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Acute myeloid leukemia patients' clinical response to idasanutlin (RG7388) is associated with pre-treatment MDM2 protein expression in leukemic blasts.

Identifieur interne : 001E84 ( PubMed/Corpus ); précédent : 001E83; suivant : 001E85

Acute myeloid leukemia patients' clinical response to idasanutlin (RG7388) is associated with pre-treatment MDM2 protein expression in leukemic blasts.

Auteurs : Bernhard Reis ; Lori Jukofsky ; Gong Chen ; Giovanni Martinelli ; Hua Zhong ; W Venus So ; Michael J. Dickinson ; Mark Drummond ; Sarit Assouline ; Maneja Hashemyan ; Michel Theron ; Steven Blotner ; Je-Hwan Lee ; Margaret Kasner ; Sung-Soo Yoon ; Ruediger Rueger ; Karen Seiter ; Steven A. Middleton ; Kevin R. Kelly ; Norbert Vey ; Karen Yee ; Gwen Nichols ; Lin-Chi Chen ; William E. Pierceall

Source :

RBID : pubmed:26869629
DOI: 10.3324/haematol.2015.139717
PubMed: 26869629

Links to Exploration step

pubmed:26869629

Le document en format XML

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<nlm:affiliation>Roche Innovation Center New York, Roche Pharma Research and Early Development, NY, USA.</nlm:affiliation>
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<name sortKey="Theron, Michel" sort="Theron, Michel" uniqKey="Theron M" first="Michel" last="Theron">Michel Theron</name>
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<name sortKey="Lee, Je Hwan" sort="Lee, Je Hwan" uniqKey="Lee J" first="Je-Hwan" last="Lee">Je-Hwan Lee</name>
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<nlm:affiliation>Department of Hematology, Asian Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.</nlm:affiliation>
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<nlm:affiliation>Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.</nlm:affiliation>
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<name sortKey="Yoon, Sung Soo" sort="Yoon, Sung Soo" uniqKey="Yoon S" first="Sung-Soo" last="Yoon">Sung-Soo Yoon</name>
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<nlm:affiliation>Roche Innovation Center Penzberg, Roche Pharma Research and Early Development, Germany.</nlm:affiliation>
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<name sortKey="Seiter, Karen" sort="Seiter, Karen" uniqKey="Seiter K" first="Karen" last="Seiter">Karen Seiter</name>
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<nlm:affiliation>New York Medical College, Valhalla, NY, USA.</nlm:affiliation>
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<name sortKey="Middleton, Steven A" sort="Middleton, Steven A" uniqKey="Middleton S" first="Steven A" last="Middleton">Steven A. Middleton</name>
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<nlm:affiliation>Roche Innovation Center New York, Roche Pharma Research and Early Development, NY, USA.</nlm:affiliation>
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<name sortKey="Kelly, Kevin R" sort="Kelly, Kevin R" uniqKey="Kelly K" first="Kevin R" last="Kelly">Kevin R. Kelly</name>
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<nlm:affiliation>University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA, USA.</nlm:affiliation>
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<name sortKey="Vey, Norbert" sort="Vey, Norbert" uniqKey="Vey N" first="Norbert" last="Vey">Norbert Vey</name>
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<nlm:affiliation>Hematology, Institut Paoli Calmettes, Marseilles, France.</nlm:affiliation>
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<name sortKey="Yee, Karen" sort="Yee, Karen" uniqKey="Yee K" first="Karen" last="Yee">Karen Yee</name>
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<nlm:affiliation>Princess Margaret Hospital, Toronto, ON, Canada.</nlm:affiliation>
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<name sortKey="Nichols, Gwen" sort="Nichols, Gwen" uniqKey="Nichols G" first="Gwen" last="Nichols">Gwen Nichols</name>
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<nlm:affiliation>Roche Innovation Center New York, Roche Pharma Research and Early Development, NY, USA.</nlm:affiliation>
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<name sortKey="Chen, Lin Chi" sort="Chen, Lin Chi" uniqKey="Chen L" first="Lin-Chi" last="Chen">Lin-Chi Chen</name>
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<nlm:affiliation>Roche Innovation Center New York, Roche Pharma Research and Early Development, NY, USA.</nlm:affiliation>
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<RefSource>EMBO Mol Med. 2011 Nov;3(11):623-36</RefSource>
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<RefSource>Elife. 2015 May 12;4:null</RefSource>
<PMID Version="1">25965177</PMID>
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<RefSource>Science. 2004 Feb 6;303(5659):844-8</RefSource>
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<RefSource>Biomark Med. 2015;9(1):25-34</RefSource>
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<RefSource>Br J Haematol. 2015 Nov;171(3):432-5</RefSource>
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<RefSource>Lancet Oncol. 2012 Nov;13(11):1133-40</RefSource>
<PMID Version="1">23084521</PMID>
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<RefSource>Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1888-93</RefSource>
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<Keyword MajorTopicYN="N">MDM2 antagonism</Keyword>
<Keyword MajorTopicYN="N">complementary diagnostics</Keyword>
<Keyword MajorTopicYN="N">flow cytometry</Keyword>
<Keyword MajorTopicYN="N">idasanutlin</Keyword>
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