Diversity in cell motility reveals the dynamic nature of the formation of zebrafish taste sensory organs.
Identifieur interne : 001D24 ( PubMed/Corpus ); précédent : 001D23; suivant : 001D25Diversity in cell motility reveals the dynamic nature of the formation of zebrafish taste sensory organs.
Auteurs : Marina Soulika ; Anna-Lila Kaushik ; Benjamin Mathieu ; Raquel Lourenço ; Anna Z. Komisarczuk ; Sebastian Alejo Romano ; Adrien Jouary ; Alicia Lardennois ; Nicolas Tissot ; Shinji Okada ; Keiko Abe ; Thomas S. Becker ; Marika KapsimaliSource :
- Development (Cambridge, England) [ 1477-9129 ] ; 2016.
English descriptors
- KwdEn :
- Animals, Basic Helix-Loop-Helix Transcription Factors (metabolism), Cell Count, Cell Differentiation, Cell Lineage, Cell Movement, Enhancer Elements, Genetic (genetics), Larva (cytology), Larva (metabolism), Organogenesis, Serotonin (metabolism), Taste Buds (cytology), Taste Buds (growth & development), Zebrafish (physiology), Zebrafish Proteins (metabolism).
- MESH :
- chemical , metabolism : Basic Helix-Loop-Helix Transcription Factors, Serotonin, Zebrafish Proteins.
- cytology : Larva, Taste Buds.
- genetics : Enhancer Elements, Genetic.
- growth & development : Taste Buds.
- metabolism : Larva.
- physiology : Zebrafish.
- Animals, Cell Count, Cell Differentiation, Cell Lineage, Cell Movement, Organogenesis.
Abstract
Taste buds are sensory organs in jawed vertebrates, composed of distinct cell types that detect and transduce specific taste qualities. Taste bud cells differentiate from oropharyngeal epithelial progenitors, which are localized mainly in proximity to the forming organs. Despite recent progress in elucidating the molecular interactions required for taste bud cell development and function, the cell behavior underlying the organ assembly is poorly defined. Here, we used time-lapse imaging to observe the formation of taste buds in live zebrafish larvae. We found that tg(fgf8a.dr17)-expressing cells form taste buds and get rearranged within the forming organs. In addition, differentiating cells move from the epithelium to the forming organs and can be displaced between developing organs. During organ formation, tg(fgf8a.dr17) and type II taste bud cells are displaced in random, directed or confined mode relative to the taste bud they join or by which they are maintained. Finally, ascl1a activity in the 5-HT/type III cell is required to direct and maintain tg(fgf8a.dr17)-expressing cells into the taste bud. We propose that diversity in displacement modes of differentiating cells acts as a key mechanism for the highly dynamic process of taste bud assembly.
DOI: 10.1242/dev.134817
PubMed: 27122167
Links to Exploration step
pubmed:27122167Le document en format XML
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Komisarczuk</name><affiliation><nlm:affiliation>Developmental Neurobiology and Genomics, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Romano, Sebastian Alejo" sort="Romano, Sebastian Alejo" uniqKey="Romano S" first="Sebastian Alejo" last="Romano">Sebastian Alejo Romano</name><affiliation><nlm:affiliation>IBENS, Ecole Normale Supérieure, CNRS UMR8197, INSERM U1024, 75230 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Jouary, Adrien" sort="Jouary, Adrien" uniqKey="Jouary A" first="Adrien" last="Jouary">Adrien Jouary</name><affiliation><nlm:affiliation>IBENS, Ecole Normale Supérieure, CNRS UMR8197, INSERM U1024, 75230 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lardennois, Alicia" sort="Lardennois, Alicia" uniqKey="Lardennois A" first="Alicia" last="Lardennois">Alicia Lardennois</name><affiliation><nlm:affiliation>IBENS, Ecole Normale Supérieure, CNRS UMR8197, INSERM U1024, 75230 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tissot, Nicolas" sort="Tissot, Nicolas" uniqKey="Tissot N" first="Nicolas" last="Tissot">Nicolas Tissot</name><affiliation><nlm:affiliation>Institut Jacques Monod, CNRS UMR7592, University Paris Diderot, 75013 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Okada, Shinji" sort="Okada, Shinji" uniqKey="Okada S" first="Shinji" last="Okada">Shinji Okada</name><affiliation><nlm:affiliation>Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Abe, Keiko" sort="Abe, Keiko" uniqKey="Abe K" first="Keiko" last="Abe">Keiko Abe</name><affiliation><nlm:affiliation>Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Becker, Thomas S" sort="Becker, Thomas S" uniqKey="Becker T" first="Thomas S" last="Becker">Thomas S. Becker</name><affiliation><nlm:affiliation>Developmental Neurobiology and Genomics, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Kapsimali, Marika" sort="Kapsimali, Marika" uniqKey="Kapsimali M" first="Marika" last="Kapsimali">Marika Kapsimali</name><affiliation><nlm:affiliation>IBENS, Ecole Normale Supérieure, CNRS UMR8197, INSERM U1024, 75230 Paris, France marika.kapsimali@ens.fr.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27122167</idno><idno type="pmid">27122167</idno><idno type="doi">10.1242/dev.134817</idno><idno type="wicri:Area/PubMed/Corpus">001D24</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001D24</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Diversity in cell motility reveals the dynamic nature of the formation of zebrafish taste sensory organs.</title><author><name sortKey="Soulika, Marina" sort="Soulika, Marina" uniqKey="Soulika M" first="Marina" last="Soulika">Marina Soulika</name><affiliation><nlm:affiliation>IBENS, Ecole Normale Supérieure, CNRS UMR8197, INSERM U1024, 75230 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kaushik, Anna Lila" sort="Kaushik, Anna Lila" uniqKey="Kaushik A" first="Anna-Lila" last="Kaushik">Anna-Lila Kaushik</name><affiliation><nlm:affiliation>IBENS, Ecole Normale Supérieure, CNRS UMR8197, INSERM U1024, 75230 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mathieu, Benjamin" sort="Mathieu, Benjamin" uniqKey="Mathieu B" first="Benjamin" last="Mathieu">Benjamin Mathieu</name><affiliation><nlm:affiliation>IBENS, Ecole Normale Supérieure, CNRS UMR8197, INSERM U1024, 75230 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lourenco, Raquel" sort="Lourenco, Raquel" uniqKey="Lourenco R" first="Raquel" last="Lourenço">Raquel Lourenço</name><affiliation><nlm:affiliation>IBENS, Ecole Normale Supérieure, CNRS UMR8197, INSERM U1024, 75230 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Komisarczuk, Anna Z" sort="Komisarczuk, Anna Z" uniqKey="Komisarczuk A" first="Anna Z" last="Komisarczuk">Anna Z. Komisarczuk</name><affiliation><nlm:affiliation>Developmental Neurobiology and Genomics, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Romano, Sebastian Alejo" sort="Romano, Sebastian Alejo" uniqKey="Romano S" first="Sebastian Alejo" last="Romano">Sebastian Alejo Romano</name><affiliation><nlm:affiliation>IBENS, Ecole Normale Supérieure, CNRS UMR8197, INSERM U1024, 75230 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Jouary, Adrien" sort="Jouary, Adrien" uniqKey="Jouary A" first="Adrien" last="Jouary">Adrien Jouary</name><affiliation><nlm:affiliation>IBENS, Ecole Normale Supérieure, CNRS UMR8197, INSERM U1024, 75230 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lardennois, Alicia" sort="Lardennois, Alicia" uniqKey="Lardennois A" first="Alicia" last="Lardennois">Alicia Lardennois</name><affiliation><nlm:affiliation>IBENS, Ecole Normale Supérieure, CNRS UMR8197, INSERM U1024, 75230 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tissot, Nicolas" sort="Tissot, Nicolas" uniqKey="Tissot N" first="Nicolas" last="Tissot">Nicolas Tissot</name><affiliation><nlm:affiliation>Institut Jacques Monod, CNRS UMR7592, University Paris Diderot, 75013 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Okada, Shinji" sort="Okada, Shinji" uniqKey="Okada S" first="Shinji" last="Okada">Shinji Okada</name><affiliation><nlm:affiliation>Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Abe, Keiko" sort="Abe, Keiko" uniqKey="Abe K" first="Keiko" last="Abe">Keiko Abe</name><affiliation><nlm:affiliation>Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Becker, Thomas S" sort="Becker, Thomas S" uniqKey="Becker T" first="Thomas S" last="Becker">Thomas S. Becker</name><affiliation><nlm:affiliation>Developmental Neurobiology and Genomics, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Kapsimali, Marika" sort="Kapsimali, Marika" uniqKey="Kapsimali M" first="Marika" last="Kapsimali">Marika Kapsimali</name><affiliation><nlm:affiliation>IBENS, Ecole Normale Supérieure, CNRS UMR8197, INSERM U1024, 75230 Paris, France marika.kapsimali@ens.fr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Development (Cambridge, England)</title><idno type="eISSN">1477-9129</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Basic Helix-Loop-Helix Transcription Factors (metabolism)</term><term>Cell Count</term><term>Cell Differentiation</term><term>Cell Lineage</term><term>Cell Movement</term><term>Enhancer Elements, Genetic (genetics)</term><term>Larva (cytology)</term><term>Larva (metabolism)</term><term>Organogenesis</term><term>Serotonin (metabolism)</term><term>Taste Buds (cytology)</term><term>Taste Buds (growth & development)</term><term>Zebrafish (physiology)</term><term>Zebrafish Proteins (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Basic Helix-Loop-Helix Transcription Factors</term><term>Serotonin</term><term>Zebrafish Proteins</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Larva</term><term>Taste Buds</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Enhancer Elements, Genetic</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Taste Buds</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Larva</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Zebrafish</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Count</term><term>Cell Differentiation</term><term>Cell Lineage</term><term>Cell Movement</term><term>Organogenesis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Taste buds are sensory organs in jawed vertebrates, composed of distinct cell types that detect and transduce specific taste qualities. Taste bud cells differentiate from oropharyngeal epithelial progenitors, which are localized mainly in proximity to the forming organs. Despite recent progress in elucidating the molecular interactions required for taste bud cell development and function, the cell behavior underlying the organ assembly is poorly defined. Here, we used time-lapse imaging to observe the formation of taste buds in live zebrafish larvae. We found that tg(fgf8a.dr17)-expressing cells form taste buds and get rearranged within the forming organs. In addition, differentiating cells move from the epithelium to the forming organs and can be displaced between developing organs. During organ formation, tg(fgf8a.dr17) and type II taste bud cells are displaced in random, directed or confined mode relative to the taste bud they join or by which they are maintained. Finally, ascl1a activity in the 5-HT/type III cell is required to direct and maintain tg(fgf8a.dr17)-expressing cells into the taste bud. We propose that diversity in displacement modes of differentiating cells acts as a key mechanism for the highly dynamic process of taste bud assembly.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27122167</PMID><DateCreated><Year>2016</Year><Month>06</Month><Day>01</Day></DateCreated><DateCompleted><Year>2017</Year><Month>09</Month><Day>01</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1477-9129</ISSN><JournalIssue CitedMedium="Internet"><Volume>143</Volume><Issue>11</Issue><PubDate><Year>2016</Year><Month>Jun</Month><Day>01</Day></PubDate></JournalIssue><Title>Development (Cambridge, England)</Title><ISOAbbreviation>Development</ISOAbbreviation></Journal><ArticleTitle>Diversity in cell motility reveals the dynamic nature of the formation of zebrafish taste sensory organs.</ArticleTitle><Pagination><MedlinePgn>2012-24</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1242/dev.134817</ELocationID><Abstract><AbstractText>Taste buds are sensory organs in jawed vertebrates, composed of distinct cell types that detect and transduce specific taste qualities. Taste bud cells differentiate from oropharyngeal epithelial progenitors, which are localized mainly in proximity to the forming organs. Despite recent progress in elucidating the molecular interactions required for taste bud cell development and function, the cell behavior underlying the organ assembly is poorly defined. Here, we used time-lapse imaging to observe the formation of taste buds in live zebrafish larvae. We found that tg(fgf8a.dr17)-expressing cells form taste buds and get rearranged within the forming organs. In addition, differentiating cells move from the epithelium to the forming organs and can be displaced between developing organs. During organ formation, tg(fgf8a.dr17) and type II taste bud cells are displaced in random, directed or confined mode relative to the taste bud they join or by which they are maintained. Finally, ascl1a activity in the 5-HT/type III cell is required to direct and maintain tg(fgf8a.dr17)-expressing cells into the taste bud. We propose that diversity in displacement modes of differentiating cells acts as a key mechanism for the highly dynamic process of taste bud assembly.</AbstractText><CopyrightInformation>© 2016. Published by The Company of Biologists Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Soulika</LastName><ForeName>Marina</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>IBENS, Ecole Normale Supérieure, CNRS UMR8197, INSERM U1024, 75230 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaushik</LastName><ForeName>Anna-Lila</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>IBENS, Ecole Normale Supérieure, CNRS UMR8197, INSERM U1024, 75230 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mathieu</LastName><ForeName>Benjamin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>IBENS, Ecole Normale Supérieure, CNRS UMR8197, INSERM U1024, 75230 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lourenço</LastName><ForeName>Raquel</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>IBENS, Ecole Normale Supérieure, CNRS UMR8197, INSERM U1024, 75230 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Komisarczuk</LastName><ForeName>Anna Z</ForeName><Initials>AZ</Initials><AffiliationInfo><Affiliation>Developmental Neurobiology and Genomics, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Romano</LastName><ForeName>Sebastian Alejo</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>IBENS, Ecole Normale Supérieure, CNRS UMR8197, INSERM U1024, 75230 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jouary</LastName><ForeName>Adrien</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>IBENS, Ecole Normale Supérieure, CNRS UMR8197, INSERM U1024, 75230 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lardennois</LastName><ForeName>Alicia</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>IBENS, Ecole Normale Supérieure, CNRS UMR8197, INSERM U1024, 75230 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tissot</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Institut Jacques Monod, CNRS UMR7592, University Paris Diderot, 75013 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Okada</LastName><ForeName>Shinji</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abe</LastName><ForeName>Keiko</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Becker</LastName><ForeName>Thomas S</ForeName><Initials>TS</Initials><AffiliationInfo><Affiliation>Developmental Neurobiology and Genomics, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kapsimali</LastName><ForeName>Marika</ForeName><Initials>M</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-9327-5166</Identifier><AffiliationInfo><Affiliation>IBENS, Ecole Normale Supérieure, CNRS UMR8197, INSERM U1024, 75230 Paris, France marika.kapsimali@ens.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>04</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Development</MedlineTA><NlmUniqueID>8701744</NlmUniqueID><ISSNLinking>0950-1991</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051792">Basic Helix-Loop-Helix Transcription Factors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029961">Zebrafish Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C510293">achaete-scute complex-like 1a protein, zebrafish</NameOfSubstance></Chemical><Chemical><RegistryNumber>333DO1RDJY</RegistryNumber><NameOfSubstance UI="D012701">Serotonin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051792" MajorTopicYN="N">Basic Helix-Loop-Helix Transcription Factors</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002452" MajorTopicYN="N">Cell Count</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002454" MajorTopicYN="N">Cell Differentiation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019070" MajorTopicYN="N">Cell Lineage</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002465" MajorTopicYN="Y">Cell Movement</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004742" MajorTopicYN="N">Enhancer Elements, Genetic</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007814" MajorTopicYN="N">Larva</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D038081" MajorTopicYN="Y">Organogenesis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012701" MajorTopicYN="N">Serotonin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013650" MajorTopicYN="N">Taste Buds</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName><QualifierName UI="Q000254" MajorTopicYN="Y">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015027" MajorTopicYN="N">Zebrafish</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029961" MajorTopicYN="N">Zebrafish Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Ascl1a</Keyword><Keyword MajorTopicYN="N">MSD</Keyword><Keyword MajorTopicYN="N">Taste bud</Keyword><Keyword MajorTopicYN="N">Taste receptor cell</Keyword><Keyword MajorTopicYN="N">Time-lapse</Keyword><Keyword MajorTopicYN="N">fgf8a</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>01</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>04</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>4</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>4</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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