Riboflavin photoactivation by upconversion nanoparticles for cancer treatment.
Identifieur interne : 001802 ( PubMed/Corpus ); précédent : 001801; suivant : 001803Riboflavin photoactivation by upconversion nanoparticles for cancer treatment.
Auteurs : E V Khaydukov ; K E Mironova ; V A Semchishen ; A N Generalova ; A V Nechaev ; D A Khochenkov ; E V Stepanova ; O I Lebedev ; A V Zvyagin ; S M Deyev ; V Ya PanchenkoSource :
- Scientific reports [ 2045-2322 ] ; 2016.
Abstract
Riboflavin (Rf) is a vitamin and endogenous photosensitizer capable to generate reactive oxygen species (ROS) under UV-blue irradiation and kill cancer cells, which are characterized by the enhanced uptake of Rf. We confirmed its phototoxicity on human breast adenocarcinoma cells SK-BR-3 preincubated with 30-μM Rf and irradiated with ultraviolet light, and proved that such Rf concentrations (60 μM) are attainable in vivo in tumour site by systemic intravascular injection. In order to extend the Rf photosensitization depth in cancer tissue to 6 mm in depth, we purpose-designed core/shell upconversion nanoparticles (UCNPs, NaYF4:Yb(3+):Tm(3+)/NaYF4) capable to convert 2% of the deeply-penetrating excitation at 975 nm to ultraviolet-blue power. This power was expended to photosensitise Rf and kill SK-BR-3 cells preincubated with UCNPs and Rf, where the UCNP-Rf energy transfer was photon-mediated with ~14% Förster process contribution. SK-BR-3 xenograft regression in mice was observed for 50 days, following the Rf-UCNPs peritumoural injection and near-infrared light photodynamic treatment of the lesions.
DOI: 10.1038/srep35103
PubMed: 27731350
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Blokhin Russian Cancer Research Center" of Ministry of Health of the Russian Federation, 24 Kashirskoye shosse, Moscow, 115478, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Lebedev, O I" sort="Lebedev, O I" uniqKey="Lebedev O" first="O I" last="Lebedev">O I Lebedev</name><affiliation><nlm:affiliation>Laboratoire CRISMAT, UMR6508, CNRS-ENSIACEN, Universite Caen, 14050 Caen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Zvyagin, A V" sort="Zvyagin, A V" uniqKey="Zvyagin A" first="A V" last="Zvyagin">A V Zvyagin</name><affiliation><nlm:affiliation>Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Leninsky pr. 59, Moscow, 119333, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Deyev, S M" sort="Deyev, S M" uniqKey="Deyev S" first="S M" last="Deyev">S M Deyev</name><affiliation><nlm:affiliation>Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya, Moscow 117997, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Panchenko, V Ya" sort="Panchenko, V Ya" uniqKey="Panchenko V" first="V Ya" last="Panchenko">V Ya Panchenko</name><affiliation><nlm:affiliation>Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Leninsky pr. 59, Moscow, 119333, Russia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27731350</idno><idno type="pmid">27731350</idno><idno type="doi">10.1038/srep35103</idno><idno type="wicri:Area/PubMed/Corpus">001802</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001802</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Riboflavin photoactivation by upconversion nanoparticles for cancer treatment.</title><author><name sortKey="Khaydukov, E V" sort="Khaydukov, E V" uniqKey="Khaydukov E" first="E V" last="Khaydukov">E V Khaydukov</name><affiliation><nlm:affiliation>Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Leninsky pr. 59, Moscow, 119333, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Mironova, K E" sort="Mironova, K E" uniqKey="Mironova K" first="K E" last="Mironova">K E Mironova</name><affiliation><nlm:affiliation>Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Leninsky pr. 59, Moscow, 119333, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Semchishen, V A" sort="Semchishen, V A" uniqKey="Semchishen V" first="V A" last="Semchishen">V A Semchishen</name><affiliation><nlm:affiliation>Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Leninsky pr. 59, Moscow, 119333, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Generalova, A N" sort="Generalova, A N" uniqKey="Generalova A" first="A N" last="Generalova">A N Generalova</name><affiliation><nlm:affiliation>Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Leninsky pr. 59, Moscow, 119333, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Nechaev, A V" sort="Nechaev, A V" uniqKey="Nechaev A" first="A V" last="Nechaev">A V Nechaev</name><affiliation><nlm:affiliation>Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Leninsky pr. 59, Moscow, 119333, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Khochenkov, D A" sort="Khochenkov, D A" uniqKey="Khochenkov D" first="D A" last="Khochenkov">D A Khochenkov</name><affiliation><nlm:affiliation>Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Leninsky pr. 59, Moscow, 119333, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Stepanova, E V" sort="Stepanova, E V" uniqKey="Stepanova E" first="E V" last="Stepanova">E V Stepanova</name><affiliation><nlm:affiliation>FSBSI "N.N. Blokhin Russian Cancer Research Center" of Ministry of Health of the Russian Federation, 24 Kashirskoye shosse, Moscow, 115478, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Lebedev, O I" sort="Lebedev, O I" uniqKey="Lebedev O" first="O I" last="Lebedev">O I Lebedev</name><affiliation><nlm:affiliation>Laboratoire CRISMAT, UMR6508, CNRS-ENSIACEN, Universite Caen, 14050 Caen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Zvyagin, A V" sort="Zvyagin, A V" uniqKey="Zvyagin A" first="A V" last="Zvyagin">A V Zvyagin</name><affiliation><nlm:affiliation>Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Leninsky pr. 59, Moscow, 119333, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Deyev, S M" sort="Deyev, S M" uniqKey="Deyev S" first="S M" last="Deyev">S M Deyev</name><affiliation><nlm:affiliation>Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya, Moscow 117997, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Panchenko, V Ya" sort="Panchenko, V Ya" uniqKey="Panchenko V" first="V Ya" last="Panchenko">V Ya Panchenko</name><affiliation><nlm:affiliation>Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Leninsky pr. 59, Moscow, 119333, Russia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Scientific reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Riboflavin (Rf) is a vitamin and endogenous photosensitizer capable to generate reactive oxygen species (ROS) under UV-blue irradiation and kill cancer cells, which are characterized by the enhanced uptake of Rf. We confirmed its phototoxicity on human breast adenocarcinoma cells SK-BR-3 preincubated with 30-μM Rf and irradiated with ultraviolet light, and proved that such Rf concentrations (60 μM) are attainable in vivo in tumour site by systemic intravascular injection. In order to extend the Rf photosensitization depth in cancer tissue to 6 mm in depth, we purpose-designed core/shell upconversion nanoparticles (UCNPs, NaYF4:Yb(3+):Tm(3+)/NaYF4) capable to convert 2% of the deeply-penetrating excitation at 975 nm to ultraviolet-blue power. This power was expended to photosensitise Rf and kill SK-BR-3 cells preincubated with UCNPs and Rf, where the UCNP-Rf energy transfer was photon-mediated with ~14% Förster process contribution. SK-BR-3 xenograft regression in mice was observed for 50 days, following the Rf-UCNPs peritumoural injection and near-infrared light photodynamic treatment of the lesions.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">27731350</PMID><DateCreated><Year>2016</Year><Month>10</Month><Day>12</Day></DateCreated><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2045-2322</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><PubDate><Year>2016</Year><Month>Oct</Month><Day>12</Day></PubDate></JournalIssue><Title>Scientific reports</Title><ISOAbbreviation>Sci Rep</ISOAbbreviation></Journal><ArticleTitle>Riboflavin photoactivation by upconversion nanoparticles for cancer treatment.</ArticleTitle><Pagination><MedlinePgn>35103</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/srep35103</ELocationID><Abstract><AbstractText>Riboflavin (Rf) is a vitamin and endogenous photosensitizer capable to generate reactive oxygen species (ROS) under UV-blue irradiation and kill cancer cells, which are characterized by the enhanced uptake of Rf. We confirmed its phototoxicity on human breast adenocarcinoma cells SK-BR-3 preincubated with 30-μM Rf and irradiated with ultraviolet light, and proved that such Rf concentrations (60 μM) are attainable in vivo in tumour site by systemic intravascular injection. In order to extend the Rf photosensitization depth in cancer tissue to 6 mm in depth, we purpose-designed core/shell upconversion nanoparticles (UCNPs, NaYF4:Yb(3+):Tm(3+)/NaYF4) capable to convert 2% of the deeply-penetrating excitation at 975 nm to ultraviolet-blue power. This power was expended to photosensitise Rf and kill SK-BR-3 cells preincubated with UCNPs and Rf, where the UCNP-Rf energy transfer was photon-mediated with ~14% Förster process contribution. SK-BR-3 xenograft regression in mice was observed for 50 days, following the Rf-UCNPs peritumoural injection and near-infrared light photodynamic treatment of the lesions.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Khaydukov</LastName><ForeName>E V</ForeName><Initials>EV</Initials><AffiliationInfo><Affiliation>Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Leninsky pr. 59, Moscow, 119333, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mironova</LastName><ForeName>K E</ForeName><Initials>KE</Initials><AffiliationInfo><Affiliation>Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Leninsky pr. 59, Moscow, 119333, Russia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya, Moscow 117997, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Semchishen</LastName><ForeName>V A</ForeName><Initials>VA</Initials><AffiliationInfo><Affiliation>Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Leninsky pr. 59, Moscow, 119333, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Generalova</LastName><ForeName>A N</ForeName><Initials>AN</Initials><AffiliationInfo><Affiliation>Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Leninsky pr. 59, Moscow, 119333, Russia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya, Moscow 117997, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nechaev</LastName><ForeName>A V</ForeName><Initials>AV</Initials><AffiliationInfo><Affiliation>Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Leninsky pr. 59, Moscow, 119333, Russia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Fine Chemical Technologies, Moscow Technological University, 86 Prospect Vernadskogo, 119571 Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khochenkov</LastName><ForeName>D A</ForeName><Initials>DA</Initials><AffiliationInfo><Affiliation>Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Leninsky pr. 59, Moscow, 119333, Russia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>FSBSI "N.N. Blokhin Russian Cancer Research Center" of Ministry of Health of the Russian Federation, 24 Kashirskoye shosse, Moscow, 115478, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stepanova</LastName><ForeName>E V</ForeName><Initials>EV</Initials><AffiliationInfo><Affiliation>FSBSI "N.N. Blokhin Russian Cancer Research Center" of Ministry of Health of the Russian Federation, 24 Kashirskoye shosse, Moscow, 115478, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lebedev</LastName><ForeName>O I</ForeName><Initials>OI</Initials><AffiliationInfo><Affiliation>Laboratoire CRISMAT, UMR6508, CNRS-ENSIACEN, Universite Caen, 14050 Caen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zvyagin</LastName><ForeName>A V</ForeName><Initials>AV</Initials><AffiliationInfo><Affiliation>Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Leninsky pr. 59, Moscow, 119333, Russia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>ARC Centre of Excellence for Nanoscale BioPhotonics, Macquarie University, North Ryde, NSW 2109, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deyev</LastName><ForeName>S M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya, Moscow 117997, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Panchenko</LastName><ForeName>V Ya</ForeName><Initials>VY</Initials><AffiliationInfo><Affiliation>Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Leninsky pr. 59, Moscow, 119333, Russia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>10</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Sci 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