consequently, despite their importance, KIRs have been little studied in large cohorts. Statistical imputation methods developed for other complex loci (e.g., human leukocyte antigen [HLA]) on the basis of SNP data provide an inexpensive high-throughput alternative to direct laboratory typing of these loci and have enabled important findings and insights for many diseases. We present KIR∗IMP, a method for imputation of KIR copy number. We show that KIR∗IMP is highly accurate and thus allows the study of KIRs in large cohorts and enables detailed investigation of the role of KIRs in human disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26430804</PMID><DateCreated><Year>2015</Year><Month>10</Month><Day>03</Day></DateCreated><DateCompleted><Year>2016</Year><Month>01</Month><Day>05</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1537-6605</ISSN><JournalIssue CitedMedium="Internet"><Volume>97</Volume><Issue>4</Issue><PubDate><Year>2015</Year><Month>Oct</Month><Day>01</Day></PubDate></JournalIssue><Title>American journal of human genetics</Title><ISOAbbreviation>Am. J. Hum. Genet.</ISOAbbreviation></Journal><ArticleTitle>Imputation of KIR Types from SNP Variation Data.</ArticleTitle><Pagination><MedlinePgn>593-607</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ajhg.2015.09.005</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0002-9297(15)00369-9</ELocationID><Abstract><AbstractText>Large population studies of immune system genes are essential for characterizing their role in diseases, including autoimmune conditions. Of key interest are a group of genes encoding the killer cell immunoglobulin-like receptors (KIRs), which have known and hypothesized roles in autoimmune diseases, resistance to viruses, reproductive conditions, and cancer. These genes are highly polymorphic, which makes typing expensive and time consuming. Consequently, despite their importance, KIRs have been little studied in large cohorts. Statistical imputation methods developed for other complex loci (e.g., human leukocyte antigen [HLA]) on the basis of SNP data provide an inexpensive high-throughput alternative to direct laboratory typing of these loci and have enabled important findings and insights for many diseases. We present KIR∗IMP, a method for imputation of KIR copy number. We show that KIR∗IMP is highly accurate and thus allows the study of KIRs in large cohorts and enables detailed investigation of the role of KIRs in human disease.</AbstractText><CopyrightInformation>Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vukcevic</LastName><ForeName>Damjan</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Statistical Genetics, Murdoch Childrens Research Institute, Parkville, VIC 3052, Australia; School of Mathematics and Statistics, University of Melbourne, Parkville, VIC 3010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Traherne</LastName><ForeName>James A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK; Division of Immunology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Næss</LastName><ForeName>Sigrid</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Research Institute of Internal Medicine, Department of Cancer Medicine, Surgery, and Transplantation, Oslo University Hospital Rikshospitalet, Postboks 4950, Nydalen, 0424 Oslo, Norway; Norwegian PSC Research Center, Division of Cancer, Surgery, and Transplantation, Oslo University Hospital, Postboks 4950, Nydalen, 0424 Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ellinghaus</LastName><ForeName>Eva</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel, Schittenhelmstraße 12, 24105 Kiel, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kamatani</LastName><ForeName>Yoichiro</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Fondation Jean Dausset, Centre d'Etude du Polymorphisme Humain, 27 Rue Juliette Dodu, 75010 Paris, France; RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dilthey</LastName><ForeName>Alexander</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lathrop</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>McGill University and Génome Québec Innovation Centre, Montreal, 740 Dr. Penfield Avenue, Room 7104, Montreal, QC H3A 0G1, Canada; Fondation Jean Dausset, Centre d'Etude du Polymorphisme Humain, 27 Rue Juliette Dodu, 75010 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karlsen</LastName><ForeName>Tom H</ForeName><Initials>TH</Initials><AffiliationInfo><Affiliation>Research Institute of Internal Medicine, Department of Cancer Medicine, Surgery, and Transplantation, Oslo University Hospital Rikshospitalet, Postboks 4950, Nydalen, 0424 Oslo, Norway; K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Postboks 1171, Blindern, 0318 Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Franke</LastName><ForeName>Andre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel, Schittenhelmstraße 12, 24105 Kiel, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moffatt</LastName><ForeName>Miriam</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>National Heart and Lung Institute, Imperial College London, Royal Brompton Campus, Dovehouse Street, London SW3 6LY, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cookson</LastName><ForeName>William</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>National Heart and Lung Institute, Imperial College London, Royal Brompton Campus, Dovehouse Street, London SW3 6LY, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trowsdale</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK; Division of Immunology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McVean</LastName><ForeName>Gil</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sawcer</LastName><ForeName>Stephen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leslie</LastName><ForeName>Stephen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Statistical Genetics, Murdoch Childrens Research Institute, Parkville, VIC 3052, Australia; School of Mathematics and Statistics, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: stephen.leslie@mcri.edu.au.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0901682</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>100956</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>097117</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>100140</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Hum Genet</MedlineTA><NlmUniqueID>0370475</NlmUniqueID><ISSNLinking>0002-9297</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054340">Receptors, KIR</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7276-80</RefSource><PMID Version="1">1871133</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Genet. 2013 Oct;9(10):e1003938</RefSource><PMID Version="1">24204327</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Res Ther. 2011;13(1):101</RefSource><PMID Version="1">21345260</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bioinformatics. 2012 Jun 15;28(12):1598-603</RefSource><PMID Version="1">22500001</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2006 Mar 20;203(3):633-45</RefSource><PMID Version="1">16533882</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Methods. 2012 Feb;9(2):179-81</RefSource><PMID Version="1">22138821</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2010;5(12):e15115</RefSource><PMID Version="1">21206914</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genome Med. 2014 Mar 05;6(3):20</RefSource><PMID Version="1">24597950</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2013;8(6):e64683</RefSource><PMID Version="1">23762245</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Hum Genet. 2008 Jan;82(1):48-56</RefSource><PMID Version="1">18179884</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Genomics. 2014;15:274</RefSource><PMID Version="1">24720548</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2009 Oct 26;206(11):2557-72</RefSource><PMID Version="1">19858347</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2011 Aug;43(8):761-7</RefSource><PMID Version="1">21743469</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2013 Jun;45(6):670-5</RefSource><PMID Version="1">23603763</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genet Epidemiol. 2011 May;35(4):278-90</RefSource><PMID Version="1">21416505</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Genet. 2014 Apr;10(4):e1004234</RefSource><PMID Version="1">24743097</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunogenetics. 2012 Oct;64(10):719-37</RefSource><PMID Version="1">22752190</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Semin Immunol. 2008 Dec;20(6):343-52</RefSource><PMID Version="1">18635379</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genome Res. 2012 Oct;22(10):1845-54</RefSource><PMID Version="1">22948769</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Genet. 2011 Mar;7(3):e1001337</RefSource><PMID Version="1">21437273</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2010 Nov;42(11):985-90</RefSource><PMID Version="1">20953190</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Immunogenet. 2003 Jun;30(3):229-34</RefSource><PMID Version="1">12787002</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Comput Biol. 2013;9(2):e1002877</RefSource><PMID Version="1">23459081</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2011 Aug 11;476(7359):214-9</RefSource><PMID Version="1">21833088</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Methods. 2013 Jan;10(1):5-6</RefSource><PMID Version="1">23269371</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pharmacogenomics J. 2014 Apr;14(2):192-200</RefSource><PMID Version="1">23712092</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Immunol. 2013 Feb;13(2):133-44</RefSource><PMID Version="1">23334245</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bioinformatics. 2011 Apr 1;27(7):968-72</RefSource><PMID Version="1">21300701</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunol Rev. 2006 Dec;214:186-201</RefSource><PMID Version="1">17100885</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Immunol. 2008 Oct;20(5):581-7</RefSource><PMID Version="1">18675345</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2011 Feb 3;117(5):1633-40</RefSource><PMID Version="1">21059899</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D001249" MajorTopicYN="N">Asthma</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D056915" MajorTopicYN="N">DNA Copy Number Variations</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003876" MajorTopicYN="N">Dermatitis, Atopic</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005060" MajorTopicYN="N" Type="Geographic">Europe</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005190" MajorTopicYN="N">Family</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020022" MajorTopicYN="Y">Genetic Predisposition to Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059014" MajorTopicYN="N">High-Throughput Nucleotide Sequencing</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020641" MajorTopicYN="N">Polymorphism, Single Nucleotide</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D054340" MajorTopicYN="N">Receptors, KIR</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="Y">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4596914</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>04</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>09</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>10</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>10</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>1</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26430804</ArticleId><ArticleId IdType="pii">S0002-9297(15)00369-9</ArticleId><ArticleId IdType="doi">10.1016/j.ajhg.2015.09.005</ArticleId><ArticleId IdType="pmc">PMC4596914</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002831 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 002831 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:26430804
|texte= Imputation of KIR Types from SNP Variation Data.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:26430804" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |