Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients.
Identifieur interne : 001236 ( PubMed/Corpus ); précédent : 001235; suivant : 001237Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients.
Auteurs : Marie-Quitterie Picat ; Isabelle Pellegrin ; Juliette Bitard ; Linda Wittkop ; Cécile Proust-Lima ; Benoît Liquet ; Jean-François Moreau ; Fabrice Bonnet ; Patrick Blanco ; Rodolphe ThiébautSource :
- PloS one [ 1932-6203 ] ; 2017.
English descriptors
- KwdEn :
- Adult, Algorithms, Anti-Retroviral Agents (therapeutic use), Antigens, CD38 (metabolism), Autoimmunity (immunology), CD4-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (immunology), Chronic Disease, Cohort Studies, Cross-Sectional Studies, Cytomegalovirus, Female, France, HIV Infections (immunology), HIV Infections (therapy), HLA-DR Antigens (metabolism), Humans, Interferon-alpha (immunology), Lymphocyte Activation, Male, Middle Aged, Models, Statistical, Multivariate Analysis, RNA, Ribosomal, 16S (metabolism), Risk Factors, T-Lymphocytes (immunology).
- MESH :
- chemical , immunology : Interferon-alpha.
- chemical , metabolism : Antigens, CD38, HLA-DR Antigens, RNA, Ribosomal, 16S.
- chemical , therapeutic use : Anti-Retroviral Agents.
- immunology : Autoimmunity, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, HIV Infections, T-Lymphocytes.
- therapy : HIV Infections.
- Adult, Algorithms, Chronic Disease, Cohort Studies, Cross-Sectional Studies, Cytomegalovirus, Female, France, Humans, Lymphocyte Activation, Male, Middle Aged, Models, Statistical, Multivariate Analysis, Risk Factors.
Abstract
To unravel the complex relationships between cytomegalovirus-induced-, autoimmune-induced responses, microbial translocation and chronic immune activation (CIA) in successfully treated HIV-infected patients and to explore the mediating role of alpha-interferon in these processes.
DOI: 10.1371/journal.pone.0169164
PubMed: 28046052
Links to Exploration step
pubmed:28046052Le document en format XML
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<term>Antigens, CD38 (metabolism)</term>
<term>Autoimmunity (immunology)</term>
<term>CD4-Positive T-Lymphocytes (immunology)</term>
<term>CD8-Positive T-Lymphocytes (immunology)</term>
<term>Chronic Disease</term>
<term>Cohort Studies</term>
<term>Cross-Sectional Studies</term>
<term>Cytomegalovirus</term>
<term>Female</term>
<term>France</term>
<term>HIV Infections (immunology)</term>
<term>HIV Infections (therapy)</term>
<term>HLA-DR Antigens (metabolism)</term>
<term>Humans</term>
<term>Interferon-alpha (immunology)</term>
<term>Lymphocyte Activation</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Models, Statistical</term>
<term>Multivariate Analysis</term>
<term>RNA, Ribosomal, 16S (metabolism)</term>
<term>Risk Factors</term>
<term>T-Lymphocytes (immunology)</term>
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<term>HLA-DR Antigens</term>
<term>RNA, Ribosomal, 16S</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Retroviral Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Autoimmunity</term>
<term>CD4-Positive T-Lymphocytes</term>
<term>CD8-Positive T-Lymphocytes</term>
<term>HIV Infections</term>
<term>T-Lymphocytes</term>
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<term>Cross-Sectional Studies</term>
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<term>France</term>
<term>Humans</term>
<term>Lymphocyte Activation</term>
<term>Male</term>
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<front><div type="abstract" xml:lang="en">To unravel the complex relationships between cytomegalovirus-induced-, autoimmune-induced responses, microbial translocation and chronic immune activation (CIA) in successfully treated HIV-infected patients and to explore the mediating role of alpha-interferon in these processes.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28046052</PMID>
<DateCreated><Year>2017</Year>
<Month>01</Month>
<Day>03</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>09</Month>
<Day>06</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>11</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>12</Volume>
<Issue>1</Issue>
<PubDate><Year>2017</Year>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS ONE</ISOAbbreviation>
</Journal>
<ArticleTitle>Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients.</ArticleTitle>
<Pagination><MedlinePgn>e0169164</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0169164</ELocationID>
<Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To unravel the complex relationships between cytomegalovirus-induced-, autoimmune-induced responses, microbial translocation and chronic immune activation (CIA) in successfully treated HIV-infected patients and to explore the mediating role of alpha-interferon in these processes.</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">Cross-sectional study nested in the ANRS CO3 Aquitaine Cohort, a prospective hospital-based cohort of HIV-1-infected patients in South-Western France.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Patients initiated antiretroviral therapy between 2005 and 2008 and were treated with sustained virological suppression for at least two years. CIA was defined by the percentage of HLA-DR+/CD38+ among CD8+T-cells. Integrative analyses were performed using structural equation modelling (SEM).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The main analysis was performed in 57 HLA-A*0201 positive patients, due to availability of percentages of actin-, vimentin-, lamin-specific CD8+T-cells (HLA-A2-restricted tests) to further characterize autoimmune response. Cytomegalovirus-induced response was assessed by Quantiferon and pp-65 ELISPOT. SEM revealed a direct effect of cytomegalovirus-induced response on CIA (standardized estimate βstd = 0.56, p-value = 0.0004). The effect of autoimmune-induced response on CIA was indirect through alpha-interferon pathway, assessed by expression levels of 5 alpha-interferon-stimulated genes ADAR, ISG15, IFIT1, Mx1 and OAS1 (effect of autoimmune response on alpha-interferon: βstd = 0.36, p-value = 0.0401; effect of alpha-interferon on CIA: βstd = 0.39, p-value = 0.0044). There was no direct effect of autoimmune-induced response on CIA (p-value = 0.3169). Microbial translocation as measured by 16SrDNA and sCD14 in plasma was not associated with CIA. Results were consistent in 142 patients in whom cytomegalovirus and auto-immunity responses were measured by Quantiferon and anti-nuclear antibodies, respectively. All analyses performed in HLA-A*0201 positive patients and in the overall population revealed a significant effect of IFN-α latent variable on CIA.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The role of cytomegalovirus-induced response on CIA was confirmed as well as the involvement of alpha-interferon on CIA. The indirect effect of auto-immunity response on CIA revealed through the alpha-interferon pathway requires further investigation to confirm the potential role of auto-immunity for CIA in HIV-infected patients.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Picat</LastName>
<ForeName>Marie-Quitterie</ForeName>
<Initials>MQ</Initials>
<AffiliationInfo><Affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Univ. Bordeaux, ISPED, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service d'Information Médicale, USMR, CHU de Bordeaux - Pôle de Santé Publique, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>INRIA, Team SISTM, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Vaccine Research Institute-VRI, Hôpital Henri Mondor, Créteil, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pellegrin</LastName>
<ForeName>Isabelle</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bitard</LastName>
<ForeName>Juliette</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wittkop</LastName>
<ForeName>Linda</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Univ. Bordeaux, ISPED, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service d'Information Médicale, USMR, CHU de Bordeaux - Pôle de Santé Publique, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>INRIA, Team SISTM, Bordeaux, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Proust-Lima</LastName>
<ForeName>Cécile</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Univ. Bordeaux, ISPED, Bordeaux, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liquet</LastName>
<ForeName>Benoît</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Laboratoire de Mathématiques et de leurs Applications, Université de Pau et des Pays de l'Adour, UMR CNRS 5142, Pau, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>ARC Centre of Excellence for Mathematical and Statistical Frontiers, Queensland University of Technology (QUT), Brisbane, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moreau</LastName>
<ForeName>Jean-François</ForeName>
<Initials>JF</Initials>
<AffiliationInfo><Affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Univ. Bordeaux, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CNRS, UMR 5164, Bordeaux, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bonnet</LastName>
<ForeName>Fabrice</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Univ. Bordeaux, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service de Médecine Interne et maladies Infectieuses, CHU de Bordeaux, Bordeaux, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Blanco</LastName>
<ForeName>Patrick</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Univ. Bordeaux, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CNRS, UMR 5164, Bordeaux, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thiébaut</LastName>
<ForeName>Rodolphe</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Univ. Bordeaux, ISPED, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service d'Information Médicale, USMR, CHU de Bordeaux - Pôle de Santé Publique, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>INRIA, Team SISTM, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Vaccine Research Institute-VRI, Hôpital Henri Mondor, Créteil, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>ANRS CO3 Aquitaine Cohort</CollectiveName>
</Author>
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<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N">France</DescriptorName>
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<MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016898" MajorTopicYN="N">Interferon-alpha</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008213" MajorTopicYN="Y">Lymphocyte Activation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
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<CoiStatement>The authors have declared that no competing interests exist.</CoiStatement>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>08</Month>
<Day>18</Day>
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<Month>12</Month>
<Day>13</Day>
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