Worldwide Esophageal Cancer Collaboration: pathologic staging data.
Identifieur interne : 001801 ( PubMed/Corpus ); précédent : 001800; suivant : 001802Worldwide Esophageal Cancer Collaboration: pathologic staging data.
Auteurs : T W Rice ; L-Q Chen ; W L Hofstetter ; B M Smithers ; V W Rusch ; B P L. Wijnhoven ; K L Chen ; A R Davies ; X B D'Journo ; K A Kesler ; J D Luketich ; M K Ferguson ; J V R S Nen ; R. Van Hillegersberg ; W. Fang ; L. Durand ; I. Cecconello ; W H Allum ; R J Cerfolio ; M. Pera ; S M Griffin ; R. Burger ; J-F Liu ; M S Allen ; S. Law ; T J Watson ; G E Darling ; W J Scott ; A. Duranceau ; C E Denlinger ; P H Schipper ; T E M R. Lerut ; M B Orringer ; H. Ishwaran ; C. Apperson-Hansen ; L M Dipaola ; M E Semple ; E H BlackstoneSource :
- Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus [ 1442-2050 ] ; 2016.
English descriptors
- KwdEn :
- Ablation Techniques (mortality), Adult, Aged, Carcinoma (mortality), Carcinoma (pathology), Carcinoma (surgery), Esophageal Neoplasms (mortality), Esophageal Neoplasms (pathology), Esophageal Neoplasms (surgery), Esophagectomy (mortality), Esophagogastric Junction (pathology), Esophagogastric Junction (surgery), Female, Humans, Intersectoral Collaboration, Male, Middle Aged, Neoplasm Staging (mortality), Prognosis, Risk Assessment (methods).
- MESH :
- methods : Risk Assessment.
- mortality : Ablation Techniques, Carcinoma, Esophageal Neoplasms, Esophagectomy, Neoplasm Staging.
- pathology : Carcinoma, Esophageal Neoplasms, Esophagogastric Junction.
- surgery : Carcinoma, Esophageal Neoplasms, Esophagogastric Junction.
- Adult, Aged, Female, Humans, Intersectoral Collaboration, Male, Middle Aged, Prognosis.
Abstract
We report data-simple descriptions of patient characteristics, cancer categories, and non-risk-adjusted survival-for patients with pathologically staged cancer of the esophagus and esophagogastric junction after resection or ablation with no preoperative therapy from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty-three institutions from six continents submitted de-identified data using standard definitions: demographics, comorbidities, clinical cancer categories, and all-cause mortality from first management decision. Of 13,300 patients, 5,631 had squamous cell carcinoma, 7,558 adenocarcinoma, 85 adenosquamous carcinoma, and 26 undifferentiated carcinoma. Patients were older (62 years) men (80%) with normal body mass index (51%), little weight loss (1.8 kg), 0-2 ECOG performance status (83%), and a history of smoking (70%). Cancers were pT1 (24%), pT2 (15%), pT3 (50%), pN0 (52%), pM0 (93%), and pG2-G3 (78%); most involved distal esophagus (71%). Non-risk-adjusted survival for both squamous cell carcinoma and adenocarcinoma was monotonic and distinctive across pTNM. Survival was more distinctive for adenocarcinoma than squamous cell carcinoma when pT was ordered by pN. Survival for pTis-1 adenocarcinoma was better than for squamous cell carcinoma, although monotonic and distinctive for both. WECC pathologic staging data is improved over that of the 7th edition, with more patients studied and patient and cancer variables collected. These data will be the basis for the 8th edition cancer staging manuals following risk adjustment for patient, cancer, and treatment characteristics, and should direct 9th edition data collection. However, the role of pure pathologic staging as the principal point of reference for esophageal cancer staging is waning.
DOI: 10.1111/dote.12520
PubMed: 27731547
Links to Exploration step
pubmed:27731547Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Worldwide Esophageal Cancer Collaboration: pathologic staging data.</title><author><name sortKey="Rice, T W" sort="Rice, T W" uniqKey="Rice T" first="T W" last="Rice">T W Rice</name><affiliation><nlm:affiliation>Cleveland Clinic, Cleveland, Ohio, USA. ricet@ccf.org.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, L Q" sort="Chen, L Q" uniqKey="Chen L" first="L-Q" last="Chen">L-Q Chen</name><affiliation><nlm:affiliation>West China Hospital of Sichuan University, Chengdu, Sichuan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hofstetter, W L" sort="Hofstetter, W L" uniqKey="Hofstetter W" first="W L" last="Hofstetter">W L Hofstetter</name><affiliation><nlm:affiliation>University of Texas MD Anderson Hospital, Houston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Smithers, B M" sort="Smithers, B M" uniqKey="Smithers B" first="B M" last="Smithers">B M Smithers</name><affiliation><nlm:affiliation>University of Queensland, Princess Alexandra Hospital, Brisbane, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Rusch, V W" sort="Rusch, V W" uniqKey="Rusch V" first="V W" last="Rusch">V W Rusch</name><affiliation><nlm:affiliation>Memorial Sloan-Kettering Cancer Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wijnhoven, B P L" sort="Wijnhoven, B P L" uniqKey="Wijnhoven B" first="B P L" last="Wijnhoven">B P L. Wijnhoven</name><affiliation><nlm:affiliation>Erasmus Medical Center, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, K L" sort="Chen, K L" uniqKey="Chen K" first="K L" last="Chen">K L Chen</name><affiliation><nlm:affiliation>Beijing Cancer Hospital, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Davies, A R" sort="Davies, A R" uniqKey="Davies A" first="A R" last="Davies">A R Davies</name><affiliation><nlm:affiliation>Guy's & St Thomas' Hospitals, London, England.</nlm:affiliation></affiliation></author><author><name sortKey="D Journo, X B" sort="D Journo, X B" uniqKey="D Journo X" first="X B" last="D'Journo">X B D'Journo</name><affiliation><nlm:affiliation>Hôpital Nord, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kesler, K A" sort="Kesler, K A" uniqKey="Kesler K" first="K A" last="Kesler">K A Kesler</name><affiliation><nlm:affiliation>Indiana University Medical Center, Indianapolis, Indiana, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Luketich, J D" sort="Luketich, J D" uniqKey="Luketich J" first="J D" last="Luketich">J D Luketich</name><affiliation><nlm:affiliation>University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ferguson, M K" sort="Ferguson, M K" uniqKey="Ferguson M" first="M K" last="Ferguson">M K Ferguson</name><affiliation><nlm:affiliation>Department of Surgery, The University of Chicago, Chicago, Illinois, USA.</nlm:affiliation></affiliation></author><author><name sortKey="R S Nen, J V" sort="R S Nen, J V" uniqKey="R S Nen J" first="J V" last="R S Nen">J V R S Nen</name><affiliation><nlm:affiliation>Helsinki University Hospital, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Van Hillegersberg, R" sort="Van Hillegersberg, R" uniqKey="Van Hillegersberg R" first="R" last="Van Hillegersberg">R. Van Hillegersberg</name><affiliation><nlm:affiliation>University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Fang, W" sort="Fang, W" uniqKey="Fang W" first="W" last="Fang">W. Fang</name><affiliation><nlm:affiliation>Shanghai Chest Hospital, Shanghai, China.</nlm:affiliation></affiliation></author><author><name sortKey="Durand, L" sort="Durand, L" uniqKey="Durand L" first="L" last="Durand">L. Durand</name><affiliation><nlm:affiliation>Hospital de Clinicas, University of Buenos Aires, Buenos Aires, Argentina.</nlm:affiliation></affiliation></author><author><name sortKey="Cecconello, I" sort="Cecconello, I" uniqKey="Cecconello I" first="I" last="Cecconello">I. Cecconello</name><affiliation><nlm:affiliation>University of São Paulo School of Medicine, São Paulo, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Allum, W H" sort="Allum, W H" uniqKey="Allum W" first="W H" last="Allum">W H Allum</name><affiliation><nlm:affiliation>Royal Marsden NHS Foundation Trust, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Cerfolio, R J" sort="Cerfolio, R J" uniqKey="Cerfolio R" first="R J" last="Cerfolio">R J Cerfolio</name><affiliation><nlm:affiliation>Section of Thoracic Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pera, M" sort="Pera, M" uniqKey="Pera M" first="M" last="Pera">M. Pera</name><affiliation><nlm:affiliation>Hospital Universitario del Mar, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Griffin, S M" sort="Griffin, S M" uniqKey="Griffin S" first="S M" last="Griffin">S M Griffin</name><affiliation><nlm:affiliation>University of Newcastle upon Tyne, Newcastle, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Burger, R" sort="Burger, R" uniqKey="Burger R" first="R" last="Burger">R. Burger</name><affiliation><nlm:affiliation>University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, J F" sort="Liu, J F" uniqKey="Liu J" first="J-F" last="Liu">J-F Liu</name><affiliation><nlm:affiliation>Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Allen, M S" sort="Allen, M S" uniqKey="Allen M" first="M S" last="Allen">M S Allen</name><affiliation><nlm:affiliation>Mayo Clinic, Rochester, Minnesota, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Law, S" sort="Law, S" uniqKey="Law S" first="S" last="Law">S. Law</name><affiliation><nlm:affiliation>University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Watson, T J" sort="Watson, T J" uniqKey="Watson T" first="T J" last="Watson">T J Watson</name><affiliation><nlm:affiliation>University of Rochester, Rochester, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Darling, G E" sort="Darling, G E" uniqKey="Darling G" first="G E" last="Darling">G E Darling</name><affiliation><nlm:affiliation>Toronto General Hospital, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Scott, W J" sort="Scott, W J" uniqKey="Scott W" first="W J" last="Scott">W J Scott</name><affiliation><nlm:affiliation>Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Duranceau, A" sort="Duranceau, A" uniqKey="Duranceau A" first="A" last="Duranceau">A. Duranceau</name><affiliation><nlm:affiliation>University of Montreal, Montreal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Denlinger, C E" sort="Denlinger, C E" uniqKey="Denlinger C" first="C E" last="Denlinger">C E Denlinger</name><affiliation><nlm:affiliation>Medical University of South Carolina, Charleston, South Carolina, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Schipper, P H" sort="Schipper, P H" uniqKey="Schipper P" first="P H" last="Schipper">P H Schipper</name><affiliation><nlm:affiliation>Oregon Health & Science University, Portland, Oregon, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lerut, T E M R" sort="Lerut, T E M R" uniqKey="Lerut T" first="T E M R" last="Lerut">T E M R. Lerut</name><affiliation><nlm:affiliation>University Ziekenhuizen Leuven, Leuven, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Orringer, M B" sort="Orringer, M B" uniqKey="Orringer M" first="M B" last="Orringer">M B Orringer</name><affiliation><nlm:affiliation>University of Michigan, Ann Arbor, Michigan, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ishwaran, H" sort="Ishwaran, H" uniqKey="Ishwaran H" first="H" last="Ishwaran">H. Ishwaran</name><affiliation><nlm:affiliation>University of Miami, Miami, Florida, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Apperson Hansen, C" sort="Apperson Hansen, C" uniqKey="Apperson Hansen C" first="C" last="Apperson-Hansen">C. Apperson-Hansen</name><affiliation><nlm:affiliation>Case Western Reserve University, Cleveland, Ohio, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Dipaola, L M" sort="Dipaola, L M" uniqKey="Dipaola L" first="L M" last="Dipaola">L M Dipaola</name><affiliation><nlm:affiliation>Cleveland Clinic, Cleveland, Ohio, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Semple, M E" sort="Semple, M E" uniqKey="Semple M" first="M E" last="Semple">M E Semple</name><affiliation><nlm:affiliation>Cleveland Clinic, Cleveland, Ohio, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Blackstone, E H" sort="Blackstone, E H" uniqKey="Blackstone E" first="E H" last="Blackstone">E H Blackstone</name><affiliation><nlm:affiliation>Cleveland Clinic, Cleveland, Ohio, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27731547</idno><idno type="pmid">27731547</idno><idno type="doi">10.1111/dote.12520</idno><idno type="wicri:Area/PubMed/Corpus">001801</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001801</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Worldwide Esophageal Cancer Collaboration: pathologic staging data.</title><author><name sortKey="Rice, T W" sort="Rice, T W" uniqKey="Rice T" first="T W" last="Rice">T W Rice</name><affiliation><nlm:affiliation>Cleveland Clinic, Cleveland, Ohio, USA. ricet@ccf.org.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, L Q" sort="Chen, L Q" uniqKey="Chen L" first="L-Q" last="Chen">L-Q Chen</name><affiliation><nlm:affiliation>West China Hospital of Sichuan University, Chengdu, Sichuan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hofstetter, W L" sort="Hofstetter, W L" uniqKey="Hofstetter W" first="W L" last="Hofstetter">W L Hofstetter</name><affiliation><nlm:affiliation>University of Texas MD Anderson Hospital, Houston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Smithers, B M" sort="Smithers, B M" uniqKey="Smithers B" first="B M" last="Smithers">B M Smithers</name><affiliation><nlm:affiliation>University of Queensland, Princess Alexandra Hospital, Brisbane, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Rusch, V W" sort="Rusch, V W" uniqKey="Rusch V" first="V W" last="Rusch">V W Rusch</name><affiliation><nlm:affiliation>Memorial Sloan-Kettering Cancer Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wijnhoven, B P L" sort="Wijnhoven, B P L" uniqKey="Wijnhoven B" first="B P L" last="Wijnhoven">B P L. Wijnhoven</name><affiliation><nlm:affiliation>Erasmus Medical Center, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, K L" sort="Chen, K L" uniqKey="Chen K" first="K L" last="Chen">K L Chen</name><affiliation><nlm:affiliation>Beijing Cancer Hospital, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Davies, A R" sort="Davies, A R" uniqKey="Davies A" first="A R" last="Davies">A R Davies</name><affiliation><nlm:affiliation>Guy's & St Thomas' Hospitals, London, England.</nlm:affiliation></affiliation></author><author><name sortKey="D Journo, X B" sort="D Journo, X B" uniqKey="D Journo X" first="X B" last="D'Journo">X B D'Journo</name><affiliation><nlm:affiliation>Hôpital Nord, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kesler, K A" sort="Kesler, K A" uniqKey="Kesler K" first="K A" last="Kesler">K A Kesler</name><affiliation><nlm:affiliation>Indiana University Medical Center, Indianapolis, Indiana, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Luketich, J D" sort="Luketich, J D" uniqKey="Luketich J" first="J D" last="Luketich">J D Luketich</name><affiliation><nlm:affiliation>University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ferguson, M K" sort="Ferguson, M K" uniqKey="Ferguson M" first="M K" last="Ferguson">M K Ferguson</name><affiliation><nlm:affiliation>Department of Surgery, The University of Chicago, Chicago, Illinois, USA.</nlm:affiliation></affiliation></author><author><name sortKey="R S Nen, J V" sort="R S Nen, J V" uniqKey="R S Nen J" first="J V" last="R S Nen">J V R S Nen</name><affiliation><nlm:affiliation>Helsinki University Hospital, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Van Hillegersberg, R" sort="Van Hillegersberg, R" uniqKey="Van Hillegersberg R" first="R" last="Van Hillegersberg">R. Van Hillegersberg</name><affiliation><nlm:affiliation>University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Fang, W" sort="Fang, W" uniqKey="Fang W" first="W" last="Fang">W. Fang</name><affiliation><nlm:affiliation>Shanghai Chest Hospital, Shanghai, China.</nlm:affiliation></affiliation></author><author><name sortKey="Durand, L" sort="Durand, L" uniqKey="Durand L" first="L" last="Durand">L. Durand</name><affiliation><nlm:affiliation>Hospital de Clinicas, University of Buenos Aires, Buenos Aires, Argentina.</nlm:affiliation></affiliation></author><author><name sortKey="Cecconello, I" sort="Cecconello, I" uniqKey="Cecconello I" first="I" last="Cecconello">I. Cecconello</name><affiliation><nlm:affiliation>University of São Paulo School of Medicine, São Paulo, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Allum, W H" sort="Allum, W H" uniqKey="Allum W" first="W H" last="Allum">W H Allum</name><affiliation><nlm:affiliation>Royal Marsden NHS Foundation Trust, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Cerfolio, R J" sort="Cerfolio, R J" uniqKey="Cerfolio R" first="R J" last="Cerfolio">R J Cerfolio</name><affiliation><nlm:affiliation>Section of Thoracic Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pera, M" sort="Pera, M" uniqKey="Pera M" first="M" last="Pera">M. Pera</name><affiliation><nlm:affiliation>Hospital Universitario del Mar, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Griffin, S M" sort="Griffin, S M" uniqKey="Griffin S" first="S M" last="Griffin">S M Griffin</name><affiliation><nlm:affiliation>University of Newcastle upon Tyne, Newcastle, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Burger, R" sort="Burger, R" uniqKey="Burger R" first="R" last="Burger">R. Burger</name><affiliation><nlm:affiliation>University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, J F" sort="Liu, J F" uniqKey="Liu J" first="J-F" last="Liu">J-F Liu</name><affiliation><nlm:affiliation>Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Allen, M S" sort="Allen, M S" uniqKey="Allen M" first="M S" last="Allen">M S Allen</name><affiliation><nlm:affiliation>Mayo Clinic, Rochester, Minnesota, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Law, S" sort="Law, S" uniqKey="Law S" first="S" last="Law">S. Law</name><affiliation><nlm:affiliation>University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Watson, T J" sort="Watson, T J" uniqKey="Watson T" first="T J" last="Watson">T J Watson</name><affiliation><nlm:affiliation>University of Rochester, Rochester, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Darling, G E" sort="Darling, G E" uniqKey="Darling G" first="G E" last="Darling">G E Darling</name><affiliation><nlm:affiliation>Toronto General Hospital, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Scott, W J" sort="Scott, W J" uniqKey="Scott W" first="W J" last="Scott">W J Scott</name><affiliation><nlm:affiliation>Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Duranceau, A" sort="Duranceau, A" uniqKey="Duranceau A" first="A" last="Duranceau">A. Duranceau</name><affiliation><nlm:affiliation>University of Montreal, Montreal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Denlinger, C E" sort="Denlinger, C E" uniqKey="Denlinger C" first="C E" last="Denlinger">C E Denlinger</name><affiliation><nlm:affiliation>Medical University of South Carolina, Charleston, South Carolina, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Schipper, P H" sort="Schipper, P H" uniqKey="Schipper P" first="P H" last="Schipper">P H Schipper</name><affiliation><nlm:affiliation>Oregon Health & Science University, Portland, Oregon, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lerut, T E M R" sort="Lerut, T E M R" uniqKey="Lerut T" first="T E M R" last="Lerut">T E M R. Lerut</name><affiliation><nlm:affiliation>University Ziekenhuizen Leuven, Leuven, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Orringer, M B" sort="Orringer, M B" uniqKey="Orringer M" first="M B" last="Orringer">M B Orringer</name><affiliation><nlm:affiliation>University of Michigan, Ann Arbor, Michigan, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ishwaran, H" sort="Ishwaran, H" uniqKey="Ishwaran H" first="H" last="Ishwaran">H. Ishwaran</name><affiliation><nlm:affiliation>University of Miami, Miami, Florida, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Apperson Hansen, C" sort="Apperson Hansen, C" uniqKey="Apperson Hansen C" first="C" last="Apperson-Hansen">C. Apperson-Hansen</name><affiliation><nlm:affiliation>Case Western Reserve University, Cleveland, Ohio, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Dipaola, L M" sort="Dipaola, L M" uniqKey="Dipaola L" first="L M" last="Dipaola">L M Dipaola</name><affiliation><nlm:affiliation>Cleveland Clinic, Cleveland, Ohio, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Semple, M E" sort="Semple, M E" uniqKey="Semple M" first="M E" last="Semple">M E Semple</name><affiliation><nlm:affiliation>Cleveland Clinic, Cleveland, Ohio, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Blackstone, E H" sort="Blackstone, E H" uniqKey="Blackstone E" first="E H" last="Blackstone">E H Blackstone</name><affiliation><nlm:affiliation>Cleveland Clinic, Cleveland, Ohio, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus</title><idno type="eISSN">1442-2050</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Ablation Techniques (mortality)</term><term>Adult</term><term>Aged</term><term>Carcinoma (mortality)</term><term>Carcinoma (pathology)</term><term>Carcinoma (surgery)</term><term>Esophageal Neoplasms (mortality)</term><term>Esophageal Neoplasms (pathology)</term><term>Esophageal Neoplasms (surgery)</term><term>Esophagectomy (mortality)</term><term>Esophagogastric Junction (pathology)</term><term>Esophagogastric Junction (surgery)</term><term>Female</term><term>Humans</term><term>Intersectoral Collaboration</term><term>Male</term><term>Middle Aged</term><term>Neoplasm Staging (mortality)</term><term>Prognosis</term><term>Risk Assessment (methods)</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Risk Assessment</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Ablation Techniques</term><term>Carcinoma</term><term>Esophageal Neoplasms</term><term>Esophagectomy</term><term>Neoplasm Staging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma</term><term>Esophageal Neoplasms</term><term>Esophagogastric Junction</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Carcinoma</term><term>Esophageal Neoplasms</term><term>Esophagogastric Junction</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Intersectoral Collaboration</term><term>Male</term><term>Middle Aged</term><term>Prognosis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We report data-simple descriptions of patient characteristics, cancer categories, and non-risk-adjusted survival-for patients with pathologically staged cancer of the esophagus and esophagogastric junction after resection or ablation with no preoperative therapy from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty-three institutions from six continents submitted de-identified data using standard definitions: demographics, comorbidities, clinical cancer categories, and all-cause mortality from first management decision. Of 13,300 patients, 5,631 had squamous cell carcinoma, 7,558 adenocarcinoma, 85 adenosquamous carcinoma, and 26 undifferentiated carcinoma. Patients were older (62 years) men (80%) with normal body mass index (51%), little weight loss (1.8 kg), 0-2 ECOG performance status (83%), and a history of smoking (70%). Cancers were pT1 (24%), pT2 (15%), pT3 (50%), pN0 (52%), pM0 (93%), and pG2-G3 (78%); most involved distal esophagus (71%). Non-risk-adjusted survival for both squamous cell carcinoma and adenocarcinoma was monotonic and distinctive across pTNM. Survival was more distinctive for adenocarcinoma than squamous cell carcinoma when pT was ordered by pN. Survival for pTis-1 adenocarcinoma was better than for squamous cell carcinoma, although monotonic and distinctive for both. WECC pathologic staging data is improved over that of the 7th edition, with more patients studied and patient and cancer variables collected. These data will be the basis for the 8th edition cancer staging manuals following risk adjustment for patient, cancer, and treatment characteristics, and should direct 9th edition data collection. However, the role of pure pathologic staging as the principal point of reference for esophageal cancer staging is waning.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27731547</PMID><DateCreated><Year>2016</Year><Month>10</Month><Day>12</Day></DateCreated><DateCompleted><Year>2017</Year><Month>02</Month><Day>01</Day></DateCompleted><DateRevised><Year>2017</Year><Month>08</Month><Day>29</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1442-2050</ISSN><JournalIssue CitedMedium="Internet"><Volume>29</Volume><Issue>7</Issue><PubDate><Year>2016</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus</Title><ISOAbbreviation>Dis. Esophagus</ISOAbbreviation></Journal><ArticleTitle>Worldwide Esophageal Cancer Collaboration: pathologic staging data.</ArticleTitle><Pagination><MedlinePgn>724-733</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/dote.12520</ELocationID><Abstract><AbstractText>We report data-simple descriptions of patient characteristics, cancer categories, and non-risk-adjusted survival-for patients with pathologically staged cancer of the esophagus and esophagogastric junction after resection or ablation with no preoperative therapy from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty-three institutions from six continents submitted de-identified data using standard definitions: demographics, comorbidities, clinical cancer categories, and all-cause mortality from first management decision. Of 13,300 patients, 5,631 had squamous cell carcinoma, 7,558 adenocarcinoma, 85 adenosquamous carcinoma, and 26 undifferentiated carcinoma. Patients were older (62 years) men (80%) with normal body mass index (51%), little weight loss (1.8 kg), 0-2 ECOG performance status (83%), and a history of smoking (70%). Cancers were pT1 (24%), pT2 (15%), pT3 (50%), pN0 (52%), pM0 (93%), and pG2-G3 (78%); most involved distal esophagus (71%). Non-risk-adjusted survival for both squamous cell carcinoma and adenocarcinoma was monotonic and distinctive across pTNM. Survival was more distinctive for adenocarcinoma than squamous cell carcinoma when pT was ordered by pN. Survival for pTis-1 adenocarcinoma was better than for squamous cell carcinoma, although monotonic and distinctive for both. WECC pathologic staging data is improved over that of the 7th edition, with more patients studied and patient and cancer variables collected. These data will be the basis for the 8th edition cancer staging manuals following risk adjustment for patient, cancer, and treatment characteristics, and should direct 9th edition data collection. However, the role of pure pathologic staging as the principal point of reference for esophageal cancer staging is waning.</AbstractText><CopyrightInformation>© 2016 International Society for Diseases of the Esophagus.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rice</LastName><ForeName>T W</ForeName><Initials>TW</Initials><AffiliationInfo><Affiliation>Cleveland Clinic, Cleveland, Ohio, USA. ricet@ccf.org.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>L-Q</ForeName><Initials>LQ</Initials><AffiliationInfo><Affiliation>West China Hospital of Sichuan University, Chengdu, Sichuan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hofstetter</LastName><ForeName>W L</ForeName><Initials>WL</Initials><AffiliationInfo><Affiliation>University of Texas MD Anderson Hospital, Houston, Texas, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smithers</LastName><ForeName>B M</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>University of Queensland, Princess Alexandra Hospital, Brisbane, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rusch</LastName><ForeName>V W</ForeName><Initials>VW</Initials><AffiliationInfo><Affiliation>Memorial Sloan-Kettering Cancer Center, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wijnhoven</LastName><ForeName>B P L</ForeName><Initials>BP</Initials><AffiliationInfo><Affiliation>Erasmus Medical Center, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>K L</ForeName><Initials>KL</Initials><AffiliationInfo><Affiliation>Beijing Cancer Hospital, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Davies</LastName><ForeName>A R</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>Guy's & St Thomas' Hospitals, London, England.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>D'Journo</LastName><ForeName>X B</ForeName><Initials>XB</Initials><AffiliationInfo><Affiliation>Hôpital Nord, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kesler</LastName><ForeName>K A</ForeName><Initials>KA</Initials><AffiliationInfo><Affiliation>Indiana University Medical Center, Indianapolis, Indiana, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luketich</LastName><ForeName>J D</ForeName><Initials>JD</Initials><AffiliationInfo><Affiliation>University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferguson</LastName><ForeName>M K</ForeName><Initials>MK</Initials><AffiliationInfo><Affiliation>Department of Surgery, The University of Chicago, Chicago, Illinois, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Räsänen</LastName><ForeName>J V</ForeName><Initials>JV</Initials><AffiliationInfo><Affiliation>Helsinki University Hospital, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Hillegersberg</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>University Medical Center Utrecht, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fang</LastName><ForeName>W</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Shanghai Chest Hospital, Shanghai, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Durand</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Hospital de Clinicas, University of Buenos Aires, Buenos Aires, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cecconello</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>University of São Paulo School of Medicine, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allum</LastName><ForeName>W H</ForeName><Initials>WH</Initials><AffiliationInfo><Affiliation>Royal Marsden NHS Foundation Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cerfolio</LastName><ForeName>R J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Section of Thoracic Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pera</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Hospital Universitario del Mar, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Griffin</LastName><ForeName>S M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>University of Newcastle upon Tyne, Newcastle, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burger</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>J-F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allen</LastName><ForeName>M S</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Mayo Clinic, Rochester, Minnesota, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Law</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Watson</LastName><ForeName>T J</ForeName><Initials>TJ</Initials><AffiliationInfo><Affiliation>University of Rochester, Rochester, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Darling</LastName><ForeName>G E</ForeName><Initials>GE</Initials><AffiliationInfo><Affiliation>Toronto General Hospital, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scott</LastName><ForeName>W J</ForeName><Initials>WJ</Initials><AffiliationInfo><Affiliation>Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duranceau</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>University of Montreal, Montreal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Denlinger</LastName><ForeName>C E</ForeName><Initials>CE</Initials><AffiliationInfo><Affiliation>Medical University of South Carolina, Charleston, South Carolina, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schipper</LastName><ForeName>P H</ForeName><Initials>PH</Initials><AffiliationInfo><Affiliation>Oregon Health & Science University, Portland, Oregon, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lerut</LastName><ForeName>T E M R</ForeName><Initials>TE</Initials><AffiliationInfo><Affiliation>University Ziekenhuizen Leuven, Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Orringer</LastName><ForeName>M B</ForeName><Initials>MB</Initials><AffiliationInfo><Affiliation>University of Michigan, Ann Arbor, Michigan, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ishwaran</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>University of Miami, Miami, Florida, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Apperson-Hansen</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Case Western Reserve University, Cleveland, Ohio, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>DiPaola</LastName><ForeName>L M</ForeName><Initials>LM</Initials><AffiliationInfo><Affiliation>Cleveland Clinic, Cleveland, Ohio, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Semple</LastName><ForeName>M E</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>Cleveland Clinic, Cleveland, Ohio, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blackstone</LastName><ForeName>E H</ForeName><Initials>EH</Initials><AffiliationInfo><Affiliation>Cleveland Clinic, Cleveland, Ohio, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 CA163739</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Dis Esophagus</MedlineTA><NlmUniqueID>8809160</NlmUniqueID><ISSNLinking>1120-8694</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D055011" MajorTopicYN="N">Ablation Techniques</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002277" MajorTopicYN="N">Carcinoma</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004938" MajorTopicYN="N">Esophageal Neoplasms</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016629" MajorTopicYN="N">Esophagectomy</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004943" MajorTopicYN="N">Esophagogastric Junction</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000070516" MajorTopicYN="N">Intersectoral Collaboration</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009367" MajorTopicYN="N">Neoplasm Staging</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">cancer staging</Keyword><Keyword MajorTopicYN="N">decision-making</Keyword><Keyword MajorTopicYN="N">esophagectomy</Keyword><Keyword MajorTopicYN="N">prognostication</Keyword><Keyword MajorTopicYN="N">survival</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>04</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>05</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>06</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>10</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>10</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>2</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27731547</ArticleId><ArticleId IdType="doi">10.1111/dote.12520</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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