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Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies.

Identifieur interne : 002720 ( PubMed/Corpus ); précédent : 002719; suivant : 002721

Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies.

Auteurs : Timothy J. Key ; Paul N. Appleby ; Ruth C. Travis ; Demetrius Albanes ; Anthony J. Alberg ; Aurelio Barricarte ; Amanda Black ; Heiner Boeing ; H Bas Bueno-De-Mesquita ; June M. Chan ; Chu Chen ; Michael B. Cook ; Jenny L. Donovan ; Pilar Galan ; Rebecca Gilbert ; Graham G. Giles ; Edward Giovannucci ; Gary E. Goodman ; Phyllis J. Goodman ; Marc J. Gunter ; Freddie C. Hamdy ; Markku Heliövaara ; Kathy J. Helzlsouer ; Brian E. Henderson ; Serge Hercberg ; Judy Hoffman-Bolton ; Robert N. Hoover ; Mattias Johansson ; Kay-Tee Khaw ; Irena B. King ; Paul Knekt ; Laurence N. Kolonel ; Loic Le Marchand ; Satu M Nnistö ; Richard M. Martin ; Haakon E. Meyer ; Alison M. Mondul ; Kristin A. Moy ; David E. Neal ; Marian L. Neuhouser ; Domenico Palli ; Elizabeth A. Platz ; Camille Pouchieu ; Harri Rissanen ; Jeannette M. Schenk ; Gianluca Severi ; Meir J. Stampfer ; Anne Tj Nneland ; Mathilde Touvier ; Antonia Trichopoulou ; Stephanie J. Weinstein ; Regina G. Ziegler ; Cindy Ke Zhou ; Naomi E. Allen

Source :

RBID : pubmed:26447150

English descriptors

Abstract

Individual studies have suggested that circulating carotenoids, retinol, or tocopherols may be associated with prostate cancer risk, but the studies have not been large enough to provide precise estimates of associations, particularly by stage and grade of disease.

DOI: 10.3945/ajcn.115.114306
PubMed: 26447150

Links to Exploration step

pubmed:26447150

Le document en format XML

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<name sortKey="Mondul, Alison M" sort="Mondul, Alison M" uniqKey="Mondul A" first="Alison M" last="Mondul">Alison M. Mondul</name>
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<name sortKey="Platz, Elizabeth A" sort="Platz, Elizabeth A" uniqKey="Platz E" first="Elizabeth A" last="Platz">Elizabeth A. Platz</name>
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<name sortKey="Zhou, Cindy Ke" sort="Zhou, Cindy Ke" uniqKey="Zhou C" first="Cindy Ke" last="Zhou">Cindy Ke Zhou</name>
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<title xml:lang="en">Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies.</title>
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<name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name>
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<nlm:affiliation>Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:affiliation>
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<name sortKey="Alberg, Anthony J" sort="Alberg, Anthony J" uniqKey="Alberg A" first="Anthony J" last="Alberg">Anthony J. Alberg</name>
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<nlm:affiliation>Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC;</nlm:affiliation>
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<name sortKey="Barricarte, Aurelio" sort="Barricarte, Aurelio" uniqKey="Barricarte A" first="Aurelio" last="Barricarte">Aurelio Barricarte</name>
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<nlm:affiliation>Navarre Public Health Institute, Pamplona, Spain, and Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), Spain;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Black, Amanda" sort="Black, Amanda" uniqKey="Black A" first="Amanda" last="Black">Amanda Black</name>
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<nlm:affiliation>Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:affiliation>
</affiliation>
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<name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name>
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<nlm:affiliation>Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany;</nlm:affiliation>
</affiliation>
</author>
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<name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H Bas" last="Bueno-De-Mesquita">H Bas Bueno-De-Mesquita</name>
<affiliation>
<nlm:affiliation>National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands; Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, Netherlands; School of Public Health, Imperial College, London, United Kingdom;</nlm:affiliation>
</affiliation>
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<name sortKey="Chan, June M" sort="Chan, June M" uniqKey="Chan J" first="June M" last="Chan">June M. Chan</name>
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<nlm:affiliation>Departments of Epidemiology & Biostatistics and Urology, University of California, San Francisco, San Francisco, CA;</nlm:affiliation>
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<author>
<name sortKey="Chen, Chu" sort="Chen, Chu" uniqKey="Chen C" first="Chu" last="Chen">Chu Chen</name>
<affiliation>
<nlm:affiliation>Public Health Sciences Division, Program in Epidemiology.</nlm:affiliation>
</affiliation>
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<name sortKey="Cook, Michael B" sort="Cook, Michael B" uniqKey="Cook M" first="Michael B" last="Cook">Michael B. Cook</name>
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</author>
<author>
<name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L" last="Donovan">Jenny L. Donovan</name>
<affiliation>
<nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name>
<affiliation>
<nlm:affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team (Nutritional Epidemiology Research Team), Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, Bobigny, France;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Gilbert, Rebecca" sort="Gilbert, Rebecca" uniqKey="Gilbert R" first="Rebecca" last="Gilbert">Rebecca Gilbert</name>
<affiliation>
<nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name>
<affiliation>
<nlm:affiliation>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Giovannucci, Edward" sort="Giovannucci, Edward" uniqKey="Giovannucci E" first="Edward" last="Giovannucci">Edward Giovannucci</name>
<affiliation>
<nlm:affiliation>Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Goodman, Gary E" sort="Goodman, Gary E" uniqKey="Goodman G" first="Gary E" last="Goodman">Gary E. Goodman</name>
<affiliation>
<nlm:affiliation>Departments of Epidemiology and Environmental Health, University of Washington, Seattle, WA;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Goodman, Phyllis J" sort="Goodman, Phyllis J" uniqKey="Goodman P" first="Phyllis J" last="Goodman">Phyllis J. Goodman</name>
<affiliation>
<nlm:affiliation>SWOG Statistical Center.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J" last="Gunter">Marc J. Gunter</name>
<affiliation>
<nlm:affiliation>School of Public Health, Imperial College, London, United Kingdom;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C" last="Hamdy">Freddie C. Hamdy</name>
<affiliation>
<nlm:affiliation>Department of Surgery, and.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Heliovaara, Markku" sort="Heliovaara, Markku" uniqKey="Heliovaara M" first="Markku" last="Heliövaara">Markku Heliövaara</name>
<affiliation>
<nlm:affiliation>National Institute for Health and Welfare, Helsinki, Finland;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Helzlsouer, Kathy J" sort="Helzlsouer, Kathy J" uniqKey="Helzlsouer K" first="Kathy J" last="Helzlsouer">Kathy J. Helzlsouer</name>
<affiliation>
<nlm:affiliation>Prevention and Research Center Mercy Medical Center, Baltimore, MD;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E" last="Henderson">Brian E. Henderson</name>
<affiliation>
<nlm:affiliation>Keck School of Medicine, University of Southern California, Los Angeles, CA;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name>
<affiliation>
<nlm:affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team (Nutritional Epidemiology Research Team), Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, Bobigny, France;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Hoffman Bolton, Judy" sort="Hoffman Bolton, Judy" uniqKey="Hoffman Bolton J" first="Judy" last="Hoffman-Bolton">Judy Hoffman-Bolton</name>
<affiliation>
<nlm:affiliation>George W Comstock Center for Public Health Research and Prevention, Hagerstown, MD;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N" last="Hoover">Robert N. Hoover</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name>
<affiliation>
<nlm:affiliation>International Agency for Research on Cancer, Lyon, France; Department for Biobank Research, Umeå University, Umeå, Sweden;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name>
<affiliation>
<nlm:affiliation>Department of Public Health and Primary Care and.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="King, Irena B" sort="King, Irena B" uniqKey="King I" first="Irena B" last="King">Irena B. King</name>
<affiliation>
<nlm:affiliation>Public Health Sciences Core Laboratories, Department of Internal Medicine, University of New Mexico, Albuquerque, NM.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Knekt, Paul" sort="Knekt, Paul" uniqKey="Knekt P" first="Paul" last="Knekt">Paul Knekt</name>
<affiliation>
<nlm:affiliation>National Institute for Health and Welfare, Helsinki, Finland;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N" last="Kolonel">Laurence N. Kolonel</name>
<affiliation>
<nlm:affiliation>University of Hawaii Cancer Center, Honolulu, HI;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name>
<affiliation>
<nlm:affiliation>University of Hawaii Cancer Center, Honolulu, HI;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="M Nnisto, Satu" sort="M Nnisto, Satu" uniqKey="M Nnisto S" first="Satu" last="M Nnistö">Satu M Nnistö</name>
<affiliation>
<nlm:affiliation>National Institute for Health and Welfare, Helsinki, Finland;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Martin, Richard M" sort="Martin, Richard M" uniqKey="Martin R" first="Richard M" last="Martin">Richard M. Martin</name>
<affiliation>
<nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom; Medical Research Council/University of Bristol Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; National Institute for Health Research, Bristol Biomedical Research Unit in Nutrition, Bristol, United Kingdom;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Meyer, Haakon E" sort="Meyer, Haakon E" uniqKey="Meyer H" first="Haakon E" last="Meyer">Haakon E. Meyer</name>
<affiliation>
<nlm:affiliation>Department of Community Medicine, Faculty of Medicine, University of Oslo and Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Mondul, Alison M" sort="Mondul, Alison M" uniqKey="Mondul A" first="Alison M" last="Mondul">Alison M. Mondul</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Moy, Kristin A" sort="Moy, Kristin A" uniqKey="Moy K" first="Kristin A" last="Moy">Kristin A. Moy</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E" last="Neal">David E. Neal</name>
<affiliation>
<nlm:affiliation>Department of Oncology, University of Cambridge, Cambridge, United Kingdom;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Neuhouser, Marian L" sort="Neuhouser, Marian L" uniqKey="Neuhouser M" first="Marian L" last="Neuhouser">Marian L. Neuhouser</name>
<affiliation>
<nlm:affiliation>Division of Public Health Sciences, and.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name>
<affiliation>
<nlm:affiliation>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Platz, Elizabeth A" sort="Platz, Elizabeth A" uniqKey="Platz E" first="Elizabeth A" last="Platz">Elizabeth A. Platz</name>
<affiliation>
<nlm:affiliation>Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Pouchieu, Camille" sort="Pouchieu, Camille" uniqKey="Pouchieu C" first="Camille" last="Pouchieu">Camille Pouchieu</name>
<affiliation>
<nlm:affiliation>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Rissanen, Harri" sort="Rissanen, Harri" uniqKey="Rissanen H" first="Harri" last="Rissanen">Harri Rissanen</name>
<affiliation>
<nlm:affiliation>National Institute for Health and Welfare, Helsinki, Finland;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Schenk, Jeannette M" sort="Schenk, Jeannette M" uniqKey="Schenk J" first="Jeannette M" last="Schenk">Jeannette M. Schenk</name>
<affiliation>
<nlm:affiliation>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation>
<nlm:affiliation>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Stampfer, Meir J" sort="Stampfer, Meir J" uniqKey="Stampfer M" first="Meir J" last="Stampfer">Meir J. Stampfer</name>
<affiliation>
<nlm:affiliation>Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name>
<affiliation>
<nlm:affiliation>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Touvier, Mathilde" sort="Touvier, Mathilde" uniqKey="Touvier M" first="Mathilde" last="Touvier">Mathilde Touvier</name>
<affiliation>
<nlm:affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team (Nutritional Epidemiology Research Team), Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, Bobigny, France;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name>
<affiliation>
<nlm:affiliation>Hellenic Health Foundation and Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece and.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Weinstein, Stephanie J" sort="Weinstein, Stephanie J" uniqKey="Weinstein S" first="Stephanie J" last="Weinstein">Stephanie J. Weinstein</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Ziegler, Regina G" sort="Ziegler, Regina G" uniqKey="Ziegler R" first="Regina G" last="Ziegler">Regina G. Ziegler</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Zhou, Cindy Ke" sort="Zhou, Cindy Ke" uniqKey="Zhou C" first="Cindy Ke" last="Zhou">Cindy Ke Zhou</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Allen, Naomi E" sort="Allen, Naomi E" uniqKey="Allen N" first="Naomi E" last="Allen">Naomi E. Allen</name>
<affiliation>
<nlm:affiliation>Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom;</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series>
<title level="j">The American journal of clinical nutrition</title>
<idno type="eISSN">1938-3207</idno>
<imprint>
<date when="2015" type="published">2015</date>
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<term>Adult</term>
<term>Biomarkers (blood)</term>
<term>Carotenoids (blood)</term>
<term>Case-Control Studies</term>
<term>Cohort Studies</term>
<term>Cross-Sectional Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Meta-Analysis as Topic</term>
<term>Middle Aged</term>
<term>Neoplasm Grading</term>
<term>Neoplasm Staging</term>
<term>Observational Studies as Topic</term>
<term>Prospective Studies</term>
<term>Prostate (pathology)</term>
<term>Prostatic Neoplasms (blood)</term>
<term>Prostatic Neoplasms (epidemiology)</term>
<term>Prostatic Neoplasms (pathology)</term>
<term>Risk Factors</term>
<term>Vitamin A (blood)</term>
<term>alpha-Tocopherol (blood)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en">
<term>Biomarkers</term>
<term>Carotenoids</term>
<term>Vitamin A</term>
<term>alpha-Tocopherol</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en">
<term>Prostatic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en">
<term>Prostatic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Prostate</term>
<term>Prostatic Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adult</term>
<term>Case-Control Studies</term>
<term>Cohort Studies</term>
<term>Cross-Sectional Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Meta-Analysis as Topic</term>
<term>Middle Aged</term>
<term>Neoplasm Grading</term>
<term>Neoplasm Staging</term>
<term>Observational Studies as Topic</term>
<term>Prospective Studies</term>
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<front>
<div type="abstract" xml:lang="en">Individual studies have suggested that circulating carotenoids, retinol, or tocopherols may be associated with prostate cancer risk, but the studies have not been large enough to provide precise estimates of associations, particularly by stage and grade of disease.</div>
</front>
</TEI>
<pubmed>
<MedlineCitation Status="MEDLINE" Owner="NLM">
<PMID Version="1">26447150</PMID>
<DateCreated>
<Year>2015</Year>
<Month>11</Month>
<Day>03</Day>
</DateCreated>
<DateCompleted>
<Year>2016</Year>
<Month>02</Month>
<Day>08</Day>
</DateCompleted>
<DateRevised>
<Year>2017</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">1938-3207</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>102</Volume>
<Issue>5</Issue>
<PubDate>
<Year>2015</Year>
<Month>Nov</Month>
</PubDate>
</JournalIssue>
<Title>The American journal of clinical nutrition</Title>
<ISOAbbreviation>Am. J. Clin. Nutr.</ISOAbbreviation>
</Journal>
<ArticleTitle>Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies.</ArticleTitle>
<Pagination>
<MedlinePgn>1142-57</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.3945/ajcn.115.114306</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Individual studies have suggested that circulating carotenoids, retinol, or tocopherols may be associated with prostate cancer risk, but the studies have not been large enough to provide precise estimates of associations, particularly by stage and grade of disease.</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">The objective of this study was to conduct a pooled analysis of the associations of the concentrations of 7 carotenoids, retinol, α-tocopherol, and γ-tocopherol with risk of prostate cancer and to describe whether any associations differ by stage or grade of the disease or other factors.</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">Principal investigators of prospective studies provided individual participant data for prostate cancer cases and controls. Risk by study-specific fifths of each biomarker was estimated by using multivariable-adjusted conditional logistic regression in matched case-control sets.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Data were available for up to 11,239 cases (including 1654 advanced stage and 1741 aggressive) and 18,541 controls from 15 studies. Lycopene was not associated with overall risk of prostate cancer, but there was statistically significant heterogeneity by stage of disease, and the OR for aggressive disease for the highest compared with the lowest fifth of lycopene was 0.65 (95% CI: 0.46, 0.91; P-trend = 0.032). No other carotenoid was significantly associated with overall risk of prostate cancer or with risk of advanced-stage or aggressive disease. For retinol, the OR for the highest compared with the lowest fifth was 1.13 (95% CI: 1.04, 1.22; P-trend = 0.015). For α-tocopherol, the OR for the highest compared with the lowest fifth was 0.86 (95% CI: 0.78, 0.94; P-trend < 0.001), with significant heterogeneity by stage of disease; the OR for aggressive prostate cancer was 0.74 (95% CI: 0.59, 0.92; P-trend = 0.001). γ-Tocopherol was not associated with risk.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Overall prostate cancer risk was positively associated with retinol and inversely associated with α-tocopherol, and risk of aggressive prostate cancer was inversely associated with lycopene and α-tocopherol. Whether these associations reflect causal relations is unclear.</AbstractText>
<CopyrightInformation>© 2015 American Society for Nutrition.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Key</LastName>
<ForeName>Timothy J</ForeName>
<Initials>TJ</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-2294-307X</Identifier>
<AffiliationInfo>
<Affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, tim.key@ceu.ox.ac.uk.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Appleby</LastName>
<ForeName>Paul N</ForeName>
<Initials>PN</Initials>
<AffiliationInfo>
<Affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Travis</LastName>
<ForeName>Ruth C</ForeName>
<Initials>RC</Initials>
<AffiliationInfo>
<Affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Albanes</LastName>
<ForeName>Demetrius</ForeName>
<Initials>D</Initials>
<AffiliationInfo>
<Affiliation>Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Alberg</LastName>
<ForeName>Anthony J</ForeName>
<Initials>AJ</Initials>
<AffiliationInfo>
<Affiliation>Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Barricarte</LastName>
<ForeName>Aurelio</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Navarre Public Health Institute, Pamplona, Spain, and Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), Spain;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Black</LastName>
<ForeName>Amanda</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Boeing</LastName>
<ForeName>Heiner</ForeName>
<Initials>H</Initials>
<AffiliationInfo>
<Affiliation>Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Bueno-de-Mesquita</LastName>
<ForeName>H Bas</ForeName>
<Initials>HB</Initials>
<AffiliationInfo>
<Affiliation>National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands; Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, Netherlands; School of Public Health, Imperial College, London, United Kingdom;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Chan</LastName>
<ForeName>June M</ForeName>
<Initials>JM</Initials>
<AffiliationInfo>
<Affiliation>Departments of Epidemiology & Biostatistics and Urology, University of California, San Francisco, San Francisco, CA;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Chen</LastName>
<ForeName>Chu</ForeName>
<Initials>C</Initials>
<AffiliationInfo>
<Affiliation>Public Health Sciences Division, Program in Epidemiology.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Cook</LastName>
<ForeName>Michael B</ForeName>
<Initials>MB</Initials>
<AffiliationInfo>
<Affiliation>Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Donovan</LastName>
<ForeName>Jenny L</ForeName>
<Initials>JL</Initials>
<AffiliationInfo>
<Affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Galan</LastName>
<ForeName>Pilar</ForeName>
<Initials>P</Initials>
<AffiliationInfo>
<Affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team (Nutritional Epidemiology Research Team), Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, Bobigny, France;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Gilbert</LastName>
<ForeName>Rebecca</ForeName>
<Initials>R</Initials>
<AffiliationInfo>
<Affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Giles</LastName>
<ForeName>Graham G</ForeName>
<Initials>GG</Initials>
<AffiliationInfo>
<Affiliation>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Giovannucci</LastName>
<ForeName>Edward</ForeName>
<Initials>E</Initials>
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