AustralieFrV1, PubMed, Corpus, bibRecord, 001723

Worldwide Esophageal Cancer Collaboration: neoadjuvant pathologic staging data.

Identifieur interne : 001723 ( PubMed/Corpus ); précédent : 001722; suivant : 001724

Worldwide Esophageal Cancer Collaboration: neoadjuvant pathologic staging data.

Auteurs : T W Rice ; T E M R. Lerut ; M B Orringer ; L-Q Chen ; W L Hofstetter ; B M Smithers ; V W Rusch ; J. Van Lanschot ; K N Chen ; A R Davies ; X B D'Journo ; K A Kesler ; J D Luketich ; M K Ferguson ; J V R S Nen ; R. Van Hillegersberg ; W. Fang ; L. Durand ; W H Allum ; I. Cecconello ; R J Cerfolio ; M. Pera ; S M Griffin ; R. Burger ; J-F Liu ; M S Allen ; S. Law ; T J Watson ; G E Darling ; W J Scott ; A. Duranceau ; C E Denlinger ; P H Schipper ; H. Ishwaran ; C. Apperson-Hansen ; L M Dipaola ; M E Semple ; E H Blackstone

Source :

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus [ 1442-2050 ] ; 2016.

RBID : pubmed:27731548

English descriptors

KwdEn :
- Adult, Aged, Carcinoma (mortality), Carcinoma (pathology), Carcinoma (therapy), Esophageal Neoplasms (mortality), Esophageal Neoplasms (pathology), Esophageal Neoplasms (therapy), Female, Humans, Intersectoral Collaboration, Male, Middle Aged, Neoadjuvant Therapy (mortality), Neoplasm Staging (mortality), Prognosis, Risk Assessment (methods).
MESH :
- methods : Risk Assessment.
- mortality : Carcinoma, Esophageal Neoplasms, Neoadjuvant Therapy, Neoplasm Staging.
- pathology : Carcinoma, Esophageal Neoplasms.
- therapy : Carcinoma, Esophageal Neoplasms.
- Adult, Aged, Female, Humans, Intersectoral Collaboration, Male, Middle Aged, Prognosis.

Abstract

To address uncertainty of whether pathologic stage groupings after neoadjuvant therapy (ypTNM) for esophageal cancer share prognostic implications with pathologic groupings after esophagectomy alone (pTNM), we report data-simple descriptions of patient characteristics, cancer categories, and non-risk-adjusted survival-for pathologically staged cancers after neoadjuvant therapy from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty-three institutions from six continents submitted data using variables with standard definitions: demographics, comorbidities, clinical cancer categories, and all-cause mortality from first management decision. Of 7,773 pathologically staged neoadjuvant patients, 2,045 had squamous cell carcinoma, 5,686 adenocarcinoma, 31 adenosquamous carcinoma, and 11 undifferentiated carcinoma. Patients were older (61 years) men (83%) with normal (40%) or overweight (35%) body mass index, 0-1 Eastern Cooperative Oncology Group performance status (96%), and a history of smoking (69%). Cancers were ypT0 (20%), ypT1 (13%), ypT2 (18%), ypT3 (44%), ypN0 (55%), ypM0 (94%), and G2-G3 (72%); most involved the distal esophagus (80%). Non-risk-adjusted survival for yp categories was unequally depressed, more for earlier categories than later, compared with equivalent categories from prior WECC data for esophagectomy-alone patients. Thus, survival of patients with ypT0-2N0M0 cancers was intermediate and similar regardless of ypT; survival for ypN+ cancers was poor. Because prognoses for ypTNM and pTNM categories are dissimilar, prognostication should be based on separate ypTNM categories and groupings. These data will be the basis for the 8th edition cancer staging manuals following risk adjustment for patient, cancer, and treatment characteristics and should direct 9th edition data collection.

DOI: 10.1111/dote.12513
PubMed: 27731548

Links to Exploration step

pubmed:27731548

Le document en format XML

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<author><name sortKey="Rice, T W" sort="Rice, T W" uniqKey="Rice T" first="T W" last="Rice">T W Rice</name>
<affiliation><nlm:affiliation>Cleveland Clinic, Cleveland, Ohio, USA. ricet@ccf.org.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Lerut, T E M R" sort="Lerut, T E M R" uniqKey="Lerut T" first="T E M R" last="Lerut">T E M R. Lerut</name>
<affiliation><nlm:affiliation>University Ziekenhuizen Leuven, Leuven, Belgium.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Orringer, M B" sort="Orringer, M B" uniqKey="Orringer M" first="M B" last="Orringer">M B Orringer</name>
<affiliation><nlm:affiliation>University of Michigan, Ann Arbor, Michigan, USA.</nlm:affiliation>
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<author><name sortKey="Chen, L Q" sort="Chen, L Q" uniqKey="Chen L" first="L-Q" last="Chen">L-Q Chen</name>
<affiliation><nlm:affiliation>West China Hospital of Sichuan University, Chengdu, Sichuan, China.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Hofstetter, W L" sort="Hofstetter, W L" uniqKey="Hofstetter W" first="W L" last="Hofstetter">W L Hofstetter</name>
<affiliation><nlm:affiliation>University of Texas MD Anderson Hospital, Houston, Texas, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Smithers, B M" sort="Smithers, B M" uniqKey="Smithers B" first="B M" last="Smithers">B M Smithers</name>
<affiliation><nlm:affiliation>University of Queensland, Princess Alexandra Hospital, Brisbane, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rusch, V W" sort="Rusch, V W" uniqKey="Rusch V" first="V W" last="Rusch">V W Rusch</name>
<affiliation><nlm:affiliation>Memorial Sloan-Kettering Cancer Center, New York, New York, USA.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Van Lanschot, J" sort="Van Lanschot, J" uniqKey="Van Lanschot J" first="J" last="Van Lanschot">J. Van Lanschot</name>
<affiliation><nlm:affiliation>Erasmus Medical Center, Rotterdam, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chen, K N" sort="Chen, K N" uniqKey="Chen K" first="K N" last="Chen">K N Chen</name>
<affiliation><nlm:affiliation>Beijing Cancer Hospital, Beijing, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Davies, A R" sort="Davies, A R" uniqKey="Davies A" first="A R" last="Davies">A R Davies</name>
<affiliation><nlm:affiliation>Guy's & St. Thomas' Hospitals, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="D Journo, X B" sort="D Journo, X B" uniqKey="D Journo X" first="X B" last="D'Journo">X B D'Journo</name>
<affiliation><nlm:affiliation>Hôpital Nord, Marseille, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kesler, K A" sort="Kesler, K A" uniqKey="Kesler K" first="K A" last="Kesler">K A Kesler</name>
<affiliation><nlm:affiliation>Indiana University Medical Center, Indianapolis, Indiana, USA.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Luketich, J D" sort="Luketich, J D" uniqKey="Luketich J" first="J D" last="Luketich">J D Luketich</name>
<affiliation><nlm:affiliation>University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ferguson, M K" sort="Ferguson, M K" uniqKey="Ferguson M" first="M K" last="Ferguson">M K Ferguson</name>
<affiliation><nlm:affiliation>Department of Surgery, The University of Chicago, Chicago, Illinois, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="R S Nen, J V" sort="R S Nen, J V" uniqKey="R S Nen J" first="J V" last="R S Nen">J V R S Nen</name>
<affiliation><nlm:affiliation>Helsinki University Hospital, Helsinki, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Van Hillegersberg, R" sort="Van Hillegersberg, R" uniqKey="Van Hillegersberg R" first="R" last="Van Hillegersberg">R. Van Hillegersberg</name>
<affiliation><nlm:affiliation>University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Fang, W" sort="Fang, W" uniqKey="Fang W" first="W" last="Fang">W. Fang</name>
<affiliation><nlm:affiliation>Shanghai Chest Hospital, Shanghai, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Durand, L" sort="Durand, L" uniqKey="Durand L" first="L" last="Durand">L. Durand</name>
<affiliation><nlm:affiliation>Hospital de Clinicas, University of Buenos Aires, Buenos Aires, Argentina.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Allum, W H" sort="Allum, W H" uniqKey="Allum W" first="W H" last="Allum">W H Allum</name>
<affiliation><nlm:affiliation>Royal Marsden NHS Foundation Trust, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cecconello, I" sort="Cecconello, I" uniqKey="Cecconello I" first="I" last="Cecconello">I. Cecconello</name>
<affiliation><nlm:affiliation>University of São Paulo, São Paulo, Brazil.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cerfolio, R J" sort="Cerfolio, R J" uniqKey="Cerfolio R" first="R J" last="Cerfolio">R J Cerfolio</name>
<affiliation><nlm:affiliation>University of Alabama at Birmingham, Birmingham, Alabama, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pera, M" sort="Pera, M" uniqKey="Pera M" first="M" last="Pera">M. Pera</name>
<affiliation><nlm:affiliation>Hospital Universitario del Mar, Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Griffin, S M" sort="Griffin, S M" uniqKey="Griffin S" first="S M" last="Griffin">S M Griffin</name>
<affiliation><nlm:affiliation>University of Newcastle upon Tyne, Newcastle, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Burger, R" sort="Burger, R" uniqKey="Burger R" first="R" last="Burger">R. Burger</name>
<affiliation><nlm:affiliation>Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Liu, J F" sort="Liu, J F" uniqKey="Liu J" first="J-F" last="Liu">J-F Liu</name>
<affiliation><nlm:affiliation>Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Allen, M S" sort="Allen, M S" uniqKey="Allen M" first="M S" last="Allen">M S Allen</name>
<affiliation><nlm:affiliation>Mayo Clinic, Rochester, Minnesota, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Law, S" sort="Law, S" uniqKey="Law S" first="S" last="Law">S. Law</name>
<affiliation><nlm:affiliation>University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Watson, T J" sort="Watson, T J" uniqKey="Watson T" first="T J" last="Watson">T J Watson</name>
<affiliation><nlm:affiliation>University of Rochester, Rochester, New York, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Darling, G E" sort="Darling, G E" uniqKey="Darling G" first="G E" last="Darling">G E Darling</name>
<affiliation><nlm:affiliation>Toronto General Hospital, Toronto, Ontario, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Scott, W J" sort="Scott, W J" uniqKey="Scott W" first="W J" last="Scott">W J Scott</name>
<affiliation><nlm:affiliation>Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Duranceau, A" sort="Duranceau, A" uniqKey="Duranceau A" first="A" last="Duranceau">A. Duranceau</name>
<affiliation><nlm:affiliation>University of Montreal, Montreal, Quebec, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Denlinger, C E" sort="Denlinger, C E" uniqKey="Denlinger C" first="C E" last="Denlinger">C E Denlinger</name>
<affiliation><nlm:affiliation>Medical University of South Carolina, Charleston, South Carolina, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Schipper, P H" sort="Schipper, P H" uniqKey="Schipper P" first="P H" last="Schipper">P H Schipper</name>
<affiliation><nlm:affiliation>Oregon Health & Science University, Portland, Oregon, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ishwaran, H" sort="Ishwaran, H" uniqKey="Ishwaran H" first="H" last="Ishwaran">H. Ishwaran</name>
<affiliation><nlm:affiliation>University of Miami, Miami, Florida, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Apperson Hansen, C" sort="Apperson Hansen, C" uniqKey="Apperson Hansen C" first="C" last="Apperson-Hansen">C. Apperson-Hansen</name>
<affiliation><nlm:affiliation>Case Western Reserve University, Cleveland, Ohio, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dipaola, L M" sort="Dipaola, L M" uniqKey="Dipaola L" first="L M" last="Dipaola">L M Dipaola</name>
<affiliation><nlm:affiliation>Cleveland Clinic, Cleveland, Ohio, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Semple, M E" sort="Semple, M E" uniqKey="Semple M" first="M E" last="Semple">M E Semple</name>
<affiliation><nlm:affiliation>Cleveland Clinic, Cleveland, Ohio, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Blackstone, E H" sort="Blackstone, E H" uniqKey="Blackstone E" first="E H" last="Blackstone">E H Blackstone</name>
<affiliation><nlm:affiliation>Cleveland Clinic, Cleveland, Ohio, USA.</nlm:affiliation>
</affiliation>
</author>
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<date when="2016">2016</date>
<idno type="RBID">pubmed:27731548</idno>
<idno type="pmid">27731548</idno>
<idno type="doi">10.1111/dote.12513</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Worldwide Esophageal Cancer Collaboration: neoadjuvant pathologic staging data.</title>
<author><name sortKey="Rice, T W" sort="Rice, T W" uniqKey="Rice T" first="T W" last="Rice">T W Rice</name>
<affiliation><nlm:affiliation>Cleveland Clinic, Cleveland, Ohio, USA. ricet@ccf.org.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lerut, T E M R" sort="Lerut, T E M R" uniqKey="Lerut T" first="T E M R" last="Lerut">T E M R. Lerut</name>
<affiliation><nlm:affiliation>University Ziekenhuizen Leuven, Leuven, Belgium.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Orringer, M B" sort="Orringer, M B" uniqKey="Orringer M" first="M B" last="Orringer">M B Orringer</name>
<affiliation><nlm:affiliation>University of Michigan, Ann Arbor, Michigan, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chen, L Q" sort="Chen, L Q" uniqKey="Chen L" first="L-Q" last="Chen">L-Q Chen</name>
<affiliation><nlm:affiliation>West China Hospital of Sichuan University, Chengdu, Sichuan, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hofstetter, W L" sort="Hofstetter, W L" uniqKey="Hofstetter W" first="W L" last="Hofstetter">W L Hofstetter</name>
<affiliation><nlm:affiliation>University of Texas MD Anderson Hospital, Houston, Texas, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Smithers, B M" sort="Smithers, B M" uniqKey="Smithers B" first="B M" last="Smithers">B M Smithers</name>
<affiliation><nlm:affiliation>University of Queensland, Princess Alexandra Hospital, Brisbane, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rusch, V W" sort="Rusch, V W" uniqKey="Rusch V" first="V W" last="Rusch">V W Rusch</name>
<affiliation><nlm:affiliation>Memorial Sloan-Kettering Cancer Center, New York, New York, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Van Lanschot, J" sort="Van Lanschot, J" uniqKey="Van Lanschot J" first="J" last="Van Lanschot">J. Van Lanschot</name>
<affiliation><nlm:affiliation>Erasmus Medical Center, Rotterdam, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chen, K N" sort="Chen, K N" uniqKey="Chen K" first="K N" last="Chen">K N Chen</name>
<affiliation><nlm:affiliation>Beijing Cancer Hospital, Beijing, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Davies, A R" sort="Davies, A R" uniqKey="Davies A" first="A R" last="Davies">A R Davies</name>
<affiliation><nlm:affiliation>Guy's & St. Thomas' Hospitals, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="D Journo, X B" sort="D Journo, X B" uniqKey="D Journo X" first="X B" last="D'Journo">X B D'Journo</name>
<affiliation><nlm:affiliation>Hôpital Nord, Marseille, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kesler, K A" sort="Kesler, K A" uniqKey="Kesler K" first="K A" last="Kesler">K A Kesler</name>
<affiliation><nlm:affiliation>Indiana University Medical Center, Indianapolis, Indiana, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Luketich, J D" sort="Luketich, J D" uniqKey="Luketich J" first="J D" last="Luketich">J D Luketich</name>
<affiliation><nlm:affiliation>University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ferguson, M K" sort="Ferguson, M K" uniqKey="Ferguson M" first="M K" last="Ferguson">M K Ferguson</name>
<affiliation><nlm:affiliation>Department of Surgery, The University of Chicago, Chicago, Illinois, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="R S Nen, J V" sort="R S Nen, J V" uniqKey="R S Nen J" first="J V" last="R S Nen">J V R S Nen</name>
<affiliation><nlm:affiliation>Helsinki University Hospital, Helsinki, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Van Hillegersberg, R" sort="Van Hillegersberg, R" uniqKey="Van Hillegersberg R" first="R" last="Van Hillegersberg">R. Van Hillegersberg</name>
<affiliation><nlm:affiliation>University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Fang, W" sort="Fang, W" uniqKey="Fang W" first="W" last="Fang">W. Fang</name>
<affiliation><nlm:affiliation>Shanghai Chest Hospital, Shanghai, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Durand, L" sort="Durand, L" uniqKey="Durand L" first="L" last="Durand">L. Durand</name>
<affiliation><nlm:affiliation>Hospital de Clinicas, University of Buenos Aires, Buenos Aires, Argentina.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Allum, W H" sort="Allum, W H" uniqKey="Allum W" first="W H" last="Allum">W H Allum</name>
<affiliation><nlm:affiliation>Royal Marsden NHS Foundation Trust, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cecconello, I" sort="Cecconello, I" uniqKey="Cecconello I" first="I" last="Cecconello">I. Cecconello</name>
<affiliation><nlm:affiliation>University of São Paulo, São Paulo, Brazil.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cerfolio, R J" sort="Cerfolio, R J" uniqKey="Cerfolio R" first="R J" last="Cerfolio">R J Cerfolio</name>
<affiliation><nlm:affiliation>University of Alabama at Birmingham, Birmingham, Alabama, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pera, M" sort="Pera, M" uniqKey="Pera M" first="M" last="Pera">M. Pera</name>
<affiliation><nlm:affiliation>Hospital Universitario del Mar, Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Griffin, S M" sort="Griffin, S M" uniqKey="Griffin S" first="S M" last="Griffin">S M Griffin</name>
<affiliation><nlm:affiliation>University of Newcastle upon Tyne, Newcastle, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Burger, R" sort="Burger, R" uniqKey="Burger R" first="R" last="Burger">R. Burger</name>
<affiliation><nlm:affiliation>Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Liu, J F" sort="Liu, J F" uniqKey="Liu J" first="J-F" last="Liu">J-F Liu</name>
<affiliation><nlm:affiliation>Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Allen, M S" sort="Allen, M S" uniqKey="Allen M" first="M S" last="Allen">M S Allen</name>
<affiliation><nlm:affiliation>Mayo Clinic, Rochester, Minnesota, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Law, S" sort="Law, S" uniqKey="Law S" first="S" last="Law">S. Law</name>
<affiliation><nlm:affiliation>University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Watson, T J" sort="Watson, T J" uniqKey="Watson T" first="T J" last="Watson">T J Watson</name>
<affiliation><nlm:affiliation>University of Rochester, Rochester, New York, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Darling, G E" sort="Darling, G E" uniqKey="Darling G" first="G E" last="Darling">G E Darling</name>
<affiliation><nlm:affiliation>Toronto General Hospital, Toronto, Ontario, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Scott, W J" sort="Scott, W J" uniqKey="Scott W" first="W J" last="Scott">W J Scott</name>
<affiliation><nlm:affiliation>Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Duranceau, A" sort="Duranceau, A" uniqKey="Duranceau A" first="A" last="Duranceau">A. Duranceau</name>
<affiliation><nlm:affiliation>University of Montreal, Montreal, Quebec, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Denlinger, C E" sort="Denlinger, C E" uniqKey="Denlinger C" first="C E" last="Denlinger">C E Denlinger</name>
<affiliation><nlm:affiliation>Medical University of South Carolina, Charleston, South Carolina, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Schipper, P H" sort="Schipper, P H" uniqKey="Schipper P" first="P H" last="Schipper">P H Schipper</name>
<affiliation><nlm:affiliation>Oregon Health & Science University, Portland, Oregon, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ishwaran, H" sort="Ishwaran, H" uniqKey="Ishwaran H" first="H" last="Ishwaran">H. Ishwaran</name>
<affiliation><nlm:affiliation>University of Miami, Miami, Florida, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Apperson Hansen, C" sort="Apperson Hansen, C" uniqKey="Apperson Hansen C" first="C" last="Apperson-Hansen">C. Apperson-Hansen</name>
<affiliation><nlm:affiliation>Case Western Reserve University, Cleveland, Ohio, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dipaola, L M" sort="Dipaola, L M" uniqKey="Dipaola L" first="L M" last="Dipaola">L M Dipaola</name>
<affiliation><nlm:affiliation>Cleveland Clinic, Cleveland, Ohio, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Semple, M E" sort="Semple, M E" uniqKey="Semple M" first="M E" last="Semple">M E Semple</name>
<affiliation><nlm:affiliation>Cleveland Clinic, Cleveland, Ohio, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Blackstone, E H" sort="Blackstone, E H" uniqKey="Blackstone E" first="E H" last="Blackstone">E H Blackstone</name>
<affiliation><nlm:affiliation>Cleveland Clinic, Cleveland, Ohio, USA.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus</title>
<idno type="eISSN">1442-2050</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
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<term>Carcinoma (mortality)</term>
<term>Carcinoma (pathology)</term>
<term>Carcinoma (therapy)</term>
<term>Esophageal Neoplasms (mortality)</term>
<term>Esophageal Neoplasms (pathology)</term>
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<front><div type="abstract" xml:lang="en">To address uncertainty of whether pathologic stage groupings after neoadjuvant therapy (ypTNM) for esophageal cancer share prognostic implications with pathologic groupings after esophagectomy alone (pTNM), we report data-simple descriptions of patient characteristics, cancer categories, and non-risk-adjusted survival-for pathologically staged cancers after neoadjuvant therapy from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty-three institutions from six continents submitted data using variables with standard definitions: demographics, comorbidities, clinical cancer categories, and all-cause mortality from first management decision. Of 7,773 pathologically staged neoadjuvant patients, 2,045 had squamous cell carcinoma, 5,686 adenocarcinoma, 31 adenosquamous carcinoma, and 11 undifferentiated carcinoma. Patients were older (61 years) men (83%) with normal (40%) or overweight (35%) body mass index, 0-1 Eastern Cooperative Oncology Group performance status (96%), and a history of smoking (69%). Cancers were ypT0 (20%), ypT1 (13%), ypT2 (18%), ypT3 (44%), ypN0 (55%), ypM0 (94%), and G2-G3 (72%); most involved the distal esophagus (80%). Non-risk-adjusted survival for yp categories was unequally depressed, more for earlier categories than later, compared with equivalent categories from prior WECC data for esophagectomy-alone patients. Thus, survival of patients with ypT0-2N0M0 cancers was intermediate and similar regardless of ypT; survival for ypN+ cancers was poor. Because prognoses for ypTNM and pTNM categories are dissimilar, prognostication should be based on separate ypTNM categories and groupings. These data will be the basis for the 8th edition cancer staging manuals following risk adjustment for patient, cancer, and treatment characteristics and should direct 9th edition data collection.</div>
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<DateCreated><Year>2016</Year>
<Month>10</Month>
<Day>12</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>02</Month>
<Day>01</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>10</Month>
<Day>01</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1442-2050</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>29</Volume>
<Issue>7</Issue>
<PubDate><Year>2016</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus</Title>
<ISOAbbreviation>Dis. Esophagus</ISOAbbreviation>
</Journal>
<ArticleTitle>Worldwide Esophageal Cancer Collaboration: neoadjuvant pathologic staging data.</ArticleTitle>
<Pagination><MedlinePgn>715-723</MedlinePgn>
</Pagination>
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<Abstract><AbstractText>To address uncertainty of whether pathologic stage groupings after neoadjuvant therapy (ypTNM) for esophageal cancer share prognostic implications with pathologic groupings after esophagectomy alone (pTNM), we report data-simple descriptions of patient characteristics, cancer categories, and non-risk-adjusted survival-for pathologically staged cancers after neoadjuvant therapy from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty-three institutions from six continents submitted data using variables with standard definitions: demographics, comorbidities, clinical cancer categories, and all-cause mortality from first management decision. Of 7,773 pathologically staged neoadjuvant patients, 2,045 had squamous cell carcinoma, 5,686 adenocarcinoma, 31 adenosquamous carcinoma, and 11 undifferentiated carcinoma. Patients were older (61 years) men (83%) with normal (40%) or overweight (35%) body mass index, 0-1 Eastern Cooperative Oncology Group performance status (96%), and a history of smoking (69%). Cancers were ypT0 (20%), ypT1 (13%), ypT2 (18%), ypT3 (44%), ypN0 (55%), ypM0 (94%), and G2-G3 (72%); most involved the distal esophagus (80%). Non-risk-adjusted survival for yp categories was unequally depressed, more for earlier categories than later, compared with equivalent categories from prior WECC data for esophagectomy-alone patients. Thus, survival of patients with ypT0-2N0M0 cancers was intermediate and similar regardless of ypT; survival for ypN+ cancers was poor. Because prognoses for ypTNM and pTNM categories are dissimilar, prognostication should be based on separate ypTNM categories and groupings. These data will be the basis for the 8th edition cancer staging manuals following risk adjustment for patient, cancer, and treatment characteristics and should direct 9th edition data collection.</AbstractText>
<CopyrightInformation>© 2016 International Society for Diseases of the Esophagus.</CopyrightInformation>
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<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Cancer. 2010 Aug 15;116(16):3763-73</RefSource>
<PMID Version="1">20564099</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Natl Cancer Inst. 2002 Feb 6;94(3):167-73</RefSource>
<PMID Version="1">11830606</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Dis Esophagus. 2009;22(1):1-8</RefSource>
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</CommentsCorrections>
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<PMID Version="1">27731549</PMID>
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<PMID Version="1">10483939</PMID>
</CommentsCorrections>
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Worldwide Esophageal Cancer Collaboration: neoadjuvant pathologic staging data.

Worldwide Esophageal Cancer Collaboration: neoadjuvant pathologic staging data.

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