Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients.
Identifieur interne : 001236 ( PubMed/Corpus ); précédent : 001235; suivant : 001237Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients.
Auteurs : Marie-Quitterie Picat ; Isabelle Pellegrin ; Juliette Bitard ; Linda Wittkop ; Cécile Proust-Lima ; Benoît Liquet ; Jean-François Moreau ; Fabrice Bonnet ; Patrick Blanco ; Rodolphe ThiébautSource :
- PloS one [ 1932-6203 ] ; 2017.
English descriptors
- KwdEn :
- Adult, Algorithms, Anti-Retroviral Agents (therapeutic use), Antigens, CD38 (metabolism), Autoimmunity (immunology), CD4-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (immunology), Chronic Disease, Cohort Studies, Cross-Sectional Studies, Cytomegalovirus, Female, France, HIV Infections (immunology), HIV Infections (therapy), HLA-DR Antigens (metabolism), Humans, Interferon-alpha (immunology), Lymphocyte Activation, Male, Middle Aged, Models, Statistical, Multivariate Analysis, RNA, Ribosomal, 16S (metabolism), Risk Factors, T-Lymphocytes (immunology).
- MESH :
- chemical , immunology : Interferon-alpha.
- chemical , metabolism : Antigens, CD38, HLA-DR Antigens, RNA, Ribosomal, 16S.
- chemical , therapeutic use : Anti-Retroviral Agents.
- immunology : Autoimmunity, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, HIV Infections, T-Lymphocytes.
- therapy : HIV Infections.
- Adult, Algorithms, Chronic Disease, Cohort Studies, Cross-Sectional Studies, Cytomegalovirus, Female, France, Humans, Lymphocyte Activation, Male, Middle Aged, Models, Statistical, Multivariate Analysis, Risk Factors.
Abstract
To unravel the complex relationships between cytomegalovirus-induced-, autoimmune-induced responses, microbial translocation and chronic immune activation (CIA) in successfully treated HIV-infected patients and to explore the mediating role of alpha-interferon in these processes.
DOI: 10.1371/journal.pone.0169164
PubMed: 28046052
Links to Exploration step
pubmed:28046052Le document en format XML
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d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Wittkop, Linda" sort="Wittkop, Linda" uniqKey="Wittkop L" first="Linda" last="Wittkop">Linda Wittkop</name><affiliation><nlm:affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Proust Lima, Cecile" sort="Proust Lima, Cecile" uniqKey="Proust Lima C" first="Cécile" last="Proust-Lima">Cécile Proust-Lima</name><affiliation><nlm:affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Liquet, Benoit" sort="Liquet, Benoit" uniqKey="Liquet B" first="Benoît" last="Liquet">Benoît Liquet</name><affiliation><nlm:affiliation>Laboratoire de Mathématiques et de leurs Applications, Université de Pau et des Pays de l'Adour, UMR CNRS 5142, Pau, France.</nlm:affiliation></affiliation></author><author><name sortKey="Moreau, Jean Francois" sort="Moreau, Jean Francois" uniqKey="Moreau J" first="Jean-François" last="Moreau">Jean-François Moreau</name><affiliation><nlm:affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name><affiliation><nlm:affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Blanco, Patrick" sort="Blanco, Patrick" uniqKey="Blanco P" first="Patrick" last="Blanco">Patrick Blanco</name><affiliation><nlm:affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Thiebaut, Rodolphe" sort="Thiebaut, Rodolphe" uniqKey="Thiebaut R" first="Rodolphe" last="Thiébaut">Rodolphe Thiébaut</name><affiliation><nlm:affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28046052</idno><idno type="pmid">28046052</idno><idno type="doi">10.1371/journal.pone.0169164</idno><idno type="wicri:Area/PubMed/Corpus">001236</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001236</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients.</title><author><name sortKey="Picat, Marie Quitterie" sort="Picat, Marie Quitterie" uniqKey="Picat M" first="Marie-Quitterie" last="Picat">Marie-Quitterie Picat</name><affiliation><nlm:affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pellegrin, Isabelle" sort="Pellegrin, Isabelle" uniqKey="Pellegrin I" first="Isabelle" last="Pellegrin">Isabelle Pellegrin</name><affiliation><nlm:affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bitard, Juliette" sort="Bitard, Juliette" uniqKey="Bitard J" first="Juliette" last="Bitard">Juliette Bitard</name><affiliation><nlm:affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Wittkop, Linda" sort="Wittkop, Linda" uniqKey="Wittkop L" first="Linda" last="Wittkop">Linda Wittkop</name><affiliation><nlm:affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Proust Lima, Cecile" sort="Proust Lima, Cecile" uniqKey="Proust Lima C" first="Cécile" last="Proust-Lima">Cécile Proust-Lima</name><affiliation><nlm:affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Liquet, Benoit" sort="Liquet, Benoit" uniqKey="Liquet B" first="Benoît" last="Liquet">Benoît Liquet</name><affiliation><nlm:affiliation>Laboratoire de Mathématiques et de leurs Applications, Université de Pau et des Pays de l'Adour, UMR CNRS 5142, Pau, France.</nlm:affiliation></affiliation></author><author><name sortKey="Moreau, Jean Francois" sort="Moreau, Jean Francois" uniqKey="Moreau J" first="Jean-François" last="Moreau">Jean-François Moreau</name><affiliation><nlm:affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name><affiliation><nlm:affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Blanco, Patrick" sort="Blanco, Patrick" uniqKey="Blanco P" first="Patrick" last="Blanco">Patrick Blanco</name><affiliation><nlm:affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Thiebaut, Rodolphe" sort="Thiebaut, Rodolphe" uniqKey="Thiebaut R" first="Rodolphe" last="Thiébaut">Rodolphe Thiébaut</name><affiliation><nlm:affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Algorithms</term><term>Anti-Retroviral Agents (therapeutic use)</term><term>Antigens, CD38 (metabolism)</term><term>Autoimmunity (immunology)</term><term>CD4-Positive T-Lymphocytes (immunology)</term><term>CD8-Positive T-Lymphocytes (immunology)</term><term>Chronic Disease</term><term>Cohort Studies</term><term>Cross-Sectional Studies</term><term>Cytomegalovirus</term><term>Female</term><term>France</term><term>HIV Infections (immunology)</term><term>HIV Infections (therapy)</term><term>HLA-DR Antigens (metabolism)</term><term>Humans</term><term>Interferon-alpha (immunology)</term><term>Lymphocyte Activation</term><term>Male</term><term>Middle Aged</term><term>Models, Statistical</term><term>Multivariate Analysis</term><term>RNA, Ribosomal, 16S (metabolism)</term><term>Risk Factors</term><term>T-Lymphocytes (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Interferon-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, CD38</term><term>HLA-DR Antigens</term><term>RNA, Ribosomal, 16S</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Retroviral Agents</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Autoimmunity</term><term>CD4-Positive T-Lymphocytes</term><term>CD8-Positive T-Lymphocytes</term><term>HIV Infections</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Algorithms</term><term>Chronic Disease</term><term>Cohort Studies</term><term>Cross-Sectional Studies</term><term>Cytomegalovirus</term><term>Female</term><term>France</term><term>Humans</term><term>Lymphocyte Activation</term><term>Male</term><term>Middle Aged</term><term>Models, Statistical</term><term>Multivariate Analysis</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To unravel the complex relationships between cytomegalovirus-induced-, autoimmune-induced responses, microbial translocation and chronic immune activation (CIA) in successfully treated HIV-infected patients and to explore the mediating role of alpha-interferon in these processes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28046052</PMID><DateCreated><Year>2017</Year><Month>01</Month><Day>03</Day></DateCreated><DateCompleted><Year>2017</Year><Month>09</Month><Day>06</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>12</Volume><Issue>1</Issue><PubDate><Year>2017</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients.</ArticleTitle><Pagination><MedlinePgn>e0169164</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0169164</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To unravel the complex relationships between cytomegalovirus-induced-, autoimmune-induced responses, microbial translocation and chronic immune activation (CIA) in successfully treated HIV-infected patients and to explore the mediating role of alpha-interferon in these processes.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Cross-sectional study nested in the ANRS CO3 Aquitaine Cohort, a prospective hospital-based cohort of HIV-1-infected patients in South-Western France.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Patients initiated antiretroviral therapy between 2005 and 2008 and were treated with sustained virological suppression for at least two years. CIA was defined by the percentage of HLA-DR+/CD38+ among CD8+T-cells. Integrative analyses were performed using structural equation modelling (SEM).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The main analysis was performed in 57 HLA-A*0201 positive patients, due to availability of percentages of actin-, vimentin-, lamin-specific CD8+T-cells (HLA-A2-restricted tests) to further characterize autoimmune response. Cytomegalovirus-induced response was assessed by Quantiferon and pp-65 ELISPOT. SEM revealed a direct effect of cytomegalovirus-induced response on CIA (standardized estimate βstd = 0.56, p-value = 0.0004). The effect of autoimmune-induced response on CIA was indirect through alpha-interferon pathway, assessed by expression levels of 5 alpha-interferon-stimulated genes ADAR, ISG15, IFIT1, Mx1 and OAS1 (effect of autoimmune response on alpha-interferon: βstd = 0.36, p-value = 0.0401; effect of alpha-interferon on CIA: βstd = 0.39, p-value = 0.0044). There was no direct effect of autoimmune-induced response on CIA (p-value = 0.3169). Microbial translocation as measured by 16SrDNA and sCD14 in plasma was not associated with CIA. Results were consistent in 142 patients in whom cytomegalovirus and auto-immunity responses were measured by Quantiferon and anti-nuclear antibodies, respectively. All analyses performed in HLA-A*0201 positive patients and in the overall population revealed a significant effect of IFN-α latent variable on CIA.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The role of cytomegalovirus-induced response on CIA was confirmed as well as the involvement of alpha-interferon on CIA. The indirect effect of auto-immunity response on CIA revealed through the alpha-interferon pathway requires further investigation to confirm the potential role of auto-immunity for CIA in HIV-infected patients.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Picat</LastName><ForeName>Marie-Quitterie</ForeName><Initials>MQ</Initials><AffiliationInfo><Affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Univ. Bordeaux, ISPED, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service d'Information Médicale, USMR, CHU de Bordeaux - Pôle de Santé Publique, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INRIA, Team SISTM, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Vaccine Research Institute-VRI, Hôpital Henri Mondor, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pellegrin</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bitard</LastName><ForeName>Juliette</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wittkop</LastName><ForeName>Linda</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Univ. Bordeaux, ISPED, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service d'Information Médicale, USMR, CHU de Bordeaux - Pôle de Santé Publique, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INRIA, Team SISTM, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Proust-Lima</LastName><ForeName>Cécile</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Univ. Bordeaux, ISPED, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liquet</LastName><ForeName>Benoît</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Laboratoire de Mathématiques et de leurs Applications, Université de Pau et des Pays de l'Adour, UMR CNRS 5142, Pau, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>ARC Centre of Excellence for Mathematical and Statistical Frontiers, Queensland University of Technology (QUT), Brisbane, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moreau</LastName><ForeName>Jean-François</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Univ. Bordeaux, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS, UMR 5164, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bonnet</LastName><ForeName>Fabrice</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Univ. Bordeaux, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service de Médecine Interne et maladies Infectieuses, CHU de Bordeaux, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blanco</LastName><ForeName>Patrick</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Univ. Bordeaux, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS, UMR 5164, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thiébaut</LastName><ForeName>Rodolphe</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Univ. Bordeaux, ISPED, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service d'Information Médicale, USMR, CHU de Bordeaux - Pôle de Santé Publique, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INRIA, Team SISTM, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Vaccine Research Institute-VRI, Hôpital Henri Mondor, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>ANRS CO3 Aquitaine Cohort</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>01</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044966">Anti-Retroviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006684">HLA-DR Antigens</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016898">Interferon-alpha</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012336">RNA, Ribosomal, 16S</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.2.2.5</RegistryNumber><NameOfSubstance UI="D051997">Antigens, CD38</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>BMC Immunol. 2007 Oct 26;8:27</RefSource><PMID Version="1">17963513</PMID></CommentsCorrections><CommentsCorrections 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UI="D015496" MajorTopicYN="N">CD4-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018414" MajorTopicYN="N">CD8-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002908" MajorTopicYN="N">Chronic Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003587" MajorTopicYN="N">Cytomegalovirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N">France</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006684" MajorTopicYN="N">HLA-DR Antigens</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016898" MajorTopicYN="N">Interferon-alpha</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008213" MajorTopicYN="Y">Lymphocyte Activation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015233" MajorTopicYN="N">Models, Statistical</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015999" MajorTopicYN="N">Multivariate Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012336" MajorTopicYN="N">RNA, Ribosomal, 16S</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013601" MajorTopicYN="N">T-Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList><CoiStatement>The authors have declared that no competing interests exist.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>08</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>12</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>1</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>1</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28046052</ArticleId><ArticleId IdType="doi">10.1371/journal.pone.0169164</ArticleId><ArticleId IdType="pii">PONE-D-16-33104</ArticleId><ArticleId IdType="pmc">PMC5207686</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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