Present and future therapies of hepatitis B: From discovery to cure.
Identifieur interne : 002684 ( PubMed/Corpus ); précédent : 002683; suivant : 002685Present and future therapies of hepatitis B: From discovery to cure.
Auteurs : T Jake Liang ; Timothy M. Block ; Brian J. Mcmahon ; Marc G. Ghany ; Stephan Urban ; Ju-Tao Guo ; Stephen Locarnini ; Fabien Zoulim ; Kyong-Mi Chang ; Anna S. LokSource :
- Hepatology (Baltimore, Md.) [ 1527-3350 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Antiviral Agents.
- drug therapy : Hepatitis B.
- Drug Discovery, Forecasting, Humans, Remission Induction.
Abstract
Hepatitis B virus (HBV) is a significant global pathogen, infecting more than 240 million people worldwide. While treatment for HBV has improved, HBV patients often require lifelong therapies and cure is still a challenging goal. Recent advances in technologies and pharmaceutical sciences have heralded a new horizon of innovative therapeutic approaches that are bringing us closer to the possibility of a functional cure of chronic HBV infection. In this article, we review the current state of science in HBV therapy and highlight new and exciting therapeutic strategies spurred by recent scientific advances. Some of these therapies have already entered into clinical phase, and we will likely see more of them moving along the development pipeline.
DOI: 10.1002/hep.28025
PubMed: 26239691
Links to Exploration step
pubmed:26239691Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Present and future therapies of hepatitis B: From discovery to cure.</title><author><name sortKey="Liang, T Jake" sort="Liang, T Jake" uniqKey="Liang T" first="T Jake" last="Liang">T Jake Liang</name><affiliation><nlm:affiliation>Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Block, Timothy M" sort="Block, Timothy M" uniqKey="Block T" first="Timothy M" last="Block">Timothy M. Block</name><affiliation><nlm:affiliation>Baruch S. Blumberg Institute, Doylestown, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Mcmahon, Brian J" sort="Mcmahon, Brian J" uniqKey="Mcmahon B" first="Brian J" last="Mcmahon">Brian J. Mcmahon</name><affiliation><nlm:affiliation>National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK.</nlm:affiliation></affiliation></author><author><name sortKey="Ghany, Marc G" sort="Ghany, Marc G" uniqKey="Ghany M" first="Marc G" last="Ghany">Marc G. Ghany</name><affiliation><nlm:affiliation>Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Urban, Stephan" sort="Urban, Stephan" uniqKey="Urban S" first="Stephan" last="Urban">Stephan Urban</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Molecular Virology and German Center for Infection Diseases, University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Guo, Ju Tao" sort="Guo, Ju Tao" uniqKey="Guo J" first="Ju-Tao" last="Guo">Ju-Tao Guo</name><affiliation><nlm:affiliation>Baruch S. Blumberg Institute, Doylestown, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Locarnini, Stephen" sort="Locarnini, Stephen" uniqKey="Locarnini S" first="Stephen" last="Locarnini">Stephen Locarnini</name><affiliation><nlm:affiliation>Hepatology Department, Lyon University and Cancer Research Center of Lyon, INSERM U1052, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Zoulim, Fabien" sort="Zoulim, Fabien" uniqKey="Zoulim F" first="Fabien" last="Zoulim">Fabien Zoulim</name><affiliation><nlm:affiliation>Victorian Infectious Diseases Reference Laboratory, Doherty Institute, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Chang, Kyong Mi" sort="Chang, Kyong Mi" uniqKey="Chang K" first="Kyong-Mi" last="Chang">Kyong-Mi Chang</name><affiliation><nlm:affiliation>Department of Medicine, Philadelphia Veterans Affairs Medical Center and the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Lok, Anna S" sort="Lok, Anna S" uniqKey="Lok A" first="Anna S" last="Lok">Anna S. Lok</name><affiliation><nlm:affiliation>Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26239691</idno><idno type="pmid">26239691</idno><idno type="doi">10.1002/hep.28025</idno><idno type="wicri:Area/PubMed/Corpus">002684</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002684</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Present and future therapies of hepatitis B: From discovery to cure.</title><author><name sortKey="Liang, T Jake" sort="Liang, T Jake" uniqKey="Liang T" first="T Jake" last="Liang">T Jake Liang</name><affiliation><nlm:affiliation>Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Block, Timothy M" sort="Block, Timothy M" uniqKey="Block T" first="Timothy M" last="Block">Timothy M. Block</name><affiliation><nlm:affiliation>Baruch S. Blumberg Institute, Doylestown, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Mcmahon, Brian J" sort="Mcmahon, Brian J" uniqKey="Mcmahon B" first="Brian J" last="Mcmahon">Brian J. Mcmahon</name><affiliation><nlm:affiliation>National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK.</nlm:affiliation></affiliation></author><author><name sortKey="Ghany, Marc G" sort="Ghany, Marc G" uniqKey="Ghany M" first="Marc G" last="Ghany">Marc G. Ghany</name><affiliation><nlm:affiliation>Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Urban, Stephan" sort="Urban, Stephan" uniqKey="Urban S" first="Stephan" last="Urban">Stephan Urban</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Molecular Virology and German Center for Infection Diseases, University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Guo, Ju Tao" sort="Guo, Ju Tao" uniqKey="Guo J" first="Ju-Tao" last="Guo">Ju-Tao Guo</name><affiliation><nlm:affiliation>Baruch S. Blumberg Institute, Doylestown, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Locarnini, Stephen" sort="Locarnini, Stephen" uniqKey="Locarnini S" first="Stephen" last="Locarnini">Stephen Locarnini</name><affiliation><nlm:affiliation>Hepatology Department, Lyon University and Cancer Research Center of Lyon, INSERM U1052, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Zoulim, Fabien" sort="Zoulim, Fabien" uniqKey="Zoulim F" first="Fabien" last="Zoulim">Fabien Zoulim</name><affiliation><nlm:affiliation>Victorian Infectious Diseases Reference Laboratory, Doherty Institute, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Chang, Kyong Mi" sort="Chang, Kyong Mi" uniqKey="Chang K" first="Kyong-Mi" last="Chang">Kyong-Mi Chang</name><affiliation><nlm:affiliation>Department of Medicine, Philadelphia Veterans Affairs Medical Center and the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Lok, Anna S" sort="Lok, Anna S" uniqKey="Lok A" first="Anna S" last="Lok">Anna S. Lok</name><affiliation><nlm:affiliation>Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Hepatology (Baltimore, Md.)</title><idno type="eISSN">1527-3350</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (therapeutic use)</term><term>Drug Discovery</term><term>Forecasting</term><term>Hepatitis B (drug therapy)</term><term>Humans</term><term>Remission Induction</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hepatitis B</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Discovery</term><term>Forecasting</term><term>Humans</term><term>Remission Induction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hepatitis B virus (HBV) is a significant global pathogen, infecting more than 240 million people worldwide. While treatment for HBV has improved, HBV patients often require lifelong therapies and cure is still a challenging goal. Recent advances in technologies and pharmaceutical sciences have heralded a new horizon of innovative therapeutic approaches that are bringing us closer to the possibility of a functional cure of chronic HBV infection. In this article, we review the current state of science in HBV therapy and highlight new and exciting therapeutic strategies spurred by recent scientific advances. Some of these therapies have already entered into clinical phase, and we will likely see more of them moving along the development pipeline.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26239691</PMID><DateCreated><Year>2015</Year><Month>12</Month><Day>16</Day></DateCreated><DateCompleted><Year>2016</Year><Month>04</Month><Day>14</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1527-3350</ISSN><JournalIssue CitedMedium="Internet"><Volume>62</Volume><Issue>6</Issue><PubDate><Year>2015</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Hepatology (Baltimore, Md.)</Title><ISOAbbreviation>Hepatology</ISOAbbreviation></Journal><ArticleTitle>Present and future therapies of hepatitis B: From discovery to cure.</ArticleTitle><Pagination><MedlinePgn>1893-908</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/hep.28025</ELocationID><Abstract><AbstractText Label="UNLABELLED">Hepatitis B virus (HBV) is a significant global pathogen, infecting more than 240 million people worldwide. While treatment for HBV has improved, HBV patients often require lifelong therapies and cure is still a challenging goal. Recent advances in technologies and pharmaceutical sciences have heralded a new horizon of innovative therapeutic approaches that are bringing us closer to the possibility of a functional cure of chronic HBV infection. In this article, we review the current state of science in HBV therapy and highlight new and exciting therapeutic strategies spurred by recent scientific advances. Some of these therapies have already entered into clinical phase, and we will likely see more of them moving along the development pipeline.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">With growing interest in developing and efforts to develop more effective therapies for HBV, the challenging goal of a cure may be well within reach in the near future.</AbstractText><CopyrightInformation>© 2015 by the American Association for the Study of Liver Diseases. This article has been contributed to by U.S. Government employees and their work is in the public domain in the U.S.A.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liang</LastName><ForeName>T Jake</ForeName><Initials>TJ</Initials><AffiliationInfo><Affiliation>Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Block</LastName><ForeName>Timothy M</ForeName><Initials>TM</Initials><AffiliationInfo><Affiliation>Baruch S. Blumberg Institute, Doylestown, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McMahon</LastName><ForeName>Brian J</ForeName><Initials>BJ</Initials><AffiliationInfo><Affiliation>National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghany</LastName><ForeName>Marc G</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Urban</LastName><ForeName>Stephan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, Molecular Virology and German Center for Infection Diseases, University Hospital Heidelberg, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Ju-Tao</ForeName><Initials>JT</Initials><AffiliationInfo><Affiliation>Baruch S. Blumberg Institute, Doylestown, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Locarnini</LastName><ForeName>Stephen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Hepatology Department, Lyon University and Cancer Research Center of Lyon, INSERM U1052, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zoulim</LastName><ForeName>Fabien</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Victorian Infectious Diseases Reference Laboratory, Doherty Institute, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Kyong-Mi</ForeName><Initials>KM</Initials><AffiliationInfo><Affiliation>Department of Medicine, Philadelphia Veterans Affairs Medical Center and the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lok</LastName><ForeName>Anna S</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>ZIA DK054500-18</GrantID><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>ZIA DK054500-16</GrantID><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>ZIA DK054500-17</GrantID><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI113267</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>ZIA DK054500-19</GrantID><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>Z01 DK054517-02</GrantID><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI104636</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>Z99 DK999999</GrantID><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>10</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Hepatology</MedlineTA><NlmUniqueID>8302946</NlmUniqueID><ISSNLinking>0270-9139</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Gut. 2015 Jan;64(1):139-47</RefSource><PMID 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Induction</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>03</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>07</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>8</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>8</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>4</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26239691</ArticleId><ArticleId IdType="doi">10.1002/hep.28025</ArticleId><ArticleId IdType="pmc">PMC4681668</ArticleId><ArticleId IdType="mid">NIHMS725423</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour 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